遺伝子 : Two-component system histidine kinase VanS (VANSB)

遺伝子情報

ID	NRULE_0286
遺伝子ID	VANSB
作成日	2014/07/11
タンパク質名	Protein name Full Two-component system histidine kinase VanS EC EC 2.7.13.3 Synonym Full Sensor protein VanS
遺伝子名	vanSB
遺伝子条件	BLASTP; Q47745; hit=1; score=1900; pid=90
参照	Gene Ontology GO GO:0016021, C:integral component of membrane, IEA:UniProtKB-KW GO:0005886, C:plasma membrane, IEA:UniProtKB-SubCell GO:0005524, F:ATP binding, IEA:UniProtKB-KW GO:0000155, F:phosphorelay sensor kinase activity, IEA:InterPro GO:0046677, P:response to antibiotic, IEA:UniProtKB-KW Phylogenomic databases eggNOG COG0642, - Enzyme and pathway databases BioCyc EFAE226185:GHI1-2254-MONOMER, - BRENDA 2.7.13.3, 2095 Family and domain databases InterPro IPR003661, EnvZ-like_dim/P IPR003660, HAMP_linker_domain IPR003594, HATPase_ATP-bd IPR005467, Sig_transdc_His_kinase_core IPR009082, Sig_transdc_His_kinase_dimeric Pfam PF00672, HAMP, 1 PF02518, HATPase_c, 1 PF00512, HisKA, 1 SMART SM00304, HAMP, 1 SM00387, HATPase_c, 1 SM00388, HisKA, 1 PROSITE PS50885, HAMP, 1 PS50109, HIS_KIN, 1
配列の特徴	Q47745 Enterococcus faecalis (strain ATCC 700802 / V583). MOD_RES 233 Phosphohistidine; by autocatalysis (By similarity).
注釈	Function Member of the two-component regulatory system VanS/VanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates VanR by phosphorylation Catalytic activity ATP + protein L-histidine = ADP + protein N-phospho-L-histidine Sequence similarities Contains 1 HAMP domain Contains 1 histidine kinase domain
参考文献	Q47745 Enterococcus faecalis (strain ATCC 700802 / V583). 8631706 Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. (J Bacteriol. 1996)

関与する機能

機能名
Vancomycin resistance (via D-Ala-D-Lac precursor)

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