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Function : 4-hydroxyphenylacetate degradation

Function Description

ID NFUNC_0068
Created 2013-04-18
Description Degrading 4-hydroxyphenylacetate by first converting it into 3,4-dihydroxyphenylacetate (homoprotocatechuate), which is then degraded into TCA cycle intermediates via an inducible meta-cleavage pathway.
Comment
Subunit structure
4-HPA 3-monooxygenase consists of a reductase component (NRULE_0085 or NRULE_0086) and an oxygenase component (flavin reductase) (NRULE_0101 or NRULE_0102)
Cross Reference UniPathway UPA00208
KEGG Pathway Tyrosine metabolism

Function Constitution

TypePattern Component Gene
4-hydroxyphenylacetate degradation(NFUNC_0068)
RequireA
HPAB1
(NRULE_0085)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
HPAC
(NRULE_0102)
4-hydroxyphenylacetate 3-monooxygenase reductase component
HPAD1
(NRULE_0193)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
B
HPAB1
(NRULE_0085)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
HPAC
(NRULE_0102)
4-hydroxyphenylacetate 3-monooxygenase reductase component
HPAD2
(NRULE_0194)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
C
HPAB1
(NRULE_0085)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
FADR1
(NRULE_0101)
NADH-dependent flavin reductase
HPAD1
(NRULE_0193)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
D
HPAB1
(NRULE_0085)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
FADR1
(NRULE_0101)
NADH-dependent flavin reductase
HPAD2
(NRULE_0194)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
E
HPAB2
(NRULE_0086)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
FADR1
(NRULE_0101)
NADH-dependent flavin reductase
HPAD2
(NRULE_0194)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
F
HPAB2
(NRULE_0086)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
FADR1
(NRULE_0101)
NADH-dependent flavin reductase
HPAD1
(NRULE_0193)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
G
HPAB2
(NRULE_0086)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
HPAC
(NRULE_0102)
4-hydroxyphenylacetate 3-monooxygenase reductase component
HPAD2
(NRULE_0194)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase
H
HPAB2
(NRULE_0086)
4-hydroxyphenylacetate 3-monooxygenase oxygenase component
HPAC
(NRULE_0102)
4-hydroxyphenylacetate 3-monooxygenase reductase component
HPAD1
(NRULE_0193)
Homoprotocatechuate 2,3-dioxygenase
HPAE
(NRULE_0195)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
HPAF
(NRULE_0196)
5-carboxymethyl-2-hydroxymuconate Delta-isomerase
HPAG
(NRULE_0197)
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
HPAH
(NRULE_0198)
2-oxo-hepta-3-ene-1,7-dioate hydratase
HPAI
(NRULE_0199)
2,4-dihydroxyhept-2-ene-1,7-dioate aldolase

Potential Functional Microbe

Scientific nameNBRC No.
Enterobacter hormaechei105718
Escherichia coli13500
Escherichia coli3972
Escherichia fergusonii102419