Monen_00030 : CDS information

Location

Organism	Streptomyces cinnamonensis
Strain	ATCC 15413
Entry name	Monensin
Contig	AF440781
Start / Stop / Direction	2,211 / 3,152 / + [in whole cluster] 2,211 / 3,152 / + [in contig]
Location	2211..3152 [in whole cluster] 2211..3152 [in contig]
Type	CDS
Length	942 bp (313 aa)

Annotation

Category	4.1 transcriptional regulator
Product	putative LysR family transcriptional regulator
Product (GenBank)	hypothetical DNA binding protein
Gene
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)	SCN_3
Reference	ACC Q846Y8 PmId [12940979] Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. (Mol Microbiol. , 2003) comment monensin生合成 gene clusterの解析論文。 ORF3: Transcriptional regulator clusterの両脇に見られた一次代謝関連酵素のひとつ。本文中に詳細記載なし。
Family/Domain	FD IPR000847, IPR005119 comment [IPR000847] HTH transcriptional regulator, LysR (Domain) [IPR005119] LysR, substrate-binding (Domain)

Sequence

>putative LysR family transcriptional regulator [hypothetical DNA binding protein]
MLDVRRLHLLRELDRRGTIAAVAEALTFTASAVSQQLGVLEREAGVPLLERSGRRVVLTP
AGRSLVAHADAVLNRLEQAVAELAGARDGIGGPLRIGTFPSGGHTIVPGALAELASRHPA
LEPMVREIDSARVSDGLRAGELDVALVHDYDFVPATPDTTVDEVPLLEEPMYLVTHAADT
ATDSGSGSTLAALLGPCAEVPWITARDGTTGHAMAVRACQAAGFQPRIRHQVNDFRTVLA
LVAAGQGAGFVPRMAAEPSPAGVVLTKLPLFRRSKVAFRAGGGAHPAIAAFVAAATTAVE
RMAGSRGPAGGSE

>putative LysR family transcriptional regulator [hypothetical DNA binding protein]
ATGCTCGATGTCCGTCGCCTCCATCTGCTCCGCGAACTCGACCGGCGGGGCACCATCGCC
GCCGTGGCCGAAGCGCTGACCTTCACCGCGTCCGCCGTCTCCCAGCAGCTCGGCGTGCTG
GAGAGGGAGGCGGGCGTGCCGCTGTTGGAACGCAGCGGCAGGCGCGTGGTCCTCACGCCC
GCAGGACGCTCCCTCGTCGCACACGCCGACGCGGTGCTGAACCGTCTCGAACAGGCGGTC
GCCGAGCTGGCGGGCGCACGGGACGGCATCGGCGGGCCGCTGCGCATCGGGACGTTCCCT
TCCGGCGGCCACACCATCGTCCCCGGCGCGCTGGCCGAACTGGCCTCTCGTCACCCCGCG
TTGGAGCCGATGGTGCGGGAGATCGACTCCGCGCGCGTCTCCGACGGTCTGCGGGCCGGT
GAGCTGGACGTGGCCCTCGTACACGACTACGACTTCGTACCCGCGACGCCGGACACGACC
GTGGACGAGGTGCCTCTGCTCGAAGAGCCGATGTACCTCGTCACCCATGCCGCGGACACT
GCCACGGACTCCGGCTCCGGGAGCACACTGGCAGCGCTGCTCGGGCCCTGTGCCGAGGTT
CCGTGGATCACGGCGCGGGACGGCACGACCGGTCACGCGATGGCTGTACGCGCCTGTCAG
GCCGCCGGGTTCCAGCCCAGGATCCGCCACCAGGTCAACGACTTCCGCACGGTGCTGGCT
CTGGTCGCCGCCGGGCAGGGGGCCGGGTTCGTGCCGCGGATGGCCGCCGAGCCGAGCCCC
GCGGGCGTGGTGCTCACGAAGCTGCCGCTGTTCCGTCGCTCGAAGGTCGCGTTCCGTGCG
GGCGGCGGTGCCCATCCGGCGATCGCCGCTTTCGTGGCCGCGGCGACGACGGCGGTCGAA
CGCATGGCGGGTTCACGAGGCCCGGCCGGCGGCTCTGAGTGA

Feature

BLASTP Database:UniProtKB:2011_09	show BLAST table
InterPro Database:interpro:38.0	IPR000847 Transcription regulator HTH, LysR (Domain) PF00126 HTH_1 PS50931 HTH_LYSR IPR005119 LysR, substrate-binding (Domain) PF03466 LysR_substrate IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain) G3DSA:1.10.10.10 Wing_hlx_DNA_bd
SignalP	Bacteria, Gram-negative
TMHMM	No significant hit

Monen_00020 Monen_00040