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遺伝子 : D-specific alpha-keto acid dehydrogenase (VANH)

遺伝子情報

ID NRULE_0266
遺伝子ID VANH
作成日 2014/06/19
タンパク質名
Protein name
Full
D-specific alpha-keto acid dehydrogenase
EC
EC 1.1.1.-
Synonym
Full
D-lactate dehydrogenase
遺伝子名 vanH
遺伝子条件 BLASTP; O33805; hit=1; score=800; pid=50
参照
Gene Ontology
GO
GO:0051287, F:NAD binding, IEA:InterPro
GO:0016616, F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, IEA:InterPro
Family and domain databases
InterPro
IPR006139, D-isomer_2_OHA_DH_cat_dom
IPR006140, D-isomer_2_OHA_DH_NAD-bd
IPR016040, NAD(P)-bd_dom
Pfam
PF00389, 2-Hacid_dh, 1
PF02826, 2-Hacid_dh_C, 1
PROSITE
PS00065, D_2_HYDROXYACID_DH_1, 1
PS00670, D_2_HYDROXYACID_DH_2, 1
PS00671, D_2_HYDROXYACID_DH_3, 1
配列の特徴 該当データなし
注釈
Sequence similarities
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
参考文献
O33805 Streptomyces toyocaensis.
10387095
Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism. (Biochemistry. 1999)



関与する機能

機能名
Vancomycin resistance (via D-Ala-D-Lac precursor)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Amycolatopsis azurea14573C791_3572Vancomycin resistance protein VanH
Amycolatopsis mediterranei13415RAM_42570D-lactate dehydrogenase
Catenulispora acidiphila102108Caci_5794D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Conexibacter woesei100937Cwoe_1413D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Kribbella flavida14399Kfla_3619D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Ktedonobacter racemiferKrac_9314D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Saccharothrix espanaensis15066BN6_49770D-specific alpha-keto acid dehydrogenase
Stackebrandtia nassauensis102104Snas_5355D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Streptomyces sviceus13980SSEG_10120D-isomer specific 2-hydroxyacid dehydrogenase
Tsukamurella paurometabola16120Tpau_0524D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein