| ID |
NRULE_0179 |
| 遺伝子ID |
GSMT |
| 作成日 |
2013/03/27 |
| タンパク質名 |
Protein name
- Full
- Glycine/sarcosine N-methyltransferase
- EC
- EC 2.1.1.156
|
| 遺伝子名 |
該当データなし |
| 遺伝子条件 |
PIRSF; PIRSF000385; hit=1 |
| 参照 |
Gene Ontology
- GO
- GO:0017174, F:glycine N-meth,yltransferase activity, IDA:UniProtKB
- GO:0052730, F:sarcosine N-methyltransferase activity, IDA:UniProtKB
- GO:0019286, P:glycine betaine biosynthetic process from glycine, IDA:UniProtKB
Enzyme and pathway databases
- BRENDA
- 2.1.1.156;,
- UniPathway
- UPA00530, UER00381
- UPA00530, UER00382
Family and domain databases
- InterPro
- IPR014369, Gly/Sar_N_MeTrfase
- PIRSF
- PIRSF000385, Gly_N-mtase, 1
- PROSITE
- PS51600, SAM_GNMT, 1
|
| 配列の特徴 |
Q83WC4 Aphanothece halophytica.
| BINDING | 28 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 36 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 45 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 69 | S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). |
| BINDING | 90 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 134 | S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). |
| BINDING | 136 | Substrate (By similarity). |
| BINDING | 169 | Substrate (Probable). |
| BINDING | 208 | Substrate (By similarity). |
|
| 注釈 |
- Function
- Catalyzes the methylation of glycine and sarcosine to sarcosine and dimethylglycine, respectively, with S- adenosylmethionine (AdoMet) acting as the methyl donor
- Catalytic activity
- S-adenosyl-L-methionine + glycine = S- adenosyl-L-homocysteine + sarcosine
2 S-adenosyl-L-methionine + glycine = 2 S- adenosyl-L-homocysteine + N,N-dimethylglycine
- Pathway
- Amine and polyamine biosynthesis; betaine biosynthesis via glycine pathway; betaine from glycine: step 1/3
Amine and polyamine biosynthesis; betaine biosynthesis via glycine pathway; betaine from glycine: step 2/3
- Subunit structure
- Monomer
- Sequence similarities
- Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family
|
| 参考文献 |
- Q83WC4 Aphanothece halophytica.
- 12466265
- Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica. (J Biol Chem. 2003)
|
