BLAST table : Oxtet_00200

DB	UniProtKB

	accession	Evalue	Score	Ident.	link	product	gene	organism	ec
1	Q3S8P6_STRRM (Q3S8P6)	0.0	688	100%	UniProt GenBank	OxyT	oxyT	Streptomyces rimosus
2	Q70J81_STRGR (Q70J81)	4e-77	293	47%	UniProt GenBank	O-methyltransferase	cmmMI	Streptomyces griseus subsp. griseus
3	D6MSX0_9ACTO (D6MSX0)	5e-74	282	48%	UniProt GenBank	SsfM1	ssfM1	Streptomyces sp. SF2575
4	Q53658_STRAU (Q53658)	2e-72	277	46%	UniProt GenBank	Possible enzyme methylating tetracycline	cts6	Streptomyces aureofaciens
5	Q194P7_STRAA (Q194P7)	4e-71	273	45%	UniProt GenBank	O-methyltransferase	mtmMI	Streptomyces argillaceus
6	E8L6E2_9RHIZ (E8L6E2)	5e-58	229	38%	UniProt GenBank	O-methyltransferase family 2	Met49242DRAFT_3035	Methylocystis sp. ATCC 49242
7	B0LJ52_9ACTO (B0LJ52)	8e-56	222	41%	UniProt GenBank	Lcz35	lcz35	Streptomyces sanglieri
8	D2AY59_STRRD (D2AY59)	9e-55	218	40%	UniProt GenBank	O-methyltransferase family protein	Sros_4165	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
9	E8YT36_9BURK (E8YT36)	1e-54	218	40%	UniProt GenBank	O-methyltransferase family 2	BC1001_5255	Burkholderia sp. CCGE1001
10	F4XTC6_9CYAN (F4XTC6)	2e-54	217	39%	UniProt GenBank	O-methyltransferase	LYNGBM3L_29010	Lyngbya majuscula 3L
11	B0LJ18_9ACTO (B0LJ18)	8e-54	215	42%	UniProt GenBank	Lct35	lct35	Streptomyces rishiriensis
12	B5IJZ5_9CHRO (B5IJZ5)	1e-53	214	37%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO	CPCC7001_993	Cyanobium sp. PCC 7001
13	D5QMD4_METTR (D5QMD4)	6e-53	213	39%	UniProt GenBank	O-methyltransferase family 2	MettrDRAFT_0960	Methylosinus trichosporium OB3b
14	E1TE69_BURSG (E1TE69)	8e-53	212	40%	UniProt GenBank	O-methyltransferase family 2	BC1003_4162	Burkholderia sp. (strain CCGE1003)
15	Q01QE9_SOLUE (Q01QE9)	9e-53	212	36%	UniProt GenBank	O-methyltransferase, family 2	Acid_7210	Solibacter usitatus (strain Ellin6076)
16	D2SYZ3_MICEC (D2SYZ3)	1e-52	211	41%	UniProt GenBank	O-methyltransferase		Micromonospora echinospora subsp. challisensis
17	B5WKQ7_9BURK (B5WKQ7)	2e-52	211	38%	UniProt GenBank	O-methyltransferase family 2	BH160DRAFT_3660	Burkholderia sp. H160
18	TCMO_STRGA (P39896)	2e-52	211	43%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase tcmO	tcmO	Streptomyces glaucescens	2.1.1.- niceE keggE
19	A0SZW0_9ACTO (A0SZW0)	3e-52	210	39%	UniProt GenBank	PdmT	pdmT	Actinomadura hibisca
20	Q8KSX2_9ACTO (Q8KSX2)	4e-52	209	44%	UniProt GenBank	Putative methyltransferase GrhL	grhL	Streptomyces sp. JP95
21	D5W6P9_BURSC (D5W6P9)	1e-51	208	38%	UniProt GenBank	O-methyltransferase family 2	BC1002_1107	Burkholderia sp. (strain CCGE1002)
22	Q46PN2_CUPPJ (Q46PN2)	2e-50	204	37%	UniProt GenBank	O-methyltransferase, family 2	Reut_B5557	Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) Alcaligenes eutrophus Ralstonia eutropha
23	A3YY93_9SYNE (A3YY93)	3e-50	203	35%	UniProt GenBank	O-methyltransferase, family 2	WH5701_08334	Synechococcus sp. WH 5701
24	A7DWK6_STRTE (A7DWK6)	2e-49	201	40%	UniProt GenBank	Putative methyltransferase	llpMII	Streptomyces tendae	2.1.1.- niceE keggE
25	B2HRS9_MYCMM (B2HRS9)	5e-49	199	37%	UniProt GenBank	Methyltransferase/methylase	MMAR_0934	Mycobacterium marinum (strain ATCC BAA-535 / M)
26	F4FBS8_VERMA (F4FBS8)	5e-49	199	38%	UniProt GenBank	O-methyltransferase family 2	VAB18032_18130	Verrucosispora maris (strain AB-18-032)
27	D8I4M6_AMYMU (D8I4M6)	6e-49	199	38%	UniProt GenBank	O-methyltransferase family protein	AMED_5440	Amycolatopsis mediterranei (strain U-32)
28	B8IQN6_METNO (B8IQN6)	9e-49	198	37%	UniProt GenBank	O-methyltransferase family 2	Mnod_5718	Methylobacterium nodulans (strain ORS2060 / LMG 21967)
29	Q7D9M4_MYCTU (Q7D9M4)	2e-48	197	38%	UniProt GenBank	Tetracenpmycin polyketide synthesis 8-o-methyltransferase	tcmO MT0593	Mycobacterium tuberculosis	2.1.1.- niceE keggE
30	C6DTT8_MYCTK (C6DTT8)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TBMG_00572	Mycobacterium tuberculosis (strain KZN 1435 / MDR)
31	E9ZG14_MYCTU (E9ZG14)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMMG_03943	Mycobacterium tuberculosis CDC1551A
32	E2WED1_MYCTU (E2WED1)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMLG_03715	Mycobacterium tuberculosis SUMu012
33	E2W2F3_MYCTU (E2W2F3)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMKG_02904	Mycobacterium tuberculosis SUMu011
34	E2VR50_MYCTU (E2VR50)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMJG_02311	Mycobacterium tuberculosis SUMu010
35	E2VEV1_MYCTU (E2VEV1)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMIG_01468	Mycobacterium tuberculosis SUMu009
36	E2V5J0_MYCTU (E2V5J0)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMHG_03589	Mycobacterium tuberculosis SUMu008
37	E2UUB1_MYCTU (E2UUB1)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMGG_03581	Mycobacterium tuberculosis SUMu007
38	E2UI58_MYCTU (E2UI58)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMFG_01869	Mycobacterium tuberculosis SUMu006
39	E2U762_MYCTU (E2U762)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMEG_03151	Mycobacterium tuberculosis SUMu005
40	E2TV91_MYCTU (E2TV91)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMDG_03856	Mycobacterium tuberculosis SUMu004
41	E2TIK6_MYCTU (E2TIK6)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMCG_03944	Mycobacterium tuberculosis SUMu003
42	E2T8S5_MYCTU (E2T8S5)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMBG_03804	Mycobacterium tuberculosis SUMu002
43	E1H6D5_MYCTU (E1H6D5)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TMAG_03572	Mycobacterium tuberculosis SUMu001
44	A2VFP7_MYCTU (A2VFP7)	2e-48	197	38%	UniProt GenBank	Putative uncharacterized protein	TBCG_00562	Mycobacterium tuberculosis C
45	O53764_MYCTU (O53764)	2e-48	197	38%	UniProt GenBank	PROBABLE METHYLTRANSFERASE/METHYLASE	Rv0567	Mycobacterium tuberculosis	2.1.1.- niceE keggE
46	A5WJT1_MYCTF (A5WJT1)	2e-48	197	38%	UniProt GenBank	Hypothetical methyltransferase	TBFG_10577	Mycobacterium tuberculosis (strain F11)
47	A5TZU7_MYCTA (A5TZU7)	2e-48	197	38%	UniProt GenBank	Tetracenpmycin polyketide synthesis 8-o-methyltransferase	MRA_0574	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)
48	F7WRF0_MYCTU (F7WRF0)	2e-48	197	38%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-o-methyltransferase	CCDC5180_0525	Mycobacterium tuberculosis CCDC5180
49	F7WML9_MYCTU (F7WML9)	2e-48	197	38%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-o-methyltransferase	CCDC5079_0533	Mycobacterium tuberculosis CCDC5079
50	F2VBK0_MYCTU (F2VBK0)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TBPG_00238	Mycobacterium tuberculosis W-148
51	F2GML2_MYCTU (F2GML2)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TBSG_00578	Mycobacterium tuberculosis KZN 4207
52	D7EN41_MYCTU (D7EN41)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TBAG_03182	Mycobacterium tuberculosis 94_M4241A
53	D6F1H0_MYCTU (D6F1H0)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TBLG_02695	Mycobacterium tuberculosis T46
54	D5ZCU7_MYCTU (D5ZCU7)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TBJG_04119	Mycobacterium tuberculosis T17
55	D5Z0E3_MYCTU (D5Z0E3)	2e-48	197	38%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	TBIG_03509	Mycobacterium tuberculosis GM 1503
56	D5YNL4_MYCTU (D5YNL4)	2e-48	197	38%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	TBBG_03286	Mycobacterium tuberculosis 02_1987
57	D5YCQ5_MYCTU (D5YCQ5)	2e-48	197	38%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	TBGG_03722	Mycobacterium tuberculosis EAS054
58	D5Y0N6_MYCTU (D5Y0N6)	2e-48	197	38%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	TBEG_03969	Mycobacterium tuberculosis T85
59	D5XQJ2_MYCTU (D5XQJ2)	2e-48	197	38%	UniProt GenBank	Methyltransferase/methylase	TBDG_04101	Mycobacterium tuberculosis T92
60	A4KEQ0_MYCTU (A4KEQ0)	2e-48	197	38%	UniProt GenBank	Hypothetical methyltransferase/methylase	TBHG_00564	Mycobacterium tuberculosis str. Haarlem
61	Q09AX9_STIAD (Q09AX9)	2e-48	197	37%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO	STAUR_4619 STIAU_6869	Stigmatella aurantiaca (strain DW4/3-1)	2.1.1.- niceE keggE
62	A0PLX6_MYCUA (A0PLX6)	2e-48	197	37%	UniProt GenBank	Methyltransferase/methylase	MUL_0686	Mycobacterium ulcerans (strain Agy99)
63	B9XHA2_9BACT (B9XHA2)	1e-47	195	34%	UniProt GenBank	O-methyltransferase family 2	Cflav_PD3595	Pedosphaera parvula Ellin514
64	Q7U1R6_MYCBO (Q7U1R6)	1e-47	195	38%	UniProt GenBank	PROBABLE METHYLTRANSFERASE/METHYLASE	Mb0582	Mycobacterium bovis	2.1.1.- niceE keggE
65	C1AKP7_MYCBT (C1AKP7)	1e-47	195	38%	UniProt GenBank	Putative methyltransferase/methylase	JTY_0582	Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)
66	A1KG44_MYCBP (A1KG44)	1e-47	195	38%	UniProt GenBank	Probable methyltransferase/methylase	BCG_0612	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	2.1.1.- niceE keggE
67	F8M2E8_9MYCO (F8M2E8)	1e-47	195	38%	UniProt GenBank	Putative methyltransferase/methylase	MAF_05740	Mycobacterium africanum GM041182	2.1.1.- niceE keggE
68	D6FYI0_MYCTU (D6FYI0)	1e-47	195	38%	UniProt GenBank	Methyltransferase/methylase	TBOG_01003	Mycobacterium tuberculosis K85
69	B2JR16_BURP8 (B2JR16)	1e-47	195	38%	UniProt GenBank	O-methyltransferase family 2	Bphy_4597	Burkholderia phymatum (strain DSM 17167 / STM815)
70	D2AY61_STRRD (D2AY61)	1e-46	191	39%	UniProt GenBank	O-methyltransferase family protein	Sros_4167	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
71	D8PJ97_9BACT (D8PJ97)	2e-46	191	34%	UniProt GenBank	O-methyltransferase, family 2	NIDE3796	Candidatus Nitrospira defluvii	2.1.1.- niceE keggE
72	A7DWL1_STRTE (A7DWL1)	5e-46	189	38%	UniProt GenBank	Putative O-methyltransferase	llpMIV	Streptomyces tendae	2.1.1.- niceE keggE
73	D9WHF4_9ACTO (D9WHF4)	4e-45	186	35%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	SSOG_08794	Streptomyces himastatinicus ATCC 53653
74	Q2Y6M3_NITMU (Q2Y6M3)	2e-44	184	33%	UniProt GenBank	Putative transcriptional regulator	Nmul_A2307	Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849)
75	B4R7V6_PHEZH (B4R7V6)	3e-43	180	36%	UniProt GenBank	Methyltransferase/methylase	PHZ_c1075	Phenylobacterium zucineum (strain HLK1)
76	D5MRJ4_9ACTO (D5MRJ4)	7e-43	179	38%	UniProt GenBank	Putative O-methyltransferase	hrbU	Streptomyces sp. 2238-SVT4
77	A9F1L5_SORC5 (A9F1L5)	2e-42	177	33%	UniProt GenBank	Putative Methyltransferase	sce1219	Sorangium cellulosum (strain So ce56) Polyangium cellulosum (strain So ce56)	2.1.1.- niceE keggE
78	A7DWL9_STRTE (A7DWL9)	3e-42	177	36%	UniProt GenBank	Putative O-methyltransferase	llpMVI	Streptomyces tendae	2.1.1.- niceE keggE
79	A7DWK8_STRTE (A7DWK8)	4e-41	173	35%	UniProt GenBank	Putative O-methyltransferase	llpMIII	Streptomyces tendae	2.1.1.- niceE keggE
80	A4FDN1_SACEN (A4FDN1)	1e-39	168	35%	UniProt GenBank	Putative 8-O-methyltransferase	tcmO SACE_2878	Saccharopolyspora erythraea (strain NRRL 23338)	2.1.1.- niceE keggE
81	B5IIH6_9CHRO (B5IIH6)	8e-39	165	33%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyl transferase TcmO	CPCC7001_2675	Cyanobium sp. PCC 7001
82	B8HT32_CYAP4 (B8HT32)	2e-38	164	32%	UniProt GenBank	O-methyltransferase family 2	Cyan7425_0437	Cyanothece sp. (strain PCC 7425 / ATCC 29141)
83	E0KDC5_STRVO (E0KDC5)	9e-38	162	40%	UniProt GenBank	Putative transcriptional regulator	StrviDRAFT_0652	Streptomyces violaceusniger Tu 4113
84	B4XY98_9ACTO (B4XY98)	2e-37	161	39%	UniProt GenBank	Azi5	azi5	Streptomyces sahachiroi
85	Q02AU7_SOLUE (Q02AU7)	6e-37	159	32%	UniProt GenBank	Hydroxyneurosporene-O-methyltransferase	Acid_0820	Solibacter usitatus (strain Ellin6076)	2.1.1.- niceE keggE
86	C3AEA4_BACMY (C3AEA4)	1e-34	152	30%	UniProt GenBank	O-methyltransferase, family 2	bmyco0001_51000	Bacillus mycoides DSM 2048
87	Q7UX33_RHOBA (Q7UX33)	2e-33	147	29%	UniProt GenBank	Hydroxyindole O-methyltransferase	hioM RB1595	Rhodopirellula baltica	2.1.1.4 niceE keggE
88	B5BR83_9ACTO (B5BR83)	9e-33	145	38%	UniProt GenBank	O-methyltransferase, family 2		Streptomyces albulus
89	D9WE14_9ACTO (D9WE14)	9e-32	142	36%	UniProt GenBank	Tetracenomycin polyketide synthesis 8-O-methyltransferase	SSOG_00786	Streptomyces himastatinicus ATCC 53653
90	Q5R8Q9_PONAB (Q5R8Q9)	3e-31	140	29%	UniProt GenBank	Putative uncharacterized protein DKFZp469F1025	DKFZp469F1025	Pongo abelii Sumatran orangutan
91	B5GRJ9_STRCL (B5GRJ9)	3e-31	140	36%	UniProt GenBank	O-methyltransferase O-methyltransferase family protein	SCLAV_4965 SSCG_01973	Streptomyces clavuligerus ATCC 27064
92	ASML_HUMAN (O95671)	3e-30	137	30%	UniProt GenBank	N-acetylserotonin O-methyltransferase-like protein	ASMTL	Homo sapiens Human
93	F5GXH4_HUMAN (F5GXH4)	3e-30	137	30%	UniProt GenBank	Uncharacterized protein	ASMTL	Homo sapiens Human
94	E7ER97_HUMAN (E7ER97)	4e-30	137	30%	UniProt GenBank	Uncharacterized protein	ASMTL	Homo sapiens Human
95	Q5RCV9_PONAB (Q5RCV9)	5e-30	136	30%	UniProt GenBank	Putative uncharacterized protein DKFZp468C2312	DKFZp468C2312	Pongo abelii Sumatran orangutan
96	B4DX75_HUMAN (B4DX75)	5e-30	136	30%	UniProt GenBank	cDNA FLJ58813, highly similar to N-acetylserotonin O-methyltransferase-like protein		Homo sapiens Human
97	B3KM43_HUMAN (B3KM43)	5e-30	136	30%	UniProt GenBank	cDNA FLJ10228 fis, clone HEMBB1000119, highly similar to N-acetylserotonin O-methyltransferase-like protein		Homo sapiens Human
98	B4DRF1_HUMAN (B4DRF1)	5e-30	136	29%	UniProt GenBank	cDNA FLJ55355, highly similar to N-acetylserotonin O-methyltransferase-like protein		Homo sapiens Human
99	F5XMS3_9ACTO (F5XMS3)	9e-30	135	33%	UniProt GenBank	Putative O-methyltransferase	MLP_09820	Microlunatus phosphovorus NM-1	2.1.1.- niceE keggE
100	B4DN81_HUMAN (B4DN81)	9e-30	135	29%	UniProt GenBank	cDNA FLJ59356, highly similar to N-acetylserotonin O-methyltransferase-like protein		Homo sapiens Human

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

Q3S8P6_STRRM
(Q3S8P6)

0.0

688

100%

Product: OxyT
Gene: oxyT
Organism: Streptomyces rimosus

1uniprot[Pubmed] 16597959
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.(Appl. Environ. Microbiol.) [2006]

D6MSX0_9ACTO
(D6MSX0)

5e-74

282

48%

Product: SsfM1
Gene: ssfM1
Organism: Streptomyces sp. SF2575

1uniprot[Pubmed] 19908837
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.(J. Am. Chem. Soc.) [2009]

Q53658_STRAU
(Q53658)

2e-72

277

46%

Product: Possible enzyme methylating tetracycline
Gene: cts6
Organism: Streptomyces aureofaciens

1uniprot[Pubmed] 7612997 [Medline] 95337551
Cloning and nucleotide sequence of the gene responsible for chlorination of tetracycline.(Biosci. Biotechnol. Biochem.) [1995]

Q194P7_STRAA
(Q194P7)

4e-71

273

45%

Product: O-methyltransferase
Gene: mtmMI
Organism: Streptomyces argillaceus

[pubmed all]
1uniprot[Pubmed] 8654997 [Medline] 96257259 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin.(Gene) [1996]
2uniprot[Pubmed] 8757400 [Medline] 96335144 An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus.(Mol. Gen. Genet.) [1996]
3uniprot[Pubmed] 9150235 [Medline] 97294479 Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin.(J. Bacteriol.) [1997]
4uniprot[Pubmed] 9733697 [Medline] 98406047 Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin.(J. Bacteriol.) [1998]
5uniprot[Pubmed] 10102355 [Medline] 99200478 Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus.(Mol. Gen. Genet.) [1999]
6uniprot[Pubmed] 9889148 [Medline] 99111236 Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin.(Chem. Biol.) [1999]
7uniprot[Pubmed] 10660060 [Medline] 20123456 Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.(Mol. Gen. Genet.) [2000]
8uniprot[Pubmed] 11254130 [Medline] 21148776 The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.(Mol. Gen. Genet.) [2001]
9uniprot[Pubmed] 12733914 [Medline] 22619809 Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.(J. Am. Chem. Soc.) [2003]
10uniprot[Pubmed] 9917296 [Medline] 99115752 The structure of mithramycin reinvestigated.(J. Nat. Prod.) [1999]
11uniprot[Pubmed] 11853433 [Medline] 21843297 Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.(J. Am. Chem. Soc.) [2002]
12uniprot[Pubmed] 10652287 [Medline] 20119254 Characterization of two polyketide methyltransferases involved in the biosynthesis of the antitumor drug mithramycin by Streptomyces argillaceus.(J. Biol. Chem.) [2000]
13uniprot[Pubmed] 10779713 [Medline] 20243461 Insertional inactivation of mtrX and mtrY genes from the mithramycin gene cluster affects production and growth of the producer organism Streptomyces argillaceus.(FEMS Microbiol. Lett.) [2000]
14uniprot[Pubmed] 12022840 [Medline] 22017994 Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.(J. Am. Chem. Soc.) [2002]
15uniprot[Pubmed] 12813091 [Medline] 22697398 Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin.(J. Bacteriol.) [2003]
16uniprot[Pubmed] 8807845 [Medline] 97113238 Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents.(Chem. Biol.) [1996]
17uniprot[Pubmed] 14660589 MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.(J. Biol. Chem.) [2004]
18uniprot[Pubmed] 9375253 [Medline] 98042823 Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.(Chem. Biol.) [1997]
19uniprot[Pubmed] 15712316 Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.(Chembiochem) [2005]
20uniprot[Pubmed] 10760873 The Novel Hybrid Antitumor Compound Premithramycinone H Provides Indirect Evidence for a Tricyclic Intermediate of the Biosynthesis of the Aureolic Acid Antibiotic Mithramycin.(Angew. Chem. Int. Ed.) [2000]

E8L6E2_9RHIZ
(E8L6E2)

5e-58

229

38%

Product: O-methyltransferase family 2
Gene: Met49242DRAFT_3035
Organism: Methylocystis sp. ATCC 49242

1uniprot[Pubmed] 21441518
Genome Sequence of the Methanotrophic Alphaproteobacterium Methylocystis sp. Strain Rockwell (ATCC 49242).(J. Bacteriol.) [2011]

B0LJ52_9ACTO
(B0LJ52)

8e-56

222

41%

Product: Lcz35
Gene: lcz35
Organism: Streptomyces sanglieri

1uniprot[Pubmed] 18070976
Biosynthetic investigations of lactonamycin and lactonamycin z: cloning of the biosynthetic gene clusters and discovery of an unusual starter unit.(Antimicrob. Agents Chemother.) [2008]

D2AY59_STRRD
(D2AY59)

9e-55

218

40%

Product: O-methyltransferase family protein
Gene: Sros_4165
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

F4XTC6_9CYAN
(F4XTC6)

2e-54

217

39%

Product: O-methyltransferase
Gene: LYNGBM3L_29010
Organism: Lyngbya majuscula 3L

1uniprot
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.(Proc. Natl. Acad. Sci. U.S.A.) [2011]

B0LJ18_9ACTO
(B0LJ18)

8e-54

215

42%

Product: Lct35
Gene: lct35
Organism: Streptomyces rishiriensis

D5QMD4_METTR
(D5QMD4)

6e-53

213

39%

Product: O-methyltransferase family 2
Gene: MettrDRAFT_0960
Organism: Methylosinus trichosporium OB3b

1uniprot[Pubmed] 20952571
Genome Sequence of the Obligate Methanotroph Methylosinus trichosporium Strain OB3b.(J. Bacteriol.) [2010]

Q01QE9_SOLUE
(Q01QE9)

9e-53

212

36%

Product: O-methyltransferase, family 2
Gene: Acid_7210
Organism: Solibacter usitatus (strain Ellin6076)

1uniprot[Pubmed] 19201974
Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils.(Appl. Environ. Microbiol.) [2009]

D2SYZ3_MICEC
(D2SYZ3)

1e-52

211

41%

Product: O-methyltransferase
Gene
Organism: Micromonospora echinospora subsp. challisensis

1uniprot[Pubmed] 19680283
TLN-05220, TLN-05223, new Echinosporamicin-type antibiotics, and proposed revision of the structure of bravomicins(*).(J. Antibiot.) [2009]

TCMO_STRGA
(P39896)

2e-52

211

43%

Product: Tetracenomycin polyketide synthesis 8-O-methyl transferase tcmO
Gene: tcmO
Organism: Streptomyces glaucescens

1uniprot[Pubmed] 1548230 [Medline] 92193265
Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase.(J. Bacteriol.) [1992]

Q8KSX2_9ACTO
(Q8KSX2)

4e-52

209

44%

Product: Putative methyltransferase GrhL
Gene: grhL
Organism: Streptomyces sp. JP95

1uniprot[Pubmed] 12323376 [Medline] 22235582
A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.(Chem. Biol.) [2002]

A7DWK6_STRTE
(A7DWK6)

2e-49

201

40%

Product: Putative methyltransferase
Gene: llpMII
Organism: Streptomyces tendae

1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]

B2HRS9_MYCMM
(B2HRS9)

5e-49

199

37%

Product: Methyltransferase/methylase
Gene: MMAR_0934
Organism: Mycobacterium marinum (strain ATCC BAA-535 / M)

1uniprot[Pubmed] 18403782
Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.(Genome Res.) [2008]

F4FBS8_VERMA
(F4FBS8)

5e-49

199

38%

Product: O-methyltransferase family 2
Gene: VAB18032_18130
Organism: Verrucosispora maris (strain AB-18-032)

1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]

D8I4M6_AMYMU
(D8I4M6)

6e-49

199

38%

Product: O-methyltransferase family protein
Gene: AMED_5440
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

Q7D9M4_MYCTU
(Q7D9M4)

2e-48

197

38%

Product: Tetracenpmycin polyketide synthesis 8-o-methyltransferase
Gene: tcmO
MT0593
Organism: Mycobacterium tuberculosis

1uniprot[Pubmed] 12218036 [Medline] 22206494
Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.(J. Bacteriol.) [2002]

O53764_MYCTU
(O53764)

2e-48

197

38%

Product: PROBABLE METHYLTRANSFERASE/METHYLASE
Gene: Rv0567
Organism: Mycobacterium tuberculosis

1uniprot[Pubmed] 9634230 [Medline] 98295987
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.(Nature) [1998]

A0PLX6_MYCUA
(A0PLX6)

2e-48

197

37%

Product: Methyltransferase/methylase
Gene: MUL_0686
Organism: Mycobacterium ulcerans (strain Agy99)

1uniprot[Pubmed] 17210928
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.(Genome Res.) [2007]

B9XHA2_9BACT
(B9XHA2)

1e-47

195

34%

Product: O-methyltransferase family 2
Gene: Cflav_PD3595
Organism: Pedosphaera parvula Ellin514

1uniprot[Pubmed] 21460084
Genome Sequence of 'Pedosphaera parvula' Ellin514, an Aerobic Verrucomicrobial Isolate from Pasture Soil.(J. Bacteriol.) [2011]

Q7U1R6_MYCBO
(Q7U1R6)

1e-47

195

38%

Product: PROBABLE METHYLTRANSFERASE/METHYLASE
Gene: Mb0582
Organism: Mycobacterium bovis

1uniprot[Pubmed] 12788972 [Medline] 22709107
The complete genome sequence of Mycobacterium bovis.(Proc. Natl. Acad. Sci. U.S.A.) [2003]

C1AKP7_MYCBT
(C1AKP7)

1e-47

195

38%

Product: Putative methyltransferase/methylase
Gene: JTY_0582
Organism: Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)

1uniprot[Pubmed] 19200449
Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains.(Vaccine) [2009]

A1KG44_MYCBP
(A1KG44)

1e-47

195

38%

Product: Probable methyltransferase/methylase
Gene: BCG_0612
Organism: Mycobacterium bovis (strain BCG / Pasteur 1173P2)

1uniprot[Pubmed] 17372194
Genome plasticity of BCG and impact on vaccine efficacy.(Proc. Natl. Acad. Sci. U.S.A.) [2007]

D2AY61_STRRD
(D2AY61)

1e-46

191

39%

Product: O-methyltransferase family protein
Gene: Sros_4167
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

D8PJ97_9BACT
(D8PJ97)

2e-46

191

34%

Product: O-methyltransferase, family 2
Gene: NIDE3796
Organism: Candidatus Nitrospira defluvii

1uniprot
A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria.(Proc. Natl. Acad. Sci. U.S.A.) [2010]

A7DWL1_STRTE
(A7DWL1)

5e-46

189

38%

Product: Putative O-methyltransferase
Gene: llpMIV
Organism: Streptomyces tendae

1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]

B4R7V6_PHEZH
(B4R7V6)

3e-43

180

36%

Product: Methyltransferase/methylase
Gene: PHZ_c1075
Organism: Phenylobacterium zucineum (strain HLK1)

1uniprot[Pubmed] 18700039
Complete genome of Phenylobacterium zucineum - a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562.(BMC Genomics) [2008]

D5MRJ4_9ACTO
(D5MRJ4)

7e-43

179

38%

Product: Putative O-methyltransferase
Gene: hrbU
Organism: Streptomyces sp. 2238-SVT4

1uniprot[Pubmed] 20453135
Cloning and characterization of a gene cluster for hatomarubigin biosynthesis in Streptomyces sp. strain 2238-SVT4.(Appl. Environ. Microbiol.) [2010]

A9F1L5_SORC5
(A9F1L5)

2e-42

177

33%

Product: Putative Methyltransferase
Gene: sce1219
Organism: Sorangium cellulosum (strain So ce56)
Polyangium cellulosum (strain So ce56)

1uniprot[Pubmed] 17965706
Complete genome sequence of the myxobacterium Sorangium cellulosum.(Nat. Biotechnol.) [2007]

A7DWL9_STRTE
(A7DWL9)

3e-42

177

36%

Product: Putative O-methyltransferase
Gene: llpMVI
Organism: Streptomyces tendae

1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]

A7DWK8_STRTE
(A7DWK8)

4e-41

173

35%

Product: Putative O-methyltransferase
Gene: llpMIII
Organism: Streptomyces tendae

1uniprot
Isolation of the lysolipin gene cluster of Streptomyces tendae Tu 4042.(Gene) [2010]

A4FDN1_SACEN
(A4FDN1)

1e-39

168

35%

Product: Putative 8-O-methyltransferase
Gene: tcmO
SACE_2878
Organism: Saccharopolyspora erythraea (strain NRRL 23338)

1uniprot[Pubmed] 17369815
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338.(Nat. Biotechnol.) [2007]

B4XY98_9ACTO
(B4XY98)

2e-37

161

39%

Product: Azi5
Gene: azi5
Organism: Streptomyces sahachiroi

1uniprot[Pubmed] 18635006
Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.(Chem. Biol.) [2008]

Q02AU7_SOLUE
(Q02AU7)

6e-37

159

32%

Product: Hydroxyneurosporene-O-methyltransferase
Gene: Acid_0820
Organism: Solibacter usitatus (strain Ellin6076)

1uniprot[Pubmed] 19201974
Three genomes from the phylum Acidobacteria provide insight into the lifestyles of these microorganisms in soils.(Appl. Environ. Microbiol.) [2009]

Q7UX33_RHOBA
(Q7UX33)

2e-33

147

29%

Product: Hydroxyindole O-methyltransferase
Gene: hioM
RB1595
Organism: Rhodopirellula baltica

1uniprot[Pubmed] 12835416 [Medline] 22735913
Complete genome sequence of the marine planctomycete Pirellula sp. strain 1.(Proc. Natl. Acad. Sci. U.S.A.) [2003]

B5BR83_9ACTO
(B5BR83)

9e-33

145

38%

Product: O-methyltransferase, family 2
Gene
Organism: Streptomyces albulus

1uniprot[Pubmed] 18997795
Epsilon-poly-L-lysine dispersity is controlled by a highly unusual nonribosomal peptide synthetase.(Nat. Chem. Biol.) [2008]

B5GRJ9_STRCL
(B5GRJ9)

3e-31

140

36%

Product: O-methyltransferase
O-methyltransferase family protein
Gene: SCLAV_4965
SSCG_01973
Organism: Streptomyces clavuligerus ATCC 27064

1uniprot[Pubmed] 20624727
The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.(Genome Biol. Evol.) [2010]

ASML_HUMAN
(O95671)

3e-30

137

30%

Product: N-acetylserotonin O-methyltransferase-like protein
Gene: ASMTL
Organism: Homo sapiens
Human

[pubmed all]
1uniprot[Pubmed] 9736779 [Medline] 98409506 Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL.(Hum. Mol. Genet.) [1998]
2uniprot[Pubmed] 14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.(Nat. Genet.) [2004]
3uniprot[Pubmed] 15772651 The DNA sequence of the human X chromosome.(Nature) [2005]
4uniprot[Pubmed] 15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).(Genome Res.) [2004]
5uniprot[Pubmed] 17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.(Cell) [2006]
6uniprot[Pubmed] 18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.(Mol. Cell) [2008]
7uniprot[Pubmed] 18669648 A quantitative atlas of mitotic phosphorylation.(Proc. Natl. Acad. Sci. U.S.A.) [2008]
8uniprot[Pubmed] 18318008 Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.(Proteomics) [2008]
9uniprot[Pubmed] 19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.(Anal. Chem.) [2009]
10uniprot[Pubmed] 19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.(Sci. Signal.) [2009]
11uniprot[Pubmed] 21269460 Initial characterization of the human central proteome.(BMC Syst. Biol.) [2011]

F5GXH4_HUMAN
(F5GXH4)

3e-30

137

30%

Product: Uncharacterized protein
Gene: ASMTL
Organism: Homo sapiens
Human

1uniprot[Pubmed] 15772651
The DNA sequence of the human X chromosome.(Nature) [2005]

E7ER97_HUMAN
(E7ER97)

4e-30

137

30%

Product: Uncharacterized protein
Gene: ASMTL
Organism: Homo sapiens
Human

1uniprot[Pubmed] 15772651
The DNA sequence of the human X chromosome.(Nature) [2005]

B3KM43_HUMAN
(B3KM43)

5e-30

136

30%

Product: cDNA FLJ10228 fis, clone HEMBB1000119, highly similar to N-acetylserotonin O-methyltransferase-like protein
Gene
Organism: Homo sapiens
Human

1uniprot[Pubmed] 14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.(Nat. Genet.) [2004]