English site

遺伝子 : D-alanyl-D-alanine carboxypeptidase (VANYA)

遺伝子情報

ID NRULE_0274
遺伝子ID VANYA
作成日 2014/06/30
タンパク質名
Protein name
Full
D-alanyl-D-alanine carboxypeptidase
Short
D-Ala-D-Ala carboxypeptidase
D,D-carboxypeptidase
EC
EC 3.4.16.4
遺伝子名 vanY
遺伝子条件 BLASTP; P37711; hit=1; score=600; pid=50
参照
Gene Ontology
GO
GO:0016021, C:integral component of membrane, IEA:UniProtKB-KW
GO:0005886, C:plasma membrane, IEA:UniProtKB-SubCell
GO:0009002, F:serine-type D-Ala-D-Ala carboxypeptidase activity, IEA:UniProtKB-EC
GO:0009252, P:peptidoglycan biosynthetic process, IEA:UniProtKB-KW
GO:0008360, P:regulation of cell shape, IEA:UniProtKB-KW
GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Family and domain databases
InterPro
IPR009045, Hedgehog_sig/DD-Pept_Zn-bd_dom
IPR003709, Pept_M15B/M15C
Pfam
PF02557, VanY, 1
配列の特徴 該当データなし
注釈
Function
Vancomycin-inducible, penicillin-resistant, DD-carboxypeptidase that hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors. Insensitive to beta-lactams
Catalytic activity
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine
Sequence similarities
Belongs to the peptidase M15B family
参考文献
P37711 Enterococcus faecium (Streptococcus faecium).
1398115
Sequence of the vanY gene required for production of a vancomycin-inducible D,D-carboxypeptidase in Enterococcus faecium BM4147. (Gene. 1992)
1510448
Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147. (Antimicrob Agents Chemother. 1992)
8380148
Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. (J Bacteriol. 1993)
10094630
Requirement of the VanY and VanX D,D-peptidases for glycopeptide resistance in enterococci. (Mol Microbiol. 1998)



関与する機能

機能名
Vancomycin resistance (via D-Ala-D-Lac precursor)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Bacillus pseudomycoides101232bpmyx0001_8610D-alanyl-D-alanine carboxypeptidase
Paenibacillus alvei3343PAV_2c05290D-alanyl-D-alanine carboxypeptidase VanY