Alip_00130 : CDS information

Location

Organism	Streptomyces aureofaciens
Strain	Tü117
Entry name	Alpha-lipomycin
Contig	DQ176871
Start / Stop / Direction	16,927 / 23,706 / + [in whole cluster] 16,927 / 23,706 / + [in contig]
Location	16927..23706 [in whole cluster] 16927..23706 [in contig]
Type	CDS
Length	6,780 bp (2,259 aa)

Annotation

Category	1.1 PKS
Product	polyketide synthase
Product (GenBank)	LipPks1
Gene
Gene (GenBank)	lipPks1
EC number
Keyword
Note
Note (GenBank)	putative type I polyketide synthase
Reference	ACC Q30CS2 PmId [16723573] Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin. (Antimicrob Agents Chemother. , 2006) [23692164] Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase. (Biochemistry. , 2013) [24169801] Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic alpha-lipomycin. (J Antibiot (Tokyo). , 2014) [26976746] Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit. (Biochemistry. , 2016) comment [PMID:16723573](2006) alpha-lipomycin生合成遺伝子クラスターに関する文献。 lipPks1(2,259 aa): PKS I alpha-lipomycinを合成するPKSをコードする。 starter unitはisobutyryl-CoA --- [PMID:23692164](2013) abstract 6-deoxyerythronolide B synthase由来のTE domainを含むrecombinant LipPks1をE.coliで産生させ、その基質特異性をin vitroで検証。 isobutyryl-CoAを含むいくつかのacyl-CoAsがstarter基質として受け入れられたが、acetyl-CoAでの産物は観察されなかった。 --- [PMID:24169801](2014) [PMID:23692164]において、LipPks1はisobutyryl-CoAを含むいくつかの異なるacyl-CoAsをstarter基質として受け入れることができ、その中でも2-methylbutyryl-CoAのkcat/Km値はisobutyryl-CoAの値に匹敵することが報告された。そこで2-methylbutyryl-CoAのよく知られた前駆体であるisoleucineの存在下でS. aureofaciens Tu117を育てたところ、新規alpha-lipomycin類似体 21-methyl-alpha-lipomycinを分離することができた。この類似体は、alpha-lipomycinと変わらない抗菌活性を示した。このように、種々の同定可能な薬剤候補を増やして薬剤発見を促進するためには、PKSs loading didomainのin vitro kinetic parametersを測定することが重要である。

PKS/NRPS Module

0		isobutyryl-CoA
1		methylmalonyl-CoA

AT	171..489

ACP	540..614

KS	639..1017

AT	1177..1496

KR	1811..1991

ACP	2101..2171

Sequence

>polyketide synthase [LipPks1]
MAGPPPFPRRRGPSGRRRCGGRATPGSVRDRTGRRPAAVPSRAVCAADLCEENDDGSKNV
SEHRGSAGGSVLFPRTGTVLPWVLTGPGAAAVRARSEALRTHLRASTEWSPAGVGQALLA
GTGAGADTHRAVVLAGDRAQTLNALAALSAGADHPAVFTSTRADASPAGPVFVFPGQGSQ
WTGMARELLDSAPVFARKLHDCADAFAPYLGHSLLDSVTGAAGGPEPVGADVVQPALFAV
MVALTDLWNAAGVAPGALLGHSLGELAAAHVAGVLSLDDSARVVARWSQAQATLAGRGDM
VSVLLPADELADLLDRRWPGRLVVAVENGPGSAVASGDLDAAAELVAHLTAEGIHARRVD
VGLAAHSPHIDAILPRIRADIAPIRAHTPSIPVYSALHGGALDGTPMDAAYWCRNLRSTV
RFADATRAALEAGHTTFVEVSPHPVLTTAMEVSATRAAHAATVLGTLRRGEGGPSRFLAS
LAELHVSGGDADLRTVLPASQAAGLPETVLTAGPRGESADGDSRHEVLCARLAPLDPAER
RAQLLTVVRESAAAALDGDDQGSIDGRRTFRDLGITSLAAVGIRDRLHSATGLRLSPTVV
FDHPTPDALAAHLDTELFGTGADAEPAPAAGGRAVPHDEPMAIVGMACRYPGGVGAPADL
WRTVLAGVDAVGPLPADRGWNIADGYDPELAGPGRFSQREGGFLHDAAEFDAEFFGISPR
EALAMDPQQRLALESAWEAIEDAGLDAHSLRGSRTGVFLGLITQDYGPRAGEPTTRAGAV
EGHLFLGSTGSVASGRLSYTLGLEGPSLTIDTACSSSLVALHEACQALRTGDCDMALTGG
VTVMPSTGMLVEFSRQRGLSPDGRCKAFSASADGFGLAEGVGMLVVERLSDARRLGHRVL
AVVRGSAVNQDGASNGLSAPSGPAQQRVIRQALVNAGVQASQVDVVEAHGTGTKLGDPIE
AQALQATYGQGRPAERPLWLGSLKSNIGHAQAAAGVGGVIKMVMALREGVLPPTLHADEP
SPHIDWSAGQVRLLTEEREWPEAGHPRRAAVSSFGVSGTNAHVILEAAPGTGGAPEVSDG
VLGSAPETVPWVLSAASPDALRAQAERLRGHVAERPGLASADVAFALATRRTALEYRAVA
VGAERDELLDTLDALSAGRPAPRAVPGDAAAHSRRPVFVFPGQGSQWAGMAVELLDSSPV
FADSMHACSEALNEFVDWNLLEVLRSGDEELSNRVDVVQPVLWAVMVSLAALWQACGVRP
AAVVGHSQGEIAAAVVAGALSLRDGARVVALRSAVIARLLAGKGAMASVALASDTVRERL
TPWEGRLSLAAVNGPSSSVVCGHLDALDEFVSALEHDGVRVRRIAVDYASHSVFVEQAEE
ELRNVLTEVSPLPGQVPFYSTVTGAVLDTTTLDAGYWYRNLRQTVRFEETVRELTRRGHD
AFIEVSAHPVLTVGIQDTLEATGTRHAVCGTLRRGEGGAQRLLTSLGEAWVAGIAVDWSR
LTPTTTAVQLPTYAFQHQRYWLDSTTANTGDRPAADRDTAFWEAVQHTDLDAFAAELDIA
PDAPLGTVLPALADWRQRLRTAAAVDAWRYRTAFKRLPDAPGAPVLTGSWLAVVPVRHLD
DPSVTTSLDAVAKAGAEVVQLAIEDADADVDRLTERLRGLVAGLGAAPAGIMSFLGLDEE
RHRDHPAMPSGLATSLALVRALGRAGIGAPLWMVTREAVAAGQDTHPHAPLGSLIWGLGQ
VTALEHADRWGGLIDLPGVCDARVARMLCAGLSGRGAEDQLALRPSGTFVRRLAHIPGEQ
RAARRSWQPRGTVIVTGGTGALGAVLARWLATEDAEHLVLTGRRGADAPGAERLRDELVA
TGARVTLAACDVADRKAVAALLDELAADGETVRAVLHAAGVADLTSLENTGPEAFAAGVA
AKVDGALHLTELLDHDSLDAFVLFSSIAGVWGSGDHGAYAAANAFLNALAEYNRARGIPT
TSIAWGVWNAFGVEGAGGISEAVDLDQLHRRGLPLIEPELGLTALRRALDRDETVLTVAP
VAWERFFPLFSAARPRPLFEDLPQVRALSAPVPTTAGPAVEPGRRGSGLGDLPLTDRDSA
LLALVRGESASVLGYERPDRLDPDRALRDVGFDSLTAMELRNRLATATGLTLPAALVFDH
PTPLAIAAYLKAELYGPDPGDDSSVLTELDGLSQRLAAIDPDTNTRLEITLRLRSLLTQW
SEPDGGRTTAETATATSTTALESASADEVLAFIDTELGI

>polyketide synthase [LipPks1]
GTGGCGGGGCCTCCGCCGTTCCCCCGACGGCGGGGGCCCAGCGGCCGTCGGCGGTGCGGC
GGACGGGCCACCCCCGGATCCGTGCGTGACCGGACCGGGCGGCGCCCGGCCGCCGTGCCG
TCACGGGCCGTCTGTGCCGCAGACCTTTGTGAAGAGAACGACGACGGGAGCAAGAACGTG
TCCGAACACCGTGGCAGTGCAGGCGGCTCCGTACTGTTCCCCCGGACGGGGACCGTGCTG
CCCTGGGTCCTGACCGGTCCCGGCGCCGCCGCCGTGCGGGCCCGTTCCGAGGCTCTGCGC
ACGCATCTCCGCGCGAGCACCGAATGGTCGCCGGCCGGCGTCGGACAGGCCCTCCTCGCC
GGGACTGGAGCCGGGGCGGACACCCACCGGGCCGTCGTACTCGCCGGGGACCGCGCGCAG
ACCCTGAACGCGCTCGCCGCGCTGTCCGCCGGCGCCGACCACCCGGCGGTGTTCACCAGC
ACCCGCGCGGACGCCTCCCCCGCGGGGCCGGTGTTCGTCTTCCCGGGGCAGGGCTCCCAG
TGGACCGGCATGGCCCGCGAACTCCTCGACTCCGCACCGGTGTTCGCCCGTAAGCTGCAC
GACTGCGCCGACGCGTTCGCCCCCTACCTGGGCCACTCCCTGCTGGACTCCGTGACGGGC
GCGGCCGGCGGTCCCGAGCCGGTCGGCGCCGACGTGGTGCAGCCCGCGCTGTTCGCGGTC
ATGGTGGCGCTGACCGACCTGTGGAACGCGGCCGGGGTCGCCCCCGGGGCCTTGCTCGGC
CACAGCCTCGGTGAGCTGGCCGCCGCGCATGTCGCCGGGGTGCTGTCGCTGGACGACAGC
GCCCGGGTCGTGGCCCGCTGGAGCCAGGCGCAGGCCACCCTCGCCGGGCGCGGCGACATG
GTGTCGGTGCTGCTGCCCGCCGACGAACTCGCCGACCTGCTCGACCGGCGCTGGCCGGGC
AGGCTGGTCGTCGCCGTGGAGAACGGCCCCGGCTCGGCCGTCGCCTCCGGTGACCTGGAC
GCCGCGGCGGAACTCGTGGCGCACCTCACCGCCGAGGGCATCCACGCCCGGCGCGTCGAC
GTGGGACTCGCCGCGCACTCCCCGCACATCGACGCGATCCTCCCGCGCATCCGCGCGGAC
ATCGCCCCCATCCGCGCCCACACCCCGAGCATCCCGGTCTACTCCGCGCTGCACGGCGGA
GCGCTGGACGGCACGCCCATGGACGCCGCCTACTGGTGCCGCAACCTGCGCTCCACCGTC
CGCTTCGCCGACGCCACCCGTGCGGCGCTGGAAGCCGGGCACACCACGTTCGTCGAGGTC
AGCCCGCACCCGGTGCTCACCACCGCCATGGAGGTCTCCGCGACCCGGGCGGCCCATGCG
GCCACCGTCCTCGGCACCCTGCGCCGCGGCGAGGGCGGTCCGTCCCGCTTCCTCGCGTCC
CTGGCCGAGCTGCACGTGTCCGGCGGTGACGCCGACCTGCGGACCGTCCTGCCCGCTTCG
CAAGCCGCAGGACTGCCGGAGACGGTCCTCACCGCCGGGCCGCGCGGGGAGTCCGCGGAC
GGCGACTCCCGGCACGAGGTGCTCTGCGCCCGCCTGGCGCCGCTCGACCCGGCCGAACGC
CGCGCCCAGCTGCTGACCGTGGTGCGGGAGTCCGCCGCCGCGGCGCTCGACGGCGACGAC
CAGGGCTCCATCGACGGCCGGCGCACCTTCCGGGACCTCGGCATCACCTCGCTTGCCGCC
GTCGGCATCCGCGACCGGCTGCACTCCGCGACCGGGCTGCGGCTCTCCCCGACCGTCGTC
TTCGACCACCCCACGCCGGACGCGCTCGCCGCCCATCTGGACACCGAGCTGTTCGGCACC
GGTGCCGACGCGGAGCCCGCACCGGCCGCCGGGGGCCGGGCAGTGCCGCACGACGAACCC
ATGGCAATCGTCGGCATGGCGTGCCGCTACCCGGGTGGCGTGGGCGCCCCCGCCGACCTG
TGGCGCACGGTCCTCGCCGGTGTCGATGCGGTCGGCCCGCTGCCCGCGGACCGCGGCTGG
AACATCGCCGACGGCTACGACCCCGAGCTGGCCGGCCCCGGCCGGTTCTCCCAGCGCGAG
GGCGGATTCCTCCACGACGCCGCCGAGTTCGACGCGGAGTTCTTCGGGATCTCGCCGCGC
GAGGCGCTCGCCATGGACCCGCAGCAGCGGCTCGCCCTGGAGTCCGCCTGGGAGGCGATC
GAGGACGCCGGACTCGACGCGCACTCCCTCAGGGGCTCCCGCACCGGCGTGTTCCTCGGC
CTCATCACCCAGGACTACGGCCCTCGCGCCGGCGAGCCCACCACGCGGGCCGGCGCCGTC
GAGGGGCACCTGTTCCTCGGTTCCACCGGCAGCGTCGCCTCCGGCCGCCTCTCCTACACG
CTCGGCCTGGAGGGGCCGTCGCTGACCATCGACACCGCCTGTTCCTCGTCGCTGGTCGCG
CTGCACGAGGCGTGCCAGGCGCTGCGCACCGGTGACTGTGACATGGCGCTGACCGGCGGT
GTCACCGTGATGCCGAGCACCGGCATGCTCGTCGAGTTCTCCCGCCAGCGGGGCCTGTCC
CCCGACGGGCGGTGCAAGGCGTTCTCCGCGTCCGCCGACGGCTTCGGTCTGGCCGAGGGC
GTGGGCATGCTCGTCGTCGAGCGGCTGTCGGACGCGCGGCGGCTGGGTCACCGGGTGCTG
GCGGTGGTGCGGGGCAGCGCGGTCAACCAGGACGGTGCGTCGAACGGGCTGAGCGCCCCC
AGTGGCCCCGCCCAGCAGCGAGTGATCCGGCAGGCACTGGTGAACGCCGGAGTGCAGGCC
TCCCAGGTGGACGTCGTGGAGGCGCACGGCACGGGCACCAAGCTCGGCGACCCCATCGAG
GCGCAGGCACTCCAGGCGACCTACGGACAAGGCCGGCCCGCCGAACGGCCGCTGTGGCTG
GGGTCGTTGAAGTCCAACATCGGGCACGCGCAGGCGGCGGCCGGTGTCGGCGGTGTGATC
AAGATGGTGATGGCGCTGCGCGAAGGCGTCCTGCCGCCCACCCTGCACGCCGACGAGCCG
TCGCCGCACATCGACTGGTCGGCGGGCCAGGTGCGGCTGTTGACCGAGGAGCGGGAGTGG
CCCGAGGCCGGGCATCCGCGCCGGGCCGCGGTGTCGTCGTTCGGTGTGAGCGGCACCAAC
GCCCACGTGATCCTCGAAGCCGCCCCCGGGACCGGCGGTGCGCCCGAAGTGTCCGACGGC
GTCCTCGGCAGCGCGCCCGAAACCGTGCCGTGGGTGCTGTCCGCCGCGTCCCCCGATGCC
CTGCGCGCGCAGGCCGAGCGGCTGCGCGGACACGTGGCCGAGCGACCTGGACTGGCCTCC
GCCGACGTGGCGTTCGCCCTCGCGACGAGGCGTACTGCGCTGGAGTACCGGGCCGTCGCC
GTGGGCGCCGAGCGCGACGAACTCCTCGACACCCTGGACGCGTTGAGCGCCGGACGCCCC
GCTCCCCGTGCCGTGCCGGGTGACGCGGCCGCCCATTCCCGCCGTCCCGTTTTCGTGTTT
CCGGGGCAGGGGTCGCAGTGGGCGGGAATGGCAGTGGAACTGCTGGACTCGTCGCCGGTG
TTCGCGGACTCCATGCACGCCTGCAGCGAGGCGCTGAACGAGTTCGTGGACTGGAACCTG
CTGGAGGTTCTAAGGAGCGGCGACGAGGAACTGTCGAACCGCGTCGACGTGGTGCAACCG
GTGCTGTGGGCAGTGATGGTCTCCCTGGCCGCGCTGTGGCAGGCCTGCGGGGTGCGGCCT
GCCGCGGTGGTGGGCCACTCCCAGGGTGAGATCGCCGCCGCCGTGGTGGCCGGCGCCCTG
TCCCTGCGCGACGGCGCGCGAGTGGTCGCACTGCGCAGCGCAGTGATCGCCCGCCTCCTG
GCAGGCAAGGGCGCCATGGCCTCCGTCGCACTGGCCTCCGACACCGTACGAGAACGCCTC
ACACCATGGGAAGGACGCCTGTCCCTGGCAGCCGTCAACGGCCCCTCGTCAAGCGTGGTC
TGCGGACACCTCGACGCACTGGACGAATTCGTCAGCGCACTCGAACACGACGGCGTCAGA
GTACGGCGCATCGCCGTCGACTACGCCTCACACTCGGTCTTCGTGGAACAGGCGGAGGAA
GAACTCCGCAACGTCCTGACCGAAGTCTCCCCCCTGCCGGGCCAGGTCCCCTTCTACTCC
ACCGTCACCGGCGCAGTCCTCGACACCACCACACTCGACGCCGGCTACTGGTACCGCAAC
CTGCGACAGACCGTGCGCTTCGAGGAAACCGTACGCGAGCTGACCCGCCGGGGCCACGAC
GCCTTCATCGAAGTCAGCGCGCACCCAGTACTCACCGTCGGCATCCAGGACACCCTGGAA
GCCACCGGCACCCGGCACGCCGTCTGCGGCACACTGCGCCGAGGAGAAGGCGGAGCACAA
CGGCTGCTCACCTCACTGGGCGAAGCATGGGTCGCCGGCATCGCAGTCGACTGGTCCCGA
CTGACACCCACCACAACTGCGGTGCAACTGCCCACCTACGCCTTCCAGCACCAGCGCTAC
TGGCTCGACAGCACCACCGCGAACACCGGTGACCGGCCCGCCGCGGACCGGGACACCGCT
TTCTGGGAGGCGGTCCAGCACACCGACCTGGACGCTTTCGCCGCCGAACTGGACATCGCG
CCCGACGCCCCGCTCGGCACCGTTCTGCCCGCGCTCGCCGACTGGCGGCAGCGCCTGCGG
ACCGCGGCGGCCGTGGACGCGTGGCGCTACCGGACCGCCTTCAAGCGCCTGCCCGACGCG
CCCGGCGCCCCGGTCCTCACCGGATCCTGGCTGGCCGTCGTACCGGTACGGCACCTGGAC
GACCCGTCCGTCACCACGTCCCTGGACGCCGTGGCGAAGGCCGGCGCCGAGGTGGTCCAG
TTGGCGATCGAGGACGCCGATGCCGACGTGGACCGGCTCACCGAGCGGCTGCGCGGCCTC
GTCGCCGGCCTCGGCGCGGCACCGGCCGGGATCATGTCGTTCCTCGGTCTGGACGAGGAG
CGCCACCGCGACCATCCGGCCATGCCGAGCGGGCTGGCGACCAGCCTCGCCCTGGTGCGC
GCCCTCGGCCGGGCCGGGATCGGCGCCCCGCTGTGGATGGTGACCCGGGAGGCCGTCGCG
GCCGGCCAGGACACCCATCCGCACGCCCCGCTGGGCTCGCTGATCTGGGGCCTCGGCCAG
GTCACGGCCCTGGAACACGCCGACCGGTGGGGCGGGTTGATCGACTTGCCCGGCGTCTGC
GACGCCCGCGTCGCGCGCATGCTGTGCGCCGGGCTGTCCGGTCGCGGTGCCGAGGACCAG
CTGGCCCTGCGTCCCTCGGGCACCTTCGTCCGCCGGCTCGCCCACATCCCCGGCGAGCAG
CGGGCCGCCCGGCGCAGCTGGCAGCCGCGGGGCACGGTGATCGTCACCGGCGGCACCGGC
GCCCTCGGAGCCGTCCTCGCCCGGTGGCTGGCCACCGAGGATGCCGAGCACCTGGTGCTC
ACCGGGCGCCGCGGAGCCGACGCTCCCGGTGCCGAGCGGTTGCGCGACGAACTCGTCGCG
ACCGGCGCCCGTGTCACCCTCGCCGCCTGCGACGTCGCCGACCGCAAGGCCGTGGCGGCG
CTCCTCGACGAGCTCGCCGCCGACGGGGAGACCGTACGCGCGGTGCTGCACGCCGCGGGC
GTCGCGGACCTGACCTCTCTGGAGAACACCGGCCCGGAGGCGTTCGCCGCCGGAGTCGCC
GCCAAGGTCGACGGCGCCCTGCACCTCACCGAACTCCTCGACCACGACTCTCTGGACGCG
TTCGTCCTGTTCTCCTCGATCGCCGGAGTGTGGGGCAGCGGCGACCACGGCGCCTACGCC
GCCGCCAACGCGTTCCTCAACGCGCTCGCCGAGTACAACCGCGCGCGCGGCATTCCGACC
ACCTCCATCGCCTGGGGGGTGTGGAACGCGTTCGGCGTCGAGGGCGCCGGCGGCATCTCC
GAGGCCGTCGACCTCGACCAACTGCACCGGCGAGGCCTGCCCCTCATCGAACCCGAGCTG
GGCCTCACCGCGCTGCGGCGGGCCCTGGACCGCGACGAGACCGTGCTCACCGTGGCACCC
GTCGCCTGGGAGCGGTTCTTCCCCCTGTTCAGCGCGGCCCGCCCGCGACCGCTGTTCGAG
GACCTGCCGCAGGTCAGGGCACTGTCCGCGCCGGTGCCCACGACCGCGGGCCCGGCCGTT
GAGCCCGGTCGGCGCGGCTCCGGGCTCGGAGACCTGCCGCTCACCGACCGGGACAGCGCC
CTGCTCGCCCTGGTCCGCGGCGAGTCCGCCTCCGTGCTGGGCTACGAGCGGCCCGACCGG
CTCGACCCCGACCGAGCCCTGCGCGACGTCGGCTTCGACTCCCTCACCGCGATGGAGCTG
CGCAACCGGCTGGCCACGGCCACCGGCCTCACCCTGCCCGCCGCGCTGGTCTTCGACCAC
CCGACACCGCTCGCCATCGCCGCGTACCTCAAGGCCGAGCTGTACGGGCCCGACCCGGGC
GACGACAGCTCCGTCCTCACCGAACTGGACGGGCTGTCCCAGCGGCTGGCGGCCATCGAC
CCGGACACCAACACCCGGCTCGAGATCACCCTGCGGCTGCGCTCGCTGCTCACGCAGTGG
AGCGAGCCGGACGGCGGCCGTACCACGGCCGAAACGGCCACGGCCACCTCCACCACGGCA
CTCGAGTCGGCCAGCGCCGACGAGGTGCTGGCCTTCATCGACACCGAACTCGGCATATGA

[0] AT	171..489

[0] isobutyryl-CoA	363..367

[0] ACP	540..614

[1] KS	639..1017

[1] AT	1177..1496

[1] methylmalonyl-CoA	1368..1372

[1] KR	1811..1991

[1] ACP	2101..2171

[0] AT	511..1467

[0] isobutyryl-CoA	1087..1101

[0] ACP	1618..1842

[1] KS	1915..3051

[1] AT	3529..4488

[1] methylmalonyl-CoA	4102..4116

[1] KR	5431..5973

[1] ACP	6301..6513

Feature

BLASTP Database:UniProtKB:2011_09	show BLAST table
InterPro Database:interpro:38.0	IPR001227 Acyl transferase domain (Domain) G3DSA:3.40.366.10 Ac_transferase_reg IPR006162 Phosphopantetheine attachment site (PTM) PS00012 PHOSPHOPANTETHEINE IPR009081 Acyl carrier protein-like (Domain) PF00550 PP-binding SSF47336 ACP_like G3DSA:1.10.1200.10 ACP_like PS50075 ACP_DOMAIN IPR013968 Polyketide synthase, KR (Domain) PF08659 KR IPR014030 Beta-ketoacyl synthase, N-terminal (Domain) PF00109 ketoacyl-synt IPR014031 Beta-ketoacyl synthase, C-terminal (Domain) PF02801 Ketoacyl-synt_C IPR014043 Acyl transferase (Domain) PF00698 Acyl_transf_1 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain) SSF52151 Acyl_Trfase/lysoPlipase IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain) SSF55048 Malonyl_transacylase_ACP-bd IPR016038 Thiolase-like, subgroup (Domain) G3DSA:3.40.47.10 Thiolase-like_subgr IPR016039 Thiolase-like (Domain) SSF53901 Thiolase-like IPR016040 NAD(P)-binding domain (Domain) G3DSA:3.40.50.720 NAD(P)-bd IPR018201 Beta-ketoacyl synthase, active site (Active_site) PS00606 B_KETOACYL_SYNTHASE IPR020801 Polyketide synthase, acyl transferase domain (Domain) SM00827 PKS_AT IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain) SM00823 PKS_PP IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain) SM00825 PKS_KS IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain) SM00822 PKS_KR
SignalP	No significant hit
TMHMM	No significant hit

Alip_00120 Alip_00140