遺伝子 : Hygromycin-B 4-O-kinase (HPH)

遺伝子情報

ID	NRULE_0174
遺伝子ID	HPH
作成日	2013/03/21
タンパク質名	Protein name Full Hygromycin-B 4-O-kinase EC EC 2.7.1.163 Synonym Full APH(4) Hygromycin B phosphotransferase Hygromycin-B kinase
遺伝子名	hph
遺伝子条件	BLASTP; P00557; hit=1; score=400; pid=35
参照	Gene Ontology GO GO:0005524, F:ATP binding, IEA:UniProtKB-KW GO:0016301, F:kinase activity, IEA:UniProtKB-KW GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Family and domain databases InterPro IPR002575, Aminoglycoside_PTrfase Pfam PF01636, APH, 1
配列の特徴	P00557 Escherichia coli. ACT_SITE 198 Proton acceptor (By similarity).
注釈	Function The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin Catalytic activity ATP + hygromycin B = ADP + 4-O- phosphohygromycin B Sequence similarities Belongs to the aminoglycoside phosphotransferase family
参考文献	P00557 Escherichia coli. 6314265 Analysis of a bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing. (Nucleic Acids Res. 1983)

関与する機能

機能名
Aminoglycoside resistance (by aminoglycoside O-phosphotransferase)
Hygromycin resistance

該当CDS

学名	NBRC番号	CDS	タンパク質名
Conexibacter woesei	100937	Cwoe_2613	Hygromycin-B kinase
Ktedonobacter racemifer		Krac_0432	Hygromycin-B kinase