| ID |
NRULE_0229 |
| 遺伝子ID |
HAS |
| 作成日 |
2013/06/27 |
| タンパク質名 |
Protein name
- Full
- Hyaluronan synthase
- EC
- EC 2.4.1.212
Synonym
- Full
- Hyaluronate synthase
Hyaluronic acid synthase - Short
- HA synthase
|
| 遺伝子名 |
hasA |
| 遺伝子条件 |
BLASTP; Q5X9A9; hit=1; score=900; pid=45 |
| 参照 |
Gene Ontology
- GO
- GO:0016021, C:integral to membrane, IEA:UniProtKB-KW
- GO:0005886, C:plasma membrane, IEA:UniProtKB-SubCell
- GO:0050501, F:hyaluronan synthase activity, IEA:EC
- GO:0030213, P:hyaluronan biosynthetic process, IEA:UniProtKB-UniPathway
- GO:0009405, P:pathogenesis, IEA:UniProtKB-KW
Phylogenomic databases
- eggNOG
- COG1215, -
- HOGENOM
- HOG000235649, -
- KO
- K00752, -
Enzyme and pathway databases
- UniPathway
- UPA00341, -
Family and domain databases
- InterPro
- IPR001173, Glyco_trans_2
- Pfam
- PF00535, Glycos_transf_2, 1
|
| 配列の特徴 |
該当データなし |
| 注釈 |
- Function
- Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant
- Catalytic activity
- UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan)
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)
- Cofactor
- Magnesium
- Pathway
- Glycan biosynthesis; hyaluronan biosynthesis
- Sequence similarities
- Belongs to the NodC/HAS family
|
| 参考文献 |
- Q5X9A9 Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
- 8366070
- Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes. (J Biol Chem. 1993)
|
