BLAST table : Polk_00370

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	C0JWD2_9ACTO (C0JWD2)	1e-137	491	100%	UniProt GenBank	PokT2	pokT2	Streptomyces diastatochromogenes
2	Q194R2_STRAA (Q194R2)	1e-66	257	58%	UniProt GenBank	Ketoreductase	mtmTII	Streptomyces argillaceus
3	D7BZT7_STRBB (D7BZT7)	4e-59	232	54%	UniProt GenBank	Acetoacetyl-CoA reductase	SBI_06872	Streptomyces bingchenggensis (strain BCW-1)
4	Q70J64_STRGR (Q70J64)	7e-58	228	52%	UniProt GenBank	Ketoreductase	cmmTII	Streptomyces griseus subsp. griseus
5	D2AY70_STRRD (D2AY70)	7e-53	211	50%	UniProt GenBank	Acetoacetyl-CoA reductase	Sros_4176	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
6	A7DWL7_STRTE (A7DWL7)	2e-52	210	48%	UniProt GenBank	Putative reductase	llpZIV	Streptomyces tendae	1.1.1.- niceE keggE
7	Q8KSY1_9ACTO (Q8KSY1)	3e-48	196	49%	UniProt GenBank	Putative 3-oxoacyl-ACP reductase GrhO2	grhO2	Streptomyces sp. JP95
8	D2BF84_STRRD (D2BF84)	5e-43	179	46%	UniProt GenBank	Short chain dehydrogenase/reductase	Sros_5485	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
9	Q8KY44_STRCU (Q8KY44)	1e-40	171	45%	UniProt GenBank	RubJ	rubJ	Streptomyces collinus
10	D1A269_THECD (D1A269)	8e-37	158	42%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Tcur_4195	Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)
11	A6DWC8_9RHOB (A6DWC8)	3e-35	153	40%	UniProt GenBank	Acetoacetyl-CoA reductase	RTM1035_16997	Roseovarius sp. TM1035
12	D2PNP6_KRIFD (D2PNP6)	7e-35	151	40%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Kfla_1804	Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399)
13	B8FRS3_DESHD (B8FRS3)	7e-35	151	39%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	Dhaf_3817	Desulfitobacterium hafniense (strain DCB-2 / DSM 10664)
14	Q24U43_DESHY (Q24U43)	3e-34	149	39%	UniProt GenBank	Putative uncharacterized protein	DSY2660	Desulfitobacterium hafniense (strain Y51)
15	Q8GE35_HELMO (Q8GE35)	3e-34	149	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier protein] reductase		Heliobacillus mobilis	1.1.1.100 niceE keggE
16	F2J0A7_POLGS (F2J0A7)	3e-34	149	39%	UniProt GenBank	Acetoacetyl-CoA reductase subfamily	SL003B_0203	Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1)
17	E8RKW5_9CAUL (E8RKW5)	5e-34	149	39%	UniProt GenBank	Acetoacetyl-CoA reductase	Astex_0842	Asticcacaulis excentricus CB 48
18	A3W567_9RHOB (A3W567)	8e-34	148	40%	UniProt GenBank	Acetoacetyl-CoA reductase	ROS217_11191	Roseovarius sp. 217
19	C3MAK9_RHISN (C3MAK9)	2e-33	147	40%	UniProt GenBank	Acetoacetyl-CoA reductase	NGR_c32710	Rhizobium sp. (strain NGR234)
20	A8U0P7_9PROT (A8U0P7)	3e-33	146	38%	UniProt GenBank	Acetoacetyl-CoA reductase	BAL199_09710	alpha proteobacterium BAL199
21	D4KDT6_9FIRM (D4KDT6)	4e-33	145	36%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	MHY_17600	Megamonas hypermegale ART12/1	1.1.1.100 niceE keggE
22	F4QPE9_9CAUL (F4QPE9)	4e-33	145	39%	UniProt GenBank	Acetoacetyl-CoA reductase	ABI_26220	Asticcacaulis biprosthecum C19	1.1.1.36 niceE keggE
23	E2Z9U0_9FIRM (E2Z9U0)	5e-33	145	39%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	HMPREF9429_00196	Megasphaera micronuciformis F0359
24	A5VF71_SPHWW (A5VF71)	6e-33	145	39%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	Swit_4599	Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)	1.1.1.100 niceE keggE
25	D0DBA3_9RHOB (D0DBA3)	6e-33	145	40%	UniProt GenBank	Acetoacetyl-CoA reductase	CSE45_2903	Citreicella sp. SE45	1.1.1.36 niceE keggE
26	D2S4A3_GEOOG (D2S4A3)	6e-33	145	39%	UniProt GenBank	Short-chain dehydrogenase/reductase SDR	Gobs_2422	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)
27	D0CQB9_9RHOB (D0CQB9)	6e-33	145	39%	UniProt GenBank	Acetoacetyl-CoA reductase	SL1157_0673	Silicibacter lacuscaerulensis ITI-1157	1.1.1.36 niceE keggE
28	Q1NA22_9SPHN (Q1NA22)	1e-32	144	39%	UniProt GenBank	Acetoacetyl-CoA reductase	SKA58_12175	Sphingomonas sp. SKA58
29	B9QVM6_9RHOB (B9QVM6)	2e-32	144	37%	UniProt GenBank	Acetoacetyl-CoA reductase subfamily	SADFL11_5251	Labrenzia alexandrii DFL-11	1.1.1.36 niceE keggE
30	Q0FIN9_9RHOB (Q0FIN9)	2e-32	144	40%	UniProt GenBank	Acetoacetyl-CoA reductase	R2601_11861	Pelagibaca bermudensis HTCC2601
31	Q2RXR7_RHORT (Q2RXR7)	2e-32	144	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	Rru_A0273	Rhodospirillum rubrum (strain ATCC 11170 / NCIB 8255)	1.1.1.100 niceE keggE
32	B7QRZ7_9RHOB (B7QRZ7)	2e-32	144	39%	UniProt GenBank	Acetoacetyl-CoA reductase	RR11_1411	Ruegeria sp. R11	1.1.1.36 niceE keggE
33	B0UPG3_METS4 (B0UPG3)	2e-32	143	38%	UniProt GenBank	Acetoacetyl-CoA reductase	M446_5281	Methylobacterium sp. (strain 4-46)
34	E2NN97_9FIRM (E2NN97)	2e-32	143	37%	UniProt GenBank	Putative uncharacterized protein	CATMIT_00021	Catenibacterium mitsuokai DSM 15897
35	A0NWY3_9RHOB (A0NWY3)	2e-32	143	37%	UniProt GenBank	Short-chain dehydrogenase/reductase	SIAM614_26693	Labrenzia aggregata IAM 12614
36	D3NX21_AZOS1 (D3NX21)	2e-32	143	37%	UniProt GenBank	Acetoacetyl-CoA reductase	phbB AZL_023120	Azospirillum sp. (strain B510)	1.1.1.36 niceE keggE
37	A6FM76_9RHOB (A6FM76)	2e-32	143	39%	UniProt GenBank	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA RAZWK3B_04700	Roseobacter sp. AzwK-3b
38	B6R6G0_9RHOB (B6R6G0)	3e-32	143	37%	UniProt GenBank	Acetoacetyl-CoA reductase	PJE062_3398	Pseudovibrio sp. JE062	1.1.1.36 niceE keggE
39	B0TGW0_HELMI (B0TGW0)	4e-32	142	37%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	fabG Helmi_20960 HM1_2165	Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
40	E2CG68_9RHOB (E2CG68)	5e-32	142	37%	UniProt GenBank	Acetoacetyl-CoA reductase	TRICHSKD4_2205	Roseibium sp. TrichSKD4
41	C8PW99_9GAMM (C8PW99)	5e-32	142	39%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	fabG ENHAE0001_2247	Enhydrobacter aerosaccus SK60	1.1.1.100 niceE keggE
42	E8L1Z8_9RHIZ (E8L1Z8)	5e-32	142	39%	UniProt GenBank	Acetoacetyl-CoA reductase	Met49242DRAFT_1564	Methylocystis sp. ATCC 49242
43	F2F653_SOLSS (F2F653)	6e-32	142	35%	UniProt GenBank	Dehydrogenase with different specificities	fabG SSIL_3034	Solibacillus silvestris (strain StLB046) Bacillus silvestris
44	A4BPY3_9GAMM (A4BPY3)	7e-32	142	37%	UniProt GenBank	3-ketoacyl-(Acyl-carrier-protein) reductase	fabG NB231_04495	Nitrococcus mobilis Nb-231	1.1.1.100 niceE keggE
45	A3VB24_9RHOB (A3VB24)	7e-32	141	39%	UniProt GenBank	Acetoacetyl-CoA reductase	RB2654_16036	Maritimibacter alkaliphilus HTCC2654
46	F5J7B5_9RHIZ (F5J7B5)	8e-32	141	40%	UniProt GenBank	Acetoacetyl CoA reductase; poly-beta-hydroxybutyrate biosynthesis	phbB AGRO_1047	Agrobacterium sp. ATCC 31749
47	A3JXV4_9RHOB (A3JXV4)	9e-32	141	40%	UniProt GenBank	Acetoacetyl-CoA reductase	SSE37_20082	Sagittula stellata E-37
48	B0UGS8_METS4 (B0UGS8)	1e-31	141	38%	UniProt GenBank	Acetoacetyl-CoA reductase	M446_1247	Methylobacterium sp. (strain 4-46)
49	Q0A9Z0_ALHEH (Q0A9Z0)	1e-31	141	36%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	Mlg_0994	Alkalilimnicola ehrlichei (strain MLHE-1)	1.1.1.100 niceE keggE
50	A7IJZ4_XANP2 (A7IJZ4)	1e-31	141	39%	UniProt GenBank	Acetoacetyl-CoA reductase	Xaut_3107	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
51	Q7CWA4_AGRT5 (Q7CWA4)	1e-31	140	40%	UniProt GenBank	Acetoacetyl CoA reductase; poly-beta-hydroxybutyrate biosynthesis	phbB Atu2770	Agrobacterium tumefaciens (strain C58 / ATCC 33970)
52	F7Z3Y0_BACCO (F7Z3Y0)	2e-31	140	36%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	fabG BCO26_1098	Bacillus coagulans 2-6
53	D5QN72_METTR (D5QN72)	2e-31	140	38%	UniProt GenBank	Acetoacetyl-CoA reductase	MettrDRAFT_1248	Methylosinus trichosporium OB3b
54	F7X1R0_RHIME (F7X1R0)	2e-31	140	40%	UniProt GenBank	PhbB	phbB SM11_chr3389	Sinorhizobium meliloti SM11	1.1.1.36 niceE keggE
55	F6E570_RHIME (F6E570)	2e-31	140	40%	UniProt GenBank	Acetoacetyl-CoA reductase	Sinme_3258	Sinorhizobium meliloti AK83	1.1.1.36 niceE keggE
56	F6BUW1_RHIME (F6BUW1)	2e-31	140	40%	UniProt GenBank	Acetoacetyl-CoA reductase	SinmeB_3033	Sinorhizobium meliloti BL225C	1.1.1.36 niceE keggE
57	PHBB_RHIME (P50205)	2e-31	140	40%	UniProt GenBank	Acetoacetyl-CoA reductase	phbB R03261 SMc03878	Rhizobium meliloti Ensifer meliloti Sinorhizobium meliloti	1.1.1.36 niceE keggE
58	Q28V53_JANSC (Q28V53)	2e-31	140	39%	UniProt GenBank	Acetoacetyl-CoA reductase	Jann_0492	Jannaschia sp. (strain CCS1)
59	B5J0F4_9RHOB (B5J0F4)	2e-31	140	38%	UniProt GenBank	Acetoacetyl-CoA reductase subfamily	OA307_4748	Octadecabacter antarcticus 307	1.1.1.36 niceE keggE
60	PHBB_ZOORA (P23238)	3e-31	140	39%	UniProt GenBank	Acetoacetyl-CoA reductase	phbB	Zoogloea ramigera	1.1.1.36 niceE keggE
61	C9LSK7_9FIRM (C9LSK7)	3e-31	140	37%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase 3-oxoacyl-[acyl-carrier-protein] reductase	SELSPUOL_00432 Selsp_1727	Selenomonas sputigena ATCC 35185	1.1.1.100 niceE keggE
62	D9WDH3_9ACTO (D9WDH3)	3e-31	139	40%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	SSOG_06894	Streptomyces himastatinicus ATCC 53653
63	Q1GKW3_SILST (Q1GKW3)	3e-31	139	37%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	TM1040_3736	Silicibacter sp. (strain TM1040)	1.1.1.100 niceE keggE
64	C9CSH8_9RHOB (C9CSH8)	3e-31	139	37%	UniProt GenBank	Acetoacetyl-CoA reductase	SCH4B_0404	Silicibacter sp. TrichCH4B	1.1.1.36 niceE keggE
65	B8IFT4_METNO (B8IFT4)	4e-31	139	38%	UniProt GenBank	Acetoacetyl-CoA reductase	Mnod_4780 Mnod_5916	Methylobacterium nodulans (strain ORS2060 / LMG 21967)
66	Q2S6I1_SALRD (Q2S6I1)	4e-31	139	38%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	fabG SRU_0045	Salinibacter ruber (strain DSM 13855 / M31)	1.1.1.100 niceE keggE
67	D5H4K9_SALRM (D5H4K9)	4e-31	139	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	fabG SRM_00043	Salinibacter ruber (strain M8)	1.1.1.100 niceE keggE
68	D5DZ99_BACMQ (D5DZ99)	4e-31	139	37%	UniProt GenBank	Acetoacetyl-CoA reductase	phaB BMQ_1230	Bacillus megaterium (strain ATCC 12872 / QMB1551)	1.1.1.36 niceE keggE
69	Q9ZF93_BACME (Q9ZF93)	4e-31	139	37%	UniProt GenBank	3-ketoacyl-CoA reductase PhaB	phaB	Bacillus megaterium
70	D6GQY4_FILAD (D6GQY4)	4e-31	139	35%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	HMPREF0389_01112	Filifactor alocis (strain ATCC 35896 / D40 B5) Fusobacterium alocis
71	B9NL39_9RHOB (B9NL39)	4e-31	139	38%	UniProt GenBank	Acetoacetyl-CoA reductase	phbB RKLH11_2295	Rhodobacteraceae bacterium KLH11	1.1.1.36 niceE keggE
72	B1LV70_METRJ (B1LV70)	5e-31	139	36%	UniProt GenBank	Acetoacetyl-CoA reductase	Mrad2831_5119	Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831)
73	F1ZDT3_9SPHN (F1ZDT3)	5e-31	139	38%	UniProt GenBank	Acetoacetyl-CoA reductase	Y88_3538	Novosphingobium nitrogenifigens DSM 19370
74	B1Z7L4_METPB (B1Z7L4)	5e-31	139	36%	UniProt GenBank	Acetoacetyl-CoA reductase	Mpop_3668	Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001)
75	A5ETG5_BRASB (A5ETG5)	5e-31	139	39%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	phbB BBta_7613	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)	1.1.1.100 niceE keggE
76	Q7NVH9_CHRVO (Q7NVH9)	6e-31	139	37%	UniProt GenBank	Acetoacetyl-CoA reductase	phaB CV_2364	Chromobacterium violaceum	1.1.1.36 niceE keggE
77	B7K8Q5_CYAP7 (B7K8Q5)	6e-31	138	37%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	PCC7424_2848	Cyanothece sp. (strain PCC 7424) Synechococcus sp. (strain ATCC 29155)
78	A4YKS4_BRASO (A4YKS4)	6e-31	138	39%	UniProt GenBank	Acetoacetyl-coA reductase	phbB BRADO0563	Bradyrhizobium sp. (strain ORS278)	1.1.1.36 niceE keggE
79	A7B3K3_RUMGN (A7B3K3)	6e-31	138	35%	UniProt GenBank	Putative uncharacterized protein	RUMGNA_02133	Ruminococcus gnavus ATCC 29149
80	D9I8F9_BACMY (D9I8F9)	8e-31	138	38%	UniProt GenBank	Acetoacetyl CoA reductase	phaB	Bacillus mycoides
81	D4YZT2_SPHJU (D4YZT2)	8e-31	138	37%	UniProt GenBank	Acetoacetyl-CoA reductase	phbB SJA_C1-10300	Sphingobium japonicum (strain NBRC 101211 / UT26S)	1.1.1.36 niceE keggE
82	B9JI06_AGRRK (B9JI06)	8e-31	138	39%	UniProt GenBank	Acetoacetyl-CoA reductase protein	phbB Arad_8221	Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
83	F6F2S6_SPHCR (F6F2S6)	9e-31	138	37%	UniProt GenBank	Acetoacetyl-CoA reductase	Sphch_3122	Sphingobium chlorophenolicum L-1	1.1.1.36 niceE keggE
84	D5DCX7_BACMD (D5DCX7)	9e-31	138	37%	UniProt GenBank	Acetoacetyl-CoA reductase	phaB BMD_1215	Bacillus megaterium (strain DSM 319)	1.1.1.36 niceE keggE
85	E6VKS3_RHOPX (E6VKS3)	1e-30	137	39%	UniProt GenBank	Acetoacetyl-CoA reductase	Rpdx1_0562	Rhodopseudomonas palustris (strain DX-1)
86	Q9KA03_BACHD (Q9KA03)	1e-30	137	37%	UniProt GenBank	3-oxoacyl-(Acyl-carrier protein) reductase	fabG BH2491	Bacillus halodurans	1.1.1.100 niceE keggE
87	F5UJL5_9CYAN (F5UJL5)	1e-30	137	37%	UniProt GenBank	3-oxoacyl-(Acyl-carrier-protein) reductase	MicvaDRAFT_0995	Microcoleus vaginatus FGP-2	1.1.1.100 niceE keggE
88	C2PC36_BACCE (C2PC36)	1e-30	137	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	bcere0006_11680	Bacillus cereus MM3
89	C2W5H6_BACCE (C2W5H6)	1e-30	137	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	bcere0022_10430	Bacillus cereus Rock3-44
90	C2V8Y3_BACCE (C2V8Y3)	1e-30	137	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	bcere0020_11520	Bacillus cereus Rock3-29
91	C2USI5_BACCE (C2USI5)	1e-30	137	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	bcere0019_11790	Bacillus cereus Rock3-28
92	C2TUF7_BACCE (C2TUF7)	1e-30	137	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	bcere0017_11500	Bacillus cereus Rock1-3
93	D5TTP1_BACT1 (D5TTP1)	1e-30	137	38%	UniProt GenBank	Acetoacetyl-CoA reductase	phbB BMB171_C1160	Bacillus thuringiensis (strain BMB171)
94	D9I8G0_BACCE (D9I8G0)	1e-30	137	38%	UniProt GenBank	Acetoacetyl CoA reductase	phaB	Bacillus cereus
95	C2YNT6_BACCE (C2YNT6)	1e-30	137	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	bcere0028_11870	Bacillus cereus AH1271
96	C2Y7V3_BACCE (C2Y7V3)	1e-30	137	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	bcere0027_12090	Bacillus cereus AH676
97	C2RK96_BACCE (C2RK96)	1e-30	137	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	bcere0012_11820	Bacillus cereus BDRD-ST24
98	A3WHC3_9SPHN (A3WHC3)	1e-30	137	37%	UniProt GenBank	Acetoacetyl-CoA reductase	NAP1_13873	Erythrobacter sp. NAP1
99	B2IE55_BEII9 (B2IE55)	1e-30	137	37%	UniProt GenBank	Acetoacetyl-CoA reductase	Bind_0426	Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIB 8712)
100	C3BHN4_9BACI (C3BHN4)	1e-30	137	38%	UniProt GenBank	3-oxoacyl-[acyl-carrier-protein] reductase	bpmyx0001_11800	Bacillus pseudomycoides DSM 12442

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

C0JWD2_9ACTO
(C0JWD2)

1e-137

491

100%

Product: PokT2
Gene: pokT2
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

Q194R2_STRAA
(Q194R2)

1e-66

257

58%

Product: Ketoreductase
Gene: mtmTII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

D7BZT7_STRBB
(D7BZT7)

4e-59

232

54%

Product: Acetoacetyl-CoA reductase
Gene: SBI_06872
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

D2AY70_STRRD
(D2AY70)

7e-53

211

50%

Product: Acetoacetyl-CoA reductase
Gene: Sros_4176
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

A7DWL7_STRTE
(A7DWL7)

2e-52

210

48%

Product: Putative reductase
Gene: llpZIV
Organism: Streptomyces tendae

1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]

Q8KSY1_9ACTO
(Q8KSY1)

3e-48

196

49%

Product: Putative 3-oxoacyl-ACP reductase GrhO2
Gene: grhO2
Organism: Streptomyces sp. JP95

1uniprot[Pubmed] 12323376 [Medline] 22235582
A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002]

D2BF84_STRRD
(D2BF84)

5e-43

179

46%

Product: Short chain dehydrogenase/reductase
Gene: Sros_5485
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

D1A269_THECD
(D1A269)

8e-37

158

42%

Product: Short-chain dehydrogenase/reductase SDR
Gene: Tcur_4195
Organism: Thermomonospora curvata (strain ATCC 19995 / DSM 43183 / JCM 3096 / NCIMB 10081)

1uniprot
Complete genome sequence of Thermomonospora curvata type strain (B9).(Stand. Genomic Sci.) [2011]

Q24U43_DESHY
(Q24U43)

3e-34

149

39%

Product: Putative uncharacterized protein
Gene: DSY2660
Organism: Desulfitobacterium hafniense (strain Y51)

1uniprot[Pubmed] 16513756
Complete genome sequence of the dehalorespiring bacterium Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides ethenogenes 195.(J. Bacteriol.) [2006]

Q8GE35_HELMO
(Q8GE35)

3e-34

149

38%

Product: 3-oxoacyl-[acyl-carrier protein] reductase
Gene
Organism: Heliobacillus mobilis

1uniprot[Pubmed] 12446909 [Medline] 22337798
Whole-genome analysis of photosynthetic prokaryotes.(Science) [2002]

F2J0A7_POLGS
(F2J0A7)

3e-34

149

39%

Product: Acetoacetyl-CoA reductase subfamily
Gene: SL003B_0203
Organism: Polymorphum gilvum (strain LMG 25793 / CGMCC 1.9160 / SL003B-26A1)

1uniprot[Pubmed] 21478361
Complete genome sequence of Polymorphum gilvum SL003B-26A1T, a crude oil-degrading bacterium from oil-polluted saline soil.(J. Bacteriol.) [2011]

C3MAK9_RHISN
(C3MAK9)

2e-33

147

40%

Product: Acetoacetyl-CoA reductase
Gene: NGR_c32710
Organism: Rhizobium sp. (strain NGR234)

1uniprot[Pubmed] 19376903
Rhizobium sp. strain NGR234 possesses a remarkable number of secretion systems.(Appl. Environ. Microbiol.) [2009]

Q0FIN9_9RHOB
(Q0FIN9)

2e-32

144

40%

Product: Acetoacetyl-CoA reductase
Gene: R2601_11861
Organism: Pelagibaca bermudensis HTCC2601

1uniprot[Pubmed] 20729358
Genome sequences of Pelagibaca bermudensis HTCC2601T and Maritimibacter alkaliphilus HTCC2654T, the type strains of two marine Roseobacter genera.(J. Bacteriol.) [2010]

D3NX21_AZOS1
(D3NX21)

2e-32

143

37%

Product: Acetoacetyl-CoA reductase
Gene: phbB
AZL_023120
Organism: Azospirillum sp. (strain B510)

1uniprot[Pubmed] 20047946
Complete genomic structure of the cultivated rice endophyte Azospirillum sp. B510.(DNA Res.) [2010]

B0TGW0_HELMI
(B0TGW0)

4e-32

142

37%

Product: 3-oxoacyl-(Acyl-carrier-protein) reductase
Gene: fabG
Helmi_20960
HM1_2165
Organism: Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)

1uniprot[Pubmed] 18441057
The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus.(J. Bacteriol.) [2008]

E8L1Z8_9RHIZ
(E8L1Z8)

5e-32

142

39%

Product: Acetoacetyl-CoA reductase
Gene: Met49242DRAFT_1564
Organism: Methylocystis sp. ATCC 49242

1uniprot[Pubmed] 21441518
Genome Sequence of the Methanotrophic Alphaproteobacterium Methylocystis sp. Strain Rockwell (ATCC 49242).(J. Bacteriol.) [2011]

A3VB24_9RHOB
(A3VB24)

7e-32

141

39%

Product: Acetoacetyl-CoA reductase
Gene: RB2654_16036
Organism: Maritimibacter alkaliphilus HTCC2654

1uniprot[Pubmed] 20729358
Genome sequences of Pelagibaca bermudensis HTCC2601T and Maritimibacter alkaliphilus HTCC2654T, the type strains of two marine Roseobacter genera.(J. Bacteriol.) [2010]

Q7CWA4_AGRT5
(Q7CWA4)

1e-31

140

40%

Product: Acetoacetyl CoA reductase; poly-beta-hydroxybutyrate biosynthesis
Gene: phbB
Atu2770
Organism: Agrobacterium tumefaciens (strain C58 / ATCC 33970)

[pubmed all]
1uniprot[Pubmed] 11743194 [Medline] 21608551 Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58.(Science) [2001]
2uniprot[Pubmed] 11743193 [Medline] 21608550 The genome of the natural genetic engineer Agrobacterium tumefaciens C58.(Science) [2001]

D5QN72_METTR
(D5QN72)

2e-31

140

38%

Product: Acetoacetyl-CoA reductase
Gene: MettrDRAFT_1248
Organism: Methylosinus trichosporium OB3b

1uniprot[Pubmed] 20952571
Genome Sequence of the Obligate Methanotroph Methylosinus trichosporium Strain OB3b.(J. Bacteriol.) [2010]

F7X1R0_RHIME
(F7X1R0)

2e-31

140

40%

Product: PhbB
Gene: phbB
SM11_chr3389
Organism: Sinorhizobium meliloti SM11

1uniprot[Pubmed] 21396969
The complete genome sequence of the dominant Sinorhizobium meliloti field isolate SM11 extends the S. meliloti pan-genome.(J. Biotechnol.) [2011]

PHBB_RHIME
(P50205)

2e-31

140

40%

Product: Acetoacetyl-CoA reductase
Gene: phbB
R03261
SMc03878
Organism: Rhizobium meliloti
Ensifer meliloti
Sinorhizobium meliloti

[pubmed all]
1uniprot[Pubmed] 7582015 [Medline] 96036213 Poly-beta-hydroxybutyrate (PHB) biosynthetic genes in Rhizobium meliloti 41.(Microbiology) [1995]
2uniprot[Pubmed] 11481430 [Medline] 21396507 Analysis of the chromosome sequence of the legume symbiont Sinorhizobium meliloti strain 1021.(Proc. Natl. Acad. Sci. U.S.A.) [2001]

PHBB_ZOORA
(P23238)

3e-31

140

39%

Product: Acetoacetyl-CoA reductase
Gene: phbB
Organism: Zoogloea ramigera

[pubmed all]
1uniprot[Pubmed] 2546004 [Medline] 89313287 Fine structural analysis of the Zoogloea ramigera phbA-phbB locus encoding beta-ketothiolase and acetoacetyl-CoA reductase: nucleotide sequence of phbB.(Mol. Microbiol.) [1989]
2uniprot[Pubmed] 3286259 [Medline] 88225101 The NADPH-linked acetoacetyl-CoA reductase from Zoogloea ramigera. Characterization and mechanistic studies of the cloned enzyme over-produced in Escherichia coli.(Eur. J. Biochem.) [1988]

Q2S6I1_SALRD
(Q2S6I1)

4e-31

139

38%

Product: 3-oxoacyl-(Acyl-carrier-protein) reductase
Gene: fabG
SRU_0045
Organism: Salinibacter ruber (strain DSM 13855 / M31)

1uniprot[Pubmed] 16330755
The genome of Salinibacter ruber: convergence and gene exchange among hyperhalophilic bacteria and archaea.(Proc. Natl. Acad. Sci. U.S.A.) [2005]

Q9ZF93_BACME
(Q9ZF93)

4e-31

139

37%

Product: 3-ketoacyl-CoA reductase PhaB
Gene: phaB
Organism: Bacillus megaterium

[pubmed all]
1uniprot[Pubmed] 9882674 [Medline] 99102223 Polyhydroxyalkanoate inclusion body-associated proteins and coding region in Bacillus megaterium.(J. Bacteriol.) [1999]
2uniprot[Pubmed] 11418564 [Medline] 21311749 PhaC and PhaR are required for polyhydroxyalkanoic acid synthase activity in Bacillus megaterium.(J. Bacteriol.) [2001]

A5ETG5_BRASB
(A5ETG5)

5e-31

139

39%

Product: 3-oxoacyl-[acyl-carrier-protein] reductase
Gene: phbB
BBta_7613
Organism: Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)

1uniprot[Pubmed] 17540897
Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.(Science) [2007]

Q7NVH9_CHRVO
(Q7NVH9)

6e-31

139

37%

Product: Acetoacetyl-CoA reductase
Gene: phaB
CV_2364
Organism: Chromobacterium violaceum

1uniprot[Pubmed] 14500782 [Medline] 22882880
The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability.(Proc. Natl. Acad. Sci. U.S.A.) [2003]

A4YKS4_BRASO
(A4YKS4)

6e-31

138

39%

Product: Acetoacetyl-coA reductase
Gene: phbB
BRADO0563
Organism: Bradyrhizobium sp. (strain ORS278)

1uniprot[Pubmed] 17540897
Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.(Science) [2007]

B9JI06_AGRRK
(B9JI06)

8e-31

138

39%

Product: Acetoacetyl-CoA reductase protein
Gene: phbB
Arad_8221
Organism: Agrobacterium radiobacter (strain K84 / ATCC BAA-868)

1uniprot[Pubmed] 19251847
Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria.(J. Bacteriol.) [2009]

Q9KA03_BACHD
(Q9KA03)

1e-30

137

37%

Product: 3-oxoacyl-(Acyl-carrier protein) reductase
Gene: fabG
BH2491
Organism: Bacillus halodurans

1uniprot[Pubmed] 11058132 [Medline] 20512582
Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis.(Nucleic Acids Res.) [2000]

D5TTP1_BACT1
(D5TTP1)

1e-30

137

38%

Product: Acetoacetyl-CoA reductase
Gene: phbB
BMB171_C1160
Organism: Bacillus thuringiensis (strain BMB171)

1uniprot[Pubmed] 20525827
Complete genome sequence of Bacillus thuringiensis mutant strain BMB171.(J. Bacteriol.) [2010]