Rule : D-specific alpha-keto acid dehydrogenase (VANH)

Rule Description

ID	NRULE_0266
Rule name	VANH
Created	2014-06-19
Protein name	Protein name Full D-specific alpha-keto acid dehydrogenase EC EC 1.1.1.- Synonym Full D-lactate dehydrogenase
Gene name	vanH
Rule Trigger	BLASTP; O33805; hit=1; score=800; pid=50
Cross Reference	Gene Ontology GO GO:0051287, F:NAD binding, IEA:InterPro GO:0016616, F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, IEA:InterPro Family and domain databases InterPro IPR006139, D-isomer_2_OHA_DH_cat_dom IPR006140, D-isomer_2_OHA_DH_NAD-bd IPR016040, NAD(P)-bd_dom Pfam PF00389, 2-Hacid_dh, 1 PF02826, 2-Hacid_dh_C, 1 PROSITE PS00065, D_2_HYDROXYACID_DH_1, 1 PS00670, D_2_HYDROXYACID_DH_2, 1 PS00671, D_2_HYDROXYACID_DH_3, 1
Feature	Not assigned
General annotation	Sequence similarities Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Reference	O33805 Streptomyces toyocaensis. 10387095 Molecular mechanism of VanHst, an alpha-ketoacid dehydrogenase required for glycopeptide antibiotic resistance from a glycopeptide producing organism. (Biochemistry. 1999)

Function name
Vancomycin resistance (via D-Ala-D-Lac precursor)


Scientific name	NBRC No.	CDS	Product name
Amycolatopsis azurea	14573	C791_3572	Vancomycin resistance protein VanH
Amycolatopsis mediterranei	13415	RAM_42570	D-lactate dehydrogenase
Catenulispora acidiphila	102108	Caci_5794	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Conexibacter woesei	100937	Cwoe_1413	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Kribbella flavida	14399	Kfla_3619	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Ktedonobacter racemifer		Krac_9314	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Saccharothrix espanaensis	15066	BN6_49770	D-specific alpha-keto acid dehydrogenase
Stackebrandtia nassauensis	102104	Snas_5355	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein
Streptomyces sviceus	13980	SSEG_10120	D-isomer specific 2-hydroxyacid dehydrogenase
Tsukamurella paurometabola	16120	Tpau_0524	D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein