Nidda_00050 Nidda_00050   Nidda_00070 Nidda_00070

Nidda_00060 : CDS information

close this sectionLocation

Organism
StrainNRRL 2821
Entry nameNiddamycin
Contig
Start / Stop / Direction35,000 / 40,639 / + [in whole cluster]
35,000 / 40,639 / + [in contig]
Location35000..40639 [in whole cluster]
35000..40639 [in contig]
TypeCDS
Length5,640 bp (1,879 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)polyketide synthase module 7
Gene
Gene (GenBank)nidA5
EC number
Keyword
Note
Note (GenBank)
  • orf5
Reference
ACC
PmId
[9393718] Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis. (J Bacteriol. , 1997)
comment
ORF5(nidA5): PKS(module7, TE)

close this sectionPKS/NRPS Module

7 malonyl-CoA
KS41..415
AT565..885
KR1212..1392
ACP1498..1568
TE1643..1856

close this sectionSequence

selected fasta
>polyketide synthase [polyketide synthase module 7]
MTRNPKMSPSIDEVLDALRTSVKETERLRRRNQELVAAAREPIAIVGMACRYPGGVSDPE
ELWQLAAEGVDAITRFPTDRGWDEAAVYSPEHRPGTTYCREGGFLAGAGDFDAAFFGISP
NEALVMDPQQRLLLETSWEALERAGVVPESLRGGRTGVFVGAAHTGYASDPARAPEGTEG
YLLTGDADAVLSGRIAYVLGLEGPAITVETACSSSLVALHLAVQSLRRGECDLALAGGVA
VMPDPTVFVEFSRQRGLAPDGRCKAFADSADGTAWAEGVGMLLVERLSDAERLGHRVLAV
VRGTAVNQDGASNGLTAPSGPAQQKVIRDALADAHLTPDDIDAVEAHGTGTPLGDPIEAG
ALLATYGHPERQTPVWLGSLKSNIGHTQAAAGIAGIIKMIQAMHHGTLPRTLHVDHPSSK
VDWKAGSLQLLAQARPWPADPDRPRRAAVSAFGVSGTNAHTIIEEPPTPAEAPERTRTLT
VLPWVLSARSEDALRDQARLLADRGGDALDIGYSLATTRAVLEHRAVTVVDDPAAAHDAL
LAVADGRPSDAVVTGIARRGRDVAFLFSGQGAQRAGAGRELYASFPVFAQALDEVAGGFD
AHLERPLLQVMFAEPGTADAALLDRTAYAQPALFAVETALFRLFESWGLMPDVLLGHSIG
GLAAAYAAGVFSSADAVRLVAARGRLMQRLPEGGAMVAVRATEQEVAELEWIAGGRAVVA
AFNGPDSLVLSGDEQAVVSAAGELAARGRRTKRLSVSHAFHSPHMDAMLADFRAVAESVT
YRTPRLPIVSEVTGRPAAPSELMDPGYWTRQIREPVRFAAAVRAARAAGAATFVELGPDA
VLSGMARECAAGDTGTAFAAALRRGRPECATVLPAAATAFVQGAHVDWAAPYEGAGARRV
DLPTYPFQHTRYWLRPAPAAARAADRTDVEEPVQSQALWAAVHDGDVKAASVQLGAEEAG
IEEPLSAVLPHLAAWHDRCRTAAETNALRYRVVWQPLPARAARRRLGGRWLVIGQDGDPL
LPDITTALHTAGADTHTLTLDPTTTDKDTLATHLTHIATAHPDGLSGILLAPTPVTPDPH
QPPLDPATTLTLTTIQALTTTPLTTPLWITTRQATTIHPTDTPNPYTARLWGLGQTAALE
HPQHWGGLIDLPEHPTPHHLHHLTTHLATSRDPNPRQPHEDQIAIRTHTTYARRLTPTTP
TTTPTPWTPPPGTILITGGTGALGTHIATWLAHKGAKHLILTSRQGPNAPGATQLQHHLT
QLGTHTTITPCDLTDPQQIENLINHINTHHPPLQAIFHTAGTPQTTPLTHLTPTQATDIL
NAKTTGAELLHHHTTHTPLHTVVHFSSAAATWGSSGQSLYAAANAHLDALAQHTHTQGQP
TTSIAWGVWGGKGMVELAPEGYLERQGVRPLRPETALAALQQALDHRDVNVTVADLDWDR
FAATLTARRPSPLISDIPQVRTARPTPRRVAAQSGPANGDRGVPRLGRARPEERRGLALH
LVRTLAAGVLGHSGAEQVDARASFRDLGFDSLAAVSLRDGLAEATGLELPAGLVFDHEDP
TALADHLSELAGRAADGASGSPAQPEGTLLAALRTAVARGRTDEAVSLMAGLAQFRPVFT
GGGRPGGLPAPVGLATGTARPRLYCCAGTAATSNPREYAHFADALRGRRDVTVLPLPGFG
DPAEPLPASLDALLADRADALLEHCGGEPFALAGHSAGANVAYALAAYLESRGSGPAAVV
LMDMYFPDDPGAMGVWRDDLLRWSLERSPVPLAEHRLTAMAGYHRLLLGSHFTALRAPVL
LARASEPLREWSGDDGPDGWRSRVPGVTSVTDVPGNHFTMLTEYAADTASAVHDWLASTV
RDNHDTPTERSPEDADVHR
selected fasta
>polyketide synthase [polyketide synthase module 7]
ATGACAAGGAACCCGAAGATGTCACCGTCCATCGACGAGGTGCTCGACGCGCTGCGTACC
TCGGTCAAGGAGACCGAGCGGCTGCGGCGGCGCAACCAGGAGCTCGTCGCCGCCGCCCGT
GAGCCGATCGCGATCGTGGGGATGGCGTGCCGCTATCCCGGCGGGGTGAGCGACCCGGAG
GAGCTGTGGCAGCTGGCCGCCGAGGGCGTCGACGCGATCACCCGCTTCCCCACCGACCGA
GGCTGGGACGAGGCCGCGGTGTACTCGCCCGAGCACCGCCCCGGCACCACCTACTGCCGC
GAGGGCGGCTTCCTCGCCGGCGCGGGTGACTTCGACGCGGCGTTCTTCGGGATCTCGCCG
AACGAGGCTCTGGTGATGGACCCCCAGCAGCGGCTGCTCCTGGAAACCTCGTGGGAGGCC
CTGGAACGCGCCGGGGTCGTGCCGGAGTCGCTGCGTGGCGGGCGGACCGGCGTGTTCGTC
GGCGCGGCACACACGGGTTACGCCTCCGACCCGGCGCGAGCGCCCGAGGGCACGGAGGGC
TACCTGCTGACCGGCGACGCCGACGCGGTGCTGTCCGGCAGGATCGCCTACGTCCTCGGC
TTGGAGGGTCCGGCCATCACCGTGGAGACGGCGTGCTCGTCGTCCCTCGTGGCCCTCCAC
CTCGCGGTGCAGTCGCTGCGGCGCGGGGAATGCGACCTGGCTCTGGCCGGGGGTGTCGCG
GTCATGCCCGACCCCACGGTGTTCGTGGAGTTCTCCCGCCAGCGCGGGCTGGCACCCGAC
GGCCGCTGCAAGGCCTTCGCCGACAGCGCCGACGGCACCGCGTGGGCCGAGGGCGTCGGC
ATGCTCCTGGTGGAGCGGTTGTCGGACGCCGAGCGGCTCGGCCACCGTGTCCTGGCCGTC
GTGCGCGGCACCGCCGTCAACCAGGACGGCGCCAGCAACGGCCTCACCGCCCCCAGCGGA
CCCGCCCAGCAGAAGGTCATCCGCGACGCCCTGGCCGACGCCCACCTCACCCCCGACGAC
ATCGACGCCGTCGAGGCCCACGGCACCGGCACCCCCCTCGGCGACCCCATCGAAGCCGGC
GCCCTGCTGGCCACCTACGGACACCCCGAGCGTCAGACACCGGTCTGGCTCGGATCGCTG
AAGTCCAACATCGGCCACACCCAGGCCGCCGCCGGCATCGCCGGAATCATCAAAATGATC
CAAGCCATGCACCACGGCACCCTGCCGCGCACCCTGCATGTCGACCATCCCAGCAGCAAG
GTCGACTGGAAGGCCGGCTCCCTCCAACTCCTCGCTCAGGCCCGGCCCTGGCCCGCCGAC
CCCGACCGGCCACGCCGCGCCGCCGTCTCCGCCTTCGGCGTCAGCGGCACCAACGCCCAC
ACCATCATCGAAGAACCACCCACCCCCGCCGAGGCACCCGAACGCACCCGCACCTTGACC
GTCCTGCCCTGGGTGCTGTCGGCTCGTTCCGAGGACGCGTTGCGTGACCAGGCGCGACTG
CTGGCCGACCGGGGCGGGGACGCCCTCGACATCGGGTACTCCCTCGCCACGACCAGGGCC
GTTCTGGAGCACCGGGCGGTCACTGTGGTGGATGATCCGGCAGCCGCGCACGACGCGCTC
CTCGCCGTGGCGGACGGGCGGCCGTCGGACGCCGTCGTGACCGGCATCGCGCGCCGGGGA
CGTGACGTGGCGTTCCTCTTCTCCGGTCAGGGCGCGCAACGAGCCGGTGCCGGACGGGAG
TTGTACGCGTCGTTCCCCGTCTTCGCGCAGGCCCTCGACGAAGTGGCGGGCGGTTTCGAC
GCCCATCTCGAACGTCCGCTGCTGCAGGTGATGTTCGCGGAGCCCGGCACGGCGGACGCC
GCCCTGCTGGACCGGACCGCTTACGCGCAGCCCGCGCTCTTCGCCGTGGAGACCGCCCTG
TTCCGGCTCTTCGAGAGCTGGGGGCTGATGCCGGACGTCCTGCTGGGCCATTCGATCGGC
GGGCTGGCCGCGGCGTACGCCGCCGGGGTGTTCTCGTCGGCGGACGCCGTCCGGCTGGTC
GCGGCGCGGGGGCGGCTGATGCAGCGGCTGCCCGAGGGCGGTGCGATGGTCGCGGTGCGC
GCCACCGAGCAGGAGGTGGCCGAGCTGGAGTGGATCGCGGGCGGAAGGGCGGTCGTCGCC
GCGTTCAACGGACCCGACTCACTCGTGCTCTCGGGGGACGAACAGGCCGTCGTGTCGGCG
GCCGGGGAACTGGCCGCCCGGGGGCGCCGTACGAAGCGGCTGTCGGTGAGCCACGCCTTC
CACTCGCCGCACATGGACGCGATGCTCGCCGACTTCCGCGCCGTCGCCGAAAGCGTCACC
TACCGCACACCGAGGCTTCCGATCGTCTCCGAGGTGACGGGACGGCCCGCCGCCCCGTCC
GAGCTCATGGACCCCGGCTACTGGACCCGCCAGATACGCGAACCGGTCCGGTTCGCCGCC
GCCGTGCGCGCCGCGCGGGCGGCCGGGGCGGCGACCTTCGTCGAACTCGGTCCCGACGCC
GTGCTGTCCGGCATGGCACGGGAGTGCGCGGCGGGCGACACCGGCACGGCGTTCGCGGCC
GCGCTGCGCCGCGGCCGCCCGGAGTGCGCGACCGTACTGCCTGCGGCGGCCACGGCCTTC
GTCCAGGGGGCCCACGTCGACTGGGCCGCGCCGTACGAGGGGGCCGGGGCGCGGCGGGTG
GACCTGCCGACGTACCCGTTCCAGCACACCCGCTACTGGCTGCGCCCGGCCCCGGCGGCG
GCACGGGCCGCGGACCGTACGGACGTGGAGGAGCCGGTCCAGTCACAGGCCCTGTGGGCA
GCGGTCCACGACGGCGACGTCAAGGCCGCCTCCGTTCAGTTGGGCGCCGAGGAGGCCGGC
ATCGAGGAGCCGCTGAGCGCGGTCCTTCCGCACCTGGCGGCCTGGCACGACCGGTGCCGC
ACCGCCGCCGAGACGAACGCGCTGCGCTACCGGGTCGTCTGGCAGCCGCTGCCGGCGAGG
GCCGCCCGGCGTCGACTCGGGGGTCGTTGGCTGGTGATCGGTCAGGACGGGGACCCCCTC
CTCCCCGACATCACCACCGCCCTGCACACCGCGGGCGCCGACACCCACACCCTCACCCTC
GACCCCACCACCACCGACAAAGACACACTCGCCACCCACCTCACCCACATCGCCACCGCC
CACCCCGACGGCCTCAGCGGCATCCTCCTCGCCCCCACCCCCGTCACACCCGACCCCCAC
CAACCCCCACTCGACCCCGCCACCACCCTCACCCTCACCACCATCCAAGCCCTCACCACA
ACCCCCCTCACCACCCCCCTGTGGATCACCACCCGCCAAGCCACCACCATCCACCCCACC
GACACCCCCAACCCCTACACCGCACGCCTCTGGGGACTCGGCCAGACCGCCGCCCTCGAA
CACCCCCAACACTGGGGCGGCCTCATCGACCTACCCGAACACCCCACACCCCACCACCTC
CACCACCTCACCACCCACCTCGCCACCAGCCGAGACCCCAACCCCCGACAACCCCACGAA
GACCAAATCGCCATCCGCACCCACACCACCTACGCTCGCCGACTCACCCCCACCACACCC
ACCACCACACCCACCCCCTGGACCCCACCCCCCGGCACCATCCTCATCACCGGCGGCACC
GGCGCCCTCGGCACCCACATCGCCACCTGGCTCGCCCACAAAGGCGCCAAACACCTCATC
CTCACCAGCCGCCAAGGACCCAACGCCCCCGGCGCCACCCAACTCCAACACCACCTCACC
CAACTCGGCACCCACACCACCATCACCCCCTGCGACCTCACCGACCCCCAACAAATCGAA
AACCTCATCAACCACATCAACACCCACCACCCACCCCTCCAAGCCATCTTCCACACCGCC
GGAACCCCACAGACCACCCCACTCACCCACCTCACCCCCACCCAAGCCACCGACATCCTC
AACGCCAAAACCACCGGCGCCGAACTCCTCCACCACCACACCACCCACACCCCCCTCCAC
ACCGTCGTCCACTTCTCCTCCGCCGCCGCCACCTGGGGCAGCAGCGGACAATCCCTCTAC
GCCGCCGCCAACGCCCACCTCGACGCCCTCGCCCAACACACCCACACCCAAGGCCAACCC
ACCACCTCCATCGCCTGGGGGGTCTGGGGTGGGAAGGGCATGGTCGAACTCGCCCCGGAG
GGCTATCTGGAGCGCCAGGGGGTGCGGCCGCTGCGGCCGGAGACGGCGCTGGCCGCGCTG
CAGCAGGCCCTCGACCACCGCGACGTCAACGTGACCGTCGCCGACCTCGACTGGGACCGG
TTCGCGGCCACCCTGACGGCGAGGCGTCCCAGCCCGCTGATCAGCGACATCCCGCAGGTC
CGCACGGCGCGCCCGACCCCCCGGCGCGTTGCCGCGCAGTCCGGTCCGGCGAACGGCGAC
CGGGGCGTGCCGCGCCTCGGGCGGGCGCGGCCCGAGGAGCGGCGTGGGCTCGCGCTGCAC
CTGGTTCGGACACTGGCCGCCGGTGTGCTCGGTCATTCCGGGGCCGAGCAGGTGGACGCG
CGGGCCTCCTTCCGCGATCTCGGCTTCGACTCACTGGCCGCGGTCAGTCTGCGGGACGGG
CTGGCCGAGGCGACCGGGCTGGAGCTGCCCGCCGGTCTGGTGTTCGACCACGAGGACCCG
ACTGCGCTGGCGGACCACCTGTCCGAGCTGGCCGGGCGCGCGGCGGACGGCGCGTCCGGG
TCGCCCGCGCAACCGGAGGGCACGCTGCTCGCCGCCCTGCGTACGGCCGTCGCCCGGGGC
CGGACCGACGAGGCGGTGTCCCTGATGGCCGGACTGGCCCAGTTCCGGCCCGTCTTCACC
GGCGGCGGACGCCCGGGCGGGCTCCCGGCGCCGGTGGGTCTCGCGACCGGGACCGCGCGG
CCGCGGCTGTACTGCTGTGCCGGCACGGCCGCCACGTCGAACCCGCGGGAGTACGCGCAT
TTCGCGGACGCCCTGCGCGGCCGCCGGGACGTGACCGTCCTGCCGCTGCCCGGCTTCGGC
GATCCGGCCGAGCCGCTGCCCGCGTCGCTGGACGCGCTGCTCGCCGACCGGGCCGACGCG
CTGCTGGAGCACTGCGGGGGCGAGCCGTTCGCCCTCGCGGGCCACTCCGCCGGCGCGAAC
GTCGCGTACGCCCTCGCCGCGTATCTGGAGTCGCGCGGCAGCGGTCCGGCGGCGGTCGTC
CTGATGGACATGTACTTCCCGGACGACCCCGGTGCGATGGGCGTATGGCGGGACGACCTG
CTGCGCTGGTCGCTGGAGCGCAGCCCGGTGCCGCTCGCGGAGCACCGGCTGACCGCCATG
GCCGGGTACCACCGGCTGCTGCTCGGCAGCCACTTCACCGCGCTGCGCGCGCCCGTGCTG
CTGGCGCGGGCCTCCGAGCCGCTGCGCGAGTGGAGCGGCGACGACGGCCCGGACGGCTGG
CGGTCCCGGGTGCCGGGGGTCACGAGCGTCACCGACGTGCCCGGCAACCACTTCACCATG
CTCACCGAGTACGCGGCGGACACGGCCTCGGCGGTCCACGACTGGCTGGCGTCCACCGTC
CGTGACAACCACGACACACCCACCGAGCGCTCCCCGGAGGACGCTGATGTACACCGATGA
[7] KS41..415
[7] AT565..885
[7] malonyl-CoA758..762
[7] KR1212..1392
[7] ACP1498..1568
[7] TE1643..1856
[7] KS121..1245
[7] AT1693..2655
[7] malonyl-CoA2272..2286
[7] KR3634..4176
[7] ACP4492..4704
[7] TE4927..5568

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001031 Thioesterase (Domain)
[1643-1856] 8.1e-43 PF00975
PF00975   Thioesterase
IPR001227 Acyl transferase domain (Domain)
[554-690] 7.90000000000016e-77 G3DSA:3.40.366.10 [758-873] 7.90000000000016e-77 G3DSA:3.40.366.10
G3DSA:3.40.366.10   Ac_transferase_reg
IPR002198 Short-chain dehydrogenase/reductase SDR (Family)
[1212-1378] 1.6e-53 PF00106
PF00106   adh_short
IPR009081 Acyl carrier protein-like (Domain)
[1502-1567] 1.1e-10 PF00550
PF00550   PP-binding
[1490-1585] 5.10001002358244e-21 SSF47336
SSF47336   ACP_like
[1498-1568] PS50075
PS50075   ACP_DOMAIN
[1499-1570] 6.90000000000001e-19 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[41-290] 1.39999999999997e-96 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[298-415] 1.99999999999999e-48 PF02801
PF02801   Ketoacyl-synt_C
IPR014043 Acyl transferase (Domain)
[565-885] 7.69999999999997e-63 PF00698
PF00698   Acyl_transf_1
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
[562-858] 3.79997359309398e-68 SSF52151
SSF52151   Acyl_Trfase/lysoPlipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
[692-757] 1.49999977583352e-16 SSF55048
SSF55048   Malonyl_transacylase_ACP-bd
IPR016038 Thiolase-like, subgroup (Domain)
[43-302] 1.60000000000002e-91 G3DSA:3.40.47.10 [303-468] 2.29999999999998e-64 G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[33-413] 6.10002656149838e-102 SSF53901
SSF53901   Thiolase-like
IPR016040 NAD(P)-binding domain (Domain)
[1212-1432] 1.6e-37 G3DSA:3.40.50.720
G3DSA:3.40.50.720   NAD(P)-bd
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[203-219] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
[566-866] 3.79997359309398e-115 SM00827
SM00827   PKS_AT
IPR020802 Polyketide synthase, thioesterase domain (Domain)
[1644-1856] 2.19999900980707e-111 SM00824
SM00824   PKS_TE
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
[1499-1571] 1.39999892049878e-26 SM00823
SM00823   PKS_PP
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
[43-468] SM00825
SM00825   PKS_KS
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
[1212-1392] 4.79998722798115e-44 SM00822
SM00822   PKS_KR
SignalP No significant hit
TMHMM No significant hit
Nidda_00050 Nidda_00050   Nidda_00070 Nidda_00070
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