| accession | DB | alignment | Evalue | Score | Ident. | link | information | pubmed |
1
|
Q3S8P7_STRRM (Q3S8P7) |
|
|
0.0 |
1003 |
100% |
|
- Product
- OxyS
- Gene
- oxyS
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16597959 Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006] |
|
2
|
Q58PK7_STRRM (Q58PK7) |
|
|
0.0 |
991 |
99% |
|
- Product
- Anhydrotetracycline oxygenase
- Gene
- otcC
- Organism
- Streptomyces rimosus
|
1uniprot[Pubmed] 16148009 Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.(J. Biol. Chem.) [2005] |
|
3
|
Q53657_STRAU (Q53657) |
|
|
1e-148 |
530 |
60% |
|
- Product
- 6-hydroxylation enzyme of tetracycline
- Gene
- cts8
- Organism
- Streptomyces aureofaciens
|
1uniprot[Pubmed] 7612997 [Medline] 95337551 Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline.(Biosci. Biotechnol. Biochem.) [1995] |
|
4
|
Q0RMN5_FRAAA (Q0RMN5) |
|
|
1e-109 |
400 |
48% |
|
- Product
- Putative polyketide oxygenase/hydroxylase
- Gene
- FRAAL2565
- Organism
- Frankia alni (strain ACN14a)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
5
|
D2ASL9_STRRD (D2ASL9) |
|
|
1e-108 |
396 |
48% |
|
- Product
- Putative monooxygenase
- Gene
- Sros_5796
- Organism
- Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
|
1uniprot Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010] |
|
8
|
A9FKP5_SORC5 (A9FKP5) |
|
|
1e-106 |
389 |
48% |
|
- Product
- Putative monooxygenase
- Gene
- yhjG3
sce4973
- Organism
- Sorangium cellulosum (strain So ce56)
Polyangium cellulosum (strain So ce56)
|
1uniprot[Pubmed] 17965706 Complete genome sequence of the myxobacterium Sorangium cellulosum.(Nat. Biotechnol.) [2007] |
|
10
|
E8VGB4_BACST (E8VGB4) |
|
|
1e-102 |
378 |
44% |
|
- Product
- Putative uncharacterized protein
- Gene
- BSn5_17135
- Organism
- Bacillus subtilis (strain BSn5)
|
1uniprot[Pubmed] 21317323 Complete genome sequence of Bacillus subtilis BSn5, an endophytic bacterium of Amorphophallus konjac with antimicrobial activity to plant pathogen Erwinia carotovora subsp. carotovora.(J. Bacteriol.) [2011] |
|
11
|
Q47QL5_THEFY (Q47QL5) |
|
|
1e-102 |
378 |
47% |
|
- Product
- Putative uncharacterized protein
- Gene
- Tfu_1216
- Organism
- Thermobifida fusca (strain YX)
|
1uniprot[Pubmed] 17209016 Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007] |
|
13
|
D8I7G5_AMYMU (D8I7G5) |
|
|
1e-102 |
377 |
45% |
|
- Product
- 3-(3-hydroxy-phenyl)propionate hydroxylase
- Gene
- mhpA
AMED_5632
- Organism
- Amycolatopsis mediterranei (strain U-32)
|
1uniprot[Pubmed] 20567260 Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010] |
|
15
|
D4FUS4_BACNA (D4FUS4) |
|
|
1e-102 |
376 |
43% |
|
- Product
- Putative uncharacterized protein yhjG
- Gene
- yhjG
BSNT_01781
- Organism
- Bacillus subtilis subsp. natto BEST195
|
1uniprot[Pubmed] 20398357 Whole genome assembly of a natto production strain Bacillus subtilis natto from very short read data.(BMC Genomics) [2010] |
|
16
|
YHJG_BACSU (O07561) |
|
|
1e-102 |
375 |
43% |
|
- Product
- Uncharacterized aromatic compound monooxygenase yhjG
- Gene
- yhjG
BSU10500
- Organism
- Bacillus subtilis
|
1uniprot[Pubmed] 9579061 [Medline] 98240224 The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus subtilis chromosome contains several dysfunctional genes, the glyB marker, many genes encoding transporter proteins, and the ubiquitous hit gene.(Microbiology) [1998] | 2uniprot[Pubmed] 9384377 [Medline] 98044033 The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.(Nature) [1997] | [pubmed all]
|
17
|
Q5YTV5_NOCFA (Q5YTV5) |
|
|
1e-101 |
375 |
48% |
|
- Product
- Putative rifampin monooxygenase
- Gene
- rox
NFA_35380
- Organism
- Nocardia farcinica
|
1uniprot[Pubmed] 15466710 The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004] |
|
18
|
Q6VMI4_STRAM (Q6VMI4) |
|
|
1e-101 |
375 |
47% |
|
- Product
- Putative oxygenase
- Gene
- alpK
DSMT0188
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 14742212 Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004] | 2uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | [pubmed all]
|
19
|
Q1RQR7_STRAM (Q1RQR7) |
|
|
1e-101 |
375 |
47% |
|
- Product
- Putative oxygenase
- Gene
- alpK
SAMT0168 SAMT0169
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|
20
|
Q92Y25_RHIME (Q92Y25) |
|
|
1e-101 |
373 |
44% |
|
- Product
- Oxidoreductase
- Gene
- RA1063
SMa1939
- Organism
- Rhizobium meliloti
Ensifer meliloti Sinorhizobium meliloti
|
1uniprot[Pubmed] 11481432 [Medline] 21396509 Nucleotide sequence and predicted functions of the entire Sinorhizobium meliloti pSymA megaplasmid.(Proc. Natl. Acad. Sci. U.S.A.) [2001] | 2uniprot[Pubmed] 11474104 [Medline] 21368234 The composite genome of the legume symbiont Sinorhizobium meliloti.(Science) [2001] | [pubmed all]
|
23
|
F7XDI8_RHIME (F7XDI8) |
|
|
1e-100 |
371 |
44% |
|
- Product
- Oxidoreductase
- Gene
- SM11_pC0540
- Organism
- Sinorhizobium meliloti SM11
|
1uniprot[Pubmed] 21396969 The complete genome sequence of the dominant Sinorhizobium meliloti field isolate SM11 extends the S. meliloti pan-genome.(J. Biotechnol.) [2011] |
|
26
|
C7Q997_CATAD (C7Q997) |
|
|
2e-99 |
367 |
46% |
|
- Product
- Monooxygenase FAD-binding
- Gene
- Caci_5384
- Organism
- Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
|
1uniprot Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).(Stand. Genomic Sci.) [2009] |
|
28
|
D2XDX8_9PSEU (D2XDX8) |
|
|
4e-99 |
366 |
44% |
|
- Product
- AzicO4
- Gene
- azicO4
- Organism
- Kibdelosporangium sp. MJ126-NF4
|
1uniprot[Pubmed] 19928906 Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009] |
|
29
|
E4N5W7_KITSK (E4N5W7) |
|
|
7e-99 |
365 |
46% |
|
- Product
- Putative monooxygenase
- Gene
- KSE_07580
- Organism
- Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 / KM-6054)
Streptomyces setae
|
1uniprot[Pubmed] 21059706 Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.(DNA Res.) [2010] |
|
31
|
D3UA07_9ACTO (D3UA07) |
|
|
1e-98 |
365 |
46% |
|
- Product
- FAD-dependent monooxygenase
- Gene
-
- Organism
- Streptomyces flaveolus
|
1uniprot Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor.(Mol. Biosyst.) [2010] |
|
35
|
Q47KZ8_THEFY (Q47KZ8) |
|
|
2e-98 |
364 |
46% |
|
- Product
- Putative rifampin monooxygenase
- Gene
- Tfu_2841
- Organism
- Thermobifida fusca (strain YX)
|
1uniprot[Pubmed] 17209016 Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifida fusca YX.(J. Bacteriol.) [2007] |
|
36
|
Q49BE3_STRHY (Q49BE3) |
|
|
4e-98 |
363 |
47% |
|
- Product
- HbmL
- Gene
- hbmL
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 16085885 Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.(Appl. Environ. Microbiol.) [2005] |
|
38
|
A4FIN7_SACEN (A4FIN7) |
|
|
6e-98 |
362 |
45% |
|
- Product
- Monooxygenase, FAD-binding protein
- Gene
- SACE_4643
- Organism
- Saccharopolyspora erythraea (strain NRRL 23338)
|
1uniprot[Pubmed] 17369815 Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007] |
|
44
|
B2HSA2_MYCMM (B2HSA2) |
|
|
3e-97 |
360 |
45% |
|
- Product
- Putative uncharacterized protein
- Gene
- MMAR_4271
- Organism
- Mycobacterium marinum (strain ATCC BAA-535 / M)
|
1uniprot[Pubmed] 18403782 Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008] |
|
45
|
Q84G26_STRHY (Q84G26) |
|
|
3e-97 |
360 |
47% |
|
- Product
- GdmL
- Gene
- gdmL
- Organism
- Streptomyces hygroscopicus
|
1uniprot[Pubmed] 12586396 [Medline] 22474162 Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.(FEMS Microbiol. Lett.) [2003] |
|
46
|
Q2HR18_9ACTO (Q2HR18) |
|
|
4e-97 |
360 |
44% |
|
- Product
- Putative oxygenase
- Gene
- schP10
- Organism
- Streptomyces sp. SCC 2136
|
1uniprot Angucyclines Sch 47554 and Sch 47555 from Streptomyces sp. SCC-2136: Cloning, Sequencing, and Characterization.(Mol. Cells) [2006] | 2uniprot Molecular cloning and characterization of biosynthetic genes cluster of Sch 47554 from Streptomyces sp. SCC 2136. [2004] |
|
49
|
Q8KU28_9NOCA (Q8KU28) |
|
|
7e-97 |
359 |
45% |
|
- Product
- Flavin-type hydroxylase
- Gene
-
- Organism
- Rhodococcus sp. NCIMB 9784
|
1uniprot[Pubmed] 12081961 [Medline] 22077259 Identification of a new class of cytochrome P450 from a Rhodococcus sp.(J. Bacteriol.) [2002] |
|
50
|
C4NYJ7_9ACTO (C4NYJ7) |
|
|
7e-97 |
359 |
45% |
|
- Product
- SaqE
- Gene
- saqE
- Organism
- Micromonospora sp. Tu 6368
|
1uniprot[Pubmed] 17497146 A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis.(Appl. Microbiol. Biotechnol.) [2007] | 2uniprot[Pubmed] 19384899 Cloning and sequencing of the biosynthetic gene cluster for saquayamycin z and galtamycin B and the elucidation of the assembly of their saccharide chains.(Chembiochem) [2009] | [pubmed all]
|
51
|
F2AAE8_RHIET (F2AAE8) |
|
|
7e-97 |
359 |
45% |
|
- Product
- Putative monooxygenase (Tetracycline 6-hydroxylase) protein
- Gene
- RHECNPAF_296003
- Organism
- Rhizobium etli CNPAF512
|
1uniprot[Pubmed] 21515775 Genome Sequence of Rhizobium etli CNPAF512, a Nitrogen-Fixing Symbiont Isolated from Bean Root Nodules in Brazil.(J. Bacteriol.) [2011] |
|
53
|
F2RC22_STRVP (F2RC22) |
|
|
9e-97 |
358 |
44% |
|
- Product
- 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
- Gene
- SVEN_5987
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
57
|
C0JWD4_9ACTO (C0JWD4) |
|
|
1e-96 |
358 |
46% |
|
- Product
- PokO4
- Gene
- pokO4
- Organism
- Streptomyces diastatochromogenes
|
1uniprot[Pubmed] 19266534 Organisation of the Biosynthetic Gene Cluster and Tailoring Enzymes in the Biosynthesis of the Tetracyclic Quinone Glycoside Antibiotic Polyketomycin.(Chembiochem) [2009] |
|
58
|
Q9S1P2_STRCO (Q9S1P2) |
|
|
2e-96 |
357 |
45% |
|
- Product
- Putative monooxygenase
- Gene
- SCO0249
- Organism
- Streptomyces coelicolor
|
1uniprot[Pubmed] 12000953 [Medline] 21996410 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).(Nature) [2002] |
|
59
|
D7AZP0_NOCDD (D7AZP0) |
|
|
2e-96 |
357 |
45% |
|
- Product
- Monooxygenase FAD-binding protein
- Gene
- Ndas_2748
- Organism
- Nocardiopsis dassonvillei (strain ATCC 23218 / DSM 43111 / IMRU 509 / JCM 7437 / NCTC 10488)
Actinomadura dassonvillei
|
1uniprot Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509T).(Stand. Genomic Sci.) [2010] |
|
61
|
C6WFM6_ACTMD (C6WFM6) |
|
|
4e-96 |
357 |
46% |
|
- Product
- Monooxygenase FAD-binding
- Gene
- Amir_2013
- Organism
- Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
|
1uniprot Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009] |
|
62
|
F4FF57_VERMA (F4FF57) |
|
|
4e-96 |
357 |
44% |
|
- Product
- FAD-dependent monooxygenase
- Gene
- VAB18032_19300
- Organism
- Verrucosispora maris (strain AB-18-032)
|
1uniprot[Pubmed] 21551311 Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011] |
|
65
|
E4W9I8_RHOE1 (E4W9I8) |
|
|
6e-96 |
356 |
45% |
|
- Product
- FAD-dependent monooxygenase
- Gene
- REQ_41440
- Organism
- Rhodococcus equi (strain 103S)
Corynebacterium equi
|
1uniprot[Pubmed] 20941392 The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.(PLoS Genet.) [2010] |
|
66
|
Q5U913_9ACTO (Q5U913) |
|
|
6e-96 |
356 |
44% |
|
- Product
- JadH
- Gene
- jadH
- Organism
- Streptomyces venezuelae
|
1uniprot[Pubmed] 15817470 Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase.(J. Biol. Chem.) [2005] |
|
69
|
Q73ZB8_MYCPA (Q73ZB8) |
|
|
2e-95 |
354 |
45% |
|
- Product
- Putative uncharacterized protein
- Gene
- MAP_1685
- Organism
- Mycobacterium paratuberculosis
|
1uniprot[Pubmed] 16116077 The complete genome sequence of Mycobacterium avium subspecies paratuberculosis.(Proc. Natl. Acad. Sci. U.S.A.) [2005] |
|
72
|
F2R776_STRVP (F2R776) |
|
|
4e-95 |
353 |
45% |
|
- Product
- Rifampin monooxygenase
- Gene
- SVEN_0481
- Organism
- Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
|
1uniprot[Pubmed] 21463507 Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes.(BMC Genomics) [2011] |
|
73
|
D2XDX3_9PSEU (D2XDX3) |
|
|
7e-95 |
352 |
43% |
|
- Product
- AzicO3
- Gene
- azicO3
- Organism
- Kibdelosporangium sp. MJ126-NF4
|
1uniprot[Pubmed] 19928906 Biosynthetic studies of aziridine formation in azicemicins.(J. Am. Chem. Soc.) [2009] |
|
80
|
Q0S0L2_RHOSR (Q0S0L2) |
|
|
6e-94 |
349 |
45% |
|
- Product
- Probable FAD-dependent monooxygenase
- Gene
- RHA1_ro07160
- Organism
- Rhodococcus sp. (strain RHA1)
|
1uniprot[Pubmed] 17030794 The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006] |
|
81
|
Q8KSX5_9ACTO (Q8KSX5) |
|
|
6e-94 |
349 |
44% |
|
- Product
- Putative FAD-dependent monooxygenase GrhO6
- Gene
- grhO6
- Organism
- Streptomyces sp. JP95
|
1uniprot[Pubmed] 12323376 [Medline] 22235582 A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002] |
|
83
|
Q65K23_BACLD (Q65K23) |
|
|
8e-94 |
349 |
40% |
|
- Product
- Putative Flavoprotein monooxygenase
YhjG
- Gene
- yhjG
BL02996 BLi01695
- Organism
- Bacillus licheniformis (strain DSM 13 / ATCC 14580)
|
1uniprot[Pubmed] 15383718 The complete genome sequence of Bacillus licheniformis DSM13, an organism with great industrial potential.(J. Mol. Microbiol. Biotechnol.) [2004] | 2uniprot[Pubmed] 15461803 Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species.(Genome Biol.) [2004] | [pubmed all]
|
90
|
A8L729_FRASN (A8L729) |
|
|
2e-93 |
348 |
44% |
|
- Product
- Pentachlorophenol monooxygenase
- Gene
- Franean1_4133
- Organism
- Frankia sp. (strain EAN1pec)
|
1uniprot[Pubmed] 17151343 Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.(Genome Res.) [2007] |
|
94
|
D3Q4G1_STANL (D3Q4G1) |
|
|
3e-93 |
347 |
44% |
|
- Product
- Monooxygenase FAD-binding protein
- Gene
- Snas_0404
- Organism
- Stackebrandtia nassauensis (strain DSM 44728 / NRRL B-16338 / NBRC 102104 / LLR-40K-21)
|
1uniprot Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-40K-21T).(Stand. Genomic Sci.) [2009] |
|
95
|
Q194P4_STRAA (Q194P4) |
|
|
3e-93 |
347 |
46% |
|
- Product
- Oxygenase
- Gene
- mtmOIV
- Organism
- Streptomyces argillaceus
|
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996] | 2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996] | 3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997] | 4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998] | 5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999] | 6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999] | 7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000] | 8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001] | 9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003] | 10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999] | 11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002] | 12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000] | 13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000] | 14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002] | 15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003] | 16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996] | 17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004] | 18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997] | 19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005] | 20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000] | 21uniprot[Pubmed] 19364090 Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway .(Biochemistry) [2009] | [pubmed all]
|
96
|
Q6VMJ3_STRAM (Q6VMJ3) |
|
|
3e-93 |
347 |
44% |
|
- Product
- Putative oxygenase
- Gene
- alpG
DSMT0179
- Organism
- Streptomyces ambofaciens
|
1uniprot[Pubmed] 14742212 Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.(Antimicrob. Agents Chemother.) [2004] | 2uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | [pubmed all]
|
97
|
Q1RQS6_STRAM (Q1RQS6) |
|
|
3e-93 |
347 |
44% |
|
- Product
- Putative oxygenase
- Gene
- alpG
SAMT0159 SAMT0160
- Organism
- Streptomyces ambofaciens ATCC 23877
|
1uniprot[Pubmed] 16952952 Intraspecific variability of the terminal inverted repeats of the linear chromosome of Streptomyces ambofaciens.(J. Bacteriol.) [2006] | 2uniprot[Pubmed] 16956972 Evolution of the terminal regions of the Streptomyces linear chromosome.(Mol. Biol. Evol.) [2006] | 3uniprot Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.(Microbiology (Mosc.)) [2006] | [pubmed all]
|
98
|
Q54171_STRFR (Q54171) |
|
|
5e-93 |
346 |
44% |
|
- Product
- Putative oxygenase
- Gene
- UrdE
- Organism
- Streptomyces fradiae
Streptomyces roseoflavus
|
1uniprot[Pubmed] 7592377 [Medline] 96042088 Cloning and characterization of a polyketide synthase from Streptomyces fradiae Tue2717 encoding the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.(J. Bacteriol.) [1995] |
|
100
|
D7C9J9_STRBB (D7C9J9) |
|
|
8e-93 |
345 |
44% |
|
- Product
- Putative uncharacterized protein
- Gene
- SBI_09593
- Organism
- Streptomyces bingchenggensis (strain BCW-1)
|
1uniprot[Pubmed] 20581206 Genome sequence of the milbemycin-producing bacterium Streptomyces bingchenggensis.(J. Bacteriol.) [2010] |
|