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機能 : 4-hydroxyphenylacetate degradation

機能情報

ID NFUNC_0068
作成日 2013/04/18
説明 Degrading 4-hydroxyphenylacetate by first converting it into 3,4-dihydroxyphenylacetate (homoprotocatechuate), which is then degraded into TCA cycle intermediates via an inducible meta-cleavage pathway.
コメント
Subunit structure
4-HPA 3-monooxygenase consists of a reductase component (NRULE_0085 or NRULE_0086) and an oxygenase component (flavin reductase) (NRULE_0101 or NRULE_0102)
参照 UniPathway UPA00208
KEGG Pathway Tyrosine metabolism

機能構成

タイプパターン 構成遺伝子
4-hydroxyphenylacetate degradation(NFUNC_0068)
必須A
HPAB1
(NRULE_0085)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
HPAC
(NRULE_0102)
4-hydroxyphenylacetate 3-monooxygenase reductase component
HPAD1
(NRULE_0193)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
B
HPAB1
(NRULE_0085)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
HPAC
(NRULE_0102)
4-hydroxyphenylacetate 3-monooxygenase reductase component
HPAD2
(NRULE_0194)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
C
HPAB1
(NRULE_0085)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
FADR1
(NRULE_0101)
NADH-dependent flavin reductase
HPAD1
(NRULE_0193)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
D
HPAB1
(NRULE_0085)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
FADR1
(NRULE_0101)
NADH-dependent flavin reductase
HPAD2
(NRULE_0194)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
E
HPAB2
(NRULE_0086)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
FADR1
(NRULE_0101)
NADH-dependent flavin reductase
HPAD2
(NRULE_0194)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
F
HPAB2
(NRULE_0086)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
FADR1
(NRULE_0101)
NADH-dependent flavin reductase
HPAD1
(NRULE_0193)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
G
HPAB2
(NRULE_0086)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
HPAC
(NRULE_0102)
4-hydroxyphenylacetate 3-monooxygenase reductase component
HPAD2
(NRULE_0194)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
H
HPAB2
(NRULE_0086)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
HPAC
(NRULE_0102)
4-hydroxyphenylacetate 3-monooxygenase reductase component
HPAD1
(NRULE_0193)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase

機能が推定される微生物

学名NBRC番号
Enterobacter hormaechei105718
Escherichia coli13500
Escherichia coli3972
Escherichia fergusonii102419