first first   Herb_00020 Herb_00020

Herb_00010 : CDS information

close this sectionLocation

Organism
StrainAM 3672
Entry nameHerbimycin A
Contig
Start / Stop / Direction2,359 / 71 / - [in whole cluster]
2,359 / 71 / - [in contig]
Locationcomplement(71..2359) [in whole cluster]
complement(71..2359) [in contig]
TypeCDS
Length2,289 bp (762 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.3 transport
Productputative cation-transporting ATPase
Product (GenBank)unknown
Gene
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)
  • ORF1p; ORF1; similar to Streptomyces coelicolor SC00860c and Streptomyces avermitilis SAV617 probable cation-transporting ATPase
Reference
ACC
PmId
[16085885] Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption. (Appl Environ Microbiol. , 2005)
comment
herbimycin生合成系gene clusterのクローニングを行い、同じbenzoquinone ansamycin系のgeldanamycin のgene clusterと比較し、一部の遺伝子欠損株を作成してその生合成における関与を調べた文献。

ORF01(2289bp):putative cation-transporting ATPase
機能実験、詳細記載無し。
Related Reference
ACC
O32220
PmId
[12644235] CopZ from Bacillus subtilis interacts in vivo with a copper exporting CPx-type ATPase CopA. (FEMS Microbiol Lett. , 2003)
comment
<BLAST 163; id=40%>
B. subtilisにおいて、copA欠損株ではcopperに対する耐性が低下し、細胞内のcopper濃度が上昇することが示されている。
Family/Domain
FD
IPR006416
comment
[IPR006416] ATPase, P-type, heavy metal translocating (Family)
Function
GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism

close this sectionSequence

selected fasta
>putative cation-transporting ATPase [unknown]
MADEPTALAAMTDLSIGGMTCAACVKRVEKKLARLDGVTATVNLATGRARVNHPPEVGPD
QLIATVEQAGYTAALPEPPRKERSEDRDAAQDARRERDRLVVTALLAVPVLVVSMVPGLQ
FRNWQWLCFVLAAPVVVWGAWPFHLRAARGLRHSAATMDTLVSLGVVASFAWSSYALFFG
GAGEPGMRMPFSLVPTASDGVAHVYLEAAVGVPLFVLAGRFLETRARLGTGAALRALARL
AGKEVSVRDGDGERLVPIEELRVGQVFVARPGERLATDGTVVEGSSAVDLSLVTGESEPV
EVGPGTPVTGGAVNAGGLLLVRATAVGADTQLSRITRLVTEAQAGKARAQRLADKAAGVF
VPVVLTLAVTVLGFWLGAGAEPQAAITASVAVLVVACPCALGLATPTALMAATGRGAQLG
VLVSGPQALEGLRHLDAVVLDKTGTLTSGQMSVARVTAVPGGLGEEELVRLAGAVEQGSE
HPLGRAITAHARRTVPGKSLPAVADFVALPGKGVRGRVADRLVEVLAPDDALPPVLAQAL
SASETAARTPVVVRVDGETEALIEVGDVLRPGSYRAVERLRRLGVRPVLATGDREAPARA
VATDLRIEEVHARCTPEDKAALVRELREQGYRVAVVGDGVNDAAALAGADLGIAMGTGTD
VAIGAADVTLVRGDIETLADAVRLARSALATIRVNLLWAFGYNAVTVPLAMVGLLNPMLA
AAAMSVSSLLVVGNSLRLRAWQPSPAGHRPSRPAAPAARKPL
selected fasta
>putative cation-transporting ATPase [unknown]
ATGGCCGACGAACCGACGGCCTTGGCCGCCATGACCGACCTCTCCATCGGCGGCATGACC
TGCGCGGCCTGTGTGAAGCGTGTCGAGAAGAAGCTGGCCAGGCTGGACGGGGTCACGGCC
ACCGTGAACCTCGCCACCGGCCGGGCCCGGGTGAACCACCCGCCCGAGGTCGGCCCGGAC
CAGCTCATCGCCACCGTCGAGCAGGCCGGCTACACCGCCGCGCTGCCCGAGCCGCCCAGG
AAGGAACGGAGCGAGGACAGGGACGCGGCGCAGGACGCCCGGCGGGAGCGCGACCGGCTG
GTGGTCACGGCGTTGCTCGCGGTCCCGGTGCTGGTCGTGTCGATGGTTCCCGGTCTCCAG
TTCCGCAACTGGCAGTGGCTGTGCTTCGTGCTCGCCGCCCCCGTCGTCGTCTGGGGAGCC
TGGCCCTTCCACCTGCGGGCGGCGCGCGGCCTGCGCCACTCGGCGGCGACCATGGACACT
CTGGTGTCGCTGGGTGTCGTGGCCTCCTTCGCCTGGTCCTCCTACGCGCTGTTCTTCGGC
GGGGCCGGCGAACCCGGGATGCGGATGCCCTTCAGCCTGGTGCCCACCGCCTCGGACGGC
GTGGCCCATGTCTATCTGGAAGCCGCCGTCGGCGTACCGCTGTTCGTCCTCGCCGGCCGC
TTCCTGGAAACGCGGGCCCGGCTGGGGACCGGCGCGGCACTGCGCGCCCTGGCCCGGCTG
GCCGGCAAGGAGGTATCGGTACGCGACGGCGACGGCGAGCGCCTGGTCCCGATCGAGGAA
CTGCGGGTCGGCCAGGTCTTCGTCGCCCGGCCCGGCGAGCGCCTGGCCACCGATGGCACG
GTGGTGGAGGGCAGCTCGGCCGTCGATCTGTCCCTGGTCACCGGGGAGAGCGAGCCGGTG
GAAGTCGGCCCCGGCACGCCCGTGACCGGCGGTGCCGTCAACGCGGGGGGCCTGCTCCTG
GTACGGGCCACCGCGGTCGGCGCCGATACCCAACTGTCCCGGATCACCCGGCTGGTGACC
GAGGCCCAGGCGGGCAAGGCACGGGCGCAGCGGCTCGCCGACAAGGCCGCGGGCGTCTTC
GTCCCGGTCGTGCTCACCCTGGCCGTCACCGTCCTCGGATTCTGGCTCGGGGCCGGTGCC
GAGCCACAGGCCGCGATCACCGCGAGCGTGGCCGTCCTGGTCGTGGCGTGCCCCTGCGCG
CTGGGCCTGGCGACCCCCACCGCGCTGATGGCGGCGACCGGCCGGGGCGCCCAACTGGGC
GTCCTGGTCAGCGGACCGCAGGCGCTGGAGGGGCTGCGGCACCTGGACGCCGTCGTACTG
GACAAGACCGGCACCCTCACTTCCGGGCAGATGAGTGTCGCCCGGGTCACCGCCGTACCG
GGCGGGCTCGGCGAGGAGGAACTGGTCCGGCTGGCGGGCGCGGTCGAACAGGGATCGGAA
CACCCGCTGGGGCGTGCCATCACCGCCCATGCCCGGCGCACCGTTCCCGGAAAGTCCCTC
CCGGCCGTGGCCGACTTCGTCGCGCTGCCGGGCAAGGGCGTGCGCGGGCGGGTGGCGGAC
CGGCTGGTCGAAGTCCTGGCCCCGGACGACGCGTTGCCCCCGGTATTGGCTCAGGCGCTG
TCGGCCTCCGAGACCGCCGCCCGTACACCGGTCGTGGTCCGCGTCGACGGCGAGACCGAG
GCACTGATCGAGGTCGGTGATGTGCTGCGCCCGGGAAGCTACCGGGCCGTGGAGCGGCTC
CGCCGCCTGGGCGTGCGACCGGTGCTCGCCACCGGCGACCGCGAGGCGCCCGCCCGCGCC
GTCGCCACCGACCTCCGCATCGAGGAGGTGCACGCCCGGTGCACCCCGGAGGACAAGGCC
GCCCTCGTCCGGGAGCTGCGGGAGCAGGGCTACCGGGTCGCCGTCGTCGGTGACGGGGTC
AACGACGCGGCCGCCCTGGCCGGCGCCGACCTCGGCATCGCCATGGGCACGGGCACGGAT
GTGGCGATCGGGGCGGCCGATGTGACCCTGGTACGCGGTGACATCGAGACCCTGGCGGAC
GCGGTCCGCCTCGCCCGCAGTGCGCTCGCCACGATCCGCGTCAATCTGCTCTGGGCGTTC
GGCTACAACGCCGTGACCGTACCGCTGGCCATGGTCGGCCTGCTCAACCCCATGCTCGCG
GCGGCCGCGATGTCGGTCAGCTCGCTGCTGGTGGTCGGCAACAGCCTGCGGCTACGCGCC
TGGCAGCCGTCGCCGGCCGGCCACCGCCCTTCCCGGCCCGCCGCACCTGCCGCGCGGAAG
CCACTGTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001757 ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (Family)
[215-458] 1.80000000000002e-35 TIGR01494 [547-723] 1.40000000000001e-38 TIGR01494
TIGR01494   ATPase_P-type
[289-303] 4.60000044330862e-23 PR00119 [439-453] 4.60000044330862e-23 PR00119 [583-593] 4.60000044330862e-23 PR00119 [636-655] 4.60000044330862e-23 PR00119 [659-671] 4.60000044330862e-23 PR00119
PR00119   CATATPASE
IPR005834 Haloacid dehalogenase-like hydrolase (Domain)
[436-650] 1.80000000000002e-40 PF00702
PF00702   Hydrolase
IPR006121 Heavy metal-associated domain, HMA (Domain)
[11-75] PS50846
PS50846   HMA_2
[15-72] 6e-13 PF00403
PF00403   HMA
[8-80] 3.0999994589937e-19 SSF55008
SSF55008   HeavyMe_transpt
IPR006403 ATPase, P type, cation/copper-transporter (Family)
[198-739] TIGR01511
TIGR01511   ATPase-IB1_Cu
[53-73] 2.10000037262656e-07 PR00943 [143-162] 2.10000037262656e-07 PR00943 [362-376] 2.10000037262656e-07 PR00943 [613-630] 2.10000037262656e-07 PR00943 [670-684] 2.10000037262656e-07 PR00943
PR00943   CUATPASE
IPR006404 ATPase, P-type, heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating (Family)
[203-738] 2.70000000000002e-107 TIGR01512
TIGR01512   ATPase-IB2_Cd
IPR006416 ATPase, P-type, heavy metal translocating (Family)
[158-738] TIGR01525
TIGR01525   ATPase-IB_hvy
IPR008250 ATPase, P-type, ATPase-associated domain (Domain)
[214-430] 1.29999999999998e-44 PF00122
PF00122   E1-E2_ATPase
IPR017969 Heavy-metal-associated, conserved site (Conserved_site)
[16-44] PS01047
PS01047   HMA_1
IPR018303 ATPase, P-type phosphorylation site (PTM)
[441-447] PS00154
PS00154   ATPASE_E1_E2
IPR023214 HAD-like domain (Domain)
[435-686] 9.19998414420354e-44 SSF56784
SSF56784   HAD-like_dom
[429-455] 4.39999999999997e-45 G3DSA:3.40.50.1000 [567-705] 4.39999999999997e-45 G3DSA:3.40.50.1000
G3DSA:3.40.50.1000   HAD-like_dom
IPR023299 ATPase, P-type, cytoplasmic domain N (Domain)
[456-566] 5.09999999999998e-17 G3DSA:3.40.1110.10
G3DSA:3.40.1110.10   ATPase_P-typ_cyto_domN
IPR023300 ATPase, P-type, cytoplasmic transduction domain A (Domain)
[156-339] 8.1e-20 G3DSA:2.70.150.10
G3DSA:2.70.150.10   ATPase_P-typ_cyto_domA
SignalP No significant hit
TMHMM
[99-121] Transmembrane (i-o) [126-148] Transmembrane (o-i) [161-183] Transmembrane (i-o) [203-222] Transmembrane (o-i) [356-378] Transmembrane (i-o) [383-405] Transmembrane (o-i) [694-716] Transmembrane (i-o)
Transmembrane 7   
first first   Herb_00020 Herb_00020
Page top