BLAST table : Mith_00180

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q194Q7_STRAA (Q194Q7)	0.0	861	100%	UniProt GenBank	Oxygenase	mtmOI	Streptomyces argillaceus
2	D9UBS8_STRPR (D9UBS8)	1e-129	466	61%	UniProt GenBank	Putative oxygenase	cpp6	Streptomyces pristinaespiralis	1.14.13.- niceE keggE
3	D7BZS1_STRBB (D7BZS1)	1e-123	445	57%	UniProt GenBank	Putative uncharacterized protein	SBI_06856	Streptomyces bingchenggensis (strain BCW-1)
4	B5HIW0_STRPR (B5HIW0)	1e-122	443	61%	UniProt GenBank	Oxygenase	SSDG_05097	Streptomyces pristinaespiralis ATCC 25486
5	Q70J91_STRGR (Q70J91)	1e-118	429	58%	UniProt GenBank	Oxygenase	cmmOI	Streptomyces griseus subsp. griseus
6	E8W963_STRFA (E8W963)	1e-108	397	51%	UniProt GenBank	Monooxygenase FAD-binding protein	Sfla_5329	Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD)
7	D9WNL1_9ACTO (D9WNL1)	1e-107	394	54%	UniProt GenBank	RemO protein	SSOG_05582	Streptomyces himastatinicus ATCC 53653
8	E0KZW1_STRVO (E0KZW1)	1e-107	393	53%	UniProt GenBank	Monooxygenase FAD-binding	StrviDRAFT_8189	Streptomyces violaceusniger Tu 4113
9	C0JWC5_9ACTO (C0JWC5)	1e-103	380	49%	UniProt GenBank	PokO1	pokO1	Streptomyces diastatochromogenes
10	Q3S8R0_STRRM (Q3S8R0)	1e-102	377	51%	UniProt GenBank	OxyE	oxyE	Streptomyces rimosus
11	F8B1N5_9ACTO (F8B1N5)	9e-88	328	45%	UniProt GenBank	Monooxygenase FAD-binding protein	FsymDg_0488	Frankia symbiont of Datisca glomerata
12	F8FGP3_9BACL (F8FGP3)	3e-55	220	37%	UniProt GenBank	Putative uncharacterized protein	KNP414_06908	Paenibacillus mucilaginosus KNP414
13	Q4V217_BACCZ (Q4V217)	2e-52	211	30%	UniProt GenBank	Possible monooxygenase	pE33L466_0075	Bacillus cereus (strain ZK / E33L)
14	E4NT01_HALBP (E4NT01)	1e-51	208	35%	UniProt GenBank	2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase	Hbor_14140	Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)
15	Q9KBS4_BACHD (Q9KBS4)	1e-50	205	29%	UniProt GenBank	BH1851 protein	BH1851	Bacillus halodurans
16	Q9RC56_BACHD (Q9RC56)	1e-50	205	29%	UniProt GenBank	Unknown		Bacillus halodurans
17	D7E4S4_NOSA0 (D7E4S4)	1e-46	192	32%	UniProt GenBank	Monooxygenase FAD-binding protein	Aazo_3882	Nostoc azollae (strain 0708) Anabaena azollae (strain 0708)
18	B2J543_NOSP7 (B2J543)	4e-45	187	30%	UniProt GenBank	Monooxygenase, FAD-binding	Npun_R2084	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
19	D5QVV6_METTR (D5QVV6)	1e-44	185	33%	UniProt GenBank	Monooxygenase FAD-binding	MettrDRAFT_3932	Methylosinus trichosporium OB3b
20	C5BKB1_TERTT (C5BKB1)	4e-44	184	29%	UniProt GenBank	FAD binding domain protein	TERTU_2371	Teredinibacter turnerae (strain ATCC 39867 / T7901)
21	Q1AYW7_RUBXD (Q1AYW7)	6e-44	183	33%	UniProt GenBank	Monooxygenase, FAD-binding protein	Rxyl_0437	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
22	C5C803_MICLC (C5C803)	6e-43	180	32%	UniProt GenBank	2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase	Mlut_00330	Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)
23	E7QR43_9EURY (E7QR43)	1e-42	179	36%	UniProt GenBank	Putative uncharacterized protein	ZOD2009_06329	Haladaptatus paucihalophilus DX253
24	D6U562_9CHLR (D6U562)	4e-42	177	30%	UniProt GenBank	Monooxygenase FAD-binding	Krac_2378	Ktedonobacter racemifer DSM 44963
25	D8FWE6_9CYAN (D8FWE6)	9e-42	176	33%	UniProt GenBank	Monooxygenase, FAD-binding	OSCI_1010031	Oscillatoria sp. PCC 6506	1.14.13.50 niceE keggE
26	E0IFS3_9BACL (E0IFS3)	4e-41	173	33%	UniProt GenBank	Monooxygenase FAD-binding	PaecuDRAFT_4533	Paenibacillus curdlanolyticus YK9
27	Q7NCZ9_GLOVI (Q7NCZ9)	1e-40	172	34%	UniProt GenBank	Gll2827 protein	gll2827	Gloeobacter violaceus
28	E2Q9E3_STRCL (E2Q9E3)	5e-40	170	34%	UniProt GenBank	Monooxygenase	SCLAV_0487	Streptomyces clavuligerus ATCC 27064
29	A1T290_MYCVP (A1T290)	7e-40	169	34%	UniProt GenBank	Monooxygenase, FAD-binding protein	Mvan_0442	Mycobacterium vanbaalenii (strain DSM 7251 / PYR-1)
30	A6T186_JANMA (A6T186)	8e-40	169	34%	UniProt GenBank	FAD-dependent monooxygenase	mma_2593	Janthinobacterium sp. (strain Marseille) Minibacterium massiliensis
31	D5P3H8_9MYCO (D5P3H8)	1e-39	168	34%	UniProt GenBank	Monooxygenase	HMPREF0591_0722	Mycobacterium parascrofulaceum ATCC BAA-614
32	D6TMS4_9CHLR (D6TMS4)	2e-39	167	34%	UniProt GenBank	Monooxygenase FAD-binding	Krac_8398	Ktedonobacter racemifer DSM 44963
33	C9ZCE2_STRSW (C9ZCE2)	3e-39	167	35%	UniProt GenBank	Putative oxidoreductase	SCAB_63311	Streptomyces scabies (strain 87.22) Streptomyces scabiei
34	F8J863_9RHIZ (F8J863)	5e-39	166	31%	UniProt GenBank	Monooxygenase, FAD binding	HYPMC_2846	Hyphomicrobium sp. MC1
35	D6U570_9CHLR (D6U570)	7e-39	166	34%	UniProt GenBank	Monooxygenase FAD-binding	Krac_2386	Ktedonobacter racemifer DSM 44963
36	B2ITU4_NOSP7 (B2ITU4)	7e-39	166	31%	UniProt GenBank	Monooxygenase, FAD-binding	Npun_F5941	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	1.14.13.50 niceE keggE
37	F2F9A8_SOLSS (F2F9A8)	8e-39	166	33%	UniProt GenBank	2-polyprenyl-6-methoxyphenol hydroxylase	SSIL_2212	Solibacillus silvestris (strain StLB046) Bacillus silvestris
38	D3U1W6_9BACT (D3U1W6)	2e-38	165	35%	UniProt GenBank	FAD-dependent monooxygenase		uncultured soil bacterium V167
39	D6YR79_PANVC (D6YR79)	4e-38	164	31%	UniProt GenBank	FAD-dependent monooxygenase	Pvag_pPag30443	Pantoea vagans (strain C9-1) Pantoea agglomerans (strain C9-1)
40	D8J4W3_HALJB (D8J4W3)	5e-38	163	31%	UniProt GenBank	Putative uncharacterized protein	HacjB3_10985	Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3)
41	E6WDN8_PANSA (E6WDN8)	6e-38	163	34%	UniProt GenBank	Monooxygenase FAD-binding protein	Pat9b_2029	Pantoea sp. (strain At-9b)
42	B2HIR3_MYCMM (B2HIR3)	1e-37	162	35%	UniProt GenBank	Oxidoreductase	MMAR_3394	Mycobacterium marinum (strain ATCC BAA-535 / M)
43	Q3MBG5_ANAVT (Q3MBG5)	2e-37	162	31%	UniProt GenBank	Monooxygenase, FAD-binding protein	Ava_2049	Anabaena variabilis (strain ATCC 29413 / PCC 7937)	1.14.13.50 niceE keggE
44	O65936_MYCTU (O65936)	2e-37	161	32%	UniProt GenBank	PROBABLE OXIDOREDUCTASE	Rv1751	Mycobacterium tuberculosis	1.-.-.- niceE keggE
45	C6DRD2_MYCTK (C6DRD2)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TBMG_02244	Mycobacterium tuberculosis (strain KZN 1435 / MDR)
46	A5WN71_MYCTF (A5WN71)	2e-37	161	32%	UniProt GenBank	Hypothetical oxidoreductase	TBFG_11769	Mycobacterium tuberculosis (strain F11)
47	A5U3B1_MYCTA (A5U3B1)	2e-37	161	32%	UniProt GenBank	Putative uncharacterized protein	MRA_1762	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
48	F8M9B3_9MYCO (F8M9B3)	2e-37	161	32%	UniProt GenBank	Putative oxidoreductase	MAF_17700	Mycobacterium africanum GM041182	1.-.-.- niceE keggE
49	F2V8V6_MYCTU (F2V8V6)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TBPG_01236	Mycobacterium tuberculosis W-148
50	F2GJH6_MYCTU (F2GJH6)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TBSG_02256	Mycobacterium tuberculosis KZN 4207
51	D7ERI5_MYCTU (D7ERI5)	2e-37	161	32%	UniProt GenBank	Hypothetical oxidoreductase	TBAG_00668	Mycobacterium tuberculosis 94_M4241A
52	D6FU56_MYCTU (D6FU56)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TBOG_02266	Mycobacterium tuberculosis K85
53	D5ZHQ4_MYCTU (D5ZHQ4)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TBJG_00176	Mycobacterium tuberculosis T17
54	D5Z2S1_MYCTU (D5Z2S1)	2e-37	161	32%	UniProt GenBank	Putative uncharacterized protein	TBIG_01147	Mycobacterium tuberculosis GM 1503
55	D5YFR3_MYCTU (D5YFR3)	2e-37	161	32%	UniProt GenBank	Putative uncharacterized protein	TBGG_00958	Mycobacterium tuberculosis EAS054
56	D5Y454_MYCTU (D5Y454)	2e-37	161	32%	UniProt GenBank	Putative uncharacterized protein	TBEG_02581	Mycobacterium tuberculosis T85
57	D5XU37_MYCTU (D5XU37)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TBDG_03347	Mycobacterium tuberculosis T92
58	A4KHR0_MYCTU (A4KHR0)	2e-37	161	32%	UniProt GenBank	Hypothetical oxidoreductase	TBHG_01708	Mycobacterium tuberculosis str. Haarlem
59	A2VIN2_MYCTU (A2VIN2)	2e-37	161	32%	UniProt GenBank	Putative uncharacterized protein	TBCG_01707	Mycobacterium tuberculosis C
60	Q7D810_MYCTU (Q7D810)	2e-37	161	32%	UniProt GenBank	Monooxygenase, FAD-binding	MT1794	Mycobacterium tuberculosis
61	F7WPQ1_MYCTU (F7WPQ1)	2e-37	161	32%	UniProt GenBank	Putative uncharacterized protein	CCDC5180_1606	Mycobacterium tuberculosis CCDC5180
62	F7WLE0_MYCTU (F7WLE0)	2e-37	161	32%	UniProt GenBank	Putative uncharacterized protein	CCDC5079_1622	Mycobacterium tuberculosis CCDC5079
63	E9ZJI8_MYCTU (E9ZJI8)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMMG_01005	Mycobacterium tuberculosis CDC1551A
64	E2WHQ7_MYCTU (E2WHQ7)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMLG_00736	Mycobacterium tuberculosis SUMu012
65	E2W5S3_MYCTU (E2W5S3)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMKG_02259	Mycobacterium tuberculosis SUMu011
66	E2VUI9_MYCTU (E2VUI9)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMJG_03183	Mycobacterium tuberculosis SUMu010
67	E2VI93_MYCTU (E2VI93)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMIG_02004	Mycobacterium tuberculosis SUMu009
68	E2V8Y5_MYCTU (E2V8Y5)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMHG_00932	Mycobacterium tuberculosis SUMu008
69	E2UYS2_MYCTU (E2UYS2)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMGG_00301	Mycobacterium tuberculosis SUMu007
70	E2ULH2_MYCTU (E2ULH2)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMFG_00837	Mycobacterium tuberculosis SUMu006
71	E2U9Z5_MYCTU (E2U9Z5)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMEG_01651	Mycobacterium tuberculosis SUMu005
72	E2TYL0_MYCTU (E2TYL0)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMDG_03469	Mycobacterium tuberculosis SUMu004
73	E2TLZ7_MYCTU (E2TLZ7)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMCG_03454	Mycobacterium tuberculosis SUMu003
74	E2T9N2_MYCTU (E2T9N2)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMBG_00294	Mycobacterium tuberculosis SUMu002
75	E1H9P6_MYCTU (E1H9P6)	2e-37	161	32%	UniProt GenBank	Oxidoreductase	TMAG_01586	Mycobacterium tuberculosis SUMu001
76	D5DR77_BACMQ (D5DR77)	3e-37	161	27%	UniProt GenBank	FAD binding domain protein	BMQ_2199	Bacillus megaterium (strain ATCC 12872 / QMB1551)
77	Q7TZM6_MYCBO (Q7TZM6)	4e-37	160	32%	UniProt GenBank	PROBABLE OXIDOREDUCTASE	Mb1780	Mycobacterium bovis	1.-.-.- niceE keggE
78	D5YSZ3_MYCTU (D5YSZ3)	4e-37	160	34%	UniProt GenBank	Putative uncharacterized protein	TBBG_01260	Mycobacterium tuberculosis 02_1987
79	E8V7C4_TERSS (E8V7C4)	4e-37	160	32%	UniProt GenBank	Monooxygenase FAD-binding protein	AciPR4_2033	Terriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4)
80	C1AP24_MYCBT (C1AP24)	4e-37	160	32%	UniProt GenBank	Putative uncharacterized protein	JTY_1765	Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
81	A1KJG8_MYCBP (A1KJG8)	4e-37	160	32%	UniProt GenBank	Probable oxidoreductase	BCG_1790	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	1.-.-.- niceE keggE
82	Q8YMZ4_NOSS1 (Q8YMZ4)	5e-37	160	31%	UniProt GenBank	All4780 protein	all4780	Nostoc sp. (strain PCC 7120 / UTEX 2576)
83	D5DFL0_BACMD (D5DFL0)	5e-37	160	27%	UniProt GenBank	FAD binding domain protein	BMD_2157	Bacillus megaterium (strain DSM 319)
84	B2HSP9_MYCMM (B2HSP9)	5e-37	160	34%	UniProt GenBank	Oxidoreductase	MMAR_2627	Mycobacterium marinum (strain ATCC BAA-535 / M)
85	F2ERK7_PANAA (F2ERK7)	7e-37	159	32%	UniProt GenBank	2-octaprenyl-3-methyl-6-methoxy-1 4-benzoquinol hydroxylase UbiF	ubiF PAJ_0871	Pantoea ananatis (strain AJ13355)
86	E0LSR7_9ENTR (E0LSR7)	7e-37	159	30%	UniProt GenBank	Monooxygenase FAD-binding	PanABDRAFT_0185	Pantoea sp. aB
87	D4GC91_PANAM (D4GC91)	8e-37	159	34%	UniProt GenBank	UbiF	ubiF PANA_1527	Pantoea ananatis (strain LMG 20103)
88	A4AKI4_9ACTN (A4AKI4)	3e-36	157	34%	UniProt GenBank	Putative uncharacterized protein	A20C1_12229	marine actinobacterium PHSC20C1
89	B4D4N4_9BACT (B4D4N4)	4e-36	157	34%	UniProt GenBank	Monooxygenase FAD-binding	CfE428DRAFT_3872	Chthoniobacter flavus Ellin428
90	E3EBE5_PAEPS (E3EBE5)	4e-36	157	30%	UniProt GenBank	FAD binding domain protein	PPSC2_c4673	Paenibacillus polymyxa (strain SC2) Bacillus polymyxa
91	E0RF02_PAEP6 (E0RF02)	5e-36	157	32%	UniProt GenBank	2-polyprenyl-6-methoxyphenol hydroxylase	PPE_04138	Paenibacillus polymyxa (strain E681)
92	D5QKU9_METTR (D5QKU9)	7e-36	156	33%	UniProt GenBank	Monooxygenase FAD-binding	MettrDRAFT_0425	Methylosinus trichosporium OB3b
93	A0R226_MYCS2 (A0R226)	1e-35	155	33%	UniProt GenBank	RemO protein	MSMEG_4962	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
94	F8JDL2_9RHIZ (F8JDL2)	1e-35	155	31%	UniProt GenBank	Monooxygenase, FAD binding	HYPMC_2067	Hyphomicrobium sp. MC1
95	D2S470_GEOOG (D2S470)	1e-35	155	33%	UniProt GenBank	Monooxygenase FAD-binding protein	Gobs_2386	Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 3152 / G-20)
96	F6LWA3_9BACT (F6LWA3)	2e-35	155	33%	UniProt GenBank	Monooxygenase	abeX2	uncultured bacterium AB1650
97	A8KXG5_FRASN (A8KXG5)	4e-35	154	33%	UniProt GenBank	Monooxygenase FAD-binding	Franean1_1983	Frankia sp. (strain EAN1pec)
98	Q1CYX9_MYXXD (Q1CYX9)	5e-35	153	33%	UniProt GenBank	Monooxygenase, FAD-dependent	MXAN_6265	Myxococcus xanthus (strain DK 1622)
99	E5XP92_9ACTO (E5XP92)	6e-35	153	34%	UniProt GenBank	FAD binding domain-containing protein	HMPREF9336_01314	Segniliparus rugosus ATCC BAA-974
100	F5YT19_9MYCO (F5YT19)	6e-35	153	33%	UniProt GenBank	Oxidoreductase	JDM601_4008	Mycobacterium sp. JDM601

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q194Q7_STRAA
(Q194Q7)

0.0

861

100%

Product: Oxygenase
Gene: mtmOI
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

D9UBS8_STRPR
(D9UBS8)

1e-129

466

61%

Product: Putative oxygenase
Gene: cpp6
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

D7BZS1_STRBB
(D7BZS1)

1e-123

445

57%

Product: Putative uncharacterized protein
Gene: SBI_06856
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

C0JWC5_9ACTO
(C0JWC5)

1e-103

380

49%

Product: PokO1
Gene: pokO1
Organism: Streptomyces diastatochromogenes

1uniprot[Pubmed] 19266534
Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009]

Q3S8R0_STRRM
(Q3S8R0)

1e-102

377

51%

Product: OxyE
Gene: oxyE
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

Q4V217_BACCZ
(Q4V217)

2e-52

211

30%

Product: Possible monooxygenase
Gene: pE33L466_0075
Organism: Bacillus cereus (strain ZK / E33L)

1uniprot[Pubmed] 16621833
Pathogenomic sequence analysis of Bacillus cereus and Bacillus thuringiensis isolates closely related to Bacillus anthracis.(J. Bacteriol.) [2006]

E4NT01_HALBP
(E4NT01)

1e-51

208

35%

Product: 2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase
Gene: Hbor_14140
Organism: Halogeometricum borinquense (strain ATCC 700274 / DSM 11551 / JCM 10706 / PR3)

1uniprot[Pubmed] 21304651
Complete genome sequence of Halogeometricum borinquense type strain (PR3).(Stand. Genomic Sci.) [2009]

Q9KBS4_BACHD
(Q9KBS4)

1e-50

205

29%

Product: BH1851 protein
Gene: BH1851
Organism: Bacillus halodurans

1uniprot[Pubmed] 11058132 [Medline] 20512582
Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis.(Nucleic Acids Res.) [2000]

Q9RC56_BACHD
(Q9RC56)

1e-50

205

29%

Product: Unknown
Gene
Organism: Bacillus halodurans

1uniprot[Pubmed] 10484179 [Medline] 99411980
Genetic analysis of the chromosome of alkaliphilic Bacillus halodurans C-125.(Extremophiles) [1999]

D5QVV6_METTR
(D5QVV6)

1e-44

185

33%

Product: Monooxygenase FAD-binding
Gene: MettrDRAFT_3932
Organism: Methylosinus trichosporium OB3b

1uniprot[Pubmed] 20952571
Genome Sequence of the Obligate Methanotroph Methylosinus trichosporium Strain OB3b.(J. Bacteriol.) [2010]

C5BKB1_TERTT
(C5BKB1)

4e-44

184

29%

Product: FAD binding domain protein
Gene: TERTU_2371
Organism: Teredinibacter turnerae (strain ATCC 39867 / T7901)

1uniprot[Pubmed] 19568419
The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms).(PLoS ONE) [2009]

D8FWE6_9CYAN
(D8FWE6)

9e-42

176

33%

Product: Monooxygenase, FAD-binding
Gene: OSCI_1010031
Organism: Oscillatoria sp. PCC 6506

1uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

Q7NCZ9_GLOVI
(Q7NCZ9)

1e-40

172

34%

Product: Gll2827 protein
Gene: gll2827
Organism: Gloeobacter violaceus

1uniprot[Pubmed] 14621292 [Medline] 22977040
Complete genome structure of Gloeobacter violaceus PCC 7421, a cyanobacterium that lacks thylakoids.(DNA Res.) [2003]

E2Q9E3_STRCL
(E2Q9E3)

5e-40

170

34%

Product: Monooxygenase
Gene: SCLAV_0487
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot[Pubmed] 20624727
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

A6T186_JANMA
(A6T186)

8e-40

169

34%

Product: FAD-dependent monooxygenase
Gene: mma_2593
Organism: Janthinobacterium sp. (strain Marseille)
Minibacterium massiliensis

1uniprot[Pubmed] 17722982
Genome analysis of Minibacterium massiliensis highlights the convergent evolution of water-living bacteria.(PLoS Genet.) [2007]

C9ZCE2_STRSW
(C9ZCE2)

3e-39

167

35%

Product: Putative oxidoreductase
Gene: SCAB_63311
Organism: Streptomyces scabies (strain 87.22)
Streptomyces scabiei

1uniprot[Pubmed] 20064060
Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions.(Mol. Plant Microbe Interact.) [2010]

D6YR79_PANVC
(D6YR79)

4e-38

164

31%

Product: FAD-dependent monooxygenase
Gene: Pvag_pPag30443
Organism: Pantoea vagans (strain C9-1)
Pantoea agglomerans (strain C9-1)

[pubmed all]
1uniprot[Pubmed] 20487014 Genomic and phenotypic characterization of a nonpigmented variant of Pantoea vagans biocontrol strain C9-1 lacking the 530-kb megaplasmid pPag3.(FEMS Microbiol. Lett.) [2010]
2uniprot[Pubmed] 20952567 The genome sequence of the biocontrol agent Pantoea vagans strain C9-1.(J. Bacteriol.) [2010]

D8J4W3_HALJB
(D8J4W3)

5e-38

163

31%

Product: Putative uncharacterized protein
Gene: HacjB3_10985
Organism: Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3)

1uniprot[Pubmed] 20601480
Complete genome sequence of Halalkalicoccus jeotgali B3(T), an extremely halophilic archaeon.(J. Bacteriol.) [2010]

B2HIR3_MYCMM
(B2HIR3)

1e-37

162

35%

Product: Oxidoreductase
Gene: MMAR_3394
Organism: Mycobacterium marinum (strain ATCC BAA-535 / M)

1uniprot[Pubmed] 18403782
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008]

O65936_MYCTU
(O65936)

2e-37

161

32%

Product: PROBABLE OXIDOREDUCTASE
Gene: Rv1751
Organism: Mycobacterium tuberculosis

1uniprot[Pubmed] 9634230 [Medline] 98295987
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.(Nature) [1998]

Q7D810_MYCTU
(Q7D810)

2e-37

161

32%

Product: Monooxygenase, FAD-binding
Gene: MT1794
Organism: Mycobacterium tuberculosis

1uniprot[Pubmed] 12218036 [Medline] 22206494
Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.(J. Bacteriol.) [2002]

Q7TZM6_MYCBO
(Q7TZM6)

4e-37

160

32%

Product: PROBABLE OXIDOREDUCTASE
Gene: Mb1780
Organism: Mycobacterium bovis

1uniprot[Pubmed] 12788972 [Medline] 22709107
The complete genome sequence of Mycobacterium bovis.(Proc. Natl. Acad. Sci. U.S.A.) [2003]

C1AP24_MYCBT
(C1AP24)

4e-37

160

32%

Product: Putative uncharacterized protein
Gene: JTY_1765
Organism: Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)

1uniprot[Pubmed] 19200449
Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains.(Vaccine) [2009]

A1KJG8_MYCBP
(A1KJG8)

4e-37

160

32%

Product: Probable oxidoreductase
Gene: BCG_1790
Organism: Mycobacterium bovis (strain BCG / Pasteur 1173P2)

1uniprot[Pubmed] 17372194
Genome plasticity of BCG and impact on vaccine efficacy.(Proc. Natl. Acad. Sci. U.S.A.) [2007]

Q8YMZ4_NOSS1
(Q8YMZ4)

5e-37

160

31%

Product: All4780 protein
Gene: all4780
Organism: Nostoc sp. (strain PCC 7120 / UTEX 2576)

1uniprot[Pubmed] 11759840 [Medline] 21595285
Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120.(DNA Res.) [2001]

B2HSP9_MYCMM
(B2HSP9)

5e-37

160

34%

Product: Oxidoreductase
Gene: MMAR_2627
Organism: Mycobacterium marinum (strain ATCC BAA-535 / M)

1uniprot[Pubmed] 18403782
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008]

D4GC91_PANAM
(D4GC91)

8e-37

159

34%

Product: UbiF
Gene: ubiF
PANA_1527
Organism: Pantoea ananatis (strain LMG 20103)

1uniprot[Pubmed] 20348253
Genome sequence of Pantoea ananatis LMG20103, the causative agent of Eucalyptus blight and dieback.(J. Bacteriol.) [2010]

B4D4N4_9BACT
(B4D4N4)

4e-36

157

34%

Product: Monooxygenase FAD-binding
Gene: CfE428DRAFT_3872
Organism: Chthoniobacter flavus Ellin428

1uniprot[Pubmed] 21460085
Genome Sequence of Chthoniobacter flavus Ellin428, an Aerobic Heterotrophic Soil Bacterium.(J. Bacteriol.) [2011]

E3EBE5_PAEPS
(E3EBE5)

4e-36

157

30%

Product: FAD binding domain protein
Gene: PPSC2_c4673
Organism: Paenibacillus polymyxa (strain SC2)
Bacillus polymyxa

1uniprot[Pubmed] 21037012
Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity.(J. Bacteriol.) [2011]

E0RF02_PAEP6
(E0RF02)

5e-36

157

32%

Product: 2-polyprenyl-6-methoxyphenol hydroxylase
Gene: PPE_04138
Organism: Paenibacillus polymyxa (strain E681)

1uniprot[Pubmed] 20851896
Genome sequence of the polymyxin-producing plant-probiotic rhizobacterium Paenibacillus polymyxa E681.(J. Bacteriol.) [2010]

D5QKU9_METTR
(D5QKU9)

7e-36

156

33%

Product: Monooxygenase FAD-binding
Gene: MettrDRAFT_0425
Organism: Methylosinus trichosporium OB3b

1uniprot[Pubmed] 20952571
Genome Sequence of the Obligate Methanotroph Methylosinus trichosporium Strain OB3b.(J. Bacteriol.) [2010]

F6LWA3_9BACT
(F6LWA3)

2e-35

155

33%

Product: Monooxygenase
Gene: abeX2
Organism: uncultured bacterium AB1650

1uniprot[Pubmed] 21542592
Cloning and Characterization of an Environmental DNA-Derived Gene Cluster That Encodes the Biosynthesis of the Antitumor Substance BE-54017.(J. Am. Chem. Soc.) [2011]

A8KXG5_FRASN
(A8KXG5)

4e-35

154

33%

Product: Monooxygenase FAD-binding
Gene: Franean1_1983
Organism: Frankia sp. (strain EAN1pec)

1uniprot[Pubmed] 17151343
Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007]

Q1CYX9_MYXXD
(Q1CYX9)

5e-35

153

33%

Product: Monooxygenase, FAD-dependent
Gene: MXAN_6265
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]