Pactamycin : Cluster information
Compound
| Entry name | Pactamycin |
|---|---|
| PKS Type | TypeI iterative |
| Starter Unit | acetyl-CoA |
| Chain Length | 4 |
| Sugar Unit | none |
| Classification | Aminocyclitol |
| Activity | Antibacterial Antiprotozoal Antitumor Antiviral Toxic |
| Composition | C28H38N4O8 |
Original source
| Organism | Streptomyces pactum |
|---|---|
| Strain | ATCC 27456 (=NBRC 13433) |
| Contig | AB303063 |
PKS/NRPS Module
| Pact_00200 pctS | 1 |  | acetyl-CoA malonyl-CoA |
Reference
- Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation.
- Kudo F, Kasama Y, Hirayama T, Eguchi T[PMID: 17827660]J Antibiot (Tokyo). 60 (2007) 492-503
- Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues.
- Ito T, Roongsawang N, Shirasaka N, Lu W, Flatt PM, Kasanah N, Miranda C, Mahmud T[PMID: 19670201]Chembiochem. 10 (2009) 2253-65
- Biosynthetic studies and genetic engineering of pactamycin analogs with improved selectivity toward malarial parasites.
- Lu W, Roongsawang N, Mahmud T[PMID: 21513878]Chem Biol. 18 (2011) 425-31
- A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin.
- Hirayama A, Eguchi T, Kudo F[PMID: 23744829]Chembiochem. 14 (2013) 1198-203
- Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin.
- Hirayama A, Miyanaga A, Kudo F, Eguchi T[PMID: 26426567]Chembiochem. 16 (2015) 2484-90
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Pactamycin |
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History
- 2016-12-27[Update]
- 2015-02-12[Update]
- 2013-01-16[Release]
