Monen_00190 Monen_00190   Monen_00210 Monen_00210

Monen_00200 : CDS information

close this sectionLocation

Organism
StrainATCC 15413
Entry nameMonensin
Contig
Start / Stop / Direction66,952 / 72,054 / + [in whole cluster]
66,952 / 72,054 / + [in contig]
Location66952..72054 [in whole cluster]
66952..72054 [in contig]
TypeCDS
Length5,103 bp (1,700 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)monensin polyketide synthase module 9
Gene
Gene (GenBank)monAVI
EC number
Keyword
Note
Note (GenBank)
  • MonAVI
Reference
ACC
PmId
[12940979] Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization. (Mol Microbiol. , 2003)
comment
monensin生合成 gene clusterの解析論文。

MonAVI: Polyketide synthase
module9(KS, AT, dh, KR, ACP)

close this sectionPKS/NRPS Module

9 malonyl-CoA
KS41..416
AT582..903
dh
KR1264..1433
ACP1541..1611

close this sectionSequence

selected fasta
>polyketide synthase [monensin polyketide synthase module 9]
MPGTNDMPGTEDKLRHYLKRVTADLGQTRQRLRDVEERQREPIAIVAMACRYPGGVASPE
QLWDLVASRGDAIEEFPADRGWDVAGLYHPDPDHPGTTYVREAGFLRDAARFDADFFGIN
PREALAADPQQRVLLEVSWELFERAGIDPATLKDTLTGVYAGVSSQDHMSGSRVPPEVEG
YATTGTLSSVISGRIAYTFGLEGPAVTLDTACSASLVAIHLACQALRQGDCGLAVAGGVT
VLSTPTAFVEFSRQRGLAPDGRCKPFAEAADGTGFSEGVGLILLERLSDARRNGHQVLGV
VRGSAVNQDGASNGLTAPNDVAQERVIRQALTNARVTPDAVDAVEAHGTGTTLGDPIEGN
ALLATYGKDRPADRPLWLGSVKSNIGHTQAAAGVAGVIKMVMAMRHGELPASLHIDRPTP
HVDWEGGGVRLLTDPVPWPRADRPRRAGVSSFGISGTNAHLIVEQAPAPPDTADDAPEGA
ATPGASDGLVVPWVVSARSPQALRDQALRLRDFAGDASRAPLTDVGWSLLRSRALFEQRA
VVAGRERAELLAGLAALAAGEEHPAVTRSREEAAVAASGDVVWLFSGQGSQLVGMGAGLY
ERFPVFAAAFDEVCGLLEGELGVGSGGLREVVFWGPRERLDHTVWAQAGLFALQVGLARL
WESVGVRPDVVLGHSIGEIAAAHVAGVFDLADACRVVGARARLMGGLPEGGAMCAVQATP
AELAADVDGSSVSVAAVNTPDSTVISGPSGEVDRIAGVWRERGRKTKALSVSHAFHSALM
EPMLGEFTEAIRGVKFRQPSIPLMSNVSGERAGEEITSPEYWARHVRQTVLFQPGVAQVA
AEARAFVELGPGPVLTAAAQHTLDHITEPEGPEPVVTASLHPDRPDDVAFAHAMADLHVA
GISVDWSAYFPDDPAPRTVDLPTYAFQGRRFWLADIAAPEAVSSTDGEEAGFWAAVEGAD
FQALCDTLHLKDDEHRAALETVFPALSAWRRERRERSIVDAWRYRVDWRRVELPTPVPGA
GTGPDADTGLGAWLIVAPTHGSGTWPQACARALEEAGAPVRIVEAGPHADRADMADLVQA
WRASCADDTTQLGGVLSLLALAEAPATSSDTTSHTSTSCGTGSLASHGLTGTLTLLHGLL
DAGVEAPLWCATRGAVSCGDADPLVSPSQAPVWGLGRVAALEHPELWGGLVDLPADPESL
DASALYAVLRGDGGEDQVALRRGAVLGRRLVPDATPDVAPGSSPDVSGGAAHADATSGEW
QPHGAVLVTGGVGHLADQVVRWLAASGAEHVVLLDTGPANSRGPGRNDDLAAEAAEHGTE
LTVLRSLSELTDVSVRPIRTVIHTSLPGELAPLAEVTPDALGAAVSAAARLSELPGIGSV
ETVLFFSSVTASLGSREHGAYAAANAYLDALAQRAGADAASPRTVSVGWGIWDLPDDGDV
ARGAAGLSRRQGLPPLEPQLALGALRAALDGGKGHTLVADIEWERFAPLFTLARPTRLLD
GIPAAQRVLDASSESAEASENASALRRELTALPVRERTGALLDLVRKQVAAVLRYEPGQD
VAPEKAFKDLGFDSLVVVELRNRLRAATGLRLPATLVYDYPTPRTLAAHLLDRVLPDGGA
AELPVAAHLDDLEAALTDLPADDPRRKGLVRRLQTLLWKQPDAMGAAGPADEEEQAAPED
LSTASADDMFALIDREWGTR
selected fasta
>polyketide synthase [monensin polyketide synthase module 9]
ATGCCGGGTACGAACGACATGCCGGGTACCGAGGACAAGCTCCGCCACTACCTGAAGCGA
GTGACCGCGGATCTCGGACAGACCCGTCAGCGCCTGCGCGACGTGGAGGAGCGCCAGCGG
GAACCGATCGCCATCGTCGCGATGGCCTGCCGCTACCCGGGCGGGGTGGCCTCCCCCGAG
CAGCTGTGGGACCTGGTCGCCTCACGCGGCGACGCCATCGAGGAGTTCCCCGCCGACCGC
GGCTGGGACGTGGCGGGCCTCTACCACCCCGACCCGGACCACCCCGGCACGACCTATGTA
CGAGAGGCCGGATTCCTGCGGGACGCCGCCCGCTTCGACGCCGACTTCTTCGGCATCAAC
CCGCGCGAGGCGCTCGCCGCCGACCCGCAGCAACGGGTGCTCCTCGAAGTGTCGTGGGAA
CTGTTCGAGCGGGCGGGCATCGACCCCGCCACGCTCAAGGACACCCTCACCGGCGTGTAC
GCGGGGGTGTCCAGCCAGGACCACATGTCCGGGAGCCGGGTCCCGCCGGAGGTCGAGGGC
TACGCCACCACGGGAACCCTCTCCAGCGTCATCTCCGGCCGCATCGCCTACACCTTCGGC
CTGGAGGGCCCGGCGGTGACGCTCGACACGGCGTGCTCGGCATCGCTGGTCGCGATCCAC
CTCGCCTGCCAGGCCCTGCGCCAGGGCGACTGCGGCCTGGCGGTGGCGGGAGGCGTGACC
GTACTGTCCACGCCGACGGCGTTCGTGGAGTTCTCACGCCAGCGCGGACTCGCACCGGAC
GGCCGCTGCAAGCCGTTCGCCGAGGCCGCCGACGGCACCGGATTCTCCGAGGGCGTCGGC
CTGATCCTCCTGGAACGCCTCTCCGACGCCCGCCGCAACGGACATCAAGTACTCGGCGTC
GTACGCGGATCGGCCGTCAACCAGGACGGCGCGAGCAACGGCCTGACCGCCCCGAACGAC
GTCGCCCAGGAACGCGTGATCCGCCAGGCCCTGACCAACGCCCGCGTCACCCCGGACGCC
GTCGACGCCGTGGAGGCACACGGCACCGGCACCACGCTCGGCGACCCGATCGAGGGGAAC
GCACTCCTCGCGACGTACGGAAAGGACCGCCCCGCCGACCGGCCGCTGTGGCTCGGCTCT
GTGAAGTCGAACATCGGCCACACGCAGGCGGCTGCGGGCGTCGCAGGCGTCATCAAGATG
GTGATGGCGATGCGCCACGGCGAGCTGCCCGCCTCCCTGCACATCGACCGGCCCACGCCC
CACGTGGACTGGGAGGGCGGGGGAGTGCGGTTGCTCACCGATCCCGTGCCGTGGCCACGG
GCCGACCGCCCCCGCCGCGCGGGGGTCTCCTCCTTCGGCATCAGCGGCACCAACGCCCAC
CTGATCGTGGAACAGGCCCCCGCCCCGCCCGACACGGCCGACGACGCCCCGGAAGGCGCC
GCAACCCCCGGCGCTTCCGACGGCCTCGTGGTGCCGTGGGTGGTGTCGGCCCGTAGTCCG
CAGGCCCTGCGTGATCAGGCCCTGCGTCTGCGCGACTTTGCCGGTGACGCGTCCCGAGCG
CCGCTCACCGACGTGGGCTGGTCTTTGCTGCGGTCGCGTGCGCTGTTCGAGCAGCGGGCG
GTGGTGGCGGGGCGTGAGAGGGCTGAACTGCTGGCGGGGCTGGCTGCGTTGGCCGCTGGT
GAGGAGCACCCGGCTGTGACGCGGTCCCGTGAGGAAGCGGCGGTTGCTGCGAGCGGTGAT
GTGGTGTGGCTGTTCAGTGGTCAGGGCAGTCAGTTGGTCGGTATGGGTGCTGGTTTGTAT
GAGCGGTTCCCGGTGTTTGCGGCTGCGTTTGATGAGGTGTGCGGCTTGCTGGAGGGGGAG
CTGGGGGTTGGTTCGGGTGGGTTGCGGGAGGTGGTGTTCTGGGGCCCGCGGGAGCGGTTG
GATCACACGGTGTGGGCGCAGGCGGGGTTGTTTGCGTTGCAGGTGGGGTTGGCCCGGTTG
TGGGAGTCGGTCGGGGTGCGGCCGGATGTGGTGCTCGGGCATTCGATCGGTGAGATCGCG
GCCGCGCATGTGGCGGGGGTCTTTGATCTGGCGGATGCGTGTCGGGTGGTGGGGGCGCGG
GCGCGTTTGATGGGTGGGTTGCCTGAGGGTGGGGCGATGTGTGCGGTGCAGGCCACGCCC
GCCGAGCTGGCCGCGGATGTGGATGGCTCGTCCGTGAGTGTGGCGGCGGTCAACACACCT
GACTCGACGGTGATTTCAGGTCCGTCGGGTGAGGTGGATCGGATTGCTGGGGTGTGGCGG
GAGCGTGGGCGTAAGACGAAGGCGCTGAGCGTGAGTCATGCTTTCCATTCGGCGTTGATG
GAGCCGATGCTCGGGGAGTTCACGGAAGCGATACGAGGGGTCAAGTTCAGGCAGCCGTCG
ATCCCGCTCATGAGCAATGTCTCCGGAGAGCGGGCCGGCGAGGAGATCACATCCCCGGAG
TACTGGGCGAGGCATGTACGCCAGACAGTGCTCTTCCAGCCCGGCGTCGCCCAAGTGGCC
GCTGAGGCACGCGCGTTCGTCGAACTCGGCCCCGGCCCCGTACTGACCGCCGCCGCCCAG
CACACCCTCGACCACATCACCGAGCCGGAAGGCCCCGAGCCGGTCGTCACCGCGTCCCTC
CACCCCGACCGGCCGGACGACGTGGCCTTCGCGCACGCCATGGCCGACCTCCACGTCGCC
GGTATCAGCGTGGACTGGTCGGCGTACTTCCCTGACGACCCCGCCCCCCGCACCGTCGAC
CTGCCCACCTACGCCTTCCAGGGGCGGCGCTTCTGGCTGGCGGACATCGCGGCGCCCGAG
GCCGTGTCCTCGACGGACGGTGAGGAGGCCGGGTTCTGGGCCGCCGTCGAAGGTGCGGAC
TTCCAGGCGCTCTGCGACACCCTGCACCTCAAGGACGACGAGCACCGCGCGGCTCTGGAG
ACGGTGTTCCCCGCGCTGTCCGCGTGGCGGCGCGAACGACGTGAGCGGTCGATCGTCGAT
GCCTGGCGGTACCGGGTCGACTGGCGGCGCGTCGAGCTGCCGACACCCGTTCCGGGCGCC
GGTACCGGTCCCGACGCCGACACGGGCCTCGGGGCGTGGCTGATCGTGGCTCCCACGCAC
GGGTCGGGTACTTGGCCGCAAGCCTGTGCCCGGGCGTTGGAGGAGGCGGGCGCGCCGGTA
CGTATCGTCGAGGCCGGCCCGCACGCCGACCGGGCGGACATGGCGGACCTGGTCCAGGCA
TGGCGGGCAAGCTGTGCGGACGACACCACCCAGCTCGGAGGAGTGCTCTCCCTGCTGGCT
CTCGCCGAGGCACCGGCCACCAGTTCCGACACCACTTCCCACACCAGTACCAGTTGCGGT
ACCGGCTCTCTCGCGTCCCACGGCCTCACCGGCACCTTGACGCTGCTGCACGGTCTGCTG
GATGCGGGCGTCGAAGCGCCTCTCTGGTGTGCCACGCGCGGCGCCGTGTCGTGCGGCGAC
GCCGATCCGCTCGTCTCCCCGTCGCAGGCCCCGGTCTGGGGACTCGGACGCGTGGCCGCC
CTGGAGCATCCGGAGTTGTGGGGCGGCCTGGTCGACCTGCCCGCCGACCCGGAGTCGCTC
GACGCGAGCGCGTTGTATGCGGTTCTGCGCGGAGACGGCGGCGAGGATCAGGTCGCGCTG
CGCCGGGGCGCGGTCCTCGGCCGTCGCCTGGTGCCCGACGCAACCCCGGACGTGGCCCCC
GGCTCGTCCCCGGACGTGTCCGGAGGCGCAGCCCATGCCGACGCGACCTCCGGGGAGTGG
CAGCCGCATGGTGCCGTCCTCGTCACCGGAGGCGTCGGCCACCTGGCCGATCAGGTCGTA
CGGTGGCTCGCCGCGTCCGGCGCCGAACACGTCGTACTCCTGGACACGGGCCCCGCCAAC
AGCCGTGGTCCCGGCCGGAACGACGACCTCGCCGCGGAAGCCGCCGAACACGGCACCGAG
CTGACGGTCCTGCGGTCCCTGAGCGAGCTGACAGACGTATCCGTACGTCCCATACGGACC
GTCATCCACACATCGCTGCCCGGCGAGCTCGCGCCGCTGGCCGAGGTCACCCCCGACGCG
CTCGGCGCGGCCGTGTCCGCCGCCGCGCGGCTGAGCGAACTCCCCGGCATCGGGTCAGTG
GAGACCGTGCTGTTCTTCTCCTCCGTGACGGCTTCGCTCGGCAGTAGGGAGCACGGCGCG
TACGCCGCCGCCAACGCCTACCTCGACGCCCTGGCGCAACGGGCCGGTGCCGATGCTGCG
AGCCCCCGGACGGTCTCGGTCGGGTGGGGCATCTGGGATCTGCCGGACGACGGTGACGTG
GCACGCGGCGCCGCCGGGCTGTCCCGGAGGCAGGGACTCCCGCCGCTGGAACCGCAGTTG
GCGCTCGGCGCCCTGCGCGCGGCGCTCGACGGGGGCAAGGGGCACACGCTGGTCGCCGAC
ATCGAGTGGGAGCGGTTCGCGCCGCTGTTCACGCTGGCCAGGCCCACCCGGCTGCTCGAC
GGGATCCCCGCGGCCCAGCGGGTCCTCGACGCCTCCTCGGAGAGCGCCGAGGCCTCGGAG
AACGCCTCGGCCCTCCGTCGCGAACTGACGGCCCTGCCCGTGCGGGAGCGGACCGGGGCA
CTTCTCGACCTGGTCCGCAAACAGGTGGCCGCCGTCCTGCGCTACGAGCCGGGCCAAGAC
GTGGCGCCCGAGAAGGCCTTCAAGGACCTGGGCTTCGACTCGCTCGTGGTCGTGGAGCTG
CGCAACCGGCTGCGCGCCGCCACCGGGCTCCGGCTGCCCGCCACCCTGGTCTACGACTAC
CCCACACCCCGCACCCTCGCCGCACACCTGCTGGACAGGGTGCTGCCCGACGGCGGCGCG
GCAGAGCTCCCCGTGGCCGCCCACCTGGACGACCTGGAGGCGGCCCTCACCGACCTGCCG
GCCGACGACCCCCGGCGCAAGGGCCTGGTCCGGCGTCTACAGACGCTGCTGTGGAAGCAG
CCCGACGCCATGGGGGCGGCGGGCCCCGCCGACGAGGAGGAGCAAGCCGCGCCCGAGGAC
CTGTCGACCGCGAGCGCCGACGACATGTTCGCCCTGATCGACCGGGAGTGGGGCACGCGG
TGA
[9] KS41..416
[9] AT582..903
[9] malonyl-CoA773..777
[9] KR1264..1433
[9] ACP1541..1611
[9] KS121..1248
[9] AT1744..2709
[9] malonyl-CoA2317..2331
[9] KR3790..4299
[9] ACP4621..4833

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001227 Acyl transferase domain (Domain)
[581-704] 1.69999999999998e-72 G3DSA:3.40.366.10 [772-880] 1.69999999999998e-72 G3DSA:3.40.366.10
G3DSA:3.40.366.10   Ac_transferase_reg
IPR006162 Phosphopantetheine attachment site (PTM)
[1569-1584] PS00012
PS00012   PHOSPHOPANTETHEINE
IPR009081 Acyl carrier protein-like (Domain)
[1540-1614] 1.6e-22 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
[1533-1628] 2.60000517657733e-23 SSF47336
SSF47336   ACP_like
[1544-1610] 8.20000000000001e-13 PF00550
PF00550   PP-binding
[1541-1611] PS50075
PS50075   ACP_DOMAIN
IPR013968 Polyketide synthase, KR (Domain)
[1264-1433] 6.3e-24 PF08659
PF08659   KR
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[41-290] 2.30000000000004e-92 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[298-416] 1e-46 PF02801
PF02801   Ketoacyl-synt_C
IPR014043 Acyl transferase (Domain)
[582-903] 1.10000000000001e-65 PF00698
PF00698   Acyl_transf_1
IPR015083 Polyketide synthase, docking (Domain)
[10-34] 1.8e-13 PF08990
PF08990   Docking
[4-41] 1.29999924468179e-10 SSF101173
SSF101173   Polyketide_synth_docking
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
[580-867] 2.1000026783403e-66 SSF52151
SSF52151   Acyl_Trfase/lysoPlipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
[709-772] 2.59999946718995e-15 SSF55048
SSF55048   Malonyl_transacylase_ACP-bd
IPR016038 Thiolase-like, subgroup (Domain)
[43-302] 6.10000000000004e-86 G3DSA:3.40.47.10 [303-468] 5.99999999999995e-65 G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[33-414] 3.60002015031011e-100 SSF53901
SSF53901   Thiolase-like
IPR016040 NAD(P)-binding domain (Domain)
[1264-1433] 5.59999999999999e-11 G3DSA:3.40.50.720
G3DSA:3.40.50.720   NAD(P)-bd
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[203-219] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
[584-884] 9.20006495413779e-111 SM00827
SM00827   PKS_AT
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
[1542-1614] 2.69998997787809e-36 SM00823
SM00823   PKS_PP
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
[43-468] SM00825
SM00825   PKS_KS
SignalP No significant hit
TMHMM No significant hit
Monen_00190 Monen_00190   Monen_00210 Monen_00210
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