Geldanamycin : Cluster information
Compound
Entry name | Geldanamycin |
---|---|
PKS Type | TypeI modular |
Starter Unit | 3-amino-5-hydroxybenzoic acid (AHBA) |
Chain Length | 8 |
Sugar Unit | none |
Classification | Ansamycin |
Activity | Antitumor Antivirus |
Composition | C29H40N2O9 |
Original source
Organism | Streptomyces geldanamycininus |
---|---|
Strain | NRRL 3602 (=NBRC 14620) |
Contig | AY952143 AY179507 |
PKS/NRPS Module
Gelda2_00080 gdmAI | 0 | ||
1 | methylmalonyl-CoA | ||
2 | methoxymalonyl-ACP | ||
3 | methylmalonyl-CoA | ||
Gelda2_00090 gdmAII | 4 | methylmalonyl-CoA | |
5 | methoxymalonyl-ACP | ||
Gelda2_00100 gdmAIII | 6 | malonyl-CoA | |
7 | methylmalonyl-CoA |
Reference
- Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.
- Rascher A, Hu Z, Viswanathan N, Schirmer A, Reid R, Nierman WC, Lewis M, Hutchinson CR[PMID: 12586396]FEMS Microbiol Lett. 218 (2003) 223-30
- Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.
- Rascher A, Hu Z, Buchanan GO, Reid R, Hutchinson CR[PMID: 16085885]Appl Environ Microbiol. 71 (2005) 4862-71
- Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum.
- Kubota T, Brunjes M, Frenzel T, Xu J, Kirschning A, Floss HG[PMID: 16927319]Chembiochem. 7 (2006) 1221-5
- Production of ansamycin polyketide precursors in Escherichia coli.
- Rude MA, Khosla C[PMID: 17080682]J Antibiot (Tokyo). 59 (2006) 464-70
- The missing C-17 O-methyltransferase in geldanamycin biosynthesis.
- Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B[PMID: 21682254]Org Lett. 13 (2011) 3726-9
Data download
History
- 2013-12-27[Release]