Evaluation of Biodegradation and Bioconcentraion

By analyzing the biodegradation and bioconcentration data under Chemical Substances Control Law (CSCL), the National Institute of Technology and Evaluation (NITE) considers the applicability of Quantitative Structure-Activity Relationship (QSAR) and category approaches for CSCL and the expanding role of these methods in regulatory settings.

Providing reference materials for the assessment of new chemical substances

NITE uses QSAR models validated by the NITE QSAR committees and category approach methods to provide reference materials to the Chemical Substances Council that assesses new chemical substances.

Assessment of the adequacy of the new chemical substances data from analogue

NITE assesses the adequacy of the data from the analogue submitted by manufacturers for new chemical substances notification based on predictions from QSAR models or the category approach and submits the result to the Chemical Substances Council.

• Trend analysis for biodegradation of aliphatic amines
• Attachment: The list of aliphatic amines

Cooperation for rationalization of the review of new chemical substances

NITE cooperates for rationalization of the review of new chemical substances with the Ministry of Economy, Trade and Industry (METI) as experts. This collaboration enabled the clarification of the analogue rule regarding new chemical substances notification.

• ▶ Judgment based on analogue for bioconcentration of new chemical substances
• ▶ Judgment of bioconcentration of new chemical substances having ion dissociable group
• Study of the Concentration Dependence of the Bioconcentration Factor for fish

Prediction of bioconcentration by category approach

Prediction of bioconcentration by category approach

The biodegradation and bioconcentration data under CSCL

Biodegradation and bioconcentration data conducted for the evaluations of new chemicals and existing chemicals under CSCL are available in OECD QSAR Toolbox version 3.0 data format (excel file).

Existing chemical substances

• The result of biodegradation
• The result of bioconcentration (revised on March 29, 2023)

Newly announced chemical substances

• The result of bioconcentration (judged in 2004-2007)
• The result of Log Pow (judged in 2004-2007)

Reference

• Publications
• Presentation materials etc.

Update

As of March 29, 2023.