Indanomycin : Cluster information
Compound
| Entry name | Indanomycin |
|---|---|
| PKS Type | PKS-NRPS hybrid |
| Starter Unit | L-proline |
| Chain Length | 10 |
| Sugar Unit | none |
| Classification | other |
| Activity | Antibacterial Antiprotozoal Insecticidal Ionophore |
| Composition | C31H43NO4 |
Original source
| Organism | Streptomyces antibioticus |
|---|---|
| Strain | NRRL 8167 |
| Contig | FJ545274 |
PKS/NRPS Module
| 0 |
| ||
| Indano_00160 idmL | 1 |  | malonyl-CoA not conserved HAFHS |
| 2 |  | malonyl-CoA | |
| 3 |  | ethylmalonyl-CoA | |
| Indano_00170 idmM | 4 |  | malonyl-CoA |
| 5 | | malonyl-CoA | |
| Indano_00180 idmN | 6 | | malonyl-CoA |
| 7 | | ethylmalonyl-CoA | |
| 8 | | methylmalonyl-CoA | |
| Indano_00190 idmO | 9 | | malonyl-CoA |
| Indano_00200 idmP | 10 | | methylmalonyl-CoA |
| 11 |  |
Reference
- Biosynthetic origins of the ionophore antibiotic indanomycin.
- Roege KE, Kelly WL[PMID: 19072095]Org Lett. 11 (2009) 297-300
- Analysis of the indanomycin biosynthetic gene cluster from Streptomyces antibioticus NRRL 8167.
- Li C, Roege KE, Kelly WL[PMID: 19301315]Chembiochem. 10 (2009) 1064-72
- Identification of a tetraene-containing product of the indanomycin biosynthetic pathway.
- Rommel KR, Li C, Kelly WL[PMID: 21491871]Org Lett. 13 (2011) 2536-9
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Indanomycin |
|
|
|
|
|
History
- 2012-10-02[Update]
- 2012-08-03[Update]
- 2012-06-04[Release]
