| ID |
NRULE_0181 |
| 遺伝子ID |
GSDMT |
| 作成日 |
2013/03/27 |
| タンパク質名 |
Protein name
- Full
- Glycine/sarcosine/dimethylglycine N-methyltransferase
- EC
- EC 2.1.1.156
EC 2.1.1.157 Synonym
- Full
- Dimethylglycine N-methyltransferase
|
| 遺伝子名 |
該当データなし |
| 遺伝子条件 |
BLASTP; Q9KJ20; hit=1; score=1500; pid=63 |
| 参照 |
Gene Ontology
- GO
- GO:0052729, F:dimethylglycine N-methyltransferase activity, IDA:UniProtKB
- GO:0017174, F:glycine N-methyltransferase activity, IEA:EC
- GO:0052730, F:sarcosine N-methyltransferase activity, IDA:UniProtKB
- GO:0019286, P:glycine betaine biosynthetic process from glycine, IDA:UniProtKB
Enzyme and pathway databases
- BRENDA
- 2.1.1.156;,
- UniPathway
- UPA00530, UER00381
- UPA00530, UER00382
- UPA00530, UER00383
Family and domain databases
- InterPro
- IPR014369, Gly/Sar_N_MeTrfase
- IPR013216, Methyltransf_11
- Pfam
- PF08241, Methyltransf_11, 1
- PROSITE
- PS51600, SAM_GNMT, 1
|
| 配列の特徴 |
Q9KJ20 Actinopolyspora halophila.
| BINDING | 45 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 53 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 62 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 86 | S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). |
| BINDING | 107 | S-adenosyl-L-methionine (By similarity). |
| BINDING | 152 | S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). |
| BINDING | 154 | Substrate (By similarity). |
| BINDING | 187 | Substrate (By similarity). |
| BINDING | 226 | Substrate (By similarity). |
|
| 注釈 |
- Function
- Catalyzes the methylation of glycine, sarcosine and dimethylglycine to sarcosine, dimethylglycine and betaine, respectively, with S-adenosylmethionine (AdoMet) acting as the methyl donor
- Catalytic activity
- 2 S-adenosyl-L-methionine + glycine = 2 S- adenosyl-L-homocysteine + N,N-dimethylglycine
2 S-adenosyl-L-methionine + sarcosine = 2 S- adenosyl-L-homocysteine + betaine
- Pathway
- Amine and polyamine biosynthesis; betaine biosynthesis via glycine pathway; betaine from glycine: step 1/3
Amine and polyamine biosynthesis; betaine biosynthesis via glycine pathway; betaine from glycine: step 2/3
Amine and polyamine biosynthesis; betaine biosynthesis via glycine pathway; betaine from glycine: step 3/3
- Subunit structure
- Monomer
- Sequence similarities
- Belongs to the class I-like SAM-binding methyltransferase superfamily
|
| 参考文献 |
- Q9KJ20 Actinopolyspora halophila.
- 10896953
- Extreme halophiles synthesize betaine from glycine by methylation. (J Biol Chem. 2000)
|
