Oxzol_00210 Oxzol_00210   Oxzol_00230 Oxzol_00230

Oxzol_00220 : CDS information

close this sectionLocation

Organism
StrainJA3453
Entry nameOxazolomycin
Contig
Start / Stop / Direction85,129 / 87,657 / + [in whole cluster]
85,129 / 87,657 / + [in contig]
Location85129..87657 [in whole cluster]
85129..87657 [in contig]
TypeCDS
Length2,529 bp (842 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)PKS
Gene
Gene (GenBank)ozmQ
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[20406823] Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units. (J Biol Chem. , 2010)
comment
※論文中ではLoading moduleをmodule 1としているが、本DBではLoading moduleはmodule 0とするため論文のmodule No.とずれが生じる。


oxazolomycin生合成遺伝子クラスターの報告。

ozmQ: PKS

module1(KS, ACP)　 ※論文中module2と記載

配列解析から、ozmO, ozmP, ozmQでオペロンを構成するかもしれないと言っているが、解析はしていない。

close this sectionPKS/NRPS Module

1
KS18..396
ACP736..806

close this sectionSequence

selected fasta
>polyketide synthase [PKS]
MNDQRTEQQAAAAEVRDSDIAVIGLACRFPGAATPDTFWKVLSEGRETLTHFSDEELRAA
GVAEPLLADDRYVKAGQVLVDADKFDAGLFGITRDEAELIDPQQRQFLECAYEALERAGY
DPQRGEQRIGVYAGVGLNTYLLHNLGERYRTASSVDRYRMMITNDKDFVATRTAYKLNLC
GPSVSTNTACSTSLVAVHLACLSLLSGDCTMALAGAAHIQADQGEGYLHHEGMIFSPDGH
CRAFDAKAQGTVIGNGVGAVVLKRLSDALADGDTVHAVIKGTAVNNDGSDKTGYTAPSVQ
GQAAVVAEAQEIADVGPETVSYVEAHGTATPLGDPIEVAALNQAFNREGAALAPGSCALG
SVKTNVGHLDTAAGMAGLIKTILMLRHRTLVPSLCFEAPNPEIDFAAGPFYVGTETKEWP
AGPTPRRAGVSSFGIGGTNAHVIVEEPPAVGPAPDAAAAGPRLLVLSANTPAALDTATAD
LARALRKDRDLDLSAVAQTLALGRRVLPYRRALVATGVRDAALALALGDAGRVMTAGPAD
ERPVVELVTGGGTPEHAAALYEEAAAFREHFDRCAAELGTPAAELLRGHGPDAAFAVQYA
TARALAGWGSTAPVVAADRTELPDAALRLLDGIGAQHTAGAGRPGVALLPAASAPVGTAF
LLGLIGRLWTAGDTVDWTVFHQGEPVRRVPLPTYPFERVRHWAEPHGGAAPAAGPAALTL
RDRFQGVPDAEKSALLTGFIRQEIAAVMGASDPRTVDLDTNLFDMGLDSLILIEVIAKLS
DELAHPVRSSAFVEYPTVRSFVADLGEELGIVPGTPEAAPAASGGRVSRRAQRAAARRPG
GA
selected fasta
>polyketide synthase [PKS]
ATGAACGACCAGCGAACAGAGCAGCAGGCAGCCGCGGCCGAGGTCCGGGACTCCGACATC
GCCGTCATCGGGCTCGCCTGCCGGTTCCCCGGCGCCGCCACCCCCGACACGTTCTGGAAG
GTCCTGAGCGAGGGCCGGGAGACCCTCACCCACTTCTCCGACGAGGAGCTGCGCGCGGCC
GGCGTCGCCGAGCCCCTCCTGGCCGACGACCGTTACGTGAAGGCCGGGCAGGTCCTCGTG
GACGCCGACAAGTTCGACGCGGGCCTCTTTGGCATCACCCGGGACGAGGCGGAGCTGATC
GACCCCCAGCAGCGCCAGTTCCTGGAGTGCGCGTACGAGGCCCTGGAGCGCGCGGGCTAC
GACCCGCAGCGCGGCGAGCAGAGAATCGGCGTCTACGCCGGGGTCGGCCTGAACACCTAT
CTGCTGCACAACCTCGGCGAGCGCTACCGCACCGCCTCGTCCGTGGACCGCTACCGCATG
ATGATCACGAACGACAAGGACTTCGTCGCCACCCGTACCGCCTACAAGCTGAACCTGTGC
GGCCCGAGCGTCAGCACCAACACCGCCTGCTCGACCTCGCTGGTGGCCGTGCACCTGGCC
TGCCTCAGCCTGCTCTCCGGCGACTGCACCATGGCGCTCGCGGGCGCCGCCCACATCCAG
GCCGACCAGGGCGAGGGCTACCTCCACCACGAGGGGATGATCTTCTCGCCGGACGGCCAC
TGCCGGGCCTTCGACGCCAAGGCGCAGGGAACCGTCATCGGCAACGGCGTGGGCGCCGTG
GTCCTGAAGCGGCTGAGCGACGCGCTGGCCGACGGCGACACCGTGCACGCCGTCATCAAG
GGCACCGCCGTCAACAACGACGGTTCGGACAAGACGGGTTACACCGCGCCGAGCGTCCAG
GGACAGGCCGCCGTCGTCGCCGAGGCCCAGGAGATCGCCGACGTCGGCCCGGAGACCGTC
TCGTACGTGGAGGCCCACGGCACGGCCACGCCGCTCGGCGACCCGATCGAGGTCGCCGCG
CTCAACCAGGCCTTCAACCGCGAGGGTGCCGCACTCGCCCCCGGCTCCTGCGCGCTGGGC
TCCGTCAAGACCAACGTCGGCCACCTCGACACGGCCGCGGGCATGGCGGGCCTGATCAAG
ACGATCCTGATGCTGCGCCACCGCACCCTGGTCCCGAGCCTCTGCTTCGAAGCCCCCAAC
CCGGAGATCGACTTCGCGGCGGGACCCTTCTACGTCGGCACCGAGACCAAGGAGTGGCCC
GCGGGCCCGACCCCGCGCCGGGCGGGCGTGAGCTCCTTCGGCATCGGCGGCACCAACGCC
CACGTCATCGTGGAGGAGCCGCCCGCCGTCGGCCCCGCCCCCGACGCGGCGGCGGCCGGG
CCGAGGCTCCTCGTGCTCTCCGCCAACACCCCCGCCGCGCTGGACACGGCCACCGCCGAC
CTCGCCCGCGCGCTCCGCAAGGACCGCGACCTCGACCTGTCCGCCGTGGCCCAGACCCTG
GCCCTCGGCCGCCGCGTGCTCCCCTACCGGCGCGCGCTGGTCGCCACCGGCGTACGGGAC
GCCGCGCTCGCCCTGGCCCTGGGCGACGCGGGACGGGTCATGACCGCCGGCCCCGCCGAC
GAGCGGCCGGTCGTCGAGCTGGTGACCGGCGGCGGCACGCCCGAGCACGCGGCGGCCCTG
TACGAGGAGGCGGCGGCCTTCCGCGAGCACTTCGACCGGTGCGCGGCCGAGCTGGGCACG
CCCGCCGCCGAACTGCTGCGCGGGCACGGCCCGGACGCGGCCTTCGCCGTCCAGTACGCC
ACCGCGCGGGCCCTGGCCGGCTGGGGCAGCACCGCCCCCGTGGTCGCCGCCGACCGCACC
GAGCTGCCCGACGCGGCCCTGCGTCTGCTCGACGGGATCGGCGCGCAGCACACCGCCGGC
GCCGGACGGCCCGGCGTGGCCCTGCTGCCGGCCGCGTCGGCCCCCGTCGGCACGGCGTTC
CTGCTCGGCCTCATCGGGCGGCTGTGGACGGCGGGCGACACCGTCGACTGGACGGTGTTT
CACCAGGGCGAGCCGGTACGGAGGGTGCCGCTGCCGACCTACCCCTTCGAGCGCGTACGG
CACTGGGCGGAGCCGCACGGCGGCGCGGCACCGGCCGCGGGCCCCGCGGCGCTGACCCTG
CGGGACCGCTTCCAGGGAGTGCCGGACGCGGAGAAGAGCGCCCTGCTCACCGGGTTCATC
CGGCAGGAGATCGCGGCGGTCATGGGTGCCTCCGACCCGCGGACCGTGGACCTCGACACC
AATCTGTTCGACATGGGCCTCGACTCGCTGATCCTGATCGAGGTCATCGCCAAGCTCAGC
GACGAACTGGCGCATCCGGTGCGCTCGTCGGCGTTCGTGGAGTACCCGACGGTGCGTTCG
TTCGTCGCGGACCTCGGCGAGGAGCTGGGCATCGTCCCGGGGACACCGGAGGCGGCACCC
GCCGCCTCCGGGGGCCGGGTGTCCCGCCGGGCGCAGCGGGCCGCCGCCCGCCGCCCCGGG
GGTGCGTGA
[1] KS18..396
[1] ACP736..806
[1] KS52..1188
[1] ACP2206..2418

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR006162 Phosphopantetheine attachment site (PTM)
[764-779] PS00012
PS00012   PHOSPHOPANTETHEINE
IPR009081 Acyl carrier protein-like (Domain)
[729-842] 1.80000149287196e-15 SSF47336
SSF47336   ACP_like
[739-808] 6e-13 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
[740-803] 1.2e-13 PF00550
PF00550   PP-binding
[736-806] PS50075
PS50075   ACP_DOMAIN
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[18-268] 2.59999999999995e-70 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[276-396] 7.4e-39 PF02801
PF02801   Ketoacyl-synt_C
IPR016038 Thiolase-like, subgroup (Domain)
[18-279] 4.89999999999996e-73 G3DSA:3.40.47.10 [280-448] 1.9e-61 G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[10-449] 3.99998544139406e-75 SSF53901
SSF53901   Thiolase-like
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[181-197] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
[737-809] 2.59999946718995e-16 SM00823
SM00823   PKS_PP
SignalP No significant hit
TMHMM No significant hit
Oxzol_00210 Oxzol_00210   Oxzol_00230 Oxzol_00230
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