BLAST table : Polk_00180

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	C0JWB3_9ACTO (C0JWB3)	0.0	709	100%	UniProt GenBank	PokMT1	pokMT1	Streptomyces diastatochromogenes
2	B0BLM5_9ACTO (B0BLM5)	1e-142	509	72%	UniProt GenBank	C-methyltransferase	mdpB1	Actinomadura madurae
3	F4FD33_VERMA (F4FD33)	1e-124	449	66%	UniProt GenBank	O-methyltransferase family protein	VAB18032_24825	Verrucosispora maris (strain AB-18-032)
4	D4TGJ7_9NOST (D4TGJ7)	2e-59	234	37%	UniProt GenBank	Putative uncharacterized protein	CRC_01452	Cylindrospermopsis raciborskii CS-505
5	Q10ZS1_TRIEI (Q10ZS1)	4e-59	233	39%	UniProt GenBank	O-methyltransferase, family 2	Tery_3121	Trichodesmium erythraeum (strain IMS101)
6	D7BWH9_STRBB (D7BWH9)	4e-55	219	39%	UniProt GenBank	O-methyltransferase family protein	SBI_00214	Streptomyces bingchenggensis (strain BCW-1)
7	D6R245_STRAQ (D6R245)	1e-54	218	39%	UniProt GenBank	Methyltransferase	acmI	Streptomyces anulatus Streptomyces chrysomallus
8	Q5JCL5_PSEFL (Q5JCL5)	3e-52	210	36%	UniProt GenBank	Putative methyltransferase	sfcF	Pseudomonas fluorescens
9	D6A5N3_9ACTO (D6A5N3)	3e-52	210	36%	UniProt GenBank	O-methyltransferase	SSFG_06981	Streptomyces ghanaensis ATCC 14672
10	B0CN31_STRLA (B0CN31)	3e-52	210	34%	UniProt GenBank	SAM-dependent methyltransferase	sfmM2	Streptomyces lavendulae
11	D0LMS0_HALO1 (D0LMS0)	4e-52	209	40%	UniProt GenBank	O-methyltransferase family 2	Hoch_6286	Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2)
12	E0L2Y5_STRVO (E0L2Y5)	8e-51	205	37%	UniProt GenBank	O-methyltransferase family 2	StrviDRAFT_9263	Streptomyces violaceusniger Tu 4113
13	D6R232_STRAQ (D6R232)	2e-49	201	35%	UniProt GenBank	Methyltransferase	acmL	Streptomyces anulatus Streptomyces chrysomallus
14	C0LTM6_9ACTO (C0LTM6)	3e-49	200	37%	UniProt GenBank	SibL	sibL	Streptosporangium sibiricum
15	F3NRW5_9ACTO (F3NRW5)	5e-49	199	37%	UniProt GenBank	O-methyltransferase	SGM_5879	Streptomyces griseoaurantiacus M045
16	D9WZA0_STRVR (D9WZA0)	4e-48	196	37%	UniProt GenBank	SAM-dependent methyltransferase	SSQG_05921	Streptomyces viridochromogenes DSM 40736
17	A8W7F2_9ACTO (A8W7F2)	4e-47	193	36%	UniProt GenBank	Putative aromatic C-methyltransferase		Streptomyces refuineus subsp. thermotolerans
18	B5GTK6_STRCL (B5GTK6)	3e-45	187	34%	UniProt GenBank	O-methyltransferase SAM-dependent methyltransferase	SCLAV_p0587 SSCG_02754	Streptomyces clavuligerus ATCC 27064
19	E9L1M6_9ZZZZ (E9L1M6)	4e-44	183	32%	UniProt GenBank	Putative uncharacterized protein	CA878-27	uncultured organism CA878
20	E9L1F9_9ZZZZ (E9L1F9)	7e-41	172	31%	UniProt GenBank	Putative uncharacterized protein	CA37-15	uncultured organism CA37
21	E9L1Q3_9ZZZZ (E9L1Q3)	2e-38	164	30%	UniProt GenBank	Putative uncharacterized protein	CA915-11	uncultured organism CA915
22	F5XMS3_9ACTO (F5XMS3)	4e-38	163	33%	UniProt GenBank	Putative O-methyltransferase	MLP_09820	Microlunatus phosphovorus NM-1	2.1.1.- niceE keggE
23	C3AEA4_BACMY (C3AEA4)	4e-38	163	28%	UniProt GenBank	O-methyltransferase, family 2	bmyco0001_51000	Bacillus mycoides DSM 2048
24	A4X1D9_SALTO (A4X1D9)	6e-35	152	31%	UniProt GenBank	O-methyltransferase, family 2	Strop_0204	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
25	A8LXV1_SALAI (A8LXV1)	2e-32	144	31%	UniProt GenBank	O-methyltransferase family 2	Sare_0232	Salinispora arenicola (strain CNS-205)
26	D6A8Q4_9ACTO (D6A8Q4)	2e-32	144	30%	UniProt GenBank	O-methyltransferase family 2	SSFG_07273	Streptomyces ghanaensis ATCC 14672
27	B4XY98_9ACTO (B4XY98)	2e-32	144	30%	UniProt GenBank	Azi5	azi5	Streptomyces sahachiroi
28	D3F6H0_CONWI (D3F6H0)	1e-30	138	31%	UniProt GenBank	O-methyltransferase family 2	Cwoe_2312	Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
29	E2Q8B6_STRCL (E2Q8B6)	8e-30	135	30%	UniProt GenBank	O-methyltransferase family protein	SCLAV_0372	Streptomyces clavuligerus ATCC 27064
30	D5W6P9_BURSC (D5W6P9)	3e-29	134	31%	UniProt GenBank	O-methyltransferase family 2	BC1002_1107	Burkholderia sp. (strain CCGE1002)
31	E8L6E2_9RHIZ (E8L6E2)	7e-28	129	29%	UniProt GenBank	O-methyltransferase family 2	Met49242DRAFT_3035	Methylocystis sp. ATCC 49242
32	B9XHA2_9BACT (B9XHA2)	5e-27	126	29%	UniProt GenBank	O-methyltransferase family 2	Cflav_PD3595	Pedosphaera parvula Ellin514
33	E8YT36_9BURK (E8YT36)	5e-27	126	30%	UniProt GenBank	O-methyltransferase family 2	BC1001_5255	Burkholderia sp. CCGE1001
34	E1TE69_BURSG (E1TE69)	2e-26	124	30%	UniProt GenBank	O-methyltransferase family 2	BC1003_4162	Burkholderia sp. (strain CCGE1003)
35	Q46PN2_CUPPJ (Q46PN2)	3e-26	124	29%	UniProt GenBank	O-methyltransferase, family 2	Reut_B5557	Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) Alcaligenes eutrophus Ralstonia eutropha
36	B5WKQ7_9BURK (B5WKQ7)	4e-25	120	29%	UniProt GenBank	O-methyltransferase family 2	BH160DRAFT_3660	Burkholderia sp. H160
37	B2HRS9_MYCMM (B2HRS9)	4e-25	120	29%	UniProt GenBank	Methyltransferase/methylase	MMAR_0934	Mycobacterium marinum (strain ATCC BAA-535 / M)
38	D9VDF4_9ACTO (D9VDF4)	6e-25	119	29%	UniProt GenBank	Predicted protein	SSMG_05689	Streptomyces sp. AA4
39	C4SGC7_YERMO (C4SGC7)	7e-25	119	26%	UniProt GenBank	SAM-dependent methyltransferase	ymoll0001_37470	Yersinia mollaretii ATCC 43969
40	C4S6I3_YERBE (C4S6I3)	7e-25	119	27%	UniProt GenBank	SAM-dependent methyltransferase	yberc0001_39400	Yersinia bercovieri ATCC 43970
41	Q2Y6M3_NITMU (Q2Y6M3)	7e-25	119	29%	UniProt GenBank	Putative transcriptional regulator	Nmul_A2307	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
42	B5IJZ5_9CHRO (B5IJZ5)	1e-24	119	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO	CPCC7001_993	Cyanobium sp. PCC 7001
43	A0PLX6_MYCUA (A0PLX6)	2e-24	118	29%	UniProt GenBank	Methyltransferase/methylase	MUL_0686	Mycobacterium ulcerans (strain Agy99)
44	A7DWL9_STRTE (A7DWL9)	2e-24	117	29%	UniProt GenBank	Putative O-methyltransferase	llpMVI	Streptomyces tendae	2.1.1.- niceE keggE
45	Q01QE9_SOLUE (Q01QE9)	3e-24	117	28%	UniProt GenBank	O-methyltransferase, family 2	Acid_7210	Solibacter usitatus (strain Ellin6076)
46	Q1Q4M5_9BACT (Q1Q4M5)	5e-24	116	25%	UniProt GenBank	Similar to tetracenomycin polyketide synthesis 8-O-methyltransferase	tcmO kuste4198	Candidatus Kuenenia stuttgartiensis	2.1.1.- niceE keggE
47	B5IIH6_9CHRO (B5IIH6)	5e-24	116	30%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO	CPCC7001_2675	Cyanobium sp. PCC 7001
48	B2JR16_BURP8 (B2JR16)	6e-24	116	28%	UniProt GenBank	O-methyltransferase family 2	Bphy_4597	Burkholderia phymatum (strain DSM 17167 / STM815)
49	B8IQN6_METNO (B8IQN6)	1e-23	115	28%	UniProt GenBank	O-methyltransferase family 2	Mnod_5718	Methylobacterium nodulans (strain ORS2060 / LMG 21967)
50	Q09AX9_STIAD (Q09AX9)	1e-23	115	30%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO	STAUR_4619 STIAU_6869	Stigmatella aurantiaca (strain DW4/3-1)	2.1.1.- niceE keggE
51	A4FDN1_SACEN (A4FDN1)	3e-23	114	28%	UniProt GenBank	Putative 8-O-methyltransferase	tcmO SACE_2878	Saccharopolyspora erythraea (strain NRRL 23338)	2.1.1.- niceE keggE
52	B4R7V6_PHEZH (B4R7V6)	3e-23	114	29%	UniProt GenBank	Methyltransferase/methylase	PHZ_c1075	Phenylobacterium zucineum (strain HLK1)
53	Q2T088_BURTA (Q2T088)	4e-23	113	27%	UniProt GenBank	O-methyltransferase family protein	BTH_I0855	Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)
54	F4XTC6_9CYAN (F4XTC6)	5e-23	113	28%	UniProt GenBank	O-methyltransferase	LYNGBM3L_29010	Lyngbya majuscula 3L
55	A8ZX85_DESOH (A8ZX85)	6e-23	113	27%	UniProt GenBank	O-methyltransferase family 2	Dole_2661	Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
56	C7PAY6_CHIPD (C7PAY6)	9e-23	112	28%	UniProt GenBank	Methyltransferase type 12	Cpin_1862	Chitinophaga pinensis (strain ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034)
57	D9WHF4_9ACTO (D9WHF4)	1e-22	112	28%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	SSOG_08794	Streptomyces himastatinicus ATCC 53653
58	Q7D9M4_MYCTU (Q7D9M4)	2e-22	111	29%	UniProt GenBank	Tetracenpmycin polyketide synthesis 8-o-methyltransferase	tcmO MT0593	Mycobacterium tuberculosis	2.1.1.- niceE keggE
59	O53764_MYCTU (O53764)	2e-22	111	29%	UniProt GenBank	PROBABLE METHYLTRANSFERASE/METHYLASE	Rv0567	Mycobacterium tuberculosis	2.1.1.- niceE keggE
60	C6DTT8_MYCTK (C6DTT8)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TBMG_00572	Mycobacterium tuberculosis (strain KZN 1435 / MDR)
61	A5WJT1_MYCTF (A5WJT1)	2e-22	111	29%	UniProt GenBank	Hypothetical methyltransferase	TBFG_10577	Mycobacterium tuberculosis (strain F11)
62	A5TZU7_MYCTA (A5TZU7)	2e-22	111	29%	UniProt GenBank	Tetracenpmycin polyketide synthesis 8-o-methyltransferase	MRA_0574	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
63	F7WRF0_MYCTU (F7WRF0)	2e-22	111	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-o-methyltransferase	CCDC5180_0525	Mycobacterium tuberculosis CCDC5180
64	F7WML9_MYCTU (F7WML9)	2e-22	111	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-o-methyltransferase	CCDC5079_0533	Mycobacterium tuberculosis CCDC5079
65	F2VBK0_MYCTU (F2VBK0)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TBPG_00238	Mycobacterium tuberculosis W-148
66	F2GML2_MYCTU (F2GML2)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TBSG_00578	Mycobacterium tuberculosis KZN 4207
67	E9ZG14_MYCTU (E9ZG14)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMMG_03943	Mycobacterium tuberculosis CDC1551A
68	E2WED1_MYCTU (E2WED1)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMLG_03715	Mycobacterium tuberculosis SUMu012
69	E2W2F3_MYCTU (E2W2F3)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMKG_02904	Mycobacterium tuberculosis SUMu011
70	E2VR50_MYCTU (E2VR50)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMJG_02311	Mycobacterium tuberculosis SUMu010
71	E2VEV1_MYCTU (E2VEV1)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMIG_01468	Mycobacterium tuberculosis SUMu009
72	E2V5J0_MYCTU (E2V5J0)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMHG_03589	Mycobacterium tuberculosis SUMu008
73	E2UUB1_MYCTU (E2UUB1)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMGG_03581	Mycobacterium tuberculosis SUMu007
74	E2UI58_MYCTU (E2UI58)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMFG_01869	Mycobacterium tuberculosis SUMu006
75	E2U762_MYCTU (E2U762)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMEG_03151	Mycobacterium tuberculosis SUMu005
76	E2TV91_MYCTU (E2TV91)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMDG_03856	Mycobacterium tuberculosis SUMu004
77	E2TIK6_MYCTU (E2TIK6)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMCG_03944	Mycobacterium tuberculosis SUMu003
78	E2T8S5_MYCTU (E2T8S5)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMBG_03804	Mycobacterium tuberculosis SUMu002
79	E1H6D5_MYCTU (E1H6D5)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TMAG_03572	Mycobacterium tuberculosis SUMu001
80	D7EN41_MYCTU (D7EN41)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TBAG_03182	Mycobacterium tuberculosis 94_M4241A
81	D6F1H0_MYCTU (D6F1H0)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TBLG_02695	Mycobacterium tuberculosis T46
82	D5ZCU7_MYCTU (D5ZCU7)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TBJG_04119	Mycobacterium tuberculosis T17
83	D5Z0E3_MYCTU (D5Z0E3)	2e-22	111	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	TBIG_03509	Mycobacterium tuberculosis GM 1503
84	D5YNL4_MYCTU (D5YNL4)	2e-22	111	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	TBBG_03286	Mycobacterium tuberculosis 02_1987
85	D5YCQ5_MYCTU (D5YCQ5)	2e-22	111	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	TBGG_03722	Mycobacterium tuberculosis EAS054
86	D5Y0N6_MYCTU (D5Y0N6)	2e-22	111	29%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	TBEG_03969	Mycobacterium tuberculosis T85
87	D5XQJ2_MYCTU (D5XQJ2)	2e-22	111	29%	UniProt GenBank	Methyltransferase/methylase	TBDG_04101	Mycobacterium tuberculosis T92
88	A4KEQ0_MYCTU (A4KEQ0)	2e-22	111	29%	UniProt GenBank	Hypothetical methyltransferase/methylase	TBHG_00564	Mycobacterium tuberculosis str. Haarlem
89	A2VFP7_MYCTU (A2VFP7)	2e-22	111	29%	UniProt GenBank	Putative uncharacterized protein	TBCG_00562	Mycobacterium tuberculosis C
90	D6TYB9_9CHLR (D6TYB9)	2e-22	111	27%	UniProt GenBank	O-methyltransferase family 2	Krac_4137	Ktedonobacter racemifer DSM 44963
91	D8PJ97_9BACT (D8PJ97)	2e-22	111	29%	UniProt GenBank	O-methyltransferase, family 2	NIDE3796	Candidatus Nitrospira defluvii	2.1.1.- niceE keggE
92	Q0SIR2_RHOSR (Q0SIR2)	2e-22	111	29%	UniProt GenBank	Polyketide synthesis 8-O-methyltransferase	RHA1_ro00739	Rhodococcus sp. (strain RHA1)	2.1.1.- niceE keggE
93	HIOM_BOVIN (P10950)	2e-22	111	28%	UniProt GenBank	Hydroxyindole O-methyltransferase Acetylserotonin O-methyltransferase Acetylserotonin O-methyltransferase	ASMT	Bos taurus Bovine	2.1.1.4 niceE keggE
94	Q2Y9U0_NITMU (Q2Y9U0)	2e-22	111	25%	UniProt GenBank	O-methyltransferase, family 2	Nmul_A1178	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
95	A3ZPN0_9PLAN (A3ZPN0)	2e-22	111	28%	UniProt GenBank	Putative methyltransferase	DSM3645_29042	Blastopirellula marina DSM 3645
96	C1B538_RHOOB (C1B538)	3e-22	110	30%	UniProt GenBank	Putative methyltransferase	ROP_27170	Rhodococcus opacus (strain B4)	2.1.1.- niceE keggE
97	A0SZW0_9ACTO (A0SZW0)	5e-22	110	28%	UniProt GenBank	PdmT	pdmT	Actinomadura hibisca
98	D5QMD4_METTR (D5QMD4)	7e-22	109	30%	UniProt GenBank	O-methyltransferase family 2	MettrDRAFT_0960	Methylosinus trichosporium OB3b
99	D5MRJ4_9ACTO (D5MRJ4)	8e-22	109	30%	UniProt GenBank	Putative O-methyltransferase	hrbU	Streptomyces sp. 2238-SVT4
100	D2QXW1_PIRSD (D2QXW1)	8e-22	109	27%	UniProt GenBank	O-methyltransferase family 2	Psta_3374	Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) Pirella staleyi

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

C0JWB3_9ACTO
(C0JWB3)

0.0

709

100%

Product: PokMT1
Gene: pokMT1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

B0BLM5_9ACTO
(B0BLM5)

1e-142

509

72%

Product: C-methyltransferase
Gene: mdpB1
Organism: Actinomadura madurae

[pubmed all]
1uniprot[Pubmed] 14528002 [Medline] 22922109 Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model.(Proc. Natl. Acad. Sci. U.S.A.) [2003]
2uniprot[Pubmed] 17918933 Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.(J. Am. Chem. Soc.) [2007]

F4FD33_VERMA
(F4FD33)

1e-124

449

66%

Product: O-methyltransferase family protein
Gene: VAB18032_24825
Organism: Verrucosispora maris (strain AB-18-032)

1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]

D4TGJ7_9NOST
(D4TGJ7)

2e-59

234

37%

Product: Putative uncharacterized protein
Gene: CRC_01452
Organism: Cylindrospermopsis raciborskii CS-505

1uniprot[Pubmed] 20169071
The smallest known genomes of multicellular and toxic cyanobacteria: comparison, minimal gene sets for linked traits and the evolutionary implications.(PLoS ONE) [2010]

D7BWH9_STRBB
(D7BWH9)

4e-55

219

39%

Product: O-methyltransferase family protein
Gene: SBI_00214
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

D6R245_STRAQ
(D6R245)

1e-54

218

39%

Product: Methyltransferase
Gene: acmI
Organism: Streptomyces anulatus
Streptomyces chrysomallus

[pubmed all]
1uniprot[Pubmed] 10212227 [Medline] 99230270 Molecular characterization of the genes of actinomycin synthetase I and of a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces.(J. Biol. Chem.) [1999]
2uniprot[Pubmed] 10780924 [Medline] 20243879 Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides.(Chem. Biol.) [2000]
3uniprot[Pubmed] 20304989 The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry.(J. Bacteriol.) [2010]

Q5JCL5_PSEFL
(Q5JCL5)

3e-52

210

36%

Product: Putative methyltransferase
Gene: sfcF
Organism: Pseudomonas fluorescens

1uniprot[Pubmed] 15773985
Molecular characterization of the safracin biosynthetic pathway from Pseudomonas fluorescens A2-2: designing new cytotoxic compounds.(Mol. Microbiol.) [2005]

B0CN31_STRLA
(B0CN31)

3e-52

210

34%

Product: SAM-dependent methyltransferase
Gene: sfmM2
Organism: Streptomyces lavendulae

1uniprot[Pubmed] 17981978
Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner.(J. Bacteriol.) [2008]

D6R232_STRAQ
(D6R232)

2e-49

201

35%

Product: Methyltransferase
Gene: acmL
Organism: Streptomyces anulatus
Streptomyces chrysomallus

[pubmed all]
1uniprot[Pubmed] 10212227 [Medline] 99230270 Molecular characterization of the genes of actinomycin synthetase I and of a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces.(J. Biol. Chem.) [1999]
2uniprot[Pubmed] 10780924 [Medline] 20243879 Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides.(Chem. Biol.) [2000]
3uniprot[Pubmed] 20304989 The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry.(J. Bacteriol.) [2010]

C0LTM6_9ACTO
(C0LTM6)

3e-49

200

37%

Product: SibL
Gene: sibL
Organism: Streptosporangium sibiricum

1uniprot[Pubmed] 19270142
Biosynthesis of sibiromycin, a potent antitumor antibiotic.(Appl. Environ. Microbiol.) [2009]

F3NRW5_9ACTO
(F3NRW5)

5e-49

199

37%

Product: O-methyltransferase
Gene: SGM_5879
Organism: Streptomyces griseoaurantiacus M045

1uniprot[Pubmed] 21551298
Draft Genome Sequence of the Marine Bacterium Streptomyces griseoaurantiacus M045, Which Produces Novel Manumycin-Type Antibiotics with a pABA Core Component.(J. Bacteriol.) [2011]

A8W7F2_9ACTO
(A8W7F2)

4e-47

193

36%

Product: Putative aromatic C-methyltransferase
Gene
Organism: Streptomyces refuineus subsp. thermotolerans

1uniprot[Pubmed] 17584616
Benzodiazepine biosynthesis in Streptomyces refuineus.(Chem. Biol.) [2007]

B5GTK6_STRCL
(B5GTK6)

3e-45

187

34%

Product: O-methyltransferase
SAM-dependent methyltransferase
Gene: SCLAV_p0587
SSCG_02754
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot
The sequence of a 1.8 Mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

E9L1M6_9ZZZZ
(E9L1M6)

4e-44

183

32%

Product: Putative uncharacterized protein
Gene: CA878-27
Organism: uncultured organism CA878

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

E9L1F9_9ZZZZ
(E9L1F9)

7e-41

172

31%

Product: Putative uncharacterized protein
Gene: CA37-15
Organism: uncultured organism CA37

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

E9L1Q3_9ZZZZ
(E9L1Q3)

2e-38

164

30%

Product: Putative uncharacterized protein
Gene: CA915-11
Organism: uncultured organism CA915

1uniprot[Pubmed] 20945895
Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products.(J. Am. Chem. Soc.) [2010]

B4XY98_9ACTO
(B4XY98)

2e-32

144

30%

Product: Azi5
Gene: azi5
Organism: Streptomyces sahachiroi

1uniprot[Pubmed] 18635006
Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.(Chem. Biol.) [2008]

E2Q8B6_STRCL
(E2Q8B6)

8e-30

135

30%

Product: O-methyltransferase family protein
Gene: SCLAV_0372
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot[Pubmed] 20624727
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

E8L6E2_9RHIZ
(E8L6E2)

7e-28

129

29%

Product: O-methyltransferase family 2
Gene: Met49242DRAFT_3035
Organism: Methylocystis sp. ATCC 49242

1uniprot[Pubmed] 21441518
Genome Sequence of the Methanotrophic Alphaproteobacterium Methylocystis sp. Strain Rockwell (ATCC 49242).(J. Bacteriol.) [2011]

B9XHA2_9BACT
(B9XHA2)

5e-27

126

29%

Product: O-methyltransferase family 2
Gene: Cflav_PD3595
Organism: Pedosphaera parvula Ellin514

1uniprot[Pubmed] 21460084
Genome Sequence of 'Pedosphaera parvula' Ellin514, an Aerobic Verrucomicrobial Isolate from Pasture Soil.(J. Bacteriol.) [2011]

B2HRS9_MYCMM
(B2HRS9)

4e-25

120

29%

Product: Methyltransferase/methylase
Gene: MMAR_0934
Organism: Mycobacterium marinum (strain ATCC BAA-535 / M)

1uniprot[Pubmed] 18403782
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008]

A0PLX6_MYCUA
(A0PLX6)

2e-24

118

29%

Product: Methyltransferase/methylase
Gene: MUL_0686
Organism: Mycobacterium ulcerans (strain Agy99)

1uniprot[Pubmed] 17210928
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.(Genome Res.) [2007]

A7DWL9_STRTE
(A7DWL9)

2e-24

117

29%

Product: Putative O-methyltransferase
Gene: llpMVI
Organism: Streptomyces tendae

1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]

Q01QE9_SOLUE
(Q01QE9)

3e-24

117

28%

Product: O-methyltransferase, family 2
Gene: Acid_7210
Organism: Solibacter usitatus (strain Ellin6076)

1uniprot[Pubmed] 19201974
Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils.(Appl. Environ. Microbiol.) [2009]

Q1Q4M5_9BACT
(Q1Q4M5)

5e-24

116

25%

Product: Similar to tetracenomycin polyketide synthesis 8-O-methyltransferase
Gene: tcmO
kuste4198
Organism: Candidatus Kuenenia stuttgartiensis

1uniprot[Pubmed] 16598256
Deciphering the evolution and metabolism of an anammox bacterium from a community genome.(Nature) [2006]

A4FDN1_SACEN
(A4FDN1)

3e-23

114

28%

Product: Putative 8-O-methyltransferase
Gene: tcmO
SACE_2878
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

B4R7V6_PHEZH
(B4R7V6)

3e-23

114

29%

Product: Methyltransferase/methylase
Gene: PHZ_c1075
Organism: Phenylobacterium zucineum (strain HLK1)

1uniprot[Pubmed] 18700039
Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562.(BMC Genomics) [2008]

Q2T088_BURTA
(Q2T088)

4e-23

113

27%

Product: O-methyltransferase family protein
Gene: BTH_I0855
Organism: Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301)

1uniprot[Pubmed] 16336651
Bacterial genome adaptation to niches: divergence of the potential virulence genes in three Burkholderia species of different survival strategies.(BMC Genomics) [2005]

F4XTC6_9CYAN
(F4XTC6)

5e-23

113

28%

Product: O-methyltransferase
Gene: LYNGBM3L_29010
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

Q7D9M4_MYCTU
(Q7D9M4)

2e-22

111

29%

Product: Tetracenpmycin polyketide synthesis 8-o-methyltransferase
Gene: tcmO
MT0593
Organism: Mycobacterium tuberculosis

1uniprot[Pubmed] 12218036 [Medline] 22206494
Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.(J. Bacteriol.) [2002]

O53764_MYCTU
(O53764)

2e-22

111

29%

Product: PROBABLE METHYLTRANSFERASE/METHYLASE
Gene: Rv0567
Organism: Mycobacterium tuberculosis

1uniprot[Pubmed] 9634230 [Medline] 98295987
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.(Nature) [1998]

D8PJ97_9BACT
(D8PJ97)

2e-22

111

29%

Product: O-methyltransferase, family 2
Gene: NIDE3796
Organism: Candidatus Nitrospira defluvii

1uniprot
A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

Q0SIR2_RHOSR
(Q0SIR2)

2e-22

111

29%

Product: Polyketide synthesis 8-O-methyltransferase
Gene: RHA1_ro00739
Organism: Rhodococcus sp. (strain RHA1)

1uniprot[Pubmed] 17030794
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

HIOM_BOVIN
(P10950)

2e-22

111

28%

Product: Hydroxyindole O-methyltransferase
Acetylserotonin O-methyltransferase
Acetylserotonin O-methyltransferase
Gene: ASMT
Organism: Bos taurus
Bovine

[pubmed all]
1uniprot[Pubmed] 3818627 [Medline] 87137548 Molecular cloning and nucleotide sequence of cDNA encoding hydroxyindole O-methyltransferase of bovine pineal glands.(J. Biol. Chem.) [1987]
2uniprot[Pubmed] 1544900 [Medline] 92184762 Bovine hydroxyindole-O-methyltransferase. Significant sequence revision.(J. Biol. Chem.) [1992]

D5QMD4_METTR
(D5QMD4)

7e-22

109

30%

Product: O-methyltransferase family 2
Gene: MettrDRAFT_0960
Organism: Methylosinus trichosporium OB3b

1uniprot[Pubmed] 20952571
Genome Sequence of the Obligate Methanotroph Methylosinus trichosporium Strain OB3b.(J. Bacteriol.) [2010]

D5MRJ4_9ACTO
(D5MRJ4)

8e-22

109

30%

Product: Putative O-methyltransferase
Gene: hrbU
Organism: Streptomyces sp. 2238-SVT4

1uniprot[Pubmed] 20453135
Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.(Appl. Environ. Microbiol.) [2010]

100

D2QXW1_PIRSD
(D2QXW1)

8e-22

109

27%

Product: O-methyltransferase family 2
Gene: Psta_3374
Organism: Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128)
Pirella staleyi

1uniprot
Complete genome sequence of Pirellula staleyi type strain (ATCC 27377T).(Stand. Genomic Sci.) [2009]