Chemical Management

Evaluation of Biodegradation and Bioconcentraion

日本語で表示

By analyzing the biodegradation and bioconcentration data under Chemical Substances Control Law (CSCL), the National Institute of Technology and Evaluation (NITE) considers the applicability of Quantitative Structure-Activity Relationship (QSAR) and category approaches for CSCL and the expanding role of these methods in regulatory settings.

Providing reference materials for the assessment of new chemical substances

NITE uses QSAR models validated by the NITE QSAR committees and category approach methods developed by NITE to provide reference materials to the Chemical Substances Council that assesses new chemical substances.

Assessment of the adequacy of the new chemical substances data from analogue

NITE assesses the adequacy of the data from the analogue submitted by manufacturers for new chemical substances notification based on predictions from QSAR models or the category approach and submits the result to the Chemical Substances Council.

Cooperation for rationalization of the review of new chemical substances

NITE cooperates for rationalization of the review of new chemical substances with the Ministry of Economy, Trade and Industry (METI) as experts. This collaboration enabled the clarification of the analogue rule regarding new chemical substances notification.

Prediction of bioconcentration by category approach

Prediction of bioconcentration by category approach

Release of biodegradation and bioconcentration data, and application

The Ministry of Economy, Trade, and Industry (METI) is conducting an examination of the biodegradation and bioconcentration of existing chemical substances for which data are available. As for new chemical substances (including degraded products that are exciting chemical substances), some biodegradation and bioconcentration data have been published. NITE processes those data and releases them for analysis. Please use these data for new chemical substances notification using analogue and analysis of QSAR.

Existing chemical substances

Newly announced chemical substances

Reference

Download the latest version of Adobe Reader (free)Get ADOBE READER to open and view PDF documents

Contact us

 Safety Assessment Division,  Chemical Management Center,  National Institute of Technology and Evaluation
Phone number:+81-3-3481-1735
Fax number:+81-3-3481-1950
Address:2-49-10 Nishihara, Shibuya-ku, Tokyo, 151-0066, Japan MAP
Contact Form