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遺伝子 : UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-lactate ligase (MURF2)

遺伝子情報

ID NRULE_0297
遺伝子ID MURF2
作成日 2014/07/25
タンパク質名
Protein name
Full
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-lactate ligase
Synonym
Full
D-alanyl-D-lactate-adding enzyme
UDP-MurNAc-pentapeptide synthetase
遺伝子名 murF2
遺伝子条件 BLASTP; Q70B07; hit=1; score=1500; pid=70
参照
Gene Ontology
GO
GO:0005737, C:cytoplasm, IEA:UniProtKB-SubCell
GO:0005524, F:ATP binding, IEA:UniProtKB-KW
GO:0047480, F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity, IEA:UniProtKB-EC
GO:0008766, F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity, IEA:InterPro
GO:0007049, P:cell cycle, IEA:UniProtKB-KW
GO:0051301, P:cell division, IEA:UniProtKB-KW
GO:0009252, P:peptidoglycan biosynthetic process, IEA:UniProtKB-UniPathway
GO:0008360, P:regulation of cell shape, IEA:UniProtKB-KW
Enzyme and pathway databases
UniPathway
UPA00219, -
Family and domain databases
InterPro
IPR004101, Mur_ligase_C
IPR013221, Mur_ligase_cen
IPR000713, Mur_ligase_N
IPR005863, UDP-N-AcMur-pentapeptide_synth
Pfam
PF01225, Mur_ligase, 1
PF02875, Mur_ligase_C, 1
PF08245, Mur_ligase_M, 1
TIGRFAMs
TIGR01143, murF, 1
配列の特徴 該当データなし
注釈
Function
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
Catalytic activity
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-lactate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-lactate
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis
Sequence similarities
Belongs to the MurCDEF family
参考文献
Q70B07 Actinoplanes teichomyceticus.
14702401
Organization of the teicoplanin gene cluster in Actinoplanes teichomyceticus. (Microbiology (Reading). 2004)
15500981
Glycopeptide resistance determinants from the teicoplanin producer Actinoplanes teichomyceticus. (FEMS Microbiol Lett. 2004)



関与する機能

機能名
Vancomycin resistance (via D-Ala-D-Lac precursor)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Stackebrandtia nassauensis102104Snas_5354UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diamin opimelate/D-alanyl-D-alanyl ligase
Streptomyces sviceus13980SSEG_07178UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D- alanine ligase