| ID |
NRULE_0256 |
| 遺伝子ID |
NAHK |
| 作成日 |
2013/12/26 |
| タンパク質名 |
Protein name
- Full
- N-acetylhexosamine 1-kinase
- EC
- EC 2.7.1.162
Synonym
- Full
- N-acetylgalactosamine/N-acetylglucosamine 1-kinase
|
| 遺伝子名 |
nahK |
| 遺伝子条件 |
BLASTP; E8MF12; hit=1; score=1400; pid=70 |
| 参照 |
Gene Ontology
- GO
- GO:0005524, F:ATP binding, IEA:UniProtKB-KW
- GO:0016301, F:kinase activity, IEA:UniProtKB-KW
- GO:0016773, F:phosphotransferase activity, alcohol group as acceptor, IDA:UniProtKB
- GO:0005975, P:carbohydrate metabolic process, IDA:UniProtKB
Phylogenomic databases
- HOGENOM
- HOG000001225, -
- KO
- K13059, -
Enzyme and pathway databases
- BioCyc
- MetaCyc:MONOMER-13865, -
Family and domain databases
- InterPro
- IPR002575, Aminoglycoside_PTrfase
- IPR011009, Kinase-like_dom
- Pfam
- PF01636, APH, 1
- PROSITE
- PS50011, PROTEIN_KINASE_DOM, FALSE_NEG
|
| 配列の特徴 |
該当データなし |
| 注釈 |
- Function
- Phosphorylates both N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) at similar rates. Involved in the lacto-N-biose I/galacto-N-biose (LNB/GNB) degradation pathway, which is important for host intestinal colonization by bifidobacteria. Also accepts GTP and ITP as phosphate donors. In vitro, can phosphorylate several GlcNAc and GalNAc derivatives
- Catalytic activity
- ATP + N-acetyl-D-hexosamine = ADP + N-acetyl-alpha-D-hexosamine 1-phosphate
- Cofactor
- Magnesium
- Sequence similarities
- Belongs to the protein kinase superfamily
Contains 1 protein kinase domain
|
| 参考文献 |
- E8MF12 Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b).
- 17720833
- Identification of N-acetylhexosamine 1-kinase in the complete lacto-N-biose I/galacto-N-biose metabolic pathway in Bifidobacterium longum. (Appl Environ Microbiol. 2007)
- 19683921
- Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives. (Bioorg Med Chem Lett. 2009)
- 19436918
- A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase. (Chem Commun (Camb). 2009)
|
