遺伝子 : Two-component system response regulator VanR (VANRA)

遺伝子情報

ID	NRULE_0279
遺伝子ID	VANRA
作成日	2014/07/09
タンパク質名	Protein name Full Two-component system response regulator VanR
遺伝子名	vanR
遺伝子条件	BLASTP; Q06239; hit=1; score=1000; pid=85
参照	Gene Ontology GO GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell GO:0003677, F:DNA binding, IEA:UniProtKB-KW GO:0000156, F:phosphorelay response regulator activity, IEA:InterPro GO:0006355, P:regulation of transcription, DNA-templated, IEA:UniProtKB-KW GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW GO:0006351, P:transcription, DNA-templated, IEA:UniProtKB-KW Family and domain databases InterPro IPR011006, CheY-like_superfamily IPR001867, Sig_transdc_resp-reg_C IPR016032, Sig_transdc_resp-reg_C-effctor IPR001789, Sig_transdc_resp-reg_receiver IPR011991, WHTH_DNA-bd_dom Pfam PF00072, Response_reg, 1 PF00486, Trans_reg_C, 1 SMART SM00448, REC, 1 SM00862, Trans_reg_C, 1 PROSITE PS50110, RESPONSE_REGULATORY, 1
配列の特徴	Q06239 Enterococcus faecium (Streptococcus faecium). MOD_RES 53 4-aspartylphosphate (By similarity).
注釈	Function Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance Sequence similarities Contains 1 response regulatory domain
参考文献	Q06239 Enterococcus faecium (Streptococcus faecium). 8380148 Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. (J Bacteriol. 1993) 1556077 The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. (J Bacteriol. 1992) 8981985 The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction. (J Bacteriol. 1997) 1320585 Insertional inactivation of a gene which controls expression of vancomycin resistance on plasmid pHKK100. (FEMS Microbiol Lett. 1992)

関与する機能

機能名
Vancomycin resistance (via D-Ala-D-Lac precursor)

該当CDS