遺伝子 : Hyaluronate lyase (HYSA)

遺伝子情報

ID	NRULE_0232
遺伝子ID	HYSA
作成日	2013/07/23
タンパク質名	Protein name Full Hyaluronate lyase EC EC 4.2.2.1 Synonym Full Hyaluronidase Short HYase
遺伝子名	該当データなし
遺伝子条件	BLASTP; Q53591; hit=1; score=1000; pid=35 OR BLASTP; P0CZ00; hit=1; score=2800; pid=65 OR BLASTP; O86516; hit=1; score=1800; pid=50
参照	Gene Ontology GO GO:0005576, C:extracellular region, IEA:UniProtKB-SubCell GO:0030246, F:carbohydrate binding, IEA:InterPro GO:0030340, F:hyaluronate lyase activity, IEA:EC GO:0005975, P:carbohydrate metabolic process, IEA:InterPro Phylogenomic databases eggNOG NOG305085, - HOGENOM HOG000008667, - KO K01727, - Enzyme and pathway databases BRENDA 4.2.2.1;, Family and domain databases InterPro IPR004103, Lyase_8_C IPR003159, Lyase_8_central_dom IPR012970, Lyase_8_alpha_N Pfam PF02278, Lyase_8, 1 PF02884, Lyase_8_C, 1 PF08124, Lyase_8_N, 1
配列の特徴	Q53591 Streptococcus agalactiae serotype III (strain NEM316). ACT_SITE 429   ACT_SITE 479   ACT_SITE 488
注釈	Catalytic activity Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine Sequence similarities Belongs to the polysaccharide lyase 8 family
参考文献	Q53591 Streptococcus agalactiae serotype III (strain NEM316). 7982914 Cloning and expression of the gene for group B streptococcal hyaluronate lyase. (J Biol Chem. 1994) 11527972 Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase. (J Biol Chem. 2001) P0CZ00 Propionibacterium acnes. 9115089 Cloning and sequencing of the hyaluronate lyase gene from Propionibacterium acnes. (Can J Microbiol. 1997) O86516 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). 21287626 Crystal structures of a family 8 polysaccharide lyase reveal open and highly occluded substrate-binding cleft conformations. (Proteins. 2011)

関与する機能

機能名
Hyaluronan degradation

該当CDS

学名	NBRC番号	CDS	タンパク質名
Streptomyces avermitilis	14893	SAV2704	putative polysaccharide lyase
Streptomyces cattleya	14057	SCAT_4363	putative secreted lyase
Streptomyces clavuligerus	13307	SCLAV_4483	Putative secreted lyase
Streptomyces mobaraensis	13819	H340_10635	putative secreted lyase
Streptomyces purpureus	13925	STRPU_14_03630	Putative secreted lyase
Streptomyces sviceus	13980	SSEG_00502	secreted lyase
Streptomyces venezuelae	13096	SVEN_5221	putative secreted lyase