Oligo_00130 Oligo_00130   Oligo_00150 Oligo_00150

Oligo_00140 : CDS information

close this sectionLocation

Organism
StrainATCC 31267 (=NBRC 14893)
Entry nameOligomycin
Contig
Start / Stop / Direction88,978 / 83,255 / - [in whole cluster]
88,978 / 83,255 / - [in contig]
Locationcomplement(83255..88978) [in whole cluster]
complement(83255..88978) [in contig]
TypeCDS
Length5,724 bp (1,907 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)modular polyketide synthase
Gene
Gene (GenBank)olmA5
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[11572948] Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. (Proc Natl Acad Sci U S A. , 2001)
comment
S. avermitilisのゲノムの99%をカバーしたシークエンス解析の報告。
そこで見つかった二次代謝に関するclusterについて述べている。

close this sectionPKS/NRPS Module

11 methylmalonyl-CoA
KS34..410
AT582..901
dh950..1113
KR1463..1643
ACP1748..1818

close this sectionSequence

selected fasta
>polyketide synthase [modular polyketide synthase]
MSDEEKFRDYLKRAVTEARGLQRRLREVEDKAREPIAIVGMACRFPGGAQTPEDLWHMVS
EGVDAISGFPDDRGWDLDRLYRTDAEESGASTTLEGGFLHGAGEFDADFFGISPREAIAT
DPQQRLLLETSWEALERAGVDPRSLRGSVTGVYFGGTGGDFAGLLAASPQALDGYMLTGT
SSSVLSGRVSYVLGLEGPAVTVDTACSSSLVSMHLAVQALRKDEISLALAGGVSVLATPG
AFPEFSRQGGLASDGRCKAFSSDADGTGWGEGVGVLVLERLSDARRAGHPVLAVVRETGI
NQDGASNGLTAPSGPAQRRLILRTLDDAGLATADIDVVEAHGTGTKLGDPIEARALLATY
GQDRPADRPLWLGSIKSNIGHTQYAAGVSGVIKTVMALRHGVMPKTLHVDEPTPHVDWSS
GAVRLLTENRPWPGHGRPRRAAVSSFGVSGTNAHLILEQAPEAAGATDSATDSETESESQ
SKSEEHGAVVTPPLIPWAISGRGEAALRAQAQRLLDRLSERPDLEPLDVGLALARTRSAF
EQRAVVLGADRTELVAGLRSVAEGAAVGAGVVAGRAAESGVVFVFPGQGSQWVGMGRELW
DASPVFRARMEECGQALSPYVDWSLRDVVFRDAGDPLWSRVDVVQPVLWAVMVSLAAVWR
SFGVEPAAVVGHSQGEVAAACVAGGLSLEDGARVVAVRSRLVLEKLSGKGGMVSVALPVG
DVEERLARFEGRIGVAAVNGPTSVVVSGEPDALDELLAECEESGVRARRIAVDYASHSAQ
VDALNDDLLAELADIRPKSSTVAFHSTVTGEQVDTSGLDARYWLRNMRETVAFEAAVRAT
LDEGHRNLLEISPHPVVTMAVQEVIDAAGVMAQVSGSVRRDEGGLGRLLTSLAEAYVAGA
PVDWARVFDGTGARPVDLPTYAFQRQRYWLRLPSAGSGDVTSVGLRSPGHPLLGAAVEPA
ESDGLVLTGRVSLREHPWLADHRVMGTVPLPGTAFVELAATAGDLVECPHIEELTMQAPL
TLPETGGLDLQLTVSAPDETGRREIGFFARADDEIAAAAWTRHGTGVLCPAGPVPEAAPA
VWPPRGAEPVELGDLYGQLADGPFAYGPAFHGLRAAWTRDRKVFAEVRLPQELHEQAGEY
LLHPALLDAALHAVGLGELLDTGGQPLRPFAWNGVSVHATGATALRVTLTPAGANAVSLY
AADGTGAPVVTVGSLLLRPVDVTEPGARPPAAAHSSLLSLTWTPVPLPAVGAVPWAVLGD
RPSWAGPDSGAVCHADLDALAASVAAGDPVPGFVVLDPAAGGRDDDGHPAVARERAARVL
ESARAWVSEDLDERLAPVPLVVVTRDAVGTSADDPVTGLGSAPLWGLVRSVQSENPGRFV
LLDTDGDPESGRSVPGAVASGEPEIALRGGSALVPRLSRMAVTELPDPTPGTRPGTGGTG
LDDVPGTGLDVPGTGLDALDPSRTVLVTGATGGLGTLVAGHLAERHGVRHLLLLSRRGPE
AEGAEELVGRLEKLGATVTLVACDAADREALAAVLAGIPAAHPLTAVVHCAGTAENALLA
ALTPELIDRVFRAKVDAAVHLHELTEGLDLSAFVLFSSIAGTLGGTGQGNYAAANTFLDA
LARHRRGRGLPATSLGWGLWAAERGMGGGLTDAASAGTPMRGVSALPSDEGLALFDLGWR
CAEPVVFPARLNGAALRAQAAAGSLPPVLRGLFRGPARRTAEAGGQDSGAQLRRRLAELM
PVERQETLLALVRDRIAAVLGHASSDRIETDRPFRDLGFTSLTAVELRNRLNAATGLRLP
VSLVFDYPTLGELVELLAGKLVPDGTEPAARPEDDREAAVRRTLLSIPLARLREHGLLDT
LLALADDGGAQPEAADRSDEIKSMDVAALLAMARSTTASSTASTTAQ
selected fasta
>polyketide synthase [modular polyketide synthase]
ATGTCCGACGAGGAGAAGTTCCGCGACTACCTCAAGCGGGCCGTCACCGAGGCACGCGGA
CTCCAGCGCCGGCTGCGCGAGGTCGAGGACAAGGCGCGCGAGCCGATCGCGATCGTCGGC
ATGGCGTGCCGGTTCCCCGGCGGGGCCCAGACCCCGGAAGACCTGTGGCACATGGTGTCC
GAGGGCGTGGACGCGATCTCGGGCTTCCCCGACGACCGCGGCTGGGACCTGGACCGGCTG
TACCGCACCGACGCCGAGGAGTCCGGCGCCTCCACCACACTGGAGGGCGGATTCCTGCAC
GGCGCGGGCGAGTTCGACGCGGACTTCTTCGGGATCTCCCCGCGCGAGGCGATCGCGACG
GACCCCCAGCAGCGGCTGCTCCTGGAGACCTCGTGGGAGGCGCTGGAGCGGGCCGGGGTG
GACCCGCGATCCCTGCGCGGCAGCGTCACCGGGGTGTACTTCGGCGGTACGGGCGGGGAC
TTCGCCGGTCTGCTGGCCGCGTCGCCGCAGGCACTGGACGGCTACATGCTGACCGGCACC
TCCAGCAGCGTGCTCTCCGGCCGGGTCTCGTACGTGCTCGGTCTGGAGGGGCCCGCGGTC
ACGGTGGACACGGCCTGCTCGTCCTCGCTGGTCTCCATGCATCTGGCCGTGCAGGCGCTG
CGCAAGGACGAGATCTCGCTGGCCCTGGCCGGCGGTGTCTCGGTCCTCGCGACGCCCGGC
GCGTTCCCCGAGTTCTCCCGCCAGGGCGGGCTGGCCTCCGACGGCCGCTGCAAGGCGTTC
TCGTCCGACGCCGACGGCACCGGCTGGGGCGAGGGGGTCGGTGTCCTCGTCCTCGAACGG
CTCTCCGACGCCCGGCGCGCCGGACACCCGGTGCTGGCCGTCGTACGGGAGACCGGCATC
AACCAGGACGGGGCCAGCAACGGCCTCACCGCGCCCAGCGGCCCCGCGCAGCGCCGCCTC
ATCCTGCGCACCCTCGACGACGCCGGGCTGGCCACCGCGGACATCGACGTGGTGGAGGCG
CACGGCACCGGTACGAAACTCGGTGACCCCATCGAGGCACGAGCGCTGCTGGCCACCTAC
GGCCAGGACCGGCCGGCCGACCGGCCCCTGTGGCTGGGCTCCATCAAGTCCAACATCGGC
CACACCCAGTACGCGGCCGGCGTCAGCGGCGTGATCAAGACGGTCATGGCGCTGCGGCAC
GGCGTCATGCCGAAGACCCTGCACGTGGACGAGCCGACGCCGCACGTGGACTGGTCCTCG
GGTGCGGTGCGACTGCTGACCGAGAACCGCCCGTGGCCCGGCCACGGCCGCCCCCGCCGG
GCCGCCGTGTCCTCCTTCGGCGTCAGCGGCACCAACGCGCATCTGATCCTGGAGCAGGCG
CCCGAAGCGGCCGGGGCGACGGACTCGGCAACGGACTCGGAGACGGAGTCGGAGTCGCAG
TCGAAGTCGGAGGAGCACGGTGCGGTCGTGACGCCGCCGTTGATCCCCTGGGCGATCTCC
GGGCGGGGTGAGGCCGCGCTGCGTGCGCAGGCCCAGCGGTTGCTGGACCGTCTCTCGGAG
CGTCCTGACCTGGAGCCGCTGGACGTGGGCCTCGCGCTGGCGCGGACGCGGTCGGCGTTC
GAGCAGCGGGCGGTGGTGCTGGGAGCCGACCGGACGGAACTGGTCGCGGGGTTGCGGTCG
GTGGCCGAGGGGGCCGCCGTCGGCGCCGGCGTGGTGGCGGGGCGTGCCGCCGAGTCAGGT
GTGGTGTTCGTGTTCCCGGGTCAGGGGTCGCAGTGGGTGGGGATGGGGCGGGAGTTGTGG
GACGCCTCGCCGGTGTTCCGTGCGCGGATGGAGGAGTGCGGCCAGGCGCTGAGTCCGTAC
GTCGACTGGTCGTTGAGGGATGTGGTGTTCCGGGACGCGGGGGATCCGTTGTGGTCTCGG
GTGGATGTGGTGCAGCCGGTGTTGTGGGCGGTGATGGTTTCGCTGGCGGCGGTGTGGCGT
TCGTTCGGGGTGGAGCCGGCCGCTGTCGTGGGGCATTCGCAGGGTGAGGTCGCTGCGGCG
TGCGTGGCCGGTGGTCTGTCGCTGGAGGATGGCGCCCGGGTGGTGGCGGTGCGGTCGCGG
CTGGTGCTGGAGAAGCTGTCCGGTAAGGGCGGCATGGTGTCCGTTGCGCTGCCGGTCGGG
GACGTCGAGGAGCGGCTGGCGCGGTTCGAGGGCCGGATCGGTGTCGCGGCCGTCAACGGG
CCCACCTCCGTCGTCGTCTCCGGTGAGCCCGACGCACTCGACGAACTCCTCGCGGAATGT
GAGGAGTCGGGGGTACGGGCCCGTCGTATCGCGGTGGACTACGCCTCCCACTCCGCGCAG
GTCGACGCCCTCAACGACGACCTGCTCGCCGAACTCGCCGACATCCGGCCCAAGTCGTCC
ACCGTCGCCTTCCACTCCACGGTGACCGGCGAGCAGGTGGACACCTCCGGGCTCGACGCC
CGCTACTGGCTGCGCAACATGCGGGAGACCGTCGCCTTCGAGGCCGCGGTGCGCGCCACC
CTCGACGAGGGGCACCGGAACCTGCTGGAGATCAGCCCCCATCCCGTGGTGACCATGGCC
GTTCAAGAGGTCATCGACGCGGCGGGCGTCATGGCCCAGGTGTCCGGCTCCGTGCGCCGC
GACGAGGGAGGCCTCGGCCGGCTGCTGACCTCGCTGGCCGAGGCGTACGTCGCGGGCGCG
CCCGTCGACTGGGCGCGGGTGTTCGACGGCACCGGCGCGCGGCCGGTGGACCTGCCCACG
TACGCCTTCCAGCGGCAGCGGTACTGGCTGCGCCTGCCGTCCGCCGGGTCCGGCGACGTG
ACGTCCGTCGGTCTGCGCTCCCCCGGACATCCGCTGCTCGGGGCCGCCGTGGAGCCCGCC
GAGTCCGACGGCCTCGTACTGACCGGCCGGGTCTCCCTGCGCGAGCACCCCTGGCTGGCC
GACCACCGGGTCATGGGCACGGTCCCGCTGCCGGGAACCGCGTTCGTGGAGCTGGCCGCG
ACGGCGGGCGACCTCGTCGAGTGCCCGCACATCGAGGAACTGACCATGCAGGCCCCCCTC
ACGCTGCCCGAGACCGGTGGCCTGGACCTCCAGCTCACGGTGAGCGCACCGGACGAGACC
GGGCGGCGCGAGATCGGGTTCTTCGCCCGCGCGGACGACGAGATCGCGGCGGCCGCCTGG
ACGCGGCACGGCACGGGCGTCCTGTGCCCGGCCGGTCCCGTACCGGAGGCGGCACCGGCC
GTCTGGCCGCCGCGCGGTGCCGAGCCGGTCGAACTCGGCGACCTGTACGGGCAGTTGGCG
GACGGGCCGTTCGCCTACGGGCCCGCCTTCCATGGGCTGCGGGCTGCCTGGACCCGGGAC
CGGAAGGTCTTCGCGGAGGTACGGCTCCCCCAGGAACTGCACGAGCAGGCGGGTGAGTAC
CTGCTGCATCCGGCGCTGCTCGACGCGGCGCTGCACGCGGTGGGCCTGGGCGAACTGCTG
GACACCGGCGGGCAGCCGCTGCGCCCGTTCGCCTGGAACGGTGTGTCCGTGCACGCCACC
GGTGCCACCGCTTTGCGGGTGACCCTGACGCCGGCGGGGGCGAACGCCGTGTCGCTGTAC
GCCGCCGACGGCACCGGTGCCCCGGTCGTCACGGTCGGTTCGCTGCTGCTGCGGCCGGTC
GACGTGACGGAGCCGGGGGCCCGGCCGCCGGCCGCCGCGCACTCCTCGCTGCTGTCCCTG
ACGTGGACGCCGGTTCCGTTGCCCGCCGTCGGTGCCGTGCCCTGGGCGGTGCTGGGGGAC
CGGCCGTCGTGGGCGGGCCCGGACTCCGGTGCCGTGTGCCACGCCGACCTGGACGCGCTC
GCGGCGTCGGTCGCCGCGGGTGACCCCGTGCCCGGCTTCGTCGTCCTGGATCCGGCGGCC
GGGGGCCGCGACGACGACGGGCATCCCGCCGTCGCCCGGGAACGTGCCGCGCGGGTGCTG
GAGTCGGCGCGGGCGTGGGTCTCCGAGGACCTCGACGAACGGCTCGCCCCGGTGCCGCTG
GTGGTGGTCACCAGGGACGCGGTGGGCACCTCGGCGGACGATCCGGTGACCGGCCTCGGC
TCCGCCCCGCTGTGGGGCCTCGTGCGGTCGGTCCAGTCGGAGAATCCGGGGCGTTTCGTG
CTGCTGGACACCGACGGCGACCCCGAGTCCGGACGGTCCGTGCCGGGCGCGGTCGCGTCG
GGAGAACCCGAGATCGCGTTGCGCGGCGGGTCCGCGCTGGTCCCGCGGTTGAGCCGGATG
GCGGTCACCGAGCTCCCCGACCCGACGCCCGGTACGCGGCCCGGTACGGGGGGTACGGGA
CTCGACGACGTGCCCGGTACGGGACTCGACGTGCCCGGTACGGGACTCGACGCGCTCGAC
CCGTCCCGCACGGTGCTCGTGACCGGGGCGACGGGCGGTCTGGGCACGCTGGTCGCCGGC
CATCTCGCCGAACGGCACGGCGTACGCCACCTGTTGCTGCTGAGCCGGCGCGGCCCGGAG
GCGGAGGGCGCCGAGGAGCTGGTCGGCCGGCTGGAGAAGCTGGGCGCCACGGTGACGCTG
GTCGCCTGCGACGCCGCGGACCGCGAGGCGCTGGCCGCCGTACTCGCCGGGATTCCCGCC
GCACATCCGCTGACCGCGGTGGTGCACTGCGCCGGAACCGCCGAGAACGCGCTGCTGGCA
GCGCTGACCCCGGAGCTGATCGACCGGGTCTTCCGCGCCAAGGTGGACGCGGCGGTGCAT
CTGCACGAGCTGACCGAGGGCCTGGACCTGTCCGCCTTCGTCCTGTTCTCCTCGATCGCG
GGCACCCTCGGCGGCACCGGGCAGGGCAACTACGCGGCCGCCAACACGTTCCTGGACGCG
CTCGCCCGGCACCGGCGCGGGCGCGGTCTGCCGGCCACCTCGCTGGGCTGGGGGCTGTGG
GCGGCCGAGCGCGGCATGGGCGGCGGTCTGACCGACGCGGCCTCGGCGGGCACTCCCATG
CGCGGGGTGTCCGCGCTGCCCTCCGACGAGGGCCTCGCCCTGTTCGACCTCGGCTGGCGC
TGCGCCGAGCCCGTGGTGTTCCCCGCTCGCCTCAACGGGGCCGCGCTGCGCGCCCAGGCC
GCCGCCGGCTCCCTGCCGCCGGTGCTCCGGGGGCTCTTCCGCGGCCCGGCCCGGCGGACG
GCGGAGGCCGGCGGTCAGGACTCGGGCGCCCAACTGCGGCGTCGGCTCGCGGAGCTGATG
CCGGTCGAGCGGCAGGAGACCCTGCTGGCCCTCGTACGCGACCGGATCGCCGCCGTGCTC
GGGCACGCCTCCTCGGACCGGATCGAGACGGACCGGCCGTTCCGCGACCTCGGCTTCACC
TCACTGACCGCGGTGGAGCTGCGCAACCGGCTGAACGCGGCGACCGGACTCCGACTGCCC
GTGAGCCTGGTCTTCGACTATCCGACGCTGGGCGAACTGGTGGAGTTGCTGGCGGGGAAG
CTGGTCCCGGACGGCACCGAACCGGCCGCGCGGCCCGAGGACGACCGGGAGGCGGCCGTG
CGCCGCACCCTGCTGTCCATCCCGCTCGCCCGGCTGCGCGAGCACGGACTGCTCGACACG
CTGCTGGCCCTCGCCGACGACGGCGGGGCGCAGCCGGAGGCGGCCGACCGCAGCGACGAG
ATCAAGTCCATGGACGTGGCCGCGCTGCTCGCCATGGCCAGGAGCACCACCGCGAGCTCC
ACCGCGAGCACCACCGCTCAATAG
[11] KS34..410
[11] AT582..901
[11] methylmalonyl-CoA774..778
[11] dh950..1113
[11] KR1463..1643
[11] ACP1748..1818
[11] KS100..1230
[11] AT1744..2703
[11] methylmalonyl-CoA2320..2334
[11] dh2848..3339
[11] KR4387..4929
[11] ACP5242..5454

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001227 Acyl transferase domain (Domain)
[576-705] 1.20000000000001e-70 G3DSA:3.40.366.10 [774-890] 1.20000000000001e-70 G3DSA:3.40.366.10
G3DSA:3.40.366.10   Ac_transferase_reg
IPR009081 Acyl carrier protein-like (Domain)
[1740-1835] 2.800005042611e-24 SSF47336
SSF47336   ACP_like
[1745-1821] 1.2e-22 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
[1748-1818] PS50075
PS50075   ACP_DOMAIN
[1752-1817] 2.6e-14 PF00550
PF00550   PP-binding
IPR013968 Polyketide synthase, KR (Domain)
[1464-1642] 3.60000000000002e-61 PF08659
PF08659   KR
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[34-284] 4.30000000000003e-90 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[292-410] 1.6e-45 PF02801
PF02801   Ketoacyl-synt_C
IPR014043 Acyl transferase (Domain)
[582-901] 8.29999999999993e-105 PF00698
PF00698   Acyl_transf_1
IPR015083 Polyketide synthase, docking (Domain)
[4-34] 4.60000044330862e-07 SSF101173
SSF101173   Polyketide_synth_docking
[1-27] 1.4e-09 PF08990
PF08990   Docking
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
[580-872] 3.89999861795218e-65 SSF52151
SSF52151   Acyl_Trfase/lysoPlipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
[708-773] 8.1000073432326e-20 SSF55048
SSF55048   Malonyl_transacylase_ACP-bd
IPR016038 Thiolase-like, subgroup (Domain)
[36-296] 2.59999999999995e-86 G3DSA:3.40.47.10 [298-462] 1.29999999999998e-64 G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[26-408] 8.29994113369276e-99 SSF53901
SSF53901   Thiolase-like
IPR016040 NAD(P)-binding domain (Domain)
[1463-1665] 8.30000000000004e-39 G3DSA:3.40.50.720
G3DSA:3.40.50.720   NAD(P)-bd
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[197-213] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
[584-882] 7.49999605851445e-119 SM00827
SM00827   PKS_AT
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
[1749-1821] 1.20000117458134e-34 SM00823
SM00823   PKS_PP
IPR020807 Polyketide synthase, dehydratase domain (Domain)
[950-1113] 2.1000026783403e-77 SM00826
SM00826   PKS_DH
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
[36-462] SM00825
SM00825   PKS_KS
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
[1463-1643] 3.39999972437719e-55 SM00822
SM00822   PKS_KR
SignalP No significant hit
TMHMM No significant hit
Oligo_00130 Oligo_00130   Oligo_00150 Oligo_00150
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