BLAST table : Madu_00290

DB	UniProtKB

	accession	alignment	Evalue	Score	Ident.	link	product	gene	organism	ec
1	B0BLN8_9ACTO (B0BLN8)		0.0	921	100%	UniProt GenBank	Type II condensation domain protein	mdpC5	Actinomadura madurae
2	A8LZU9_SALAI (A8LZU9)		1e-148	529	61%	UniProt GenBank	Condensation domain protein	Sare_2097	Salinispora arenicola (strain CNS-205)
3	D6AAB0_9ACTO (D6AAB0)		1e-113	414	51%	UniProt GenBank	Predicted protein	SSFG_07680	Streptomyces ghanaensis ATCC 14672
4	D9UPR8_9ACTO (D9UPR8)		1e-106	389	49%	UniProt GenBank	Type II condensation domain-containing protein	SSLG_02144	Streptomyces sp. SPB78
5	F3Z4Z7_9ACTO (F3Z4Z7)		1e-105	386	49%	UniProt GenBank	Putative condensation domain-containing protein	STTU_4301	Streptomyces sp. Tu6071
6	Q8GMG2_STRGL (Q8GMG2)		1e-105	386	47%	UniProt GenBank	C-domain type II peptide synthetase		Streptomyces globisporus
7	A4X8G5_SALTO (A4X8G5)		1e-102	376	44%	UniProt GenBank	Condensation domain protein	Strop_2721	Salinispora tropica (strain ATCC BAA-916 / DSM 44818 / CNB-440)
8	D2B8S1_STRRD (D2B8S1)		1e-101	373	45%	UniProt GenBank	Non-ribosomal peptide synthetase modules and related protein-like protein	Sros_6976	Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
9	B4VDW1_9ACTO (B4VDW1)		1e-90	338	43%	UniProt GenBank	Putative uncharacterized protein	SSAG_05959	Streptomyces sp. Mg1
10	Q0S6F3_RHOSR (Q0S6F3)	(7 hsp)	2e-48	198	35%	UniProt GenBank	Non-ribosomal peptide synthetase	RHA1_ro05102	Rhodococcus sp. (strain RHA1)
11	C0ZDL1_BREBN (C0ZDL1)	(9 hsp)	2e-47	194	33%	UniProt GenBank	Putative linear pentadecapeptide gramicidin synthetase LgrB	lgrB BBR47_28930	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
12	Q08M94_STIAD (Q08M94)		2e-46	192	32%	UniProt GenBank	Linear gramicidin synthetase subunit C	STIAU_5867	Stigmatella aurantiaca (strain DW4/3-1)	5.1.1.- niceE keggE
13	E3FE21_STIAD (E3FE21)	(3 hsp)	4e-46	190	32%	UniProt GenBank	GrsB-like Gramicidin S synthetase 2	STAUR_4846	Stigmatella aurantiaca (strain DW4/3-1)
14	A0Z9R9_NODSP (A0Z9R9)		2e-45	188	30%	UniProt GenBank	Putative uncharacterized protein	N9414_20950	Nodularia spumigena CCY9414
15	C1AUS0_RHOOB (C1AUS0)	(6 hsp)	3e-45	187	34%	UniProt GenBank	Putative non-ribosomal peptide synthetase	ROP_51630	Rhodococcus opacus (strain B4)
16	F6K7G8_9ACTO (F6K7G8)		1e-44	185	35%	UniProt GenBank	Putative peptide synthetase	pyrG	Streptomyces pyridomyceticus
17	D9V8Z7_9ACTO (D9V8Z7)	(6 hsp)	4e-44	184	34%	UniProt GenBank	Peptide synthetase ScpsB	SSMG_03148	Streptomyces sp. AA4
18	F5UM68_9CYAN (F5UM68)		9e-44	182	32%	UniProt GenBank	Amino acid adenylation domain protein	MicvaDRAFT_0614	Microcoleus vaginatus FGP-2	5.1.1.12 niceE keggE
19	Q643C7_STRHY (Q643C7)	(2 hsp)	1e-43	182	33%	UniProt GenBank	Mannopeptimycin peptide synthetase MppA	mppA	Streptomyces hygroscopicus
20	C0ZDR8_BREBN (C0ZDR8)	(5 hsp)	2e-43	181	32%	UniProt GenBank	Linear pentadecapeptide gramicidin synthetase LgrD	lgrD BBR47_29500	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
21	D3VIX8_XENNA (D3VIX8)		5e-43	180	33%	UniProt GenBank	Peptide synthetase XpsB	XNC1_2781	Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)	1.2.1.31 niceE keggE 5.1.1.11 niceE keggE
22	A9AV17_HERA2 (A9AV17)	(6 hsp)	5e-43	180	32%	UniProt GenBank	Amino acid adenylation domain	Haur_3973	Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785)
23	C0ZDL2_BREBN (C0ZDL2)	(8 hsp)	7e-43	179	31%	UniProt GenBank	Truncated linear pentadecapeptide gramicidin synthetase LgrC	lgrC BBR47_28940	Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
24	C1B0G8_RHOOB (C1B0G8)	(2 hsp)	1e-42	179	32%	UniProt GenBank	Putative non-ribosomal peptide synthetase	ROP_19210	Rhodococcus opacus (strain B4)
25	C6WBS4_ACTMD (C6WBS4)	(7 hsp)	1e-42	178	34%	UniProt GenBank	Cyclic nucleotide-binding protein	Amir_3602	Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
26	F8CAR4_MYXFU (F8CAR4)	(4 hsp)	2e-42	178	33%	UniProt GenBank	Non-ribosomal peptide synthetase	LILAB_26120	Myxococcus fulvus
27	C3JNH6_RHOER (C3JNH6)	(4 hsp)	3e-42	177	33%	UniProt GenBank	Amino acid adenylation domain protein	RHOER0001_6686	Rhodococcus erythropolis SK121
28	Q08ML9_STIAD (Q08ML9)		4e-42	177	32%	UniProt GenBank	Linear gramicidin synthetase subunit D	STIAU_0868	Stigmatella aurantiaca (strain DW4/3-1)	1.-.-.- niceE keggE 5.1.1.- niceE keggE
29	F8CDJ4_MYXFU (F8CDJ4)	(2 hsp)	6e-42	176	33%	UniProt GenBank	Non-ribosomal peptide synthetase/polyketide synthase	LILAB_27070	Myxococcus fulvus
30	A0FCL0_STRVO (A0FCL0)	(2 hsp)	6e-42	176	34%	UniProt GenBank	MerP	merP	Streptomyces violaceoniger
31	A8M7B5_SALAI (A8M7B5)		7e-42	176	35%	UniProt GenBank	Amino acid adenylation domain	Sare_2962	Salinispora arenicola (strain CNS-205)
32	LGRB_BREPA (Q70LM6)	(5 hsp)	7e-42	176	33%	UniProt GenBank	Linear gramicidin synthase subunit B ATP-dependent alanine adenylase Alanine activase ATP-dependent D-leucine adenylase D-leucine activase Leucine racemase [ATP-hydrolyzing] ATP-dependent alanine adenylase Alanine activase ATP-dependent D-valine adenylase D-valine activase Valine racemase [ATP-hydrolyzing]	lgrB	Brevibacillus parabrevis	5.1.1.- niceE keggE
33	Q091D1_STIAD (Q091D1)		7e-42	176	30%	UniProt GenBank	Putative uncharacterized protein	STIAU_0869	Stigmatella aurantiaca (strain DW4/3-1)
34	C0ZW10_RHOE4 (C0ZW10)	(9 hsp)	8e-42	176	32%	UniProt GenBank	Putative non-ribosomal peptide synthetase	RER_18370	Rhodococcus erythropolis (strain PR4 / NBRC 100887)
35	C7MU85_SACVD (C7MU85)	(7 hsp)	1e-41	176	34%	UniProt GenBank	Non-ribosomal peptide synthase/amino acid adenylation enzyme	Svir_18410	Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)
36	Q643C6_STRHY (Q643C6)	(4 hsp)	1e-41	176	35%	UniProt GenBank	Mannopeptimycin peptide synthetase MppB	mppB	Streptomyces hygroscopicus
37	E0KN04_STRVO (E0KN04)	(2 hsp)	1e-41	176	34%	UniProt GenBank	Amino acid adenylation domain protein	StrviDRAFT_3963	Streptomyces violaceusniger Tu 4113
38	Q1D6A0_MYXXD (Q1D6A0)	(11 hsp)	1e-41	176	32%	UniProt GenBank	Non-ribosomal peptide synthetase	MXAN_3636	Myxococcus xanthus (strain DK 1622)
39	LGRC_BREPA (Q70LM5)	(7 hsp)	1e-41	175	31%	UniProt GenBank	Linear gramicidin synthase subunit C ATP-dependent valine adenylase Valine activase ATP-dependent D-valine adenylase D-valine activase Valine racemase [ATP-hydrolyzing] ATP-dependent tryptophan adenylase Tryptophan activase ATP-dependent D-leucine adenylase D-leucine activase Leucine racemase [ATP-hydrolyzing] ATP-dependent tryptophan/phenylalanine/tyrosine adenylase Tryptophan/phenylalanine/tyrosine activase ATP-dependent D-leucine adenylase D-leucine activase Leucine racemase [ATP-hydrolyzing]	lgrC	Brevibacillus parabrevis	5.1.1.- niceE keggE
40	E3FPD1_STIAD (E3FPD1)	(4 hsp)	1e-41	175	32%	UniProt GenBank	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase	pcbAB STAUR_4159	Stigmatella aurantiaca (strain DW4/3-1)	6.3.2.26 niceE keggE
41	D8I014_AMYMU (D8I014)	(4 hsp)	2e-41	175	34%	UniProt GenBank	Non-ribosomal peptide synthetase	AMED_5034	Amycolatopsis mediterranei (strain U-32)
42	F8CHL5_MYXFU (F8CHL5)	(2 hsp)	2e-41	175	31%	UniProt GenBank	Non-ribosomal peptide synthase/polyketide synthase	LILAB_28145	Myxococcus fulvus
43	LGRD_BREPA (Q70LM4)	(5 hsp)	2e-41	175	30%	UniProt GenBank	Linear gramicidin synthase subunit D ATP-dependent tryptophan adenylase Tryptophan activase ATP-dependent D-leucine adenylase D-Leucine activase Leucine racemase [ATP-hydrolyzing] ATP-dependent tryptophan adenylase Tryptophan activase ATP-dependent glycine adenylase Glycine activase Linear gramicidin--PCP reductase	lgrD	Brevibacillus parabrevis	5.1.1.- niceE keggE 1.-.-.- niceE keggE
44	D6TQ90_9CHLR (D6TQ90)	(2 hsp)	2e-41	174	33%	UniProt GenBank	Amino acid adenylation domain protein	Krac_6972	Ktedonobacter racemifer DSM 44963
45	B9XGC7_9BACT (B9XGC7)	(2 hsp)	3e-41	174	30%	UniProt GenBank	Amino acid adenylation domain protein	Cflav_PD3695	Pedosphaera parvula Ellin514
46	Q5Z1X6_NOCFA (Q5Z1X6)	(4 hsp)	3e-41	174	35%	UniProt GenBank	Putative non-ribosomal peptide synthetase	NFA_7200	Nocardia farcinica
47	E5ATT5_BURRH (E5ATT5)	(5 hsp)	3e-41	174	33%	UniProt GenBank	Non-ribosomal peptide synthetase modules (EC 6.3.2.-)	RBRH_00429	Burkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)	6.3.2.- niceE keggE
48	C1AR31_RHOOB (C1AR31)	(9 hsp)	3e-41	174	33%	UniProt GenBank	Putative non-ribosomal peptide synthetase	ROP_02610	Rhodococcus opacus (strain B4)
49	D8G9C0_9CYAN (D8G9C0)		3e-41	174	30%	UniProt GenBank	Non-ribosomal peptide synthase	OSCI_4080006	Oscillatoria sp. PCC 6506	2.3.1.38 niceE keggE 6.3.2.26 niceE keggE
50	F8JMJ7_STRCT (F8JMJ7)		4e-41	174	34%	UniProt GenBank	Putative uncharacterized protein	SCAT_p0615	Streptomyces cattleya NRRL 8057
51	A8M6W3_SALAI (A8M6W3)	(6 hsp)	5e-41	173	33%	UniProt GenBank	Amino acid adenylation domain	Sare_4562	Salinispora arenicola (strain CNS-205)
52	E1VJW1_9GAMM (E1VJW1)	(4 hsp)	5e-41	173	29%	UniProt GenBank	Non-ribosomal peptide synthetase modules and related proteins	HDN1F_15200	gamma proteobacterium HdN1
53	F8CPE2_MYXFU (F8CPE2)		6e-41	173	33%	UniProt GenBank	Amino acid adenylation protein	LILAB_30115	Myxococcus fulvus
54	C3JNH5_RHOER (C3JNH5)	(4 hsp)	6e-41	173	34%	UniProt GenBank	Amino acid adenylation domain protein	RHOER0001_6685	Rhodococcus erythropolis SK121
55	Q1D5W2_MYXXD (Q1D5W2)	(11 hsp)	6e-41	173	33%	UniProt GenBank	Non-ribosomal peptide synthetase/polyketide synthase	MXAN_3779	Myxococcus xanthus (strain DK 1622)
56	D2CZD3_KARBR (D2CZD3)		7e-41	173	30%	UniProt GenBank	Nonribosomal peptide synthetase/polyketide synthase hybrid		Karenia brevis Dinoflagellate
57	F8CDJ3_MYXFU (F8CDJ3)	(4 hsp)	7e-41	173	37%	UniProt GenBank	Non-ribosomal peptide synthetase/polyketide synthase	LILAB_27065	Myxococcus fulvus
58	Q1WEL0_9ACTO (Q1WEL0)	(2 hsp)	8e-41	172	33%	UniProt GenBank	NRPS for pipecolate incorporation	merP	Streptomyces sp. NRRL 30748
59	F3J672_PSEAP (F3J672)		8e-41	172	30%	UniProt GenBank	Amino acid adenylation	PSYAP_25074	Pseudomonas syringae pv. aptata str. DSM 50252
60	D2UD59_XANAP (D2UD59)	(3 hsp)	9e-41	172	32%	UniProt GenBank	Probable non-ribosomal peptide synthetase protein	XALc_1058	Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)
61	Q333U1_9ACTO (Q333U1)		1e-40	172	33%	UniProt GenBank	NRPS protein	tioY	Micromonospora sp. ML1
62	E3FE23_STIAD (E3FE23)	(2 hsp)	2e-40	171	30%	UniProt GenBank	GrsB-like Gramicidin S synthetase 2	STAUR_4848	Stigmatella aurantiaca (strain DW4/3-1)
63	D8FWT7_9CYAN (D8FWT7)		2e-40	171	30%	UniProt GenBank	Multifunctional peptide synthetase (Modular protein)	OSCI_1100006	Oscillatoria sp. PCC 6506
64	Q08QA3_STIAD (Q08QA3)		2e-40	171	30%	UniProt GenBank	Linear gramicidin synthetase subunit D	STIAU_0001	Stigmatella aurantiaca (strain DW4/3-1)	1.-.-.- niceE keggE 5.1.1.- niceE keggE
65	F5UK78_9CYAN (F5UK78)		2e-40	171	30%	UniProt GenBank	Amino acid adenylation domain protein	MicvaDRAFT_2506	Microcoleus vaginatus FGP-2	5.1.1.12 niceE keggE
66	C1AZY4_RHOOB (C1AZY4)	(8 hsp)	2e-40	171	33%	UniProt GenBank	Putative non-ribosomal peptide synthetase	ROP_61580	Rhodococcus opacus (strain B4)
67	D6A1F1_9ACTO (D6A1F1)	(2 hsp)	3e-40	171	36%	UniProt GenBank	CDA peptide synthetase II	SSFG_00767	Streptomyces ghanaensis ATCC 14672
68	D6A1E9_9ACTO (D6A1E9)	(2 hsp)	3e-40	171	33%	UniProt GenBank	Peptide synthetase 3	SSFG_00765	Streptomyces ghanaensis ATCC 14672
69	Q1D3K9_MYXXD (Q1D3K9)	(2 hsp)	4e-40	171	34%	UniProt GenBank	Non-ribosomal peptide synthase	MXAN_4596	Myxococcus xanthus (strain DK 1622)
70	C7PS57_CHIPD (C7PS57)	(6 hsp)	4e-40	171	29%	UniProt GenBank	Amino acid adenylation domain protein	Cpin_5190	Chitinophaga pinensis (strain ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034)
71	D8HVQ5_AMYMU (D8HVQ5)		4e-40	170	33%	UniProt GenBank	Condensation domain-containing protein involved in non-ribosomal peptide synthesis	AMED_6230	Amycolatopsis mediterranei (strain U-32)
72	C1A0G2_RHOE4 (C1A0G2)	(6 hsp)	4e-40	170	33%	UniProt GenBank	Putative non-ribosomal peptide synthetase	RER_33890	Rhodococcus erythropolis (strain PR4 / NBRC 100887)
73	D0RB84_STRPR (D0RB84)	(4 hsp)	4e-40	170	35%	UniProt GenBank	Putative pristinamycin I peptide synthase 3 and 4	snbDE	Streptomyces pristinaespiralis
74	B2IXJ9_NOSP7 (B2IXJ9)	(3 hsp)	5e-40	170	31%	UniProt GenBank	Amino acid adenylation domain protein	Npun_R3025	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	5.1.1.11 niceE keggE 6.2.1.26 niceE keggE
75	C0ZW11_RHOE4 (C0ZW11)	(4 hsp)	5e-40	170	31%	UniProt GenBank	Putative non-ribosomal peptide synthetase	RER_18380	Rhodococcus erythropolis (strain PR4 / NBRC 100887)
76	A8ZKN7_ACAM1 (A8ZKN7)	(2 hsp)	6e-40	170	29%	UniProt GenBank	Peptide synthetase, putative	AM1_A0235	Acaryochloris marina (strain MBIC 11017)
77	E0KQW5_STRVO (E0KQW5)	(3 hsp)	6e-40	170	35%	UniProt GenBank	Amino acid adenylation domain protein	StrviDRAFT_5042	Streptomyces violaceusniger Tu 4113
78	F6EJ89_9MYCO (F6EJ89)	(6 hsp)	8e-40	169	31%	UniProt GenBank	Non-ribosomal peptide synthetase	AS9A_4071	Amycolicicoccus subflavus DQS3-9A1
79	D9UBK0_STRPR (D9UBK0)	(4 hsp)	9e-40	169	35%	UniProt GenBank	PI synthetase 3 and 4	snbDE	Streptomyces pristinaespiralis
80	O07944_STRPR (O07944)	(4 hsp)	9e-40	169	35%	UniProt GenBank	Pristinamycin I synthase 3 and 4	snbDE	Streptomyces pristinaespiralis
81	Q0S3K6_RHOSR (Q0S3K6)	(8 hsp)	1e-39	169	33%	UniProt GenBank	Non-ribosomal peptide synthetase	RHA1_ro06103	Rhodococcus sp. (strain RHA1)	5.1.1.13 niceE keggE 6.2.1.3 niceE keggE
82	F8CAT9_MYXFU (F8CAT9)		1e-39	169	30%	UniProt GenBank	Non-ribosomal peptide synthetase	LILAB_26245	Myxococcus fulvus
83	F5UM67_9CYAN (F5UM67)		1e-39	169	30%	UniProt GenBank	Amino acid adenylation domain protein	MicvaDRAFT_0613	Microcoleus vaginatus FGP-2	5.1.1.3 niceE keggE 6.2.1.20 niceE keggE
84	F8JMJ8_STRCT (F8JMJ8)		1e-39	169	35%	UniProt GenBank	Putative uncharacterized protein	SCAT_p0616	Streptomyces cattleya NRRL 8057
85	E0KLI0_STRVO (E0KLI0)	(3 hsp)	1e-39	169	34%	UniProt GenBank	Amino acid adenylation domain protein	StrviDRAFT_3507	Streptomyces violaceusniger Tu 4113
86	F8CAU3_MYXFU (F8CAU3)		1e-39	168	32%	UniProt GenBank	Non-ribosomal peptide synthetase	LILAB_26265	Myxococcus fulvus
87	D6BB75_9ACTO (D6BB75)	(2 hsp)	2e-39	168	32%	UniProt GenBank	Peptide synthase	SSHG_04945	Streptomyces albus J1074
88	B1T4Q2_9BURK (B1T4Q2)	(2 hsp)	2e-39	168	34%	UniProt GenBank	Amino acid adenylation domain protein	BamMEX5DRAFT_2768	Burkholderia ambifaria MEX-5
89	F3JPT7_PSESX (F3JPT7)		2e-39	168	30%	UniProt GenBank	Amino acid adenylation	PSYAR_25227	Pseudomonas syringae pv. aceris str. M302273PT
90	Q8GGS2_STRAZ (Q8GGS2)		2e-39	168	32%	UniProt GenBank	Nonribosomal peptide synthetase		Streptomyces atroolivaceus
91	E4W809_RHOE1 (E4W809)	(3 hsp)	2e-39	168	32%	UniProt GenBank	Putative non-ribosomal peptide synthetase	REQ_35950	Rhodococcus equi (strain 103S) Corynebacterium equi
92	F4FD51_VERMA (F4FD51)	(4 hsp)	2e-39	168	34%	UniProt GenBank	Amino acid adenylation	VAB18032_24915	Verrucosispora maris (strain AB-18-032)
93	E9T2L0_COREQ (E9T2L0)	(3 hsp)	2e-39	168	32%	UniProt GenBank	Exopolyphosphatase	ppx8 HMPREF0724_12901	Rhodococcus equi ATCC 33707	3.6.1.11 niceE keggE
94	E2D2P6_9BACT (E2D2P6)	(6 hsp)	3e-39	167	34%	UniProt GenBank	Non-ribosomal peptide synthase		uncultured soil bacterium
95	B2IXK1_NOSP7 (B2IXK1)	(3 hsp)	3e-39	167	29%	UniProt GenBank	Amino acid adenylation domain protein	Npun_R3027	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	2.3.1.94 niceE keggE 5.1.1.13 niceE keggE
96	F3FRG2_PSESX (F3FRG2)		3e-39	167	30%	UniProt GenBank	Amino acid adenylation	PSYJA_29116	Pseudomonas syringae pv. japonica str. M301072PT
97	B4W3U1_9CYAN (B4W3U1)		3e-39	167	28%	UniProt GenBank	Amino acid adenylation domain protein	MC7420_4295	Microcoleus chthonoplastes PCC 7420
98	Q333U0_9ACTO (Q333U0)		3e-39	167	32%	UniProt GenBank	NRPS protein	tioZ	Micromonospora sp. ML1
99	F2YRY4_9ACTO (F2YRY4)	(4 hsp)	4e-39	167	34%	UniProt GenBank	Peptide synthetase	sky29	Streptomyces sp. Acta 2897
100	D6K402_9ACTO (D6K402)		4e-39	167	36%	UniProt GenBank	Linear gramicidin synthetase LgrC	SSTG_03913	Streptomyces sp. e14

accession

alignment

Evalue

Score

Ident.

link

information

pubmed

B0BLN8_9ACTO
(B0BLN8)

0.0

921

100%

Product: Type II condensation domain protein
Gene: mdpC5
Organism: Actinomadura madurae

[pubmed all]
1uniprot[Pubmed] 14528002 [Medline] 22922109 Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model.(Proc. Natl. Acad. Sci. U.S.A.) [2003]
2uniprot[Pubmed] 17918933 Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.(J. Am. Chem. Soc.) [2007]

Q8GMG2_STRGL
(Q8GMG2)

1e-105

386

47%

Product: C-domain type II peptide synthetase
Gene
Organism: Streptomyces globisporus

1uniprot[Pubmed] 12183628 [Medline] 22171413
Biosynthesis of the enediyne antitumor antibiotic C-1027.(Science) [2002]

D2B8S1_STRRD
(D2B8S1)

1e-101

373

45%

Product: Non-ribosomal peptide synthetase modules and related protein-like protein
Gene: Sros_6976
Organism: Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)

1uniprot
Complete genome sequence of Streptosporangium roseum type strain (NI 9100T).(Stand. Genomic Sci.) [2010]

Q0S6F3_RHOSR
(Q0S6F3)

(7 hsp)

2e-48

198

35%

Product: Non-ribosomal peptide synthetase
Gene: RHA1_ro05102
Organism: Rhodococcus sp. (strain RHA1)

1uniprot[Pubmed] 17030794
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

F6K7G8_9ACTO
(F6K7G8)

1e-44

185

35%

Product: Putative peptide synthetase
Gene: pyrG
Organism: Streptomyces pyridomyceticus

1uniprot[Pubmed] 21454714
Identification and Characterization of the Pyridomycin Biosynthetic Gene Cluster of Streptomyces pyridomyceticus NRRL B-2517.(J. Biol. Chem.) [2011]

Q643C7_STRHY
(Q643C7)

(2 hsp)

1e-43

182

33%

Product: Mannopeptimycin peptide synthetase MppA
Gene: mppA
Organism: Streptomyces hygroscopicus

1uniprot[Pubmed] 16723579
Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens.(Antimicrob. Agents Chemother.) [2006]

C6WBS4_ACTMD
(C6WBS4)

(7 hsp)

1e-42

178

34%

Product: Cyclic nucleotide-binding protein
Gene: Amir_3602
Organism: Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)

1uniprot
Complete genome sequence of Actinosynnema mirum type strain (101).(Stand. Genomic Sci.) [2009]

A0FCL0_STRVO
(A0FCL0)

(2 hsp)

6e-42

176

34%

Product: MerP
Gene: merP
Organism: Streptomyces violaceoniger

1uniprot[Pubmed] 17159202
Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.(Microbiology) [2006]

LGRB_BREPA
(Q70LM6)

(5 hsp)

7e-42

176

33%

Product: Linear gramicidin synthase subunit B
ATP-dependent alanine adenylase
Alanine activase
ATP-dependent D-leucine adenylase
D-leucine activase
Leucine racemase [ATP-hydrolyzing]
ATP-dependent alanine adenylase
Alanine activase
ATP-dependent D-valine adenylase
D-valine activase
Valine racemase [ATP-hydrolyzing]
Gene: lgrB
Organism: Brevibacillus parabrevis

1uniprot[Pubmed] 14670971
The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 57 catalytic domains.(J. Biol. Chem.) [2004]

C0ZW10_RHOE4
(C0ZW10)

(9 hsp)

8e-42

176

32%

Product: Putative non-ribosomal peptide synthetase
Gene: RER_18370
Organism: Rhodococcus erythropolis (strain PR4 / NBRC 100887)

1uniprot
Sequence analysis of three plasmids harboured in Rhodococcus erythropolis strain PR4.(Environ. Microbiol.) [2006]

C7MU85_SACVD
(C7MU85)

(7 hsp)

1e-41

176

34%

Product: Non-ribosomal peptide synthase/amino acid adenylation enzyme
Gene: Svir_18410
Organism: Saccharomonospora viridis (strain ATCC 15386 / DSM 43017 / JCM 3036 / NBRC 12207 / P101)

1uniprot
Complete genome sequence of Saccharomonospora viridis type strain (P101T).(Stand. Genomic Sci.) [2009]

Q643C6_STRHY
(Q643C6)

(4 hsp)

1e-41

176

35%

Product: Mannopeptimycin peptide synthetase MppB
Gene: mppB
Organism: Streptomyces hygroscopicus

1uniprot[Pubmed] 16723579
Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens.(Antimicrob. Agents Chemother.) [2006]

Q1D6A0_MYXXD
(Q1D6A0)

(11 hsp)

1e-41

176

32%

Product: Non-ribosomal peptide synthetase
Gene: MXAN_3636
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

LGRC_BREPA
(Q70LM5)

(7 hsp)

1e-41

175

31%

Product: Linear gramicidin synthase subunit C
ATP-dependent valine adenylase
Valine activase
ATP-dependent D-valine adenylase
D-valine activase
Valine racemase [ATP-hydrolyzing]
ATP-dependent tryptophan adenylase
Tryptophan activase
ATP-dependent D-leucine adenylase
D-leucine activase
Leucine racemase [ATP-hydrolyzing]
ATP-dependent tryptophan/phenylalanine/tyrosine adenylase
Tryptophan/phenylalanine/tyrosine activase
ATP-dependent D-leucine adenylase
D-leucine activase
Leucine racemase [ATP-hydrolyzing]
Gene: lgrC
Organism: Brevibacillus parabrevis

D8I014_AMYMU
(D8I014)

(4 hsp)

2e-41

175

34%

Product: Non-ribosomal peptide synthetase
Gene: AMED_5034
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

LGRD_BREPA
(Q70LM4)

(5 hsp)

2e-41

175

30%

Product: Linear gramicidin synthase subunit D
ATP-dependent tryptophan adenylase
Tryptophan activase
ATP-dependent D-leucine adenylase
D-Leucine activase
Leucine racemase [ATP-hydrolyzing]
ATP-dependent tryptophan adenylase
Tryptophan activase
ATP-dependent glycine adenylase
Glycine activase
Linear gramicidin--PCP reductase
Gene: lgrD
Organism: Brevibacillus parabrevis

[pubmed all]
1uniprot[Pubmed] 14670971 The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 57 catalytic domains.(J. Biol. Chem.) [2004]
2uniprot[Pubmed] 15938641 Synthesis of linear gramicidin requires the cooperation of two independent reductases.(Biochemistry) [2005]

B9XGC7_9BACT
(B9XGC7)

(2 hsp)

3e-41

174

30%

Product: Amino acid adenylation domain protein
Gene: Cflav_PD3695
Organism: Pedosphaera parvula Ellin514

1uniprot[Pubmed] 21460084
Genome Sequence of 'Pedosphaera parvula' Ellin514, an Aerobic Verrucomicrobial Isolate from Pasture Soil.(J. Bacteriol.) [2011]

Q5Z1X6_NOCFA
(Q5Z1X6)

(4 hsp)

3e-41

174

35%

Product: Putative non-ribosomal peptide synthetase
Gene: NFA_7200
Organism: Nocardia farcinica

1uniprot[Pubmed] 15466710
The complete genomic sequence of Nocardia farcinica IFM 10152.(Proc. Natl. Acad. Sci. U.S.A.) [2004]

E5ATT5_BURRH
(E5ATT5)

(5 hsp)

3e-41

174

33%

Product: Non-ribosomal peptide synthetase modules (EC 6.3.2.-)
Gene: RBRH_00429
Organism: Burkholderia rhizoxinica (strain DSM 19002 / CIP 109453 / HKI 454)

1uniprot[Pubmed] 21131495
Complete genome sequence of Burkholderia rhizoxinica, an endosymbiont of Rhizopus microsporus.(J. Bacteriol.) [2011]

D8G9C0_9CYAN
(D8G9C0)

3e-41

174

30%

Product: Non-ribosomal peptide synthase
Gene: OSCI_4080006
Organism: Oscillatoria sp. PCC 6506

1uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

E1VJW1_9GAMM
(E1VJW1)

(4 hsp)

5e-41

173

29%

Product: Non-ribosomal peptide synthetase modules and related proteins
Gene: HDN1F_15200
Organism: gamma proteobacterium HdN1

1uniprot
Alkane degradation by a new type of denitrifying bacterium with possible involvement of the electron acceptor in substrate activation.(Environ. Microbiol.) [2010]

Q1D5W2_MYXXD
(Q1D5W2)

(11 hsp)

6e-41

173

33%

Product: Non-ribosomal peptide synthetase/polyketide synthase
Gene: MXAN_3779
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

D2CZD3_KARBR
(D2CZD3)

7e-41

173

30%

Product: Nonribosomal peptide synthetase/polyketide synthase hybrid
Gene
Organism: Karenia brevis
Dinoflagellate

1uniprot[Pubmed] 19468793
Characterization and Localization of a Hybrid Non-ribosomal Peptide Synthetase and Polyketide Synthase Gene from the Toxic Dinoflagellate Karenia brevis.(Mar. Biotechnol.) [2009]

Q1WEL0_9ACTO
(Q1WEL0)

(2 hsp)

8e-41

172

33%

Product: NRPS for pipecolate incorporation
Gene: merP
Organism: Streptomyces sp. NRRL 30748

1uniprot[Pubmed] 16806745
Isolation and characterization of meridamycin biosynthetic gene cluster from Streptomyces sp. NRRL 30748.(Gene) [2006]

D2UD59_XANAP
(D2UD59)

(3 hsp)

9e-41

172

32%

Product: Probable non-ribosomal peptide synthetase protein
Gene: XALc_1058
Organism: Xanthomonas albilineans (strain GPE PC73 / CFBP 7063)

1uniprot
The complete genome sequence of Xanthomonas albilineans provides new insights into the reductive genome evolution of the xylem-limited Xanthomonadaceae.(BMC Genomics) [2009]

Q333U1_9ACTO
(Q333U1)

1e-40

172

33%

Product: NRPS protein
Gene: tioY
Organism: Micromonospora sp. ML1

1uniprot
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in Streptomyces hosts.(Chembiochem) [2006]

D8FWT7_9CYAN
(D8FWT7)

2e-40

171

30%

Product: Multifunctional peptide synthetase (Modular protein)
Gene: OSCI_1100006
Organism: Oscillatoria sp. PCC 6506

1uniprot
The Genome Sequence of the Cyanobacterium Oscillatoria sp. PCC 6506 Reveals Several Gene Clusters Responsible for the Biosynthesis of Toxins and Secondary Metabolites.(J. Bacteriol.) [2010]

Q1D3K9_MYXXD
(Q1D3K9)

(2 hsp)

4e-40

171

34%

Product: Non-ribosomal peptide synthase
Gene: MXAN_4596
Organism: Myxococcus xanthus (strain DK 1622)

1uniprot[Pubmed] 17015832
Evolution of sensory complexity recorded in a myxobacterial genome.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

D8HVQ5_AMYMU
(D8HVQ5)

4e-40

170

33%

Product: Condensation domain-containing protein involved in non-ribosomal peptide synthesis
Gene: AMED_6230
Organism: Amycolatopsis mediterranei (strain U-32)

1uniprot[Pubmed] 20567260
Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.(Cell Res.) [2010]

C1A0G2_RHOE4
(C1A0G2)

(6 hsp)

4e-40

170

33%

Product: Putative non-ribosomal peptide synthetase
Gene: RER_33890
Organism: Rhodococcus erythropolis (strain PR4 / NBRC 100887)

1uniprot
Sequence analysis of three plasmids harboured in Rhodococcus erythropolis strain PR4.(Environ. Microbiol.) [2006]

C0ZW11_RHOE4
(C0ZW11)

(4 hsp)

5e-40

170

31%

Product: Putative non-ribosomal peptide synthetase
Gene: RER_18380
Organism: Rhodococcus erythropolis (strain PR4 / NBRC 100887)

1uniprot
Sequence analysis of three plasmids harboured in Rhodococcus erythropolis strain PR4.(Environ. Microbiol.) [2006]

A8ZKN7_ACAM1
(A8ZKN7)

(2 hsp)

6e-40

170

29%

Product: Peptide synthetase, putative
Gene: AM1_A0235
Organism: Acaryochloris marina (strain MBIC 11017)

1uniprot[Pubmed] 18252824
Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina.(Proc. Natl. Acad. Sci. U.S.A.) [2008]

D9UBK0_STRPR
(D9UBK0)

(4 hsp)

9e-40

169

35%

Product: PI synthetase 3 and 4
Gene: snbDE
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 21342465
Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.(Microb Biotechnol) [2011]

O07944_STRPR
(O07944)

(4 hsp)

9e-40

169

35%

Product: Pristinamycin I synthase 3 and 4
Gene: snbDE
Organism: Streptomyces pristinaespiralis

1uniprot[Pubmed] 9006024 [Medline] 97158664
Pristinamycin I biosynthesis in Streptomyces pristinaespiralis: molecular characterization of the first two structural peptide synthetase genes.(J. Bacteriol.) [1997]

Q0S3K6_RHOSR
(Q0S3K6)

(8 hsp)

1e-39

169

33%

Product: Non-ribosomal peptide synthetase
Gene: RHA1_ro06103
Organism: Rhodococcus sp. (strain RHA1)

1uniprot[Pubmed] 17030794
The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse.(Proc. Natl. Acad. Sci. U.S.A.) [2006]

Q8GGS2_STRAZ
(Q8GGS2)

2e-39

168

32%

Product: Nonribosomal peptide synthetase
Gene
Organism: Streptomyces atroolivaceus

[pubmed all]
1uniprot[Pubmed] 12446651 [Medline] 22336326 Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.(J. Bacteriol.) [2002]
2uniprot[Pubmed] 12598647 [Medline] 22531819 Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis.(Proc. Natl. Acad. Sci. U.S.A.) [2003]
3uniprot[Pubmed] 15112993 Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase.(Chem. Biol.) [2004]

E4W809_RHOE1
(E4W809)

(3 hsp)

2e-39

168

32%

Product: Putative non-ribosomal peptide synthetase
Gene: REQ_35950
Organism: Rhodococcus equi (strain 103S)
Corynebacterium equi

1uniprot[Pubmed] 20941392
The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.(PLoS Genet.) [2010]

F4FD51_VERMA
(F4FD51)

(4 hsp)

2e-39

168

34%

Product: Amino acid adenylation
Gene: VAB18032_24915
Organism: Verrucosispora maris (strain AB-18-032)

1uniprot[Pubmed] 21551311
Genome sequence of the abyssomicin- and proximicin-producing marine actinomycete Verrucosispora maris AB-18-032.(J. Bacteriol.) [2011]

E2D2P6_9BACT
(E2D2P6)

(6 hsp)

3e-39

167

34%

Product: Non-ribosomal peptide synthase
Gene
Organism: uncultured soil bacterium

1uniprot[Pubmed] 20577994
Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR.(Biopolymers) [2010]

Q333U0_9ACTO
(Q333U0)

3e-39

167

32%

Product: NRPS protein
Gene: tioZ
Organism: Micromonospora sp. ML1

1uniprot
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in Streptomyces hosts.(Chembiochem) [2006]

F2YRY4_9ACTO
(F2YRY4)

(4 hsp)

4e-39

167

34%

Product: Peptide synthetase
Gene: sky29
Organism: Streptomyces sp. Acta 2897

1uniprot[Pubmed] 21456593
Biosynthetic Gene Cluster of the Non-ribosomally Synthesized Cyclodepsipeptide Skyllamycin: Deciphering Unprecedented Ways of Unusual Hydroxylation Reactions.(J. Am. Chem. Soc.) [2011]