BLAST table : Mith_00270

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q194P8_STRAA (Q194P8)	0.0	639	100%	UniProt GenBank	C-methyltransferase	mtmMII	Streptomyces argillaceus
2	Q70J83_STRGR (Q70J83)	5e-91	339	52%	UniProt GenBank	C-methyltransferase	cmmMII	Streptomyces griseus subsp. griseus
3	F4FBQ8_VERMA (F4FBQ8)	3e-83	313	49%	UniProt GenBank	O-methyltransferase involved in albicidin biosynthesis protein	VAB18032_18030	Verrucosispora maris (strain AB-18-032)
4	D6MSU9_9ACTO (D6MSU9)	1e-55	221	39%	UniProt GenBank	SsfM3	ssfM3	Streptomyces sp. SF2575
5	Q84HG5_PSEFL (Q84HG5)	8e-49	198	37%	UniProt GenBank	QbsL	qbsL	Pseudomonas fluorescens
6	B9XKT9_9BACT (B9XKT9)	2e-38	164	33%	UniProt GenBank	Methyltransferase type 12	Cflav_PD2489	Pedosphaera parvula Ellin514
7	Q025E9_SOLUE (Q025E9)	7e-38	162	35%	UniProt GenBank	Methyltransferase type 12	Acid_2381	Solibacter usitatus (strain Ellin6076)
8	D2MKW0_9BACT (D2MKW0)	8e-37	159	32%	UniProt GenBank	O-methyltransferase, family 2	POR_1326	Candidatus Poribacteria sp. WGA-A3
9	B2J4Q3_NOSP7 (B2J4Q3)	2e-35	154	28%	UniProt GenBank	Methyltransferase type 12	Npun_R0239	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
10	B4DC13_9BACT (B4DC13)	1e-34	152	33%	UniProt GenBank	Methyltransferase type 12	CfE428DRAFT_6454	Chthoniobacter flavus Ellin428
11	D2UDG0_XANAP (D2UDG0)	1e-34	151	31%	UniProt GenBank	O-methyltransferase involved in albicidin biosynthesis protein	albII XALc_1530	Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)	2.1.1.- niceE keggE
12	Q9AIT2_XANAL (Q9AIT2)	1e-34	151	31%	UniProt GenBank	Albicidin biosynthesis methyltransferase Putative O-methyltransferase	albII	Xanthomonas albilineans
13	B8HL71_CYAP4 (B8HL71)	9e-34	149	32%	UniProt GenBank	O-methyltransferase family 2	Cyan7425_2963	Cyanothece sp. (strain PCC 7425 / ATCC 29141)
14	B3PQJ2_RHIE6 (B3PQJ2)	5e-33	146	31%	UniProt GenBank	Putative SAM-dependent methyltransferase protein	RHECIAT_CH0000851	Rhizobium etli (strain CIAT 652)
15	F2A5S2_RHIET (F2A5S2)	2e-32	144	31%	UniProt GenBank	Putative SAM-dependent methyltransferase protein	RHECNPAF_1700036	Rhizobium etli CNPAF512
16	B3Q3D0_RHIE6 (B3Q3D0)	4e-32	143	31%	UniProt GenBank	Putative SAM-dependent methyltransferase protein	RHECIAT_PC0000609	Rhizobium etli (strain CIAT 652)
17	B3DV12_METI4 (B3DV12)	2e-31	140	31%	UniProt GenBank	SAM-dependent methyltransferase	smtA Minf_1110	Methylacidiphilum infernorum (isolate V4) Methylokorus infernorum (strain V4)
18	B6A367_RHILW (B6A367)	1e-30	138	32%	UniProt GenBank	Methyltransferase type 12	Rleg2_5675	Rhizobium leguminosarum bv. trifolii (strain WSM2304)
19	D2MJR9_9BACT (D2MJR9)	8e-21	105	29%	UniProt GenBank	O-methyltransferase, family 2:Generic methyltransferase	POR_0933	Candidatus Poribacteria sp. WGA-A3
20	A4XD35_SALTO (A4XD35)	4e-20	103	30%	UniProt GenBank	Methyltransferase type 12	Strop_4414	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
21	E3T6I1_9BACT (E3T6I1)	5e-20	103	29%	UniProt GenBank	O-methyltransferase family 2		uncultured bacterium 70
22	D2L0U2_9DELT (D2L0U2)	5e-19	99.8	30%	UniProt GenBank	O-methyltransferase family 2	DFW101DRAFT_0305	Desulfovibrio sp. FW1012B
23	D1CH44_THET1 (D1CH44)	1e-18	99	32%	UniProt GenBank	Methyltransferase type 11	Tter_2164	Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)
24	F2YRZ2_9ACTO (F2YRZ2)	1e-18	98.6	29%	UniProt GenBank	O-methyltransferase	sky37	Streptomyces sp. Acta 2897
25	F8CAC2_MYXFU (F8CAC2)	1e-18	98.6	28%	UniProt GenBank	Putative O-methyltransferase	LILAB_13370	Myxococcus fulvus
26	A2AXE8_STRCM (A2AXE8)	2e-18	98.2	28%	UniProt GenBank	SAM-dependent O-methyltransferase	fnq9	Streptomyces cinnamonensis
27	D8P817_9BACT (D8P817)	3e-18	97.4	28%	UniProt GenBank	Putative O-methyltransferase, family 2	NIDE3979	Candidatus Nitrospira defluvii	2.1.1.- niceE keggE
28	F6CIK7_9FIRM (F6CIK7)	3e-18	97.4	32%	UniProt GenBank	Acetylserotonin O-methyltransferase	Desku_0280	Desulfotomaculum kuznetsovii DSM 6115	2.1.1.4 niceE keggE
29	F4FBS8_VERMA (F4FBS8)	3e-18	97.4	31%	UniProt GenBank	O-methyltransferase family 2	VAB18032_18130	Verrucosispora maris (strain AB-18-032)
30	D7C8A1_STRBB (D7C8A1)	4e-18	97.1	31%	UniProt GenBank	O-methyltransferase family 2	SBI_03169	Streptomyces bingchenggensis (strain BCW-1)
31	Q74DV1_GEOSL (Q74DV1)	5e-18	96.7	28%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-o-methyltransferase, putative	GSU1214	Geobacter sulfurreducens
32	D7AHZ5_GEOSK (D7AHZ5)	5e-18	96.7	28%	UniProt GenBank	O-methyltransferase, family 2	KN400_1188	Geobacter sulfurreducens (strain DL-1 / KN400)
33	D1C231_SPHTD (D1C231)	6e-18	96.3	30%	UniProt GenBank	O-methyltransferase family 2	Sthe_0861	Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
34	D3F6H0_CONWI (D3F6H0)	7e-18	96.3	29%	UniProt GenBank	O-methyltransferase family 2	Cwoe_2312	Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577)
35	Q1CXX7_MYXXD (Q1CXX7)	7e-18	96.3	28%	UniProt GenBank	Putative O-methyltransferase	MXAN_6628	Myxococcus xanthus (strain DK 1622)
36	E1QLS2_DESB2 (E1QLS2)	2e-17	94.7	31%	UniProt GenBank	Methyltransferase type 12	Deba_3154	Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)
37	D2QXW1_PIRSD (D2QXW1)	6e-17	93.2	31%	UniProt GenBank	O-methyltransferase family 2	Psta_3374	Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128) Pirella staleyi
38	D6A8Q4_9ACTO (D6A8Q4)	8e-17	92.4	27%	UniProt GenBank	O-methyltransferase family 2	SSFG_07273	Streptomyces ghanaensis ATCC 14672
39	Q09BC6_STIAD (Q09BC6)	9e-17	92.4	26%	UniProt GenBank	O-methyltransferase Tetracenomycin polyketide synthesis 8-o-methyltransferase, putative	STAUR_1267 STIAU_8618	Stigmatella aurantiaca (strain DW4/3-1)
40	Q2S9J5_HAHCH (Q2S9J5)	1e-16	92	27%	UniProt GenBank	SAM-dependent methyltransferase	HCH_06029	Hahella chejuensis (strain KCTC 2396)
41	D7BZK8_STRBB (D7BZK8)	1e-16	92	29%	UniProt GenBank	O-methyltransferase family protein	SBI_06793	Streptomyces bingchenggensis (strain BCW-1)
42	D8FED2_9DELT (D8FED2)	2e-16	91.7	26%	UniProt GenBank	O-methyltransferase	NPH_5510	delta proteobacterium NaphS2
43	F4XU33_9CYAN (F4XU33)	8e-16	89.4	24%	UniProt GenBank	Methylase involved in ubiquinone/menaquinone biosynthesis	LYNGBM3L_30420	Lyngbya majuscula 3L
44	A8TIU8_9PROT (A8TIU8)	9e-16	89	32%	UniProt GenBank	Probable acetylserotonin O-methyltransferase	BAL199_15988	alpha proteobacterium BAL199
45	A0SYZ8_9BURK (A0SYZ8)	9e-16	89	25%	UniProt GenBank	Putative O-methyltransferase pigF		Janthinobacterium lividum
46	A1ARH0_PELPD (A1ARH0)	1e-15	88.6	27%	UniProt GenBank	O-methyltransferase, family 2	Ppro_2333	Pelobacter propionicus (strain DSM 2379)
47	F2NJA2_DESAR (F2NJA2)	2e-15	88.2	25%	UniProt GenBank	O-methyltransferase family 2	Desac_1418	Desulfobacca acetoxidans (strain ATCC 700848 / DSM 11109 / ASRB2)
48	E1K028_DESFR (E1K028)	4e-15	86.7	29%	UniProt GenBank	O-methyltransferase family 2	DesfrDRAFT_3228	Desulfovibrio fructosovorans JJ
49	F6WEJ3_HORSE (F6WEJ3)	4e-15	86.7	29%	UniProt GenBank	Uncharacterized protein	ASMT	Equus caballus Horse
50	D2AY00_STRRD (D2AY00)	5e-15	86.7	31%	UniProt GenBank	Putative uncharacterized protein	Sros_2188	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
51	C0QH96_DESAH (C0QH96)	5e-15	86.7	26%	UniProt GenBank	SAM-dependent methyltransferase	HRM2_47060	Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
52	D6U574_9CHLR (D6U574)	5e-15	86.7	27%	UniProt GenBank	O-methyltransferase family 2	Krac_2390	Ktedonobacter racemifer DSM 44963
53	Q70DX4_9ACTO (Q70DX4)	5e-15	86.7	26%	UniProt GenBank	RemG protein	remG	Streptomyces resistomycificus
54	F8C9S7_MYXFU (F8C9S7)	6e-15	86.3	28%	UniProt GenBank	Putative O-methyltransferase	LILAB_00725	Myxococcus fulvus
55	Q02AU7_SOLUE (Q02AU7)	6e-15	86.3	27%	UniProt GenBank	Hydroxyneurosporene-O-methyltransferase	Acid_0820	Solibacter usitatus (strain Ellin6076)	2.1.1.- niceE keggE
56	A8ZX85_DESOH (A8ZX85)	1e-14	85.5	26%	UniProt GenBank	O-methyltransferase family 2	Dole_2661	Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
57	Q47FV2_DECAR (Q47FV2)	2e-14	84.7	25%	UniProt GenBank	O-methyltransferase, family 2	Daro_1530	Dechloromonas aromatica (strain RCB)
58	F8GLV2_9PROT (F8GLV2)	2e-14	84.7	25%	UniProt GenBank	O-methyltransferase family 2	Nit79A3_3300	Nitrosomonas sp. Is79A3
59	A7BPT9_9GAMM (A7BPT9)	2e-14	84.7	26%	UniProt GenBank	O-methyltransferase, family 2	BGP_5272	Beggiatoa sp. PS
60	Q469X3_METBF (Q469X3)	3e-14	84	24%	UniProt GenBank	O-methyltransferase	Mbar_A2399	Methanosarcina barkeri (strain Fusaro / DSM 804)
61	Q5W249_SERMA (Q5W249)	3e-14	84	27%	UniProt GenBank	Putative O-methyl transferase	pigF	Serratia marcescens
62	B9LZX0_GEOSF (B9LZX0)	3e-14	84	26%	UniProt GenBank	O-methyltransferase family 2	Geob_0567	Geobacter sp. (strain FRC-32)
63	A3ZPN0_9PLAN (A3ZPN0)	6e-14	83.2	29%	UniProt GenBank	Putative methyltransferase	DSM3645_29042	Blastopirellula marina DSM 3645
64	B9L1M3_THERP (B9L1M3)	7e-14	82.8	29%	UniProt GenBank	Putative hydroxyindole O-methyltransferase	trd_1284	Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
65	A8LVE9_SALAI (A8LVE9)	9e-14	82.4	30%	UniProt GenBank	Methyltransferase type 12	Sare_4888	Salinispora arenicola (strain CNS-205)
66	Q1Q4M5_9BACT (Q1Q4M5)	1e-13	82	23%	UniProt GenBank	Similar to tetracenomycin polyketide synthesis 8-O-methyltransferase	tcmO kuste4198	Candidatus Kuenenia stuttgartiensis	2.1.1.- niceE keggE
67	E2Q8B6_STRCL (E2Q8B6)	1e-13	82	29%	UniProt GenBank	O-methyltransferase family protein	SCLAV_0372	Streptomyces clavuligerus ATCC 27064
68	A8ERN2_ARCB4 (A8ERN2)	1e-13	82	18%	UniProt GenBank	O-methyltransferase	Abu_0331	Arcobacter butzleri (strain RM4018)
69	Q1DBX2_MYXXD (Q1DBX2)	1e-13	82	29%	UniProt GenBank	Putative methyltransferase	MXAN_1599	Myxococcus xanthus (strain DK 1622)
70	Q1B9Z2_MYCSS (Q1B9Z2)	1e-13	81.6	28%	UniProt GenBank	Hydroxyneurosporene-O-methyltransferase	Mmcs_2184	Mycobacterium sp. (strain MCS)	2.1.1.- niceE keggE
71	A3PYI2_MYCSJ (A3PYI2)	1e-13	81.6	28%	UniProt GenBank	Hydroxyneurosporene-O-methyltransferase	Mjls_2173	Mycobacterium sp. (strain JLS)	2.1.1.- niceE keggE
72	A1UF20_MYCSK (A1UF20)	1e-13	81.6	28%	UniProt GenBank	Hydroxyneurosporene-O-methyltransferase	Mkms_2230	Mycobacterium sp. (strain KMS)	2.1.1.- niceE keggE
73	E8L6E2_9RHIZ (E8L6E2)	1e-13	81.6	25%	UniProt GenBank	O-methyltransferase family 2	Met49242DRAFT_3035	Methylocystis sp. ATCC 49242
74	D2HFI7_AILME (D2HFI7)	2e-13	81.6	26%	UniProt GenBank	Putative uncharacterized protein	PANDA_009661	Ailuropoda melanoleuca Giant panda
75	D8PIA8_9BACT (D8PIA8)	2e-13	81.3	27%	UniProt GenBank	Putative O-methyltransferase, family 2	NIDE3307	Candidatus Nitrospira defluvii	2.1.1.- niceE keggE
76	Q2FPR0_METHJ (Q2FPR0)	2e-13	81.3	26%	UniProt GenBank	O-methyltransferase, family 2	Mhun_1336	Methanospirillum hungatei (strain JF-1 / DSM 864)
77	F8C9T0_MYXFU (F8C9T0)	2e-13	80.9	29%	UniProt GenBank	Putative methyltransferase	LILAB_00740	Myxococcus fulvus
78	D3D271_9ACTO (D3D271)	3e-13	80.9	32%	UniProt GenBank	O-methyltransferase family 2	FrEUN1fDRAFT_3892	Frankia sp. EUN1f
79	A8ZWC8_DESOH (A8ZWC8)	3e-13	80.9	24%	UniProt GenBank	O-methyltransferase family 2	Dole_0926	Desulfococcus oleovorans (strain DSM 6200 / Hxd3)
80	F4BYU8_METCG (F4BYU8)	4e-13	80.1	25%	UniProt GenBank	Methyltransferase	MCON_0961	Methanosaeta concilii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6) Methanothrix concilii
81	A4TCK4_MYCGI (A4TCK4)	5e-13	80.1	27%	UniProt GenBank	Methyltransferase type 12	Mflv_3993	Mycobacterium gilvum (strain PYR-GCK) Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK)
82	E5DHP2_STRGB (E5DHP2)	6e-13	79.7	28%	UniProt GenBank	O-methyltransferase		Streptomyces galbus
83	Q2RIK5_MOOTA (Q2RIK5)	6e-13	79.7	28%	UniProt GenBank	O-methyltransferase, family 2	Moth_1421	Moorella thermoacetica (strain ATCC 39073)
84	Q1DBW9_MYXXD (Q1DBW9)	9e-13	79.3	28%	UniProt GenBank	Putative O-methyltransferase	MXAN_1602	Myxococcus xanthus (strain DK 1622)
85	Q62B46_BURMA (Q62B46)	1e-12	79	28%	UniProt GenBank	O-methyltransferase family protein	BMAA1486	Burkholderia mallei Pseudomonas mallei
86	A2S1U2_BURM9 (A2S1U2)	1e-12	79	28%	UniProt GenBank	O-methyltransferase family protein	BMA10229_2117	Burkholderia mallei (strain NCTC 10229)
87	C4AWE0_BURMA (C4AWE0)	1e-12	79	28%	UniProt GenBank	O-methyltransferase family protein	BMAGB8_A1692	Burkholderia mallei GB8 horse 4
88	A9K553_BURMA (A9K553)	1e-12	79	28%	UniProt GenBank	O-methyltransferase	BMA10399_B2188	Burkholderia mallei ATCC 10399
89	A5XL19_BURMA (A5XL19)	1e-12	79	28%	UniProt GenBank	O-methyltransferase	BMAJHU_I0655	Burkholderia mallei JHU
90	A5TMQ4_BURMA (A5TMQ4)	1e-12	79	28%	UniProt GenBank	O-methyltransferase	BMA721280_I0654	Burkholderia mallei 2002721280
91	HIOM_MACMU (Q8HZJ0)	1e-12	78.6	26%	UniProt GenBank	Hydroxyindole O-methyltransferase Acetylserotonin O-methyltransferase Acetylserotonin O-methyltransferase	ASMT	Macaca mulatta Rhesus macaque	2.1.1.4 niceE keggE
92	E1QGJ0_DESB2 (E1QGJ0)	1e-12	78.6	26%	UniProt GenBank	Methyltransferase type 12	Deba_1315	Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)
93	Q39UW0_GEOMG (Q39UW0)	2e-12	78.6	29%	UniProt GenBank	O-methyltransferase, family 2	Gmet_1733	Geobacter metallireducens (strain GS-15 / ATCC 53774 / DSM 7210)
94	A3MCL5_BURM7 (A3MCL5)	2e-12	78.6	28%	UniProt GenBank	O-methyltransferase	BMA10247_A0802	Burkholderia mallei (strain NCTC 10247)
95	C5NAS3_BURMA (C5NAS3)	2e-12	78.6	28%	UniProt GenBank	O-methyltransferase	BMAPRL20_1539	Burkholderia mallei PRL-20
96	A5J404_BURMA (A5J404)	2e-12	78.6	28%	UniProt GenBank	O-methyltransferase	BMAFMH_E0735	Burkholderia mallei FMH
97	Q2L6E6_9ACTO (Q2L6E6)	2e-12	78.2	27%	UniProt GenBank	Probable methyltransferase		Streptomyces sp. KO-3988
98	Q0FPA1_9RHOB (Q0FPA1)	2e-12	78.2	29%	UniProt GenBank	O-methyltransferase, family 2	R2601_26831	Pelagibaca bermudensis HTCC2601
99	F3YWU3_DESAF (F3YWU3)	2e-12	78.2	28%	UniProt GenBank	Acetylserotonin O-methyltransferase	Desaf_3380	Desulfovibrio africanus str. Walvis Bay	2.1.1.4 niceE keggE
100	C1B538_RHOOB (C1B538)	2e-12	77.8	26%	UniProt GenBank	Putative methyltransferase	ROP_27170	Rhodococcus opacus (strain B4)	2.1.1.- niceE keggE

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q194P8_STRAA
(Q194P8)

0.0

639

100%

Product: C-methyltransferase
Gene: mtmMII
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

F4FBQ8_VERMA
(F4FBQ8)

3e-83

313

49%

Product: O-methyltransferase involved in albicidin biosynthesis protein
Gene: VAB18032_18030
Organism: Verrucosispora maris (strain AB-18-032)

1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]

D6MSU9_9ACTO
(D6MSU9)

1e-55

221

39%

Product: SsfM3
Gene: ssfM3
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

Q84HG5_PSEFL
(Q84HG5)

8e-49

198

37%

Product: QbsL
Gene: qbsL
Organism: Pseudomonas fluorescens

1uniprot[Pubmed] 15066027
The Pseudomonas siderophore quinolobactin is synthesized from xanthurenic acid, an intermediate of the kynurenine pathway.(Mol. Microbiol.) [2004]

B9XKT9_9BACT
(B9XKT9)

2e-38

164

33%

Product: Methyltransferase type 12
Gene: Cflav_PD2489
Organism: Pedosphaera parvula Ellin514

1uniprot[Pubmed] 21460084
Genome Sequence of 'Pedosphaera parvula' Ellin514, an Aerobic Verrucomicrobial Isolate from Pasture Soil.(J. Bacteriol.) [2011]

Q025E9_SOLUE
(Q025E9)

7e-38

162

35%

Product: Methyltransferase type 12
Gene: Acid_2381
Organism: Solibacter usitatus (strain Ellin6076)

1uniprot[Pubmed] 19201974
Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils.(Appl. Environ. Microbiol.) [2009]

D2MKW0_9BACT
(D2MKW0)

8e-37

159

32%

Product: O-methyltransferase, family 2
Gene: POR_1326
Organism: Candidatus Poribacteria sp. WGA-A3

1uniprot[Pubmed] 20613790
Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges.(ISME J.) [2010]

B4DC13_9BACT
(B4DC13)

1e-34

152

33%

Product: Methyltransferase type 12
Gene: CfE428DRAFT_6454
Organism: Chthoniobacter flavus Ellin428

1uniprot[Pubmed] 21460085
Genome Sequence of Chthoniobacter flavus Ellin428, an Aerobic Heterotrophic Soil Bacterium.(J. Bacteriol.) [2011]

D2UDG0_XANAP
(D2UDG0)

1e-34

151

31%

Product: O-methyltransferase involved in albicidin biosynthesis protein
Gene: albII
XALc_1530
Organism: Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)

1uniprot
The complete genome sequence of Xanthomonas albilineans provides new insights into the reductive genome evolution of the xylem-limited Xanthomonadaceae.(BMC Genomics) [2009]

Q9AIT2_XANAL
(Q9AIT2)

1e-34

151

31%

Product: Albicidin biosynthesis methyltransferase
Putative O-methyltransferase
Gene: albII
Organism: Xanthomonas albilineans

[pubmed all]
1uniprot[Pubmed] 11024293 [Medline] 20480700 Analysis of the genes flanking xabB: a methyltransferase gene is involved in albicidin biosynthesis in Xanthomonas albilineans.(Gene) [2000]
2uniprot[Pubmed] 15077674 Albicidin pathotoxin produced by Xanthomonas albilineans is encoded by three large PKS and NRPS genes present in a gene cluster also containing several putative modifying, regulatory, and resistance genes.(Mol. Plant Microbe Interact.) [2004]

F2A5S2_RHIET
(F2A5S2)

2e-32

144

31%

Product: Putative SAM-dependent methyltransferase protein
Gene: RHECNPAF_1700036
Organism: Rhizobium etli CNPAF512

1uniprot[Pubmed] 21515775
Genome Sequence of Rhizobium etli CNPAF512, a Nitrogen-Fixing Symbiont Isolated from Bean Root Nodules in Brazil.(J. Bacteriol.) [2011]

B3DV12_METI4
(B3DV12)

2e-31

140

31%

Product: SAM-dependent methyltransferase
Gene: smtA
Minf_1110
Organism: Methylacidiphilum infernorum (isolate V4)
Methylokorus infernorum (strain V4)

1uniprot[Pubmed] 18593465
Complete genome sequence of the extremely acidophilic methanotroph isolate V4, Methylacidiphilum infernorum, a representative of the bacterial phylum Verrucomicrobia.(Biol. Direct) [2008]

D2MJR9_9BACT
(D2MJR9)

8e-21

105

29%

Product: O-methyltransferase, family 2:Generic methyltransferase
Gene: POR_0933
Organism: Candidatus Poribacteria sp. WGA-A3

1uniprot[Pubmed] 20613790
Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges.(ISME J.) [2010]

E3T6I1_9BACT
(E3T6I1)

5e-20

103

29%

Product: O-methyltransferase family 2
Gene
Organism: uncultured bacterium 70

1uniprot[Pubmed] 20729323
Comparative analysis of acidobacterial genomic fragments from terrestrial and aquatic metagenomic libraries, with emphasis on acidobacteria subdivision 6.(Appl. Environ. Microbiol.) [2010]

D1CH44_THET1
(D1CH44)

1e-18

32%

Product: Methyltransferase type 11
Gene: Tter_2164
Organism: Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)

1uniprot
Complete genome sequence of Thermobaculum terrenum type strain (YNP1T).(Stand. Genomic Sci.) [2010]

F2YRZ2_9ACTO
(F2YRZ2)

1e-18

98.6

29%

Product: O-methyltransferase
Gene: sky37
Organism: Streptomyces sp. Acta 2897

1uniprot[Pubmed] 21456593
Biosynthetic Gene Cluster of the Non-ribosomally Synthesized Cyclodepsipeptide Skyllamycin: Deciphering Unprecedented Ways of Unusual Hydroxylation Reactions.(J. Am. Chem. Soc.) [2011]

A2AXE8_STRCM
(A2AXE8)

2e-18

98.2

28%

Product: SAM-dependent O-methyltransferase
Gene: fnq9
Organism: Streptomyces cinnamonensis

1uniprot[Pubmed] 17103476
A gene cluster for prenylated naphthoquinone and prenylated phenazine biosynthesis in Streptomyces cinnamonensis DSM 1042.(Chembiochem) [2006]

D8P817_9BACT
(D8P817)

3e-18

97.4

28%

Product: Putative O-methyltransferase, family 2
Gene: NIDE3979
Organism: Candidatus Nitrospira defluvii

1uniprot
A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

F4FBS8_VERMA
(F4FBS8)

3e-18

97.4

31%

Product: O-methyltransferase family 2
Gene: VAB18032_18130
Organism: Verrucosispora maris (strain AB-18-032)

1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]

D7C8A1_STRBB
(D7C8A1)

4e-18

97.1

31%

Product: O-methyltransferase family 2
Gene: SBI_03169
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

Q74DV1_GEOSL
(Q74DV1)

5e-18

96.7

28%

Product: Tetracenomycin polyketide synthesis 8-o-methyltransferase, putative
Gene: GSU1214
Organism: Geobacter sulfurreducens

1uniprot[Pubmed] 14671304
Genome of Geobacter sulfurreducens: metal reduction in subsurface environments.(Science) [2003]

D7AHZ5_GEOSK
(D7AHZ5)

5e-18

96.7

28%

Product: O-methyltransferase, family 2
Gene: KN400_1188
Organism: Geobacter sulfurreducens (strain DL-1 / KN400)

1uniprot[Pubmed] 20544019
De Novo assembly of the complete genome of an enhanced electricity-producing variant of Geobacter sulfurreducens using only short reads.(PLoS ONE) [2010]

Q1CXX7_MYXXD
(Q1CXX7)

7e-18

96.3

28%

Product: Putative O-methyltransferase
Gene: MXAN_6628
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

E1QLS2_DESB2
(E1QLS2)

2e-17

94.7

31%

Product: Methyltransferase type 12
Gene: Deba_3154
Organism: Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)

1uniprot
Complete genome sequence of Desulfarculus baarsii type strain (2st14).(Stand. Genomic Sci.) [2010]

D2QXW1_PIRSD
(D2QXW1)

6e-17

93.2

31%

Product: O-methyltransferase family 2
Gene: Psta_3374
Organism: Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128)
Pirella staleyi

1uniprot
Complete genome sequence of Pirellula staleyi type strain (ATCC 27377T).(Stand. Genomic Sci.) [2009]

Q2S9J5_HAHCH
(Q2S9J5)

1e-16

27%

Product: SAM-dependent methyltransferase
Gene: HCH_06029
Organism: Hahella chejuensis (strain KCTC 2396)

1uniprot[Pubmed] 16352867
Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent.(Nucleic Acids Res.) [2005]

D7BZK8_STRBB
(D7BZK8)

1e-16

29%

Product: O-methyltransferase family protein
Gene: SBI_06793
Organism: Streptomyces bingchenggensis (strain BCW-1)

1uniprot[Pubmed] 20581206
Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010]

D8FED2_9DELT
(D8FED2)

2e-16

91.7

26%

Product: O-methyltransferase
Gene: NPH_5510
Organism: delta proteobacterium NaphS2

1uniprot[Pubmed] 21124915
Genome Sequence of the Deltaproteobacterial Strain NaphS2 and Analysis of Differential Gene Expression during Anaerobic Growth on Naphthalene.(PLoS ONE) [2010]

F4XU33_9CYAN
(F4XU33)

8e-16

89.4

24%

Product: Methylase involved in ubiquinone/menaquinone biosynthesis
Gene: LYNGBM3L_30420
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

A0SYZ8_9BURK
(A0SYZ8)

9e-16

25%

Product: Putative O-methyltransferase pigF
Gene
Organism: Janthinobacterium lividum

1uniprot
Psychrotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin.(DNA Cell Biol.) [2010]

F6WEJ3_HORSE
(F6WEJ3)

4e-15

86.7

29%

Product: Uncharacterized protein
Gene: ASMT
Organism: Equus caballus
Horse

1uniprot[Pubmed] 19892987
Genome sequence, comparative analysis, and population genetics of the domestic horse.(Science) [2009]

D2AY00_STRRD
(D2AY00)

5e-15

86.7

31%

Product: Putative uncharacterized protein
Gene: Sros_2188
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

C0QH96_DESAH
(C0QH96)

5e-15

86.7

26%

Product: SAM-dependent methyltransferase
Gene: HRM2_47060
Organism: Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)

1uniprot[Pubmed] 19187283
Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide.(Environ. Microbiol.) [2009]

Q70DX4_9ACTO
(Q70DX4)

5e-15

86.7

26%

Product: RemG protein
Gene: remG
Organism: Streptomyces resistomycificus

1uniprot[Pubmed] 14982421
A gene cluster encoding resistomycin biosynthesis in Streptomyces resistomycificus; exploring polyketide cyclization beyond linear and angucyclic patterns.(J. Am. Chem. Soc.) [2004]

Q02AU7_SOLUE
(Q02AU7)

6e-15

86.3

27%

Product: Hydroxyneurosporene-O-methyltransferase
Gene: Acid_0820
Organism: Solibacter usitatus (strain Ellin6076)

1uniprot[Pubmed] 19201974
Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils.(Appl. Environ. Microbiol.) [2009]

Q469X3_METBF
(Q469X3)

3e-14

24%

Product: O-methyltransferase
Gene: Mbar_A2399
Organism: Methanosarcina barkeri (strain Fusaro / DSM 804)

1uniprot[Pubmed] 16980466
The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes.(J. Bacteriol.) [2006]

Q5W249_SERMA
(Q5W249)

3e-14

27%

Product: Putative O-methyl transferase
Gene: pigF
Organism: Serratia marcescens

1uniprot
The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species and strain dependent genome context variation.(Microbiology (Mosc.)) [2004]

B9L1M3_THERP
(B9L1M3)

7e-14

82.8

29%

Product: Putative hydroxyindole O-methyltransferase
Gene: trd_1284
Organism: Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)

1uniprot[Pubmed] 19148287
Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum.(PLoS ONE) [2009]

Q1Q4M5_9BACT
(Q1Q4M5)

1e-13

23%

Product: Similar to tetracenomycin polyketide synthesis 8-O-methyltransferase
Gene: tcmO
kuste4198
Organism: Candidatus Kuenenia stuttgartiensis

1uniprot[Pubmed] 16598256
Deciphering the evolution and metabolism of an anammox bacterium from a community genome.(Nature) [2006]

E2Q8B6_STRCL
(E2Q8B6)

1e-13

29%

Product: O-methyltransferase family protein
Gene: SCLAV_0372
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot[Pubmed] 20624727
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

A8ERN2_ARCB4
(A8ERN2)

1e-13

18%

Product: O-methyltransferase
Gene: Abu_0331
Organism: Arcobacter butzleri (strain RM4018)

1uniprot[Pubmed] 18159241
The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri.(PLoS ONE) [2007]

Q1DBX2_MYXXD
(Q1DBX2)

1e-13

29%

Product: Putative methyltransferase
Gene: MXAN_1599
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

E8L6E2_9RHIZ
(E8L6E2)

1e-13

81.6

25%

Product: O-methyltransferase family 2
Gene: Met49242DRAFT_3035
Organism: Methylocystis sp. ATCC 49242

1uniprot[Pubmed] 21441518
Genome Sequence of the Methanotrophic Alphaproteobacterium Methylocystis sp. Strain Rockwell (ATCC 49242).(J. Bacteriol.) [2011]

D2HFI7_AILME
(D2HFI7)

2e-13

81.6

26%

Product: Putative uncharacterized protein
Gene: PANDA_009661
Organism: Ailuropoda melanoleuca
Giant panda

1uniprot[Pubmed] 20010809
The sequence and de novo assembly of the giant panda genome.(Nature) [2010]

D8PIA8_9BACT
(D8PIA8)

2e-13

81.3

27%

Product: Putative O-methyltransferase, family 2
Gene: NIDE3307
Organism: Candidatus Nitrospira defluvii

1uniprot
A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

F4BYU8_METCG
(F4BYU8)

4e-13

80.1

25%

Product: Methyltransferase
Gene: MCON_0961
Organism: Methanosaeta concilii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6)
Methanothrix concilii

1uniprot[Pubmed] 21571998
Complete genome sequence of Methanosaeta concilii, a specialist in aceticlastic methanogenesis.(J. Bacteriol.) [2011]

E5DHP2_STRGB
(E5DHP2)

6e-13

79.7

28%

Product: O-methyltransferase
Gene
Organism: Streptomyces galbus

1uniprot[Pubmed] 20662933
The methoxymalonyl-acyl carrier protein biosynthesis locus and the nearby gene with the beta-ketoacyl synthase domain are involved in the biosynthesis of galbonolides in Streptomyces galbus, but these loci are separate from the modular polyketide synthase gene cluster.(FEMS Microbiol. Lett.) [2010]

Q2RIK5_MOOTA
(Q2RIK5)

6e-13

79.7

28%

Product: O-methyltransferase, family 2
Gene: Moth_1421
Organism: Moorella thermoacetica (strain ATCC 39073)

1uniprot[Pubmed] 18631365
The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum).(Environ. Microbiol.) [2008]

Q1DBW9_MYXXD
(Q1DBW9)

9e-13

79.3

28%

Product: Putative O-methyltransferase
Gene: MXAN_1602
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

Q62B46_BURMA
(Q62B46)

1e-12

28%

Product: O-methyltransferase family protein
Gene: BMAA1486
Organism: Burkholderia mallei
Pseudomonas mallei

1uniprot[Pubmed] 15377793
Structural flexibility in the Burkholderia mallei genome.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

HIOM_MACMU
(Q8HZJ0)

1e-12

78.6

26%

Product: Hydroxyindole O-methyltransferase
Acetylserotonin O-methyltransferase
Acetylserotonin O-methyltransferase
Gene: ASMT
Organism: Macaca mulatta
Rhesus macaque

1uniprot[Pubmed] 12364461 [Medline] 22250961
Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87).(J. Clin. Endocrinol. Metab.) [2002]

E1QGJ0_DESB2
(E1QGJ0)

1e-12

78.6

26%

Product: Methyltransferase type 12
Gene: Deba_1315
Organism: Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-1802 / 2st14)

1uniprot
Complete genome sequence of Desulfarculus baarsii type strain (2st14).(Stand. Genomic Sci.) [2010]

Q2L6E6_9ACTO
(Q2L6E6)

2e-12

78.2

27%

Product: Probable methyltransferase
Gene
Organism: Streptomyces sp. KO-3988

1uniprot[Pubmed] 16452404
Biosynthesis of a natural polyketide-isoprenoid hybrid compound, furaquinocin A: identification and heterologous expression of the gene cluster.(J. Bacteriol.) [2006]

Q0FPA1_9RHOB
(Q0FPA1)

2e-12

78.2

29%

Product: O-methyltransferase, family 2
Gene: R2601_26831
Organism: Pelagibaca bermudensis HTCC2601

1uniprot[Pubmed] 20729358
Genome sequences of Pelagibaca bermudensis HTCC2601T and Maritimibacter alkaliphilus HTCC2654T, the type strains of two marine Roseobacter genera.(J. Bacteriol.) [2010]