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遺伝子 : Chloromuconate cycloisomerase (CLCB)

遺伝子情報

ID NRULE_0387
遺伝子ID CLCB
作成日 2015/03/31
タンパク質名
Protein name
Full
Chloromuconate cycloisomerase
EC
EC 5.5.1.7
遺伝子名 clcB
遺伝子条件 BLASTP; P05404; hit=1; score=905; pid=63
OR
BLASTP; P42428; hit=1; score=940; pid=48
参照
Gene Ontology
GO
GO:0018850, F:chloromuconate cycloisomerase activity, IEA:UniProtKB-EC
GO:0030145, F:manganese ion binding, IEA:InterPro
GO:0018849, F:muconate cycloisomerase activity, IEA:InterPro
GO:0019439, P:aromatic compound catabolic process, IEA:UniProtKB-KW
Phylogenomic databases
KO
K01860, -
Enzyme and pathway databases
UniPathway
UPA00083, -
Family and domain databases
InterPro
IPR013370, Chloromuconate_cycloisomerase
IPR029065, Enolase_C-like
IPR029017, Enolase_N_like
IPR018110, Mandel_Rmase/mucon_lact_enz_CS
IPR013342, Mandelate_racemase_C
IPR013341, Mandelate_racemase_N_dom
IPR001354, MR/MLE/MAL
Pfam
PF01188, MR_MLE, 1
PF02746, MR_MLE_N, 1
SMART
SM00922, MR_MLE, 1
TIGRFAMs
TIGR02534, mucon_cyclo, 1
PROSITE
PS00908, MR_MLE_1, 1
PS00909, MR_MLE_2, 1
配列の特徴
P05404 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134)).
ACT_SITE165Proton acceptor.
ACT_SITE323Proton donor.
METAL194Manganese.
METAL220Manganese.
METAL245Manganese.
注釈
Catalytic activity
2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate
Cofactor
Mn(2+);
Pathway
Aromatic compound metabolism; Chlorocatechol degradation
Sequence similarities
Belongs to the mandelate racemase/muconate lactonizing enzyme family
参考文献
P05404 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134)).
15299479
Crystal structure of chloromuconate cycloisomerase from Alcaligenes eutrophus JMP134 (pJP4) at 3 A resolution. (Acta Crystallogr D Biol Crystallogr. 1994)
P42428 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134)).
12107121
Importance of different tfd genes for degradation of chloroaromatics by Ralstonia eutropha JMP134. (J Bacteriol. 2002)



関与する機能

機能名
Chlorocatechol degradation (beta-ketoadipate pathway)

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Sphingobium japonicum101211SJA_C1-21130(chloro)muconate cycloisomerase