遺伝子 : D-alanine--D-serine ligase (VANC)

遺伝子情報

ID	NRULE_0268
遺伝子ID	VANC
作成日	2014/06/27
タンパク質名	Protein name Full D-alanine--D-serine ligase Short D-Ala--D-Ser ligase EC EC 6.3.2.-
遺伝子名	該当データなし
遺伝子条件	HAMAP; MF_00047; hit=1ANDBLASTP; Q47720; hit=1; score=900; pid=50
参照	Gene Ontology GO GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell GO:0005524, F:ATP binding, IEA:UniProtKB-HAMAP GO:0008716, F:D-alanine-D-alanine ligase activity, IEA:UniProtKB-HAMAP GO:0000287, F:magnesium ion binding, IEA:UniProtKB-HAMAP GO:0030145, F:manganese ion binding, IEA:UniProtKB-HAMAP GO:0009252, P:peptidoglycan biosynthetic process, IEA:UniProtKB-HAMAP GO:0008360, P:regulation of cell shape, IEA:UniProtKB-KW Enzyme and pathway databases BioCyc MetaCyc:MONOMER-15465, - UniPathway UPA00219, - Family and domain databases HAMAP MF_00047, Dala_Dala_lig, 1 InterPro IPR011761, ATP-grasp IPR013815, ATP_grasp_subdomain_1 IPR013816, ATP_grasp_subdomain_2 IPR000291, D-Ala_lig_Van_CS IPR005905, D_ala_D_ala IPR011095, Dala_Dala_lig_C IPR011127, Dala_Dala_lig_N IPR016185, PreATP-grasp_dom Pfam PF07478, Dala_Dala_lig_C, 1 PF01820, Dala_Dala_lig_N, 1 TIGRFAMs TIGR01205, D_ala_D_alaTIGR, 1 PROSITE PS50975, ATP_GRASP, 1 PS00843, DALA_DALA_LIGASE_1, 1 PS00844, DALA_DALA_LIGASE_2, 1
配列の特徴	Q47720 Enterococcus casseliflavus (Enterococcus flavescens). NP_BIND 171 - 226 ATP (By similarity). METAL 297 Magnesium or manganese 1 (By similarity). METAL 310 Magnesium or manganese 1 (By similarity). METAL 310 Magnesium or manganese 2 (By similarity). METAL 312 Magnesium or manganese 2 (By similarity).
注釈	Function Cell wall formation (By similarity) Catalytic activity ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine Cofactor Binds 2 magnesium or manganese ions per subunit (By similarity) Pathway Cell wall biogenesis; peptidoglycan biosynthesis Sequence similarities Belongs to the D-alanine--D-alanine ligase family Contains 1 ATP-grasp domain Contains ATP-grasp domain
参考文献	Q47720 Enterococcus casseliflavus (Enterococcus flavescens). 9294159 Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase. (Proc Natl Acad Sci U S A. 1997)

関与する機能

機能名
Vancomycin resistance (via D-Ala-D-Ser precursor)

該当CDS

学名	NBRC番号	CDS	タンパク質名
Enterococcus gilvus	100696	I592_01343	hypothetical protein
Enterococcus pallens	100697	I588_03704	hypothetical protein