Megalo_00130 : CDS information

Location

Organism	Micromonospora megalomicea subsp. nigra
Strain	NRRL 3275 (=NBRC 14744)
Entry name	Megalomicin
Contig	AF263245
Start / Stop / Direction	22,867 / 33,555 / + [in whole cluster] 22,867 / 33,555 / + [in contig]
Location	22867..33555 [in whole cluster] 22867..33555 [in contig]
Type	CDS
Length	10,689 bp (3,562 aa)

Annotation

Category	1.1 PKS
Product	polyketide synthase
Product (GenBank)	megalomicin 6-deoxyerythronolide B synthase 2
Gene
Gene (GenBank)	megAII
EC number
Keyword
Note
Note (GenBank)	polyketide synthase
Reference	ACC Q9F829 PmId [10972798] Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea. (Mol Microbiol. , 2000) comment megalomicin (meg) biosynthetic gene clusterの報告。 megAII: polyketide synthase PKSのmodule 3-4をコード。

PKS/NRPS Module

3		methylmalonyl-CoA
4		methylmalonyl-CoA

KS	31..406

AT	560..880

kr	1124..1291

ACP	1391..1461

KS	1483..1856

AT	2011..2330

DH	2374..2537

ER	2823..3123

KR	3133..3313

ACP	3409..3479

Sequence

>polyketide synthase [megalomicin 6-deoxyerythronolide B synthase 2]
MTDNDKVAEYLRRATLDLRAARKRLRELQSDPIAVVGMACRLPGGVHLPQHLWDLLRQGH
ETVSTFPTGRGWDLAGLFHPDPDHPGTSYVDRGGFLDDVAGFDAEFFGISPREATAMDPQ
QRLLLETSWELVESAGIDPHSLRGTPTGVFLGVARLGYGENGTEAGDAEGYSVTGVAPAV
ASGRISYALGLEGPSISVDTACSSSLVALHLAVESLRLGESSLAVVGGAAVMATPGVFVD
FSRQRALAADGRSKAFGAAADGFGFSEGVSLVLLERLSEAESNGHEVLAVIRGSALNQDG
ASNGLAAPNGTAQRKVIRQALRNCGLTPADVDAVEAHGTGTTLGDPIEANALLDTYGRDR
DPDHPLWLGSVKSNIGHTQAAAGVTGLLKMVLALRHEELPATLHVDEPTPHVDWSSGAVR
LATRGRPWRRGDRPRRAGVSAFGISGTNAHVIVEEAPERTTERTVGGDVGPVPLVVSARS
AAALRAQAAQVAELVEGSDVGLAEVGRSLAVTRARHEHRAAVVASTRAEAVRGLREVAAV
EPRGEDTVTGVAETSGRTVVFLFPGQGSQWVGMGAELLDSAPAFADTIRACDEAMAPLQD
WSVSDVLRQEPGAPGLDRVDVVQPVLFAVMVSLARLWQSYGVTPAAVVGHSQGEIAAAHV
AGALSLADAARLVVGRSRLLRSLSGGGGMSAVALGEAEVRRRLRSWEDRISVAAVNGPRS
VVVAGEPEALREWGREREAEGVRVREIDVDYASHSPQIDRVRDELLTVTGEIEPRSAEIT
FYSTVDVRAVDGTDLDAGYWYRNLRETVRFADAMTRLADSGYDAFVEVSPHPVVVSAVAE
AVEEAGVEDAVVVGTLSRGDGGPGAFLRSAATAHCAGVDVDWTPALPGAATIPLPTYPFQ
RKPYWLRSSAPAPASHDLAYRVSWTPITPPGDGVLDGDWLVVHPGGSTGWVDGLAAAITA
GGGRVVAHPVDSVTSRTGLAEALARRDGTFRGVLSWVATDERHVEAGAVALLTLAQALGD
AGIDAPLWCLTQEAVRTPVDGDLARPAQAALHGFAQVARLELARRFGGVLDLPATVDAAG
TRLVAAVLAGGGEDVVAVRGDRLYGRRLVRATLPPPGGGFTPHGTVLVTGAAGPVGGRLA
RWLAERGATRLVLPGAHPGEELLTAIRAAGATAVVCEPEAEALRTAIGGELPTALVHAET
LTNFAGVADADPEDFAATVAAKTALPTVLAEVLGDHRLEREVYCSSVAGVWGGVGMAAYA
AGSAYLDALVEHRRARGHASASVAWTPWALPGAVDDGRLRERGLRSLDVADALGTWERLL
RAGAVSVAVADVDWSVFTEGFAAIRPTPLFDELLDRRGDPDGAPVDRPGEPAGEWGRRIA
ALSPQEQRETLLTLVGETVAEVLGHETGTEINTRRAFSELGLDSLGSMALRQRLAARTGL
RMPASLVFDHPTVTALARYLRRLVVGDSDPTPVRVFGPTDEAEPVAVVGIGCRFPGGIAT
PEDLWRVVSEGTSITTGFPTDRGWDLRRLYHPDPDHPGTSYVDRGGFLDGAPDFDPGFFG
ITPREALAMDPQQRLTLEIAWEAVERAGIDPETLLGSDTGVFVGMNGQSYLQLLTGEGDR
LNGYQGLGNSASVLSGRVAYTFGWEGPALTVDTACSSSLVAIHLAMQSLRRGECSLALAG
GVTVMADPYTFVDFSAQRGLAADGRCKAFSAQADGFALAEGVAALVLEPLSKARRNGHQV
LAVLRGSAVNQDGASNGLAAPNGPSQERVIRQALTASGLRPADVDMVEAHGTGTELGDPI
EAGALIAAYGRDRDRPLWLGSVKTNIGHTQAAAGAAGVIKAVLAMRHGVLPRSLHADELS
PHIDWADGKVEVLREARQWPPGERPRRAGVSSFGVSGTNAHVIVEEAPAEPDPEPVPAAP
GGPLPFVLHGRSVQTVRSQARTLAEHLRTTGHRDLADTARTLATGRARFDVRAAVLGTDR
EGVCAALDALAQDRPSPDVVAPAVFAARTPVLVFPGQGSQWVGMARDLLDSSEVFAESMG
RCAEALSPYTDWDLLDVVRGVGDPDPYDRVDVLQPVLFAVMVSLARLWQSYGVTPGAVVG
HSQGEIAAAHVAGALSLADAARVVALRSRVLRELDDQGGMVSVGTSRAELDSVLRRWDGR
VAVAAVNGPGTLVVAGPTAELDEFLAVAEAREMRPRRIAVRYASHSPEVARVEQRLAAEL
GTVTAVGGTVPLYSTATGDLLDTTAMDAGYWYRNLRQPVLFEHAVRSLLERGFETFIEVS
PHPVLLMAVEETAEDAERPVTGVPTLRRDHDGPSEFLRNLLGAHVHGVDVDLRPAVAHGR
LVDLPTYPFDRQRLWPKPHRRADTSSLGVRDSTHPLLHAAVDVPGHGGAVFTGRLSPDEQ
QWLTQHVVGGRNLVPGSVLVDLALTAGADVGVPVLEELVLQQPLVLTAAGALLRLSVGAA
DEDGRRPVEIHAAEDVSDPAEARWSAYATGTLAVGVAGGGRDGTQWPPPGATALTLTDHY
DTLAELGYEYGPAFQALRAAWQHGDVVYAEVSLDAVEEGYAFDPVLLDAVAQTFGLTSRA
PGKLPFAWRGVTLHATGATAVRVVATPAGPDAVALRVTDPTGQLVATVDALVVRDAGADR
DQPRGRDGDLHRLEWVRLATPDPTPAAVVHVAADGLDDLLRAGGPAPQAVVVRYRPDGDD
PTAEARHGVLWAATLVRRWLDDDRWPATTLVVATSAGVEVSPGDDVPRPGAAAVWGVLRC
AQAESPDRFVLVDGDPETPPAVPDNPQLAVRDGAVFVPRLTPLAGPVPAVADRAYRLVPG
NGGSIEAVAFAPVPDADRPLAPEEVRVAVRATGVNFRDVLLALGMYPEPAEMGTEASGVV
TEVGSGVRRFTPGQAVTGLFQGAFGPVAVADHRLLTPVPDGWRAVDAAAVPIAFTTAHYA
LHDLAGLQAGQSVLVHAAAGGVGMAAVALARRAGAEVFATASPAKHPTLRALGLDDDHIA
SSRESGFGERFAARTGGRGVDVVLNSLTGDLLDESARLLADGGVFVEMGKTDLRPAEQFR
GRYVPFDLAEAGPDRLGEILEEVVGLLAAGALDRLPVSVWELSAAPAALTHMSRGRHVGK
LVLTQPAPVHPDGTVLVTGGTGTLGRLVARHLVTGHGVPHLLVASRRGPAAPGAAELRAD
VEGLGATIEIVACDTADREALAALLDSIPADRPLTGVVHTAGVLADGLVTSIDGTATDQV
LRAKVDAAWHLHDLTRDADLSFFVLFSSAASVLAGPGQGVYAAANGVLNALAGQRRALGL
PAKALGWGLWAQASEMTSGLGDRIARTGVAALPTERALALFDAALRSGGEVLFPLSVDRS
ALRRAEYVPEVLRGAVRSTPRAANRAETPGRGLLDRLVGAPETDQVAALAELVRSHAAAV
AGYDSADQLPERKAFKDLGFDSLAAVELRNRLGVTTGVRLPSTLVFDHPTPLAVAEHLRS
ELFADSAPDVGVGARLDDLERALDALPDAQGHADVGARLEALLRRWQSRRPPETEPVTIS
DDASDDELFSMLDRRLGGGGDV

>polyketide synthase [megalomicin 6-deoxyerythronolide B synthase 2]
GTGACTGACAACGACAAGGTGGCGGAGTACCTCCGTCGTGCGACGCTCGACCTGCGGGCC
GCCCGCAAGCGCCTGCGCGAGCTGCAATCCGACCCGATCGCGGTCGTCGGCATGGCCTGC
CGCCTACCGGGCGGGGTGCACCTCCCGCAGCACCTGTGGGACCTCCTGCGCCAGGGGCAC
GAGACGGTGTCCACCTTCCCCACCGGGCGCGGCTGGGACCTGGCCGGGCTCTTCCACCCG
GACCCCGACCACCCCGGCACCAGCTACGTCGACCGGGGTGGGTTCCTCGACGACGTGGCG
GGCTTCGACGCCGAGTTCTTCGGGATCTCCCCGCGCGAGGCCACGGCCATGGACCCGCAA
CAGCGGCTGCTGTTGGAGACCAGTTGGGAGCTGGTGGAGAGCGCCGGCATCGATCCGCAC
TCCCTGCGTGGCACCCCGACCGGCGTCTTCCTCGGCGTGGCGCGGCTCGGCTACGGCGAG
AACGGCACCGAAGCCGGTGACGCCGAGGGCTATTCGGTGACCGGGGTGGCACCCGCTGTC
GCCTCCGGGCGGATCTCCTACGCCCTCGGGCTGGAGGGTCCGTCGATCAGCGTGGACACC
GCGTGCTCGTCGTCGTTGGTGGCGCTGCACCTGGCGGTCGAGTCGCTGCGGCTGGGCGAG
TCGAGTCTCGCTGTCGTCGGCGGGGCGGCGGTCATGGCGACACCAGGGGTGTTCGTCGAC
TTCAGCCGCCAGCGGGCGTTGGCCGCTGACGGCAGGTCGAAGGCCTTCGGGGCCGCCGCC
GACGGGTTCGGCTTCTCCGAGGGGGTCTCCCTCGTCCTGCTCGAACGGCTCTCCGAGGCC
GAAAGCAACGGCCACGAGGTGTTGGCTGTCATCCGTGGCTCCGCCCTCAACCAGGACGGG
GCCAGCAACGGTCTCGCCGCGCCGAACGGGACCGCCCAGCGCAAGGTGATCCGGCAGGCG
CTACGAAACTGCGGCCTGACCCCGGCCGACGTGGACGCCGTGGAGGCGCACGGCACCGGC
ACCACGCTCGGCGACCCGATCGAGGCCAACGCCCTGCTGGACACCTACGGCCGTGACCGG
GATCCGGACCACCCGCTGTGGCTGGGGTCGGTGAAGTCGAACATCGGCCACACGCAGGCG
GCGGCGGGCGTCACCGGGCTGCTCAAGATGGTGCTGGCACTGCGCCACGAGGAACTGCCC
GCCACCCTGCACGTCGACGAGCCCACCCCGCACGTGGACTGGTCCTCGGGAGCGGTACGC
CTGGCGACCCGGGGCCGGCCGTGGCGGCGGGGTGACCGGCCGAGGCGGGCCGGGGTGTCG
GCGTTCGGCATCAGCGGGACCAACGCCCACGTGATCGTCGAGGAGGCACCCGAGCGGACC
ACCGAGCGCACCGTCGGCGGCGACGTCGGCCCGGTCCCGCTCGTGGTGTCCGCCCGGTCG
GCGGCGGCGCTACGGGCCCAGGCGGCCCAGGTCGCCGAGCTGGTGGAGGGCTCCGACGTC
GGGCTGGCGGAGGTCGGGCGGAGCCTGGCCGTGACCCGGGCGCGACACGAGCACCGGGCG
GCGGTGGTGGCGTCGACCCGGGCCGAGGCGGTGCGGGGGCTGCGCGAGGTCGCGGCGGTC
GAACCGCGCGGCGAGGACACCGTCACCGGGGTCGCCGAGACGTCCGGGCGCACCGTCGTC
TTCCTCTTCCCGGGACAGGGGTCCCAGTGGGTCGGGATGGGCGCGGAGCTGCTGGACTCG
GCACCGGCGTTCGCCGACACGATCCGCGCCTGCGACGAGGCGATGGCACCGTTGCAGGAC
TGGTCGGTCTCCGACGTGCTCCGGCAGGAGCCGGGGGCACCGGGACTGGACCGGGTCGAC
GTGGTGCAGCCGGTGCTGTTCGCGGTGATGGTGTCGTTGGCGCGGTTGTGGCAGTCGTAC
GGGGTCACCCCCGCTGCGGTGGTGGGGCACTCGCAGGGGGAGATCGCCGCCGCCCACGTG
GCGGGTGCGCTCTCCCTCGCCGACGCGGCGAGGCTGGTGGTGGGCCGCAGCCGGTTGCTG
CGGTCGCTGTCCGGGGGCGGCGGCATGAGCGCCGTCGCGCTCGGTGAGGCCGAGGTACGC
CGCCGACTGCGGTCGTGGGAGGACCGGATCTCCGTGGCCGCCGTCAACGGACCCCGGTCG
GTGGTGGTGGCCGGGGAACCGGAGGCGCTGCGGGAGTGGGGACGGGAGCGGGAGGCCGAG
GGCGTACGGGTCCGCGAGATCGACGTCGACTACGCCTCGCACTCGCCGCAGATCGACAGG
GTCCGTGACGAACTCCTGACGGTCACGGGGGAGATCGAGCCCCGGTCGGCGGAGATCACC
TTCTACTCGACGGTCGACGTCCGTGCTGTCGACGGCACCGACCTGGACGCGGGGTACTGG
TACCGCAACCTGCGGGAGACGGTCCGGTTCGCCGACGCGATGACCCGGTTGGCCGACTCG
GGATACGACGCGTTCGTCGAGGTCAGCCCGCATCCGGTGGTGGTGTCGGCGGTCGCCGAG
GCGGTCGAGGAGGCAGGTGTCGAGGACGCCGTCGTCGTCGGCACCCTGTCCCGGGGCGAC
GGCGGACCGGGGGCGTTCCTGCGGTCGGCGGCCACCGCCCACTGCGCCGGTGTGGACGTC
GACTGGACGCCCGCCCTCCCGGGAGCTGCGACGATCCCGTTGCCGACGTACCCGTTCCAA
CGGAAGCCGTACTGGCTGCGGTCGTCTGCTCCCGCCCCCGCCTCCCACGATCTCGCCTAC
CGGGTGTCCTGGACGCCGATCACCCCGCCCGGGGACGGCGTACTCGACGGCGACTGGCTG
GTGGTGCACCCCGGGGGCAGCACCGGATGGGTCGACGGGTTGGCGGCGGCGATCACCGCC
GGCGGTGGCCGGGTCGTCGCCCACCCGGTGGACTCCGTGACCTCCCGGACCGGCCTGGCC
GAGGCGCTCGCCCGGCGGGACGGCACGTTCCGGGGGGTGCTGTCGTGGGTGGCGACCGAC
GAACGGCACGTCGAGGCCGGTGCGGTCGCCCTGCTGACCCTGGCGCAGGCGTTGGGTGAC
GCCGGAATCGACGCACCACTGTGGTGCCTGACCCAGGAGGCGGTCCGTACCCCCGTCGAC
GGTGACCTGGCCCGACCGGCGCAGGCCGCCCTGCACGGTTTCGCCCAGGTCGCCCGGCTG
GAGCTGGCCCGCCGCTTCGGTGGGGTGCTCGACCTGCCCGCCACCGTCGACGCCGCCGGG
ACGCGTCTGGTCGCGGCGGTCCTCGCCGGCGGCGGCGAGGACGTCGTCGCCGTCCGTGGC
GACCGTCTCTACGGCCGTCGCCTGGTCAGGGCGACCCTGCCGCCGCCCGGCGGGGGGTTC
ACCCCGCACGGCACCGTCCTGGTCACCGGCGCGGCCGGTCCGGTGGGCGGTCGGCTGGCC
CGGTGGCTCGCCGAACGGGGTGCCACCCGACTCGTCCTGCCCGGCGCACACCCGGGCGAG
GAGTTGCTGACCGCGATCCGGGCCGCCGGTGCCACCGCCGTGGTGTGCGAACCGGAGGCG
GAGGCACTGCGTACGGCGATCGGCGGGGAGTTGCCGACCGCGCTCGTACACGCCGAGACG
TTGACGAACTTCGCCGGCGTCGCCGACGCCGACCCCGAGGACTTCGCCGCCACCGTCGCG
GCGAAGACCGCGCTGCCGACGGTCCTGGCGGAGGTGCTCGGCGACCACCGCCTCGAACGG
GAGGTCTACTGCTCGTCGGTGGCCGGGGTCTGGGGTGGGGTCGGCATGGCCGCGTACGCC
GCCGGCAGCGCCTACCTCGACGCCCTGGTCGAGCACCGTCGCGCCCGGGGGCACGCCAGC
GCCTCGGTGGCCTGGACCCCGTGGGCCCTGCCCGGCGCGGTCGACGACGGTCGGCTGCGC
GAGCGCGGCCTGCGCAGCCTCGACGTGGCCGACGCCCTCGGGACGTGGGAACGTCTGCTC
CGCGCCGGTGCGGTGTCGGTGGCCGTCGCCGACGTCGACTGGTCGGTCTTCACAGAGGGT
TTCGCGGCCATCCGGCCGACCCCGCTCTTCGACGAACTCCTCGACCGGCGCGGGGACCCC
GACGGCGCGCCCGTCGACCGGCCGGGGGAGCCGGCGGGCGAGTGGGGTCGACGAATCGCG
GCGCTGTCCCCGCAGGAACAGCGGGAGACGTTGCTGACCCTCGTCGGCGAGACGGTCGCG
GAGGTGCTGGGACACGAGACCGGCACCGAGATCAACACCCGTCGGGCCTTCAGCGAACTC
GGCCTCGACTCGCTGGGCTCGATGGCCCTGCGTCAGCGCCTGGCGGCCCGTACCGGCCTG
CGGATGCCGGCCTCGCTGGTCTTCGACCACCCGACGGTCACCGCGCTCGCGCGGTACCTG
CGTCGACTGGTCGTCGGGGACTCCGACCCGACCCCGGTACGGGTGTTCGGCCCCACCGAC
GAGGCCGAACCCGTCGCCGTGGTCGGCATCGGCTGCCGGTTCCCCGGCGGCATCGCCACC
CCCGAGGACCTCTGGCGGGTGGTGTCCGAGGGCACCTCCATCACCACCGGATTCCCCACC
GACCGGGGCTGGGACCTCCGGCGGCTCTACCACCCCGACCCGGACCACCCCGGCACCAGC
TACGTCGACAGGGGGGGATTCCTCGACGGGGCCCCGGACTTCGACCCCGGGTTCTTCGGG
ATCACCCCCCGCGAGGCGCTGGCGATGGACCCGCAGCAGCGGCTCACCCTGGAGATCGCG
TGGGAGGCGGTGGAACGGGCGGGCATCGACCCGGAGACCCTCCTCGGCAGCGACACCGGC
GTCTTCGTCGGCATGAACGGCCAGTCCTACCTGCAACTGCTGACCGGGGAGGGTGACCGG
CTCAACGGCTACCAGGGGTTGGGCAACTCGGCGAGCGTGCTCTCCGGCCGTGTCGCCTAC
ACCTTCGGGTGGGAGGGGCCGGCGCTGACGGTGGACACCGCCTGCTCGTCCTCGCTGGTC
GCCATCCACCTCGCCATGCAGTCGCTGCGTCGGGGTGAGTGCTCGCTGGCGTTGGCCGGC
GGGGTGACGGTCATGGCCGACCCGTACACCTTCGTGGACTTCAGCGCACAGCGGGGGCTC
GCCGCCGACGGGCGGTGCAAGGCGTTCTCCGCGCAGGCCGACGGGTTCGCCCTCGCCGAG
GGCGTCGCGGCGCTCGTCCTCGAACCGTTGTCCAAGGCGCGGCGAAACGGCCACCAGGTG
CTGGCGGTGCTGCGCGGCAGCGCCGTCAACCAGGACGGGGCCAGCAACGGCCTCGCCGCC
CCGAACGGGCCGTCGCAGGAACGGGTGATCAGGCAGGCCCTGACCGCCTCCGGGCTGCGT
CCCGCCGACGTCGACATGGTGGAGGCGCACGGGACGGGCACCGAACTCGGCGACCCGATC
GAGGCCGGGGCGCTCATCGCGGCGTACGGCCGGGACCGGGACCGGCCGCTCTGGCTGGGC
TCGGTGAAGACGAACATCGGCCACACCCAGGCCGCCGCCGGTGCCGCCGGGGTGATCAAG
GCGGTCCTGGCGATGCGGCACGGCGTACTCCCGAGGTCGCTGCACGCCGACGAGTTGTCC
CCGCACATCGACTGGGCGGACGGGAAGGTCGAGGTGCTCCGCGAGGCACGACAGTGGCCC
CCCGGTGAGCGCCCCCGCCGCGCCGGGGTGTCCTCCTTCGGCGTCAGCGGGACCAACGCC
CACGTCATCGTCGAGGAGGCACCCGCCGAACCGGACCCCGAACCGGTTCCCGCCGCCCCG
GGCGGGCCCCTGCCCTTCGTCCTGCACGGACGCAGCGTCCAGACGGTCCGGTCCCAGGCG
CGGACCCTCGCCGAACACCTGCGCACCACCGGCCACCGGGACCTCGCCGACACCGCCCGT
ACCCTGGCCACCGGTCGCGCCCGTTTCGACGTCCGGGCCGCAGTGCTCGGCACCGACCGG
GAGGGTGTCTGCGCCGCCCTCGACGCGCTGGCGCAGGATCGCCCCTCGCCCGACGTCGTC
GCCCCGGCGGTCTTCGCCGCCCGTACCCCCGTCCTGGTCTTCCCCGGGCAGGGGTCGCAG
TGGGTCGGCATGGCCCGTGACCTGCTCGACTCCTCCGAGGTGTTCGCCGAGTCGATGGGC
CGGTGCGCCGAGGCGCTGTCGCCGTACACCGACTGGGACCTGCTCGACGTGGTCCGTGGG
GTCGGCGACCCCGACCCGTACGACCGGGTGGACGTGCTCCAGCCGGTGCTGTTCGCGGTG
ATGGTGTCGCTGGCGCGGTTGTGGCAGTCGTACGGGGTGACTCCGGGTGCGGTGGTGGGT
CACTCGCAGGGGGAGATCGCCGCCGCGCACGTGGCTGGTGCGTTGTCGTTGGCCGACGCC
GCCAGGGTGGTGGCGTTGCGCAGCCGGGTGCTGCGGGAGCTCGACGACCAGGGCGGCATG
GTGTCGGTCGGCACCTCCCGCGCCGAGTTGGACTCGGTCCTGCGCCGGTGGGACGGGCGG
GTCGCGGTGGCGGCGGTGAACGGACCCGGCACGCTCGTGGTGGCCGGACCCACCGCCGAA
CTGGACGAGTTCCTCGCGGTGGCCGAGGCCCGCGAGATGAGGCCGCGTCGGATCGCGGTG
CGCTACGCGTCGCACTCCCCGGAGGTGGCCCGGGTCGAACAGCGGCTCGCCGCCGAACTC
GGCACCGTCACCGCCGTCGGCGGCACGGTCCCGCTCTACTCCACCGCCACCGGGGACCTC
CTCGACACCACAGCCATGGACGCCGGGTACTGGTACCGCAACCTGCGCCAACCGGTGCTG
TTCGAGCACGCCGTCCGCAGCCTCCTGGAGCGGGGATTCGAGACGTTCATCGAGGTCAGC
CCGCACCCTGTGCTGCTGATGGCGGTCGAGGAGACCGCCGAGGACGCCGAGCGCCCGGTC
ACCGGCGTGCCGACGCTGCGCCGCGACCACGACGGGCCGTCGGAGTTCCTCCGCAACCTC
CTGGGGGCGCACGTGCACGGGGTCGACGTCGACCTGCGTCCGGCGGTCGCCCACGGCCGC
CTGGTCGACCTGCCCACCTACCCCTTCGACAGGCAGCGGCTCTGGCCCAAGCCGCACCGC
AGGGCCGACACCTCGTCGCTGGGGGTCCGTGACTCGACCCACCCGCTGCTGCACGCCGCA
GTCGACGTACCCGGTCACGGCGGAGCGGTGTTCACCGGGCGGCTCTCCCCCGACGAGCAG
CAGTGGCTGACCCAGCACGTGGTGGGTGGGCGGAACCTGGTGCCCGGCAGTGTCCTGGTC
GACCTCGCGCTCACCGCCGGGGCCGACGTCGGCGTGCCGGTGCTGGAGGAACTCGTCCTG
CAGCAGCCGCTGGTGTTGACCGCCGCCGGTGCGTTGCTGCGCCTGTCGGTCGGCGCCGCC
GACGAGGACGGGCGGCGGCCGGTCGAGATCCACGCCGCCGAGGACGTCTCCGACCCGGCC
GAGGCCCGGTGGTCGGCGTACGCGACCGGGACCCTCGCCGTCGGCGTGGCCGGCGGCGGC
CGGGACGGCACACAGTGGCCCCCGCCCGGCGCCACCGCCCTGACGTTGACCGACCACTAC
GACACCCTCGCCGAACTGGGCTACGAGTACGGGCCGGCGTTCCAGGCGCTGCGCGCCGCG
TGGCAGCACGGCGACGTGGTCTACGCGGAGGTGTCCCTCGACGCCGTCGAGGAGGGGTAC
GCGTTCGACCCGGTGCTGCTCGACGCCGTCGCCCAGACCTTCGGCCTGACCAGTCGCGCC
CCCGGGAAGCTCCCCTTCGCCTGGCGGGGCGTCACCCTGCACGCCACCGGGGCCACTGCG
GTACGGGTGGTGGCGACCCCCGCCGGACCGGACGCGGTGGCCCTGCGGGTCACCGACCCG
ACCGGTCAGCTCGTCGCCACGGTGGACGCCCTGGTCGTCAGGGACGCCGGGGCGGATCGG
GACCAGCCGCGCGGCCGCGACGGCGACCTGCACCGCCTGGAGTGGGTACGGCTGGCCACC
CCGGACCCGACCCCGGCGGCGGTGGTGCACGTGGCGGCCGACGGGCTCGACGACCTGCTG
CGCGCCGGTGGTCCGGCACCACAGGCCGTCGTCGTCCGCTACCGTCCCGACGGCGACGAC
CCGACGGCCGAGGCCCGTCACGGGGTGCTCTGGGCGGCCACGCTCGTGCGCCGTTGGCTC
GACGACGACCGGTGGCCCGCCACCACCCTGGTGGTGGCCACGTCCGCAGGGGTCGAGGTC
TCCCCCGGGGACGACGTGCCGCGCCCCGGGGCCGCCGCCGTGTGGGGGGTGCTGCGCTGC
GCCCAGGCGGAGTCCCCGGACCGCTTCGTGCTCGTCGACGGCGACCCGGAGACGCCCCCG
GCGGTGCCGGACAATCCGCAGCTCGCGGTCCGTGACGGTGCGGTGTTCGTGCCACGGCTG
ACGCCGCTCGCCGGTCCCGTGCCGGCCGTCGCCGACCGGGCGTACCGGCTGGTGCCCGGC
AACGGCGGCTCCATCGAGGCAGTGGCCTTCGCCCCCGTCCCCGACGCCGACCGGCCCCTG
GCGCCGGAGGAGGTACGCGTCGCCGTCCGCGCCACCGGCGTGAACTTCCGTGACGTCCTG
CTCGCGCTCGGCATGTACCCGGAACCGGCCGAGATGGGCACCGAGGCGTCCGGTGTGGTC
ACCGAGGTCGGGTCGGGTGTCCGGCGGTTCACCCCCGGCCAGGCGGTGACGGGCCTGTTC
CAGGGGGCCTTCGGGCCGGTGGCGGTCGCCGACCACCGGCTCCTCACCCCGGTCCCCGAC
GGGTGGCGGGCGGTGGACGCCGCAGCCGTACCCATCGCGTTCACCACCGCCCACTACGCG
CTGCACGACCTGGCCGGGTTGCAGGCCGGGCAGTCCGTGCTGGTCCACGCCGCCGCCGGC
GGGGTGGGGATGGCTGCCGTCGCGTTGGCCCGTCGGGCCGGGGCGGAGGTGTTCGCCACG
GCCAGCCCGGCCAAACACCCGACGCTGCGGGCGCTCGGCCTCGACGACGACCACATCGCC
TCGTCCCGGGAGAGCGGGTTCGGTGAGCGGTTCGCCGCGCGTACCGGGGGGCGGGGCGTC
GACGTGGTCCTGAACTCGCTCACCGGCGACCTGCTCGACGAGTCCGCGCGGCTGCTCGCC
GACGGCGGGGTCTTCGTCGAGATGGGCAAGACCGACCTGCGGCCGGCGGAGCAGTTCCGG
GGCCGGTACGTCCCGTTCGACCTGGCCGAGGCCGGTCCCGATCGGCTCGGCGAGATCCTG
GAGGAGGTCGTCGGTCTGCTGGCCGCCGGTGCCCTCGACCGGTTGCCGGTGTCGGTGTGG
GAGTTGTCGGCGGCCCCGGCCGCGCTCACCCACATGAGCCGGGGCCGACACGTGGGCAAG
CTCGTCCTCACCCAGCCCGCCCCCGTGCACCCCGACGGAACGGTGCTGGTCACCGGCGGG
ACCGGCACCCTGGGGCGGCTGGTCGCCCGCCACCTGGTGACCGGGCACGGCGTACCCCAC
CTCCTGGTGGCCAGCCGGCGCGGTCCGGCGGCCCCGGGCGCGGCCGAGCTGCGCGCCGAC
GTCGAAGGCCTCGGCGCGACCATCGAGATCGTCGCCTGCGACACCGCCGACCGGGAGGCG
CTCGCGGCGCTGCTCGACTCGATCCCCGCGGACCGTCCGCTGACCGGGGTGGTGCACACC
GCCGGGGTCCTGGCCGACGGGCTGGTCACCTCCATCGACGGGACCGCCACCGATCAGGTC
CTGCGGGCCAAGGTCGACGCGGCGTGGCACCTGCACGACCTGACCCGGGACGCGGACCTG
AGCTTCTTCGTGCTGTTCTCGTCGGCGGCGTCGGTGCTGGCCGGTCCCGGGCAGGGCGTG
TACGCGGCGGCCAACGGGGTCCTCAACGCCCTGGCCGGGCAACGGCGGGCCCTCGGACTG
CCCGCGAAGGCGCTCGGGTGGGGCCTGTGGGCGCAGGCCAGCGAGATGACCAGCGGCCTC
GGTGACCGGATCGCCCGTACCGGGGTCGCCGCGCTGCCGACCGAGCGGGCGCTGGCCCTG
TTCGACGCGGCTCTGCGCAGCGGCGGGGAGGTGCTGTTCCCGCTGTCTGTCGACAGGTCG
GCGCTGCGCCGGGCCGAGTACGTCCCCGAGGTGCTGCGCGGCGCGGTCCGGTCCACGCCA
CGGGCCGCCAACAGGGCCGAGACCCCGGGCCGGGGCCTGCTCGACCGTCTCGTCGGTGCA
CCCGAGACCGATCAGGTGGCCGCGCTGGCCGAGCTGGTCCGCTCGCACGCGGCGGCGGTC
GCCGGCTACGACTCGGCCGACCAGCTGCCCGAACGCAAGGCGTTCAAGGACCTCGGGTTC
GACTCGCTGGCGGCGGTGGAGCTGCGCAACCGGCTCGGCGTCACCACCGGCGTACGGCTG
CCCAGCACGCTGGTGTTCGACCACCCGACACCGCTGGCGGTGGCCGAACACCTGCGGTCG
GAGTTGTTCGCCGACTCCGCGCCGGACGTCGGGGTCGGTGCGCGCCTCGACGACCTGGAA
CGGGCGCTCGACGCCCTGCCCGACGCGCAGGGACACGCCGACGTCGGGGCCCGCCTGGAG
GCGCTGCTGCGCCGGTGGCAGAGCCGACGACCCCCGGAGACCGAGCCAGTGACGATCAGT
GACGACGCCAGTGACGACGAGCTGTTCTCGATGCTCGACAGGCGTCTCGGCGGGGGAGGG
GACGTCTAG

[3] KS	31..406

[3] AT	560..880

[3] methylmalonyl-CoA	751..755

[3] kr	1124..1291

[3] ACP	1391..1461

[4] KS	1483..1856

[4] AT	2011..2330

[4] methylmalonyl-CoA	2202..2206

[4] DH	2374..2537

[4] ER	2823..3123

[4] KR	3133..3313

[4] ACP	3409..3479

[3] KS	91..1218

[3] AT	1678..2640

[3] methylmalonyl-CoA	2251..2265

[3] kr	3370..3873

[3] ACP	4171..4383

[4] KS	4447..5568

[4] AT	6031..6990

[4] methylmalonyl-CoA	6604..6618

[4] DH	7120..7611

[4] ER	8467..9369

[4] KR	9397..9939

[4] ACP	10225..10437

Feature

BLASTP Database:UniProtKB:2011_09	show BLAST table
InterPro Database:interpro:38.0	IPR001227 Acyl transferase domain (Domain) G3DSA:3.40.366.10 Ac_transferase_reg IPR002198 Short-chain dehydrogenase/reductase SDR (Family) PF00106 adh_short IPR006162 Phosphopantetheine attachment site (PTM) PS00012 PHOSPHOPANTETHEINE IPR009081 Acyl carrier protein-like (Domain) SSF47336 ACP_like PS50075 ACP_DOMAIN G3DSA:1.10.1200.10 ACP_like PF00550 PP-binding IPR011032 GroES-like (Domain) SSF50129 GroES_like IPR013149 Alcohol dehydrogenase, C-terminal (Domain) PF00107 ADH_zinc_N IPR013154 Alcohol dehydrogenase GroES-like (Domain) PF08240 ADH_N IPR013968 Polyketide synthase, KR (Domain) PF08659 KR IPR014030 Beta-ketoacyl synthase, N-terminal (Domain) PF00109 ketoacyl-synt IPR014031 Beta-ketoacyl synthase, C-terminal (Domain) PF02801 Ketoacyl-synt_C IPR014043 Acyl transferase (Domain) PF00698 Acyl_transf_1 IPR015083 Polyketide synthase, docking (Domain) PF08990 Docking IPR015357 Erythronolide synthase, docking (Domain) PF09277 Erythro-docking SSF101166 Erythronolide_synth_docking IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain) SSF52151 Acyl_Trfase/lysoPlipase IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain) SSF55048 Malonyl_transacylase_ACP-bd IPR016038 Thiolase-like, subgroup (Domain) G3DSA:3.40.47.10 Thiolase-like_subgr IPR016039 Thiolase-like (Domain) SSF53901 Thiolase-like IPR016040 NAD(P)-binding domain (Domain) G3DSA:3.40.50.720 NAD(P)-bd IPR018201 Beta-ketoacyl synthase, active site (Active_site) PS00606 B_KETOACYL_SYNTHASE IPR020801 Polyketide synthase, acyl transferase domain (Domain) SM00827 PKS_AT IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain) SM00823 PKS_PP IPR020807 Polyketide synthase, dehydratase domain (Domain) SM00826 PKS_DH IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain) SM00825 PKS_KS IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain) SM00822 PKS_KR IPR020843 Polyketide synthase, enoylreductase (Domain) SM00829 PKS_ER
SignalP	No significant hit
TMHMM	No significant hit

Megalo_00120 Megalo_00140