| ID |
NRULE_0274 |
| 遺伝子ID |
VANYA |
| 作成日 |
2014/06/30 |
| タンパク質名 |
Protein name
- Full
- D-alanyl-D-alanine carboxypeptidase
- Short
- D-Ala-D-Ala carboxypeptidase
D,D-carboxypeptidase - EC
- EC 3.4.16.4
|
| 遺伝子名 |
vanY |
| 遺伝子条件 |
BLASTP; P37711; hit=1; score=600; pid=50 |
| 参照 |
Gene Ontology
- GO
- GO:0016021, C:integral component of membrane, IEA:UniProtKB-KW
- GO:0005886, C:plasma membrane, IEA:UniProtKB-SubCell
- GO:0009002, F:serine-type D-Ala-D-Ala carboxypeptidase activity, IEA:UniProtKB-EC
- GO:0009252, P:peptidoglycan biosynthetic process, IEA:UniProtKB-KW
- GO:0008360, P:regulation of cell shape, IEA:UniProtKB-KW
- GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW
Family and domain databases
- InterPro
- IPR009045, Hedgehog_sig/DD-Pept_Zn-bd_dom
- IPR003709, Pept_M15B/M15C
- Pfam
- PF02557, VanY, 1
|
| 配列の特徴 |
該当データなし |
| 注釈 |
- Function
- Vancomycin-inducible, penicillin-resistant, DD-carboxypeptidase that hydrolyzes depsipeptide- and D-alanyl-D-alanine-containing peptidoglycan precursors. Insensitive to beta-lactams
- Catalytic activity
- Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine
- Sequence similarities
- Belongs to the peptidase M15B family
|
| 参考文献 |
- P37711 Enterococcus faecium (Streptococcus faecium).
- 1398115
- Sequence of the vanY gene required for production of a vancomycin-inducible D,D-carboxypeptidase in Enterococcus faecium BM4147. (Gene. 1992)
- 1510448
- Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147. (Antimicrob Agents Chemother. 1992)
- 8380148
- Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. (J Bacteriol. 1993)
- 10094630
- Requirement of the VanY and VanX D,D-peptidases for glycopeptide resistance in enterococci. (Mol Microbiol. 1998)
|
