Herb_00080 : CDS information

Location

Organism	Streptomyces hygroscopicus
Strain	AM 3672
Entry name	Herbimycin A
Contig	AY947889
Start / Stop / Direction	10,286 / 9,204 / - [in whole cluster] 10,286 / 9,204 / - [in contig]
Location	complement(9204..10286) [in whole cluster] complement(9204..10286) [in contig]
Type	CDS
Length	1,083 bp (360 aa)

Annotation

Category	4.3 transport
Product	putative ABC transporter permease protein
Product (GenBank)	FtrD
Gene
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)	ORF8p; ORF8; similar to Streptomyces coelicolor SC00997
Reference	ACC Q49BF0 PmId [16085885] Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption. (Appl Environ Microbiol. , 2005) comment herbimycin生合成系gene clusterのクローニングを行い、同じbenzoquinone ansamycin系のgeldanamycin のgene clusterと比較し、一部の遺伝子欠損株を作成してその生合成における関与を調べた文献。 ORF08(1083bp):homolog of FtrD, S. coelicolor SC0997 機能実験、詳細記載無し。
Family/Domain	FD IPR000522 comment [IPR000522] Bacterial transport system permease protein (Family) Function GO:0005215 transporter activity

Sequence

>putative ABC transporter permease protein [FtrD]
MALDTTVSRKGTDARVRTRRSMPAGPLALLLAVALLAALTAAVAWGSTSIPPGEVWSVVW
RRLSGDAPRPGTNDLIVWQLRLPRALLAALVGAGLGLVGTAMQALVRNPLADPYFLGVSN
GASLGAVAAIVLGLGSGGALGLGLSGAAFAGALATFALVWAVARRGGGFAPLRLVLAGVA
IGQFLSGFTSYLVLQAGDEQQTHSVLFWLMGSLSGASWPLLAAPAVAVPAVLLLLQARAR
GLNALLMGDETAAGLGIDVVRLRRELFAVTSLLTGVLVAVSGAIAFVALMVPHVCRLVVG
GDHRRLLPVSALFGALLLVVVDIVCRTAMDTQELPVGVVTSLIGAPALLYLLDRRLGSGS

>putative ABC transporter permease protein [FtrD]
ATGGCGCTCGACACCACGGTGAGCCGGAAGGGCACCGATGCCCGTGTGCGCACCCGGCGC
TCCATGCCCGCCGGGCCGCTGGCGCTGCTCCTGGCGGTCGCGTTGCTCGCGGCCCTCACA
GCGGCGGTCGCCTGGGGTTCCACGTCGATACCGCCCGGTGAGGTGTGGAGCGTGGTCTGG
CGCAGACTGAGCGGCGACGCGCCCCGGCCCGGCACGAACGACCTGATCGTGTGGCAACTG
CGCCTGCCCCGCGCCCTGTTGGCGGCCCTGGTGGGTGCCGGGCTCGGCCTGGTCGGTACG
GCGATGCAGGCGCTCGTCCGCAACCCGCTGGCCGACCCGTACTTCCTGGGTGTCTCCAAC
GGCGCCTCCCTCGGTGCCGTCGCCGCCATCGTCCTCGGCCTCGGCAGCGGGGGAGCGCTG
GGCCTCGGTCTGTCCGGTGCCGCTTTCGCGGGAGCCCTGGCCACCTTCGCTCTCGTCTGG
GCGGTGGCGCGGCGCGGTGGCGGATTCGCGCCGCTCAGGCTGGTGCTCGCCGGGGTGGCC
ATCGGGCAGTTCCTGTCCGGCTTCACCAGCTACCTCGTTCTCCAGGCCGGGGACGAGCAG
CAGACCCACAGTGTGCTGTTCTGGCTGATGGGCAGCCTGAGCGGGGCGAGCTGGCCGCTG
CTGGCCGCCCCTGCGGTGGCGGTTCCGGCGGTCCTGCTGCTGTTGCAGGCCCGGGCCCGG
GGCCTGAACGCGCTGCTGATGGGCGATGAGACGGCGGCCGGGCTCGGCATCGACGTCGTA
CGGCTGCGCCGTGAGCTGTTCGCGGTCACCAGCCTGCTCACCGGCGTCCTCGTCGCGGTC
TCCGGGGCCATCGCCTTCGTCGCCCTCATGGTCCCCCACGTCTGCCGCCTTGTCGTCGGC
GGCGACCACCGCCGACTGCTGCCCGTGTCGGCGCTCTTCGGCGCGCTGCTGCTGGTGGTG
GTCGACATCGTGTGCCGCACGGCCATGGACACGCAGGAACTGCCGGTCGGGGTCGTCACC
TCGCTCATCGGCGCTCCGGCTCTGCTGTATCTGCTGGACCGGCGCTTGGGGAGCGGGAGT
TGA

Feature

BLASTP Database:UniProtKB:2011_09	show BLAST table
InterPro Database:interpro:38.0	IPR000522 ABC transporter, permease protein (Family) PF01032 FecCD
SignalP	Bacteria, Gram-positive Eukaryota Bacteria, Gram-negative
TMHMM	Transmembrane 9

Herb_00070 Herb_00090