遺伝子 : Two-component system histidine kinase VanS (VANS)

遺伝子情報

ID	NRULE_0290
遺伝子ID	VANS
作成日	2014/07/11
タンパク質名	Protein name Full Two-component system histidine kinase VanS
遺伝子名	vanS
遺伝子条件	BLASTP; Q9X942; hit=1; score=900; pid=55
参照	Gene Ontology GO GO:0016021, C:integral component of membrane, IEA:UniProtKB-KW GO:0005524, F:ATP binding, IEA:UniProtKB-KW GO:0000155, F:phosphorelay sensor kinase activity, IEA:InterPro Phylogenomic databases HOGENOM HOG000223177, - Family and domain databases InterPro IPR003661, EnvZ-like_dim/P IPR003660, HAMP_linker_domain IPR003594, HATPase_ATP-bd IPR005467, Sig_transdc_His_kinase_core IPR009082, Sig_transdc_His_kinase_dimeric Pfam PF00672, HAMP, 1 PF02518, HATPase_c, 1 PF00512, HisKA, 1 SMART SM00304, HAMP, 1 SM00387, HATPase_c, 1 SM00388, HisKA, 1 PROSITE PS50885, HAMP, 1 PS50109, HIS_KIN, 1
配列の特徴	該当データなし
注釈	Catalytic activity ATP + protein L-histidine = ADP + protein N-phospho-L-histidine Sequence similarities Contains histidine kinase domain
参考文献	Q9X942 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). 15130128 Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance. (Mol Microbiol. 2004) 16420361 The vancomycin resistance VanRS two-component signal transduction system of Streptomyces coelicolor. (Mol Microbiol. 2006) 20383152 A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor. (Nat Chem Biol. 2010) 23836175 In vivo studies suggest that induction of VanS-dependent vancomycin resistance requires binding of the drug to D-Ala-D-Ala termini in the peptidoglycan cell wall. (Antimicrob Agents Chemother. 2013)

関与する機能

機能名
Vancomycin resistance (via D-Ala-D-Lac precursor)

該当CDS

学名	NBRC番号	CDS	タンパク質名
Actinomadura atramentaria	14695	G339_07815	hypothetical protein
Actinoplanes missouriensis	102363	AMIS_51750	putative two-component system sensor kinase
Actinosynnema mirum	14064	Amir_4513	histidine kinase
Amycolatopsis mediterranei	13415	RAM_41825	two-component system histidine kinase
		RAM_42555	two-component system histidine kinase
Catenulispora acidiphila	102108	Caci_5789	histidine kinase
Cellulomonas fimi	15513	Celf_1889	integral membrane sensor signal transduction histidine kinase
Conexibacter woesei	100937	Cwoe_1411	integral membrane sensor signal transduction histidine kinase
Kribbella flavida	14399	Kfla_3624	histidine kinase
Microlunatus phosphovorus	101784	MLP_00340	putative two-component system histidine kinase (fragment)
Saccharothrix espanaensis	15066	BN6_49740	Integral membrane sensor signal transduction histidine kinase
Stackebrandtia nassauensis	102104	Snas_6029	histidine kinase
Streptomyces pristinaespiralis	13074	SSDG_04293	integral membrane sensor signal transduction histidine kinase
Streptomyces sviceus	13980	SSEG_08353	two component sensor kinase
		SSEG_10728	sensor histidine kinase
Streptomyces venezuelae	13096	SVEN_6833	putative two-component system sensor kinase
Streptosporangium roseum	3776	Sros_4755	Signal transduction histidine kinase-like protein
Tsukamurella paurometabola	16120	Tpau_0521	integral membrane sensor signal transduction histidine kinase
Xylanimonas cellulosilytica	107835	Xcel_1425	histidine kinase