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遺伝子 : Anthranilate 1,2-dioxygenase large subunit (ANTA)

遺伝子情報

ID NRULE_0044
遺伝子ID ANTA
作成日 2012/08/21
タンパク質名
Protein name
Full
Anthranilate 1,2-dioxygenase large subunit
EC
EC 1.14.12.1
遺伝子名 antA
遺伝子条件 TIGRFAMs; TIGR03228; hit=1
参照
Gene Ontology
GO
GO:0051537, F:2 iron, 2 sulfur cluster binding, IEA:UniProtKB-KW
GO:0018618, F:anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity, IEA:EC
GO:0005506, F:iron ion binding, IEA:InterPro
GO:0016702, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, IEA:UniProtKB-KW
GO:0019439, P:aromatic compound catabolic process, IEA:UniProtKB-KW
Enzyme and pathway databases
UniPathway
UPA01016, UER01026
Family and domain databases
InterPro
IPR017638, Anthranilate_1-2-diOase_lsu
IPR017941, Rieske_2Fe-2S
IPR015881, Ring-hydroxy_dOase_2Fe2S_BS
IPR015879, Ring_hydroxy_dOase_asu_C_dom
IPR001663, Rng_hydr_dOase-A
Pfam
PF00355, Rieske, 1
PF00848, Ring_hydroxyl_A, 1
PRINTS
PR00090, RNGDIOXGNASE
TIGRFAMs
TIGR03228, Anthran_1_2_A, 1
PROSITE
PS51296, RIESKE, 1
PS00570, RING_HYDROXYL_ALPHA, 1
配列の特徴
O85673 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
METAL93Iron-sulfur (2Fe-2S).
METAL95Iron-sulfur (2Fe-2S); via pros nitrogen.
METAL113Iron-sulfur (2Fe-2S) .
METAL116Iron-sulfur (2Fe-2S); via pros nitrogen .
METAL220Iron .
METAL225Iron .
METAL379Iron .
注釈
Function
Component of anthranilate dioxygenase multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into anthranilate to form catechol.
Catalytic activity
Anthranilate + NAD(P)H + O(2) = catechol + CO(2) + NAD(P)(+) + NH(3).
Cofactor
Binds 1 2Fe-2S cluster
Binds 1 Fe cation
Pathway
Aromatic compound metabolism; benzoate degradation via hydroxylation; catechol from anthranilate: step 1/1.
Subunit structure
The anthranilate dioxygenase multicomponent enzyme system is composed of the oxygenase component (two subunits) and the electron transfer component (ferredoxin and ferredoxin reductase).
Sequence similarities
Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family
Contains 1 Rieske domain
参考文献
O85673 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
9721284
Similarities between the antABC-encoded anthranilate dioxygenase and the benABC-encoded benzoate dioxygenase of Acinetobacter sp. strain ADP1. (J Bacteriol. 1998)
11114907
Characterization and evolution of anthranilate 1,2-dioxygenase from Acinetobacter sp. strain ADP1. (J Bacteriol. 2001)
14622009
Histidine ligand protonation and redox potential in the rieske dioxygenases: role of a conserved aspartate in anthranilate 1,2-dioxygenase. (Biochemistry. 2003)
Q84BZ3 Burkholderia cepacia (Pseudomonas cepacia).
13129960
Characterization and regulation of the genes for a novel anthranilate 1,2-dioxygenase from Burkholderia cepacia DBO1. (J Bacteriol. 2003)



関与する機能

機能名
Anthranilate degradation (via hydroxylation)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acinetobacter radioresistens102413ACRAD_20_01460anthranilate 1,2-dioxygenase large subunit
Shimwellia blattae105725EB105725_04_000703-phenylpropionate/cinnamic acid dioxygenase alpha subunit