遺伝子 : Metallo-beta-lactamase (BLAB)

遺伝子情報

ID	NRULE_0123
遺伝子ID	BLAB
作成日	2013/01/28
タンパク質名	Protein name Full Metallo-beta-lactamase EC EC 3.5.2.6 Synonym Full beta-lactamase class B
遺伝子名	該当データなし
遺伝子条件	PROSITE; PS00743; hit=1ANDPROSITE; PS00744; hit=1
参照	Gene Ontology GO GO:0008800, F:beta-lactamase activity, IEA:EC GO:0008270, F:zinc ion binding, IEA:InterPro GO:0017001, P:antibiotic catabolic process, IEA:InterPro GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Family and domain databases InterPro IPR001279, Beta-lactamas-like IPR001018, Beta-lactamase_class-B_CS Pfam PF00753, Lactamase_B, 1 SMART SM00849, Lactamase_B, 1 PROSITE PS00743, BETA_LACTAMASE_B_1, 1 PS00744, BETA_LACTAMASE_B_2, 1
配列の特徴	P04190 Bacillus cereus. METAL 116 Zinc 1; high-affinity. METAL 118 Zinc 1; high-affinity. METAL 120 Zinc 2; low-affinity. METAL 179 Zinc 1; high-affinity. METAL 198 Zinc 2; low-affinity. METAL 240 Zinc 2; low-affinity.
注釈	Catalytic activity A beta-lactam + H(2)O = a substituted beta-amino acid Cofactor Binds 2 zinc ions per subunit Subunit structure Monomer Sequence similarities Belongs to the class-B beta-lactamase family
参考文献	P25910 Bacteroides fragilis. 2121094 Cloning and sequencing of the class B beta-lactamase gene (ccrA) from Bacteroides fragilis TAL3636. (Antimicrob Agents Chemother. 1990) P04190 Bacillus cereus. 3930467 Cloning and sequencing of the metallothioprotein beta-lactamase II gene of Bacillus cereus 569/H in Escherichia coli. (J Bacteriol. 1985)

関与する機能

機能名
Ampicillin resistance
Beta-lactam antibiotic resistance
Cephalosporin resistance
Penicillin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Bacillus amyloliquefaciens	15535	BAMF_1259	Blm
Bacillus cereus	15305	BC_3440	Beta-lactamase, type II
Bacillus pseudomycoides	101232	bpmyx0001_25330	Blm
Bacillus thuringiensis	101235	bthur0008_31560	Beta-lactamase 2