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遺伝子 : 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase (HPAG)

遺伝子情報

ID NRULE_0197
遺伝子ID HPAG
作成日 2013/01/23
タンパク質名
Protein name
Full
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase/2-hydroxyhepta-2,4-diene-1,7-dioate Delta-isomerase
Short
OPET decarboxylase/HHDD isomerase
EC
EC 4.1.1.68
EC 5.3.3.-
Synonym
Full
5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase
遺伝子名 hpaG, hpcE
遺伝子条件 TIGRFAMs; TIGR02303; hit=1ANDTIGRFAMs; TIGR02305; hit=1
参照
Gene Ontology
GO
GO:0008704, F:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity, IEA:EC
GO:0018800, F:5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity, IEA:EC
GO:0046872, F:metal ion binding, IEA:UniProtKB-KW
GO:1901023, P:4-hydroxyphenylacetate catabolic process, IEA:InterPro
Phylogenomic databases
KO
K05921, -
Enzyme and pathway databases
UniPathway
UPA00208, UER00419
UPA00208, UER00420
Family and domain databases
InterPro
IPR002529, Fumarylacetoacetase_C
IPR011234, Fumarylacetoacetase_C-rel
IPR012684, HPA_isomer/decarb_C
IPR012686, HPA_isomer/decarb_N
Pfam
PF01557, FAA_hydrolase, 2
TIGRFAMs
TIGR02303, HpaG-C-term, 1
TIGR02305, HpaG-N-term, 1
配列の特徴 該当データなし
注釈
Function
Decarboxylates OPET (5-oxo-pent-3-ene-1,2,5-tricarboxylate) into HHDD (2-hydroxy-hept-2,4-diene-1,7-dioate) and isomerizes it to OHED (2-oxo-hept-3-ene-1,7-dioate)
Catalytic activity
2-oxohept-3-ene-1,7-dioate = 2-hydroxyhepta-2,4-diene-1,7-dioate
5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-ene-1,7-dioate + CO(2)
Cofactor
Magnesium
Pathway
Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 4/7
Aromatic compound metabolism; 4-hydroxyphenylacetate degradation; pyruvate and succinate semialdehyde from 4-hydroxyphenylacetate: step 5/7
Subunit structure
Monomer
Sequence similarities
Belongs to the FAH family
参考文献
P37352 Escherichia coli.
8223600
Purification, nucleotide sequence and some properties of a bifunctional isomerase/decarboxylase from the homoprotocatechuate degradative pathway of Escherichia coli C. (Eur J Biochem. 1993)
11863436
The crystal structure of HpcE, a bifunctional decarboxylase/isomerase with a multifunctional fold. (Biochemistry. 2002)



関与する機能

機能名
4-hydroxyphenylacetate degradation

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Enterobacter cloacae subsp. cloacae13535ECL_007584-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase
Enterobacter hormaechei105718HMPREF9086_18865-carboxymethyl-2-hydroxymuconate delta-isomerase
Escherichia coli3972EcolC_37024-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, HpaG1 subunit
Escherichia coli13500WFL_229604-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase
Escherichia fergusonii102419EFER_30624-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase