遺伝子 : Kanamycin nucleotidyltransferase (ANT4)

遺伝子情報

ID	NRULE_0152
遺伝子ID	ANT4
作成日	2013/03/06
タンパク質名	Protein name Full Kanamycin nucleotidyltransferase EC EC 2.7.7.-
遺伝子名	knt, aadD
遺伝子条件	PFAM; PF07827; hit=1
参照	Gene Ontology GO GO:0016779, F:nucleotidyltransferase activity, IEA:InterPro GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Family and domain databases InterPro IPR012481, KNTase_C IPR002934, Nucleotidyltransferase Pfam PF07827, KNTase_C, 1 PF01909, NTP_transf_2, 1
配列の特徴	該当データなし
注釈	Function Inactivates the antibiotic kanamycin by catalyzing the transfer of a nucleotidyl group from nucleoside triphosphates such as ATP to the 4'-hydroxyl group of the aminoglycoside Subunit structure Homodimer
参考文献	P05057 Staphylococcus aureus. 8218273 Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-A resolution. (Biochemistry. 1993) P05058 Bacillus sp. 6090428 Enzymatic and nucleotide sequence studies of a kanamycin-inactivating enzyme encoded by a plasmid from thermophilic bacilli in comparison with that encoded by plasmid pUB110. (J Bacteriol. 1984)

関与する機能

機能名
Aminoglycoside resistance (by aminoglycoside O-nucleotidyltransferase)
Kanamycin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Anaerolinea thermophila	100420	ANT_24680	putative kanamycin nucleotidyltransferase
Brevibacillus brevis	100599	BBR47_43230	probable aminoglycoside nucleotidyltransferase
Meiothermus ruber	106122	Mrub_0554	hypothetical protein
Meiothermus silvanus	106475	Mesil_0540	aminoglycoside nucleotidyltransferase
Paenibacillus alvei	3343	PAV_9c01760	KNTase C-terminal domain protein
Paenibacillus polymyxa	15309	PPT_08495	kanamycin nucleotidyltransferase