| ID |
NRULE_0145 |
| 遺伝子ID |
SUL |
| 作成日 |
2013/02/20 |
| タンパク質名 |
Protein name
- Full
- Sulfonamide-resistant dihydropteroate synthase
- EC
- EC 2.5.1.15
Synonym
- Full
- Dihydropteroate pyrophosphorylase
- Short
- DHPS
|
| 遺伝子名 |
sulI, sulII, sulA |
| 遺伝子条件 |
BLASTP; Q49184; hit=1; score=500; pid=50 OR BLASTP; P05382; hit=1; score=1400; pid=90 |
| 参照 |
Gene Ontology
- GO
- GO:0004156, F:dihydropteroate synthase activity, IDA:MTBBASE
- GO:0046872, F:metal ion binding, IEA:UniProtKB-KW
- GO:0046656, P:folic acid biosynthetic process, IEA:UniProtKB-KW
- GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
- GO:0046654, P:tetrahydrofolate biosynthetic process, IEA:UniProtKB-UniPathway
Family and domain databases
- InterPro
- IPR006390, DHP_synth
- IPR000489, Pterin-binding
- Pfam
- PF00809, Pterin_bind, 1
- TIGRFAMs
- TIGR01496, DHPS, 1
- PROSITE
- PS00792, DHPS_1, 1
- PS00793, DHPS_2, 1
- PS50972, PTERIN_BINDING, 1
|
| 配列の特徴 |
| METAL | 9 | Magnesium (By similarity). |
| BINDING | 17 | Substrate (By similarity). |
| BINDING | 82 | Substrate (By similarity). |
| BINDING | 101 | Substrate (By similarity). |
| BINDING | 173 | Substrate (By similarity). |
| BINDING | 212 | Substrate (By similarity). |
| BINDING | 246 | Substrate (By similarity). |
| BINDING | 248 | Substrate (By similarity). |
|
| 注釈 |
- Function
- DHPS catalyzes the formation of the immediate precursor of folic acid. Implicated in resistance to sulfonamide. The type II enzyme is stable whereas type I DHPS loses its activity rapidly
- Catalytic activity
- (2-amino-4-hydroxy-7,8-dihydropteridin-6- yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate
- Cofactor
- Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate (By similarity)
- Pathway
- Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate and 4-aminobenzoate: step 1/2
- Subunit structure
- Homodimer or homotrimer
- Sequence similarities
- Belongs to the DHPS family
Contains 1 pterin-binding domain
|
| 参考文献 |
- Q49184 Mycobacterium fortuitum.
- 2163027
- Transposition of an antibiotic resistance element in mycobacteria. (Nature. 1990)
- P0C002 Escherichia coli.
- 3054482
- Site-specific recombination promotes linkage between trimethoprim- and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21. (Mol Gen Genet. 1988)
- P05382 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
- 3114239
- Sulfonamide resistance in Streptococcus pneumoniae: DNA sequence of the gene encoding dihydropteroate synthase and characterization of the enzyme. (J Bacteriol. 1987)
|
