Pyrrolomycin : Cluster information
Compound
| Entry name | Pyrrolomycin |
|---|---|
| PKS Type | PKS-NRPS hybrid |
| Starter Unit | L-proline |
| Chain Length | 3 |
| Sugar Unit | none |
| Classification | Pyrrole Antibiotic |
| Activity | Antibacterial [A, B, C, D, E] Antifungal [A, B, D] Immunopotentiator [B] Toxic [C, D] |
| Composition | A: C4H2Cl2N2O2 B: C11H6Cl4N2O3 C: C11H5Cl4NO2 D: C11H4Cl5NO2 E: C10H5Cl3N2O3 J: C12H6Cl5NO2 Dioxa: C12H6Cl4N2O4 |
Original source
| Organism | Actinosporangium vitaminophilum |
|---|---|
| Strain | ATCC 31673 (=NBRC 14294) |
| Contig | EF140901 |
PKS/NRPS Module
| 0 |
| ||
| Pyrlo_00250 pyr25 | 1 |  | malonyl-CoA not conserved HAFHS(H->Y) |
| 2 |  | ||
| Pyrlo_00240 pyr24 | 3 |  | malonyl-CoA |
Reference
- Cloning and characterization of the pyrrolomycin biosynthetic gene clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. strain UC 11065.
- Zhang X, Parry RJ[PMID: 17158935]Antimicrob Agents Chemother. 51 (2007) 946-57
- Draft Genome Sequence of Streptomyces vitaminophilus ATCC 31673, a Producer of Pyrrolomycin Antibiotics, Some of Which Contain a Nitro Group.
- Mahan KM, Klingeman DM, Hettich RL, Parry RJ, Graham DE[PMID: 26798098]Genome Announc. 4 (2016)
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Pyrrolomycin |
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History
- 2016-12-27[Update]
- 2016-01-27[Update]
- 2012-10-02[Update]
- 2012-06-04[Release]
