BLAST table : Adria_00010

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q9ZAU3_STRPE (Q9ZAU3)	0.0	828	100%	UniProt GenBank	Daunorubicin C-14 hydroxylase	doxA	Streptomyces peucetius
2	Q59971_STRSQ (Q59971)	0.0	782	94%	UniProt GenBank	Daunomycin C-14 hydroxylase	doxA	Streptomyces sp
3	Q93MI2_STRPE (Q93MI2)	0.0	773	94%	UniProt GenBank	Daunomycin c-14 hydroxylase	doxA	Streptomyces peucetius subsp. caesius
4	D2BDL5_STRRD (D2BDL5)	2e-69	267	44%	UniProt GenBank	Cytochrome P-450	Sros_5343	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
5	D3Q468_STANL (D3Q468)	6e-62	243	39%	UniProt GenBank	Cytochrome P450-like protein	Snas_6336	Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
6	F8AZ18_9ACTO (F8AZ18)	3e-41	174	34%	UniProt GenBank	Peroxidase	FsymDg_2207	Frankia symbiont of Datisca glomerata	1.11.1.7 niceE keggE
7	F8JWA3_STRCT (F8JWA3)	1e-40	172	36%	UniProt GenBank	Cytochrome P450 107B1	CYP107B SCAT_2117	Streptomyces cattleya	1.14.-.- niceE keggE
8	D9WIF6_9ACTO (D9WIF6)	5e-40	170	35%	UniProt GenBank	Cytochrome P450 107B1 (P450CVIIB1)	SSOG_05228	Streptomyces himastatinicus ATCC 53653
9	D9UW26_9ACTO (D9UW26)	2e-39	168	35%	UniProt GenBank	Predicted protein	SSMG_04167	Streptomyces sp. AA4
10	D8I4V9_AMYMU (D8I4V9)	3e-39	167	35%	UniProt GenBank	Cytochrome P450	AMED_7020	Amycolatopsis mediterranei (strain U-32)
11	D5ZUW8_9ACTO (D5ZUW8)	8e-39	166	33%	UniProt GenBank	Cytochrome P450 hydroxylase	SSFG_04040	Streptomyces ghanaensis ATCC 14672
12	D9VZ35_9ACTO (D9VZ35)	2e-38	164	34%	UniProt GenBank	Cytochrome P450 hydroxylase	SSNG_02830	Streptomyces sp. C
13	B5HJI8_STRPR (B5HJI8)	6e-38	163	33%	UniProt GenBank	Cytochrome P450 hydroxylase	SSDG_05326	Streptomyces pristinaespiralis ATCC 25486
14	Q70AS4_STRPE (Q70AS4)	1e-37	162	32%	UniProt GenBank	Putative cytochrome P450	cyp0749	Streptomyces peucetius	1.14.14.1 niceE keggE
15	E8U935_DEIML (E8U935)	4e-37	160	33%	UniProt GenBank	Peroxidase	Deima_1929	Deinococcus maricopensis (strain DSM 21211 / LMG 22137 / NRRL B-23946 / LB-34)	1.11.1.7 niceE keggE
16	B5H3V7_STRCL (B5H3V7)	5e-37	160	33%	UniProt GenBank	Cytochrome P450 monooxygenase 107L14 Putative cytochrome P450	SCLAV_5564 SSCG_06256	Streptomyces clavuligerus ATCC 27064
17	B4V9T1_9ACTO (B4V9T1)	7e-37	159	34%	UniProt GenBank	Cytochrome P450	SSAG_04589	Streptomyces sp. Mg1
18	F2R6D7_STRVP (F2R6D7)	1e-36	159	34%	UniProt GenBank	Putative cytochrome P450 hydroxylase	SVEN_2902	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
19	D6B2U9_9ACTO (D6B2U9)	2e-36	158	33%	UniProt GenBank	Cytochrome P450	SSHG_03925	Streptomyces albus J1074
20	C4B4V3_9ACTO (C4B4V3)	2e-36	157	33%	UniProt GenBank	P450	dvbA	Dactylosporangium variesporum
21	F2R215_STRVP (F2R215)	2e-36	157	33%	UniProt GenBank	Putative cytochrome P450 hydroxylase	SVEN_7396	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
22	D9XHB5_STRVR (D9XHB5)	3e-36	157	32%	UniProt GenBank	Cytochrome P450 monooxygenase 107L14	SSQG_05452	Streptomyces viridochromogenes DSM 40736
23	D6Y630_THEBD (D6Y630)	5e-36	156	33%	UniProt GenBank	Cytochrome P450	Tbis_2746	Thermobispora bispora (strain ATCC 19993 / DSM 43833 / CBS 139.67 / JCM 10125 / NBRC 14880 / R51)
24	B5GZN3_STRCL (B5GZN3)	5e-36	156	34%	UniProt GenBank	Cytochrome P450 hydroxylase	SCLAV_2218 SSCG_04850	Streptomyces clavuligerus ATCC 27064
25	D6KGC0_9ACTO (D6KGC0)	5e-36	156	34%	UniProt GenBank	Putative uncharacterized protein	SSTG_05995	Streptomyces sp. e14
26	D9XWN4_9ACTO (D9XWN4)	6e-36	156	33%	UniProt GenBank	Cytochrome P450 107B1	SSRG_03767	Streptomyces griseoflavus Tu4000
27	D2BBN4_STRRD (D2BBN4)	8e-36	156	34%	UniProt GenBank	Putative cytochrome P450	Sros_3157	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
28	C9YY34_STRSW (C9YY34)	8e-36	156	33%	UniProt GenBank	Putative monooxygenase	SCAB_54411	Streptomyces scabies (strain 87.22) Streptomyces scabiei
29	D5ZPG8_9ACTO (D5ZPG8)	9e-36	155	30%	UniProt GenBank	Cytochrome P450 monooxygenase	SSFG_03469	Streptomyces ghanaensis ATCC 14672
30	Q5YXF1_NOCFA (Q5YXF1)	1e-35	155	32%	UniProt GenBank	Cytochrome P450 monooxygenase	NFA_22930	Nocardia farcinica
31	Q70AS2_STRPE (Q70AS2)	1e-35	155	32%	UniProt GenBank	Putative cytochrome P450	cyp0819	Streptomyces peucetius	1.14.14.1 niceE keggE
32	D6AXS4_9ACTO (D6AXS4)	2e-35	154	36%	UniProt GenBank	Cytochrome P450 hydroxylase	SSHG_05366	Streptomyces albus J1074
33	E4NG24_KITSK (E4NG24)	2e-35	154	34%	UniProt GenBank	Putative cytochrome P450	KSE_46730	Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054) Streptomyces setae
34	A8M6E0_SALAI (A8M6E0)	2e-35	154	33%	UniProt GenBank	Cytochrome P450	Sare_1260	Salinispora arenicola (strain CNS-205)
35	D2SFB4_GEOOG (D2SFB4)	3e-35	154	35%	UniProt GenBank	Cytochrome P450	Gobs_4206	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)
36	A4F8W1_SACEN (A4F8W1)	4e-35	154	33%	UniProt GenBank	Putative cytochrome P450	cyp23 SACE_1158	Saccharopolyspora erythraea (strain NRRL 23338)	1.14.-.- niceE keggE
37	A4X7G5_SALTO (A4X7G5)	4e-35	153	31%	UniProt GenBank	Cytochrome P450	Strop_2367	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
38	B5G9Z1_9ACTO (B5G9Z1)	5e-35	153	32%	UniProt GenBank	Cytochrome P450	SSBG_01099	Streptomyces sp. SPB74
39	D9UPI7_9ACTO (D9UPI7)	6e-35	153	32%	UniProt GenBank	Cytochrome P450 monooxygenase	SSLG_00093	Streptomyces sp. SPB78
40	C3HA20_BACTU (C3HA20)	7e-35	152	31%	UniProt GenBank	Cytochrome p450	bthur0011_53340	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
41	D2AWQ3_STRRD (D2AWQ3)	1e-34	152	32%	UniProt GenBank	Putative uncharacterized protein	Sros_6100	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
42	Q5QT15_9ACTO (Q5QT15)	1e-34	152	31%	UniProt GenBank	Putative P450 protein	staN	Streptomyces longisporoflavus
43	Q83WG6_9ACTO (Q83WG6)	1e-34	152	30%	UniProt GenBank	Cytochrome P450 StaN	staN	Streptomyces sp. TP-A0274
44	F3NS09_9ACTO (F3NS09)	1e-34	152	34%	UniProt GenBank	Cytochrome P450 hydroxylase	SGM_5923	Streptomyces griseoaurantiacus M045
45	D9XFG0_STRVR (D9XFG0)	2e-34	152	33%	UniProt GenBank	Cytochrome P450 hydroxylase	SSQG_03181	Streptomyces viridochromogenes DSM 40736
46	B5HX12_9ACTO (B5HX12)	2e-34	151	33%	UniProt GenBank	Cytochrome P450 hydroxylase	SSEG_03947	Streptomyces sviceus ATCC 29083
47	D9X2X6_STRVR (D9X2X6)	2e-34	151	32%	UniProt GenBank	Cytochrome P450 monooxygenase 105	SSQG_06331	Streptomyces viridochromogenes DSM 40736
48	F8JNB7_STRCT (F8JNB7)	2e-34	151	35%	UniProt GenBank	Cytochrome P450	SCAT_p0808	Streptomyces cattleya NRRL 8057
49	D9XTQ0_9ACTO (D9XTQ0)	2e-34	151	33%	UniProt GenBank	Cytochrome P450	SSRG_03556	Streptomyces griseoflavus Tu4000
50	Q5YR22_NOCFA (Q5YR22)	3e-34	151	32%	UniProt GenBank	Cytochrome P450 monooxygenase	NFA_45180	Nocardia farcinica
51	F4CYL5_9PSEU (F4CYL5)	3e-34	150	32%	UniProt GenBank	Cytochrome P450	Psed_4428	Pseudonocardia dioxanivorans CB1190
52	Q9F2Q0_STRCO (Q9F2Q0)	3e-34	150	33%	UniProt GenBank	Cytochrome P450 Putative cytochrome P450 hydroxylase	IT6-107MNPR-12 SCO3099	Streptomyces coelicolor
53	D6ETM0_STRLI (D6ETM0)	3e-34	150	33%	UniProt GenBank	Cytochrome P450 hydroxylase	SSPG_04435	Streptomyces lividans TK24
54	D2S3S0_GEOOG (D2S3S0)	4e-34	150	31%	UniProt GenBank	Cytochrome P450	Gobs_0142	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)
55	D8HRB1_AMYMU (D8HRB1)	6e-34	149	35%	UniProt GenBank	Cytochrome P450	AMED_4238	Amycolatopsis mediterranei (strain U-32)
56	D9VHC0_9ACTO (D9VHC0)	8e-34	149	33%	UniProt GenBank	Cytochrome P450	SSMG_06216	Streptomyces sp. AA4
57	D3D6F7_9ACTO (D3D6F7)	1e-33	149	32%	UniProt GenBank	Cytochrome P450	FrEUN1fDRAFT_5379	Frankia sp. EUN1f
58	D5ZXT1_9ACTO (D5ZXT1)	1e-33	149	33%	UniProt GenBank	Cytochrome P450 hydroxylase	SSFG_04272	Streptomyces ghanaensis ATCC 14672
59	D6U4A2_9CHLR (D6U4A2)	1e-33	148	30%	UniProt GenBank	Cytochrome P450	Krac_2047	Ktedonobacter racemifer DSM 44963
60	D5ZP95_9ACTO (D5ZP95)	1e-33	148	32%	UniProt GenBank	Cytochrome P450 monooxygenase 105	SSFG_01578	Streptomyces ghanaensis ATCC 14672
61	D1XT89_9ACTO (D1XT89)	2e-33	148	33%	UniProt GenBank	Cytochrome P450	SACTEDRAFT_5899	Streptomyces sp. SA3_actE
62	F2RCF4_STRVP (F2RCF4)	2e-33	148	35%	UniProt GenBank	Putative cytochrome P450 hydroxylase	SVEN_6119	Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
63	A9AXU5_HERA2 (A9AXU5)	2e-33	148	30%	UniProt GenBank	Cytochrome P450	Haur_2271	Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
64	D6U7X6_9CHLR (D6U7X6)	2e-33	148	31%	UniProt GenBank	Cytochrome P450	Krac_0520	Ktedonobacter racemifer DSM 44963
65	A3KJ10_STRAM (A3KJ10)	2e-33	148	33%	UniProt GenBank	Putative cytochrome P450-family protein	SAML0708	Streptomyces ambofaciens ATCC 23877
66	D9XDM0_STRVR (D9XDM0)	3e-33	147	32%	UniProt GenBank	Cytochrome P450 monooxygenase CYP105S1	SSQG_00917	Streptomyces viridochromogenes DSM 40736
67	B1VRN3_STRGG (B1VRN3)	3e-33	147	32%	UniProt GenBank	Putative cytochrome P450	SGR_622	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
68	Q82GL5_STRAW (Q82GL5)	3e-33	147	31%	UniProt GenBank	Cytochrome P450 hydroxylase	cyp19 SAV3882 SAV_3882	Streptomyces avermitilis
69	Q595R1_9ACTO (Q595R1)	3e-33	147	30%	UniProt GenBank	Cytochrome P450 monooxygenase CYP105S1	cyp230	Streptomyces tubercidicus
70	D8HZB8_AMYMU (D8HZB8)	5e-33	147	33%	UniProt GenBank	Cytochrome P450	AMED_0653	Amycolatopsis mediterranei (strain U-32)
71	C7MUK5_SACVD (C7MUK5)	5e-33	146	33%	UniProt GenBank	Cytochrome P450	Svir_26970	Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
72	Q9L142_STRCO (Q9L142)	7e-33	146	33%	UniProt GenBank	Putative cytochrome P450-family protein	SCO7417	Streptomyces coelicolor
73	Q595U2_STRPT (Q595U2)	1e-32	145	31%	UniProt GenBank	Cytochrome P450 monooxygenase CYP107Z8	ema13	Streptomyces platensis
74	D9WUX3_9ACTO (D9WUX3)	1e-32	145	33%	UniProt GenBank	Cytochrome P450 105C1	SSOG_08187	Streptomyces himastatinicus ATCC 53653
75	F0SQX1_PLABD (F0SQX1)	1e-32	145	31%	UniProt GenBank	Cytochrome P450	Plabr_2592	Planctomyces brasiliensis (strain ATCC 49424 / DSM 5305 / JCM 21570 / NBRC 103401 / IFAM 1448)
76	Q8KY32_STRCU (Q8KY32)	1e-32	145	32%	UniProt GenBank	RubU	rubU	Streptomyces collinus
77	D6K329_9ACTO (D6K329)	1e-32	145	32%	UniProt GenBank	Putative uncharacterized protein	SSTG_01776	Streptomyces sp. e14
78	C1B5P7_RHOOB (C1B5P7)	1e-32	145	34%	UniProt GenBank	Cytochrome P450	ROP_29260	Rhodococcus opacus (strain B4)
79	D6ACP4_STRFL (D6ACP4)	1e-32	145	32%	UniProt GenBank	Cytochrome P450 hydroxylase	SSGG_04007	Streptomyces roseosporus NRRL 15998
80	Q595T8_9ACTO (Q595T8)	1e-32	145	32%	UniProt GenBank	Cytochrome P450 monooxygenase CYP107Z7	ema17	Streptomyces tubercidicus
81	D2PWX0_KRIFD (D2PWX0)	1e-32	145	31%	UniProt GenBank	Cytochrome P450	Kfla_6348	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
82	D7B817_NOCDD (D7B817)	2e-32	145	33%	UniProt GenBank	Cytochrome P450	Ndas_4942	Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488) Actinomadura dassonvillei
83	Q595U0_9ACTO (Q595U0)	2e-32	145	32%	UniProt GenBank	Cytochrome P450 monooxygenase CYP107Z5v1	em15	Streptomyces lydicus
84	Q5WJE4_BACSK (Q5WJE4)	2e-32	145	31%	UniProt GenBank	Cytochrome P450	cypA ABC0972	Bacillus clausii (strain KSM-K16)
85	A6YRR3_STRVG (A6YRR3)	2e-32	145	32%	UniProt GenBank	Cytochrome P450 monooxygenase 105		Streptomyces virginiae
86	D5SL12_STRCL (D5SL12)	2e-32	145	32%	UniProt GenBank	Staurosporine biosynthesis Cytochrome P450 StaN	staN SCLAV_p1119	Streptomyces clavuligerus ATCC 27064
87	D8HZA2_AMYMU (D8HZA2)	2e-32	144	32%	UniProt GenBank	Cytochrome P450	AMED_0637	Amycolatopsis mediterranei (strain U-32)
88	O52561_AMYMD (O52561)	2e-32	144	32%	UniProt GenBank	Putative cytochrome P450 monooxygenase		Amycolatopsis mediterranei Nocardia mediterranei
89	D6EVS8_STRLI (D6EVS8)	2e-32	144	32%	UniProt GenBank	Cytochrome P450-family protein	SSPG_00430	Streptomyces lividans TK24
90	B5H2M5_STRCL (B5H2M5)	3e-32	144	32%	UniProt GenBank	Cytochrome P450 StaN	SSCG_05846	Streptomyces clavuligerus ATCC 27064
91	Q989M2_RHILO (Q989M2)	3e-32	144	31%	UniProt GenBank	Cytochrome P-450	mlr6364	Rhizobium loti Mesorhizobium loti
92	D6TVR9_9CHLR (D6TVR9)	3e-32	144	29%	UniProt GenBank	Cytochrome P450	Krac_5329	Ktedonobacter racemifer DSM 44963
93	D9XPH0_9ACTO (D9XPH0)	3e-32	144	32%	UniProt GenBank	Cytochrome P450 107B1	SSRG_06286	Streptomyces griseoflavus Tu4000
94	Q8KJK3_RHILO (Q8KJK3)	4e-32	144	31%	UniProt GenBank	PROBABLE CYTOCHROME P450-LIKE MONOOXYGENASE PROTEIN	msi071	Rhizobium loti Mesorhizobium loti
95	O52572_AMYMD (O52572)	4e-32	144	33%	UniProt GenBank	Putative cytochrome P450 monooxygenase		Amycolatopsis mediterranei Nocardia mediterranei
96	Q595U3_9ACTO (Q595U3)	4e-32	144	30%	UniProt GenBank	Cytochrome P450 monooxygenase CYP107Z9	ema12	Streptomyces tubercidicus
97	B1VKQ9_STRGG (B1VKQ9)	4e-32	143	32%	UniProt GenBank	Putative cytochrome P450	SGR_3108	Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
98	Q47L37_THEFY (Q47L37)	5e-32	143	30%	UniProt GenBank	Putative cytochrome P450	Tfu_2802	Thermobifida fusca (strain YX)
99	Q595U9_9ACTO (Q595U9)	5e-32	143	32%	UniProt GenBank	Cytochrome P450 monooxygenase CYP107Z5v2	Ema6	Streptomyces saraceticus
100	C9W348_9ACTO (C9W348)	6e-32	143	32%	UniProt GenBank	Cytochrome P450 monooxygenase	nokJ	Nonomuraea longicatena

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q9ZAU3_STRPE
(Q9ZAU3)

0.0

828

100%

Product: Daunorubicin C-14 hydroxylase
Gene: doxA
Organism: Streptomyces peucetius

1uniprot[Pubmed] 9864344 [Medline] 99084971
Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.(J. Bacteriol.) [1999]

Q59971_STRSQ
(Q59971)

0.0

782

94%

Product: Daunomycin C-14 hydroxylase
Gene: doxA
Organism: Streptomyces sp

1uniprot[Pubmed] 8655530 [Medline] 96236067
Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24.(J. Bacteriol.) [1996]

Q93MI2_STRPE
(Q93MI2)

0.0

773

94%

Product: Daunomycin c-14 hydroxylase
Gene: doxA
Organism: Streptomyces peucetius subsp. caesius

1uniprot
Molecular Cloning and Characterization of the doxA Cytochrome P-450 Hydroxylase Gene in Streptomyces peucetius subsp. caesius ATCC 27952.(J. Microbiol. Biotechnol.) [2001]

D2BDL5_STRRD
(D2BDL5)

2e-69

267

44%

Product: Cytochrome P-450
Gene: Sros_5343
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

D3Q468_STANL
(D3Q468)

6e-62

243

39%

Product: Cytochrome P450-like protein
Gene: Snas_6336
Organism: Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)

1uniprot
Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21T).(Stand. Genomic Sci.) [2009]

D8I4V9_AMYMU
(D8I4V9)

3e-39

167

35%

Product: Cytochrome P450
Gene: AMED_7020
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q70AS4_STRPE
(Q70AS4)

1e-37

162

32%

Product: Putative cytochrome P450
Gene: cyp0749
Organism: Streptomyces peucetius

1uniprot[Pubmed] 15111132
Genome analyses of Streptomyces peucetius ATCC 27952 for the identification and comparison of cytochrome P450 complement with other Streptomyces.(Arch. Biochem. Biophys.) [2004]

B5H3V7_STRCL
(B5H3V7)

5e-37

160

33%

Product: Cytochrome P450 monooxygenase 107L14
Putative cytochrome P450
Gene: SCLAV_5564
SSCG_06256
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot[Pubmed] 20624727
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

F2R6D7_STRVP
(F2R6D7)

1e-36

159

34%

Product: Putative cytochrome P450 hydroxylase
Gene: SVEN_2902
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

C4B4V3_9ACTO
(C4B4V3)

2e-36

157

33%

Product: P450
Gene: dvbA
Organism: Dactylosporangium variesporum

1uniprot
Efficient Biotransformations Using Escherichia coli with tolC acrAB Mutations Expressing Cytochrome P450 Genes.(Biosci. Biotechnol. Biochem.) [2009]

F2R215_STRVP
(F2R215)

2e-36

157

33%

Product: Putative cytochrome P450 hydroxylase
Gene: SVEN_7396
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

B5GZN3_STRCL
(B5GZN3)

5e-36

156

34%

Product: Cytochrome P450 hydroxylase
Gene: SCLAV_2218
SSCG_04850
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot[Pubmed] 20624727
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

D2BBN4_STRRD
(D2BBN4)

8e-36

156

34%

Product: Putative cytochrome P450
Gene: Sros_3157
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

C9YY34_STRSW
(C9YY34)

8e-36

156

33%

Product: Putative monooxygenase
Gene: SCAB_54411
Organism: Streptomyces scabies (strain 87.22)
Streptomyces scabiei

1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]

Q5YXF1_NOCFA
(Q5YXF1)

1e-35

155

32%

Product: Cytochrome P450 monooxygenase
Gene: NFA_22930
Organism: Nocardia farcinica

1uniprot[Pubmed] 15466710
The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

Q70AS2_STRPE
(Q70AS2)

1e-35

155

32%

Product: Putative cytochrome P450
Gene: cyp0819
Organism: Streptomyces peucetius

E4NG24_KITSK
(E4NG24)

2e-35

154

34%

Product: Putative cytochrome P450
Gene: KSE_46730
Organism: Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae

1uniprot[Pubmed] 21059706
Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010]

A4F8W1_SACEN
(A4F8W1)

4e-35

154

33%

Product: Putative cytochrome P450
Gene: cyp23
SACE_1158
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

D2AWQ3_STRRD
(D2AWQ3)

1e-34

152

32%

Product: Putative uncharacterized protein
Gene: Sros_6100
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

Q5QT15_9ACTO
(Q5QT15)

1e-34

152

31%

Product: Putative P450 protein
Gene: staN
Organism: Streptomyces longisporoflavus

1uniprot
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase.(Mol. Microbiol.) [2005]

Q83WG6_9ACTO
(Q83WG6)

1e-34

152

30%

Product: Cytochrome P450 StaN
Gene: staN
Organism: Streptomyces sp. TP-A0274

[pubmed all]
1uniprot Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis.(Tetrahedron Lett.) [2006]
2uniprot Biosynthesis of heterocyclic antibiotics in actinomycetes and an approach to synthesize the natural compounds.(Nihon Hosenkin Gakkaishi) [2006]
3uniprot[Pubmed] 12617516 [Medline] 22504382 Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.(J. Antibiot.) [2002]
4uniprot Characterization of the biosynthetic gene cluster of rebecamycin from Lechevalieria aerocolonigenes ATCC 39243.(Biosci. Biotechnol. Biochem.) [2003]
5uniprot[Pubmed] 16195595 Cytochrome P450 homolog is responsible for C-N bond formation between aglycone and deoxysugar in the staurosporine biosynthesis of Streptomyces sp. TP-A0274.(Biosci. Biotechnol. Biochem.) [2005]

F3NS09_9ACTO
(F3NS09)

1e-34

152

34%

Product: Cytochrome P450 hydroxylase
Gene: SGM_5923
Organism: Streptomyces griseoaurantiacus M045

1uniprot[Pubmed] 21551298
Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011]

Q5YR22_NOCFA
(Q5YR22)

3e-34

151

32%

Product: Cytochrome P450 monooxygenase
Gene: NFA_45180
Organism: Nocardia farcinica

1uniprot[Pubmed] 15466710
The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

Q9F2Q0_STRCO
(Q9F2Q0)

3e-34

150

33%

Product: Cytochrome P450
Putative cytochrome P450 hydroxylase
Gene: IT6-107MNPR-12
SCO3099
Organism: Streptomyces coelicolor

1uniprot[Pubmed] 12000953 [Medline] 21996410
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]

D8HRB1_AMYMU
(D8HRB1)

6e-34

149

35%

Product: Cytochrome P450
Gene: AMED_4238
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

F2RCF4_STRVP
(F2RCF4)

2e-33

148

35%

Product: Putative cytochrome P450 hydroxylase
Gene: SVEN_6119
Organism: Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)

1uniprot[Pubmed] 21463507
Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011]

A3KJ10_STRAM
(A3KJ10)

2e-33

148

33%

Product: Putative cytochrome P450-family protein
Gene: SAML0708
Organism: Streptomyces ambofaciens ATCC 23877

1uniprot[Pubmed] 16956972
Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006]

B1VRN3_STRGG
(B1VRN3)

3e-33

147

32%

Product: Putative cytochrome P450
Gene: SGR_622
Organism: Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)

1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]

Q82GL5_STRAW
(Q82GL5)

3e-33

147

31%

Product: Cytochrome P450 hydroxylase
Gene: cyp19
SAV3882
SAV_3882
Organism: Streptomyces avermitilis

1uniprot[Pubmed] 11572948 [Medline] 21477403
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.(Proc. Natl. Acad. Sci. U.S.A.) [2001]

Q595R1_9ACTO
(Q595R1)

3e-33

147

30%

Product: Cytochrome P450 monooxygenase CYP105S1
Gene: cyp230
Organism: Streptomyces tubercidicus

[pubmed all]
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005]
2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005]

D8HZB8_AMYMU
(D8HZB8)

5e-33

147

33%

Product: Cytochrome P450
Gene: AMED_0653
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

C7MUK5_SACVD
(C7MUK5)

5e-33

146

33%

Product: Cytochrome P450
Gene: Svir_26970
Organism: Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)

1uniprot
Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009]

Q9L142_STRCO
(Q9L142)

7e-33

146

33%

Product: Putative cytochrome P450-family protein
Gene: SCO7417
Organism: Streptomyces coelicolor

[pubmed all]
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002]
2uniprot[Pubmed] 12519772 [Medline] 22552375 The 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systems.(J. Biol. Chem.) [2003]

Q595U2_STRPT
(Q595U2)

1e-32

145

31%

Product: Cytochrome P450 monooxygenase CYP107Z8
Gene: ema13
Organism: Streptomyces platensis

[pubmed all]
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005]
2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005]

Q595T8_9ACTO
(Q595T8)

1e-32

145

32%

Product: Cytochrome P450 monooxygenase CYP107Z7
Gene: ema17
Organism: Streptomyces tubercidicus

[pubmed all]
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005]
2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005]

D7B817_NOCDD
(D7B817)

2e-32

145

33%

Product: Cytochrome P450
Gene: Ndas_4942
Organism: Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei

1uniprot
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010]

Q595U0_9ACTO
(Q595U0)

2e-32

145

32%

Product: Cytochrome P450 monooxygenase CYP107Z5v1
Gene: em15
Organism: Streptomyces lydicus

[pubmed all]
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005]
2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005]

A6YRR3_STRVG
(A6YRR3)

2e-32

145

32%

Product: Cytochrome P450 monooxygenase 105
Gene
Organism: Streptomyces virginiae

1uniprot[Pubmed] 19376895
Characterization of P450 FcpC, the Enzyme Responsible for Bioconversion of Diosgenone to Isonuatigenone in Streptomyces virginiae IBL-14.(Appl. Environ. Microbiol.) [2009]

D5SL12_STRCL
(D5SL12)

2e-32

145

32%

Product: Staurosporine biosynthesis Cytochrome P450 StaN
Gene: staN
SCLAV_p1119
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

D8HZA2_AMYMU
(D8HZA2)

2e-32

144

32%

Product: Cytochrome P450
Gene: AMED_0637
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

O52561_AMYMD
(O52561)

2e-32

144

32%

Product: Putative cytochrome P450 monooxygenase
Gene
Organism: Amycolatopsis mediterranei
Nocardia mediterranei

[pubmed all]
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998]
2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998]
3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001]

Q989M2_RHILO
(Q989M2)

3e-32

144

31%

Product: Cytochrome P-450
Gene: mlr6364
Organism: Rhizobium loti
Mesorhizobium loti

1uniprot[Pubmed] 11214968 [Medline] 21082930
Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti.(DNA Res.) [2000]

Q8KJK3_RHILO
(Q8KJK3)

4e-32

144

31%

Product: PROBABLE CYTOCHROME P450-LIKE MONOOXYGENASE PROTEIN
Gene: msi071
Organism: Rhizobium loti
Mesorhizobium loti

1uniprot[Pubmed] 12003951 [Medline] 21999272
Comparative sequence analysis of the symbiosis island of Mesorhizobium loti strain R7A.(J. Bacteriol.) [2002]

O52572_AMYMD
(O52572)

4e-32

144

33%

Product: Putative cytochrome P450 monooxygenase
Gene
Organism: Amycolatopsis mediterranei
Nocardia mediterranei

[pubmed all]
1uniprot[Pubmed] 9512878 [Medline] 98174059 Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.(Chem. Biol.) [1998]
2uniprot[Pubmed] 9497318 [Medline] 98165773 3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.(J. Biol. Chem.) [1998]
3uniprot[Pubmed] 11278540 [Medline] 21201076 Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.(J. Biol. Chem.) [2001]

Q595U3_9ACTO
(Q595U3)

4e-32

144

30%

Product: Cytochrome P450 monooxygenase CYP107Z9
Gene: ema12
Organism: Streptomyces tubercidicus

[pubmed all]
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005]
2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005]

B1VKQ9_STRGG
(B1VKQ9)

4e-32

143

32%

Product: Putative cytochrome P450
Gene: SGR_3108
Organism: Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)

1uniprot[Pubmed] 18375553
Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350.(J. Bacteriol.) [2008]

Q47L37_THEFY
(Q47L37)

5e-32

143

30%

Product: Putative cytochrome P450
Gene: Tfu_2802
Organism: Thermobifida fusca (strain YX)

1uniprot[Pubmed] 17209016
Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007]

Q595U9_9ACTO
(Q595U9)

5e-32

143

32%

Product: Cytochrome P450 monooxygenase CYP107Z5v2
Gene: Ema6
Organism: Streptomyces saraceticus

[pubmed all]
1uniprot[Pubmed] 16269732 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.(Appl. Environ. Microbiol.) [2005]
2uniprot[Pubmed] 16269733 Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase.(Appl. Environ. Microbiol.) [2005]

100

C9W348_9ACTO
(C9W348)

6e-32

143

32%

Product: Cytochrome P450 monooxygenase
Gene: nokJ
Organism: Nonomuraea longicatena

1uniprot[Pubmed] 19756308
Molecular cloning, sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs.(Mol. Biosyst.) [2009]