遺伝子 : Methicillin resistance regulatory protein MecI (MECI)

遺伝子情報

ID	NRULE_0131
遺伝子ID	MECI
作成日	2013/02/12
タンパク質名	Protein name Full Methicillin resistance regulatory protein MecI
遺伝子名	mecI
遺伝子条件	BLASTP; P68261; hit=1; score=590; pid=98
参照	Gene Ontology GO GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell GO:0003677, F:DNA binding, IEA:UniProtKB-KW GO:0045892, P:negative regulation of transcription, DNA-dependent, IEA:InterPro GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW GO:0006351, P:transcription, DNA-dependent, IEA:UniProtKB-KW Phylogenomic databases KO K02546, - Family and domain databases InterPro IPR005650, BlaI_family IPR011991, WHTH_trsnscrt_rep_DNA-bd Pfam PF03965, Pencillinase_R, 1 PIRSF PIRSF019455, CopR_AtkY, 1
配列の特徴	P68261 Staphylococcus aureus (strain N315). DNA_BIND 7 - 71 H-T-H motif winged type. SITE 101 - 102 Cleavage (By similarity).
注釈	Function Transcriptional repressor that constitutively blocks the transcription of the gene for the penicillin-binding protein MecA. Binds palindromic DNA with the sequence 5'-TACA-[AT]-N-TGTA-3'. Regulates genes involved in antibiotic resistance. Binds DNA as a dimer Subunit structure Monomer and homodimer Subcellular location Cytoplasm (Probable) Sequence similarities Belongs to the BlaI transcriptional regulatory family
参考文献	P68261 Staphylococcus aureus (strain N315). 1544435 Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA). (FEBS Lett. 1992)

関与する機能

機能名
Methicillin resistance

該当CDS