FD891_00010 FD891_00010   FD891_00030 FD891_00030

FD891_00020 : CDS information

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Organism
StrainA-8890
Entry nameFD-891
Contig
Start / Stop / Direction23,890 / 40,605 / + [in whole cluster]
23,890 / 40,605 / + [in contig]
Location23890..40605 [in whole cluster]
23890..40605 [in contig]
TypeCDS
Length16,716 bp (5,571 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)polyketide synthase
Gene
Gene (GenBank)gfsB
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[20589823] Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation. (Chembiochem. , 2010)
comment
FD-891生合成gene clusterの報告。

gfsB: PKS modules 5-7

module 5 (KS-MMT-DH-ER-KR-ACP)
module 6 (KS-MT-KR-ACP)
module 7 (KS-MT-DH-KR-ACP)

MT = malonyltransferase
MMT = methylmalonyltransferase

KR5, KR6, KR7 domainsはB1-type KRsで、2R-methyl and 3R-hydroxyl configurationを産生。

ユニークなtyrosine残基が存在する事から、ER5 domainによって触媒されるenoyl reductionの立体化学も2S configurationを産生すると予測。

close this sectionPKS/NRPS Module

5 methylmalonyl-CoA
6 malonyl-CoA
7 malonyl-CoA
KS58..434
AT611..928
DH976..1148
ER1478..1777
KR1787..1967
ACP2075..2145
KS2168..2544
AT2710..3033
KR3373..3552
ACP3655..3725
KS3746..4123
AT4279..4601
DH4649..4813
KR5132..5307
ACP5412..5482

close this sectionSequence

selected fasta
>polyketide synthase [polyketide synthase]
MSVPPPGATPSRTSRTKGLKDRPRMENEEKLVEYLKRATTDLRQARRRLREVEDQQQEPV
AIIGMSCRYPGDVHSPDDLWRMVADGDDGISTFPAERGWDVERLYDPDPDRPGTTYTTRG
GFLHDAHLFDAEFFGISPREALATDPQQRLLLETSWEAFERAGIDPTSLRGSHTGVFAGV
MYQDYAHRVRPVPEEFEGYLGNGSAGSIASGRVAYTFGLEGPAVTVDTACSSSLVALHLA
VQSLRQGDSTLALAGGVAIMSTPDVFVEYSRQRGLAADGRCKAFAEAADGTGWAEGVGML
LLERLSDARRNGHPVLAVVRGSAVNQDGASSRLTAPNGPSQQRVIRQALANARLTPADVD
VVEAHGTGTKLGDPIEAQALLATYGQDRPAERPLWLGSLKSNIGHTQAAAGVGGVIKMVM
AIRHGVAPRTLHVDRPTPEVDWSAGAVELLTEARPWPETDRPRRAGVSAFGVSGTNAHVI
IEQPPAIEGTGLGDDAPPTAEHPEERTPADGGPAPQPVAWPLSAKSPEALRDQARQLRHH
LTSGATASALSHPLADIGHSLATTRTAFDHRVVVLGTDHDALLRSLAALADGGTDPSVVQ
GSVRGRGRVAFVFPGQGSQWEGMARELLDTSPVFARQMQACADALSAYVDWSLHDVLRGA
PDAPGLDRVDVVQPVLWAIMISLSELWRAHGVQPSAVVGHSQGEIAAAYVAGALSLDDSA
RVVALRSKALRALSGKGGMLSVPLSEEDLTPQLAAHTGQLSIAAVNGPGSVVVSGDADAL
EGLFEELTAAGVRARKVAVDYASHSAHVEALREELLTRLGPVAPRPAKVPFYSTVTGERL
AGTEALDADYWYRNLRETVRFEQATRALLAQNIGVFVETGPHPVLAVGLQETIDATGGSA
VALGSLRRGEGGPDRFLRSLAEAYAHGAPLDWDLLFPGARRVELPTYAFQRDHYWLQIPE
GGPADAAGLGLAAVEHPLLAAATSLADGDGLIVTGRLSTRSLPWLADHAVTGTVLLPGTA
FVELALRAADLTDCHLLDELTLHTPLVVPDDDPVRVQVRVAAPDPATGRRALTVHARPES
PDGDADQEEQGAEWTLHATGYLAVGAHEPAVPDQGQWPPAGATPLDVTDLYPRLADAGYG
YGLAFQGLRAAWRLGDDVYAEAELPDEHSDQAGRYGLHPALLDAALHAAGFAGFPDGDGA
LPGPRLPFSWTGVTLSAVGARALRIRLARTGDDTLTVTLTDPAGEPVATVESLALRPLAT
NQAPRTPSDLHRVAYTPRDLPADASTAHWAVLDADDLAYALNLPSHPDRDALAALDPAPP
VVLTGWPVPDDPAPQAARTVLARALHDIQDWLADDRLADTRLVVVTHNALPADDWQDTDP
VAASLTGLLRTAQSENPGRLVLIDTDGHPASWQALPALVATGEPQAALRLGEARVPRLAP
AATDAALSVPAAVPAATDASLPVPADTSAWRLAVESPGTLDHLTLIPWAAATAPLEEGQV
RIAVRTCGVNFRDVLIALGMYPDPDMLGSEGAGRVVEVGPGVTDLAVGDRVAGILAGGFG
PLAVIDAPKVARIPDSWTWEQAASVPLAFATAWYALVDLAALAPGEKVLVHAAAGGVGMA
AVQIARHLGAEVYATASPAKWDTLRALGLDDDHIASSRDTAFAEKFPAVDVVLDSLAGEF
VDASLRLLPHGGRFVEMGKTDRRDPERIAADHPGVHYRAFDLRESGDRRLREMLDEIFAL
VEDGTLHPLPYRSWDLRRAPEAFRHMQQARHIGKIVLTVPPALDPDGTVLVTGATGTLGA
LVTRHLVTEHGVRRLLLVSRSGPQAPGADALLADLAAAGAEATLTACDTADRDQLRAVLD
AVPADHPLTAVIHTAGALDDGVLSALTPERLDAVLRPKADAAWHLHELTAGHDLAAFVLF
SSAAGLFGNAGQGNYAAANAFLDALAQHRRALGLPATSLAWGLWEERGGMTGHLDTADVG
RLSRTGVATLDSAHGLALFDAALSTGQTLLVPLPLDRAALHRQARTGSLPALLSGLVRTT
PARRTATGTAATGSVGDTLARRLTAAAPADRDRIVNDLVRDHAAAVLGHGSATAVGLGRA
FRDLGFDSLTAVELRNRLGAATGLRLPATLVFDHPTPEELAAHLRDTLLGAADSGAAAVV
TTSAEADEPLAVVAMSCRFPGGTGSPEELWELLADGGDAIGALPADRGWDLAGLYHPDPD
QPGTSYARHGGFLHDAGDFDASLFGISPREALAMDPQQRLLLETSWEAFERAGLDLRTLR
GSRTGVYVGALPSSYGGTLHDAPDGLEGHLMTGNSTSIVSGRLAYTFGLQGPAVTVDTAC
SSSLVALHLAVQALRSGEVTMALVGGATVMSNPGGLIAFSRQRGLAADGRCKAFSAAADG
MGMAEGVGMLLVERLSDAERLGHPVLAVVRGSAINQDGASNGLTAPNGPSQQRVIRDALA
DARLNASEVDVVEAHGTGTKLGDPIEAQALLATYGQDRPEERPVLLGSVKSNIGHTQAAA
GVAGVIKMVLAMRHGLLPRTLHVDEPSTQIDWNAGALSLLAEETPWPETGRPRRAAVSSF
GISGTNAHVILEQAPASVPAPASASVPGDSGEAPDPVVVPWVVSGRSADALRAQAGQLAA
WADSAAGRDTEPVDVGRALATARSFLEHRAVVVGGDRAELVEALRALATDPAAGSTAADP
DGPGGRLGLVFSGQGSQRPGMGRELYTAYPVFAAALDEVCGVLDEVMGAQPPSEGWTGSL
REVMFEVSSDLLDETGFTQPALFAFEVALYRLLESWGVAGEVVAGHSVGEIAAAHVAGVL
SLADACALVAARGRLMQALPSGGAMVAVEASEEEVAAVLAGRGDEGAGIGAVNAPGSVVV
SGVEAAVEEVAARFAGLGRRTRRLKVSHAFHSPLMDPMLAEFRRVVEGLSFAPPRMTVVS
TLTGAVASDEELCSVDYWVRHARETVRFGDAVRCMAGAEVDRFAEVGPSGVLAGLVRASV
TGEGTRAAVALQRGNRTEPGALVSALGELFVSGLPVDWATYFAGRPLRRVELPTYAFQRA
RYWLEGAAGAGGRQSAADGQDEVDAAFWEAVEHGDLSALGAGLDVDGEARLADVLPALSS
WRRRAEQASVVDAWRYRVTWAPLPEPARASATGVWLLLVPAGAEDAADATRTVEGALAEH
GGEVVKVDVAHPEADEARTALAQQITEQFIERFGVTEIGRLRGVVSLLALADGDDPRHPS
VSRGLALTLGLVQALGDMELTAPLWCLTRGAVAVDASDGVDGAVQAQVWGLGRAVALEHP
DRWGGLVDLPEYVDPRTARRLTGVLTGTGAGAGAGGLGREDQIALRATGAFGCRLTRDTV
APAGDPGEWTLSGTVLVTGGTGAVGGHVARWLAARGAERLVLVSRRGPRAPGADALRDEL
TAAGAQVEMLACDLSDGSAVTALVAGLAAGGDLTAVVHAAGVLDDGVLASLSVERCAEVL
AAKARAAHHLDLATRDVNLDAFVLFSSVSGVLGAAGQANYAAANAHLDAVALHRHALGLP
AVSVAWGPWAEGGMAGEDAAAGRLSRDGWTAMAPEPAATAMARAVAAGHPAVMIADVDWQ
RFAPAYAAVRPGNSLLTGVPEARQAQPQPWSADGERSAWASRLAGLPEEEQRTALLDLVR
GQVASVLGHASMQTIDPARAFKEIGFDSLTAVELRNRLNAATGLALPATLVFDYPTPVAL
AEYVGSQVLGTSSPAVTGPLVVAAVDEPVAIIGMSCRFPGGVQSPEELWDLVVGGRDAIS
SFPTDRGWDVDALFDPDPEKPGKTYTRHGAFLHDAAEFDPRFFGISPREASAMDPQQRLL
LETAWEAFERAGIDPAALRGSATGVFTGTNGQDYATRLRETPQGVEGYLMTGNAGSVISG
RLAYTFGLEGPAMTVDTACSASLVALHLAAQALRQGECSLALAGGATVMSTPGAFVEFSR
QGGLAADGRCKAFSASADGTGWGEGVGLLLLERLSDAERNGHPVLAVVRGSAVNQDGASN
GLTAPNGPSQQRVIRQALANARLSASEVDVVEAHGTGTRLGDPIEAQALLATYGQDRPED
RPLWLGSVKSNLGHTQAAAGVAGIIKSVMAMRHGVLPATLHVDEPTSEVDWSAGAVELLT
EARPWPEVGRPRRAAVSGFGVSGTNAHVILEQAAETGSTSEEGPAALVPTVVWPISGRDE
QALRGQARRLRERLVVEPGLSAADVGLSLATTRSCFEQRAVVVGETRDELLAGLEALAEG
REASGLVRGSARGSVNVGFLFSGQGSQRVGMGRELAERFPVFAGVFGEVCGLLDPLLPRP
LGEVIAAGPGVLGRTVFTQPALFAVEVAAARLLLSWGVRPQVVAGHSVGEIAAAHVAGVL
SLEDACALVAARGRLMEALPAGGVMVALEATEGEVAELLEAHAGAPVGVAAVNGPRAVVV
SGDASPVGEIADVVRSWGRRTKRLEVSHAFHSPLMEPMLAEFTEVVSGLEFAAPQIGFVS
AVTGGLVGADVVSRPEYWVEHVAQPVRFADAVRAAVDEAGVSLFVEVGPGGALSAMGPDC
LDETVGDKQPVVFVPSLRADRPEPLAVTTALATAHVNGVQPDWQAVFAGTGAARVELPTY
AFQRGRYWLDASVGGTGDASAVGLATLEHPLLAGVVDLAEEDRTVFTGRLSLTTHPWLAD
HAVFGSVLLPGTGFVELALAAGQYTGFGHLDELTVHAPLVLPARGAVHVQLVLDGVDDSG
RRALTVHSRPEGVAGEQTWTRHATGALTVAEAVDPPAVSAVWPPAGAIEVELDDPYERFA
AEGYAYGPAFQGLRRVWRGDGELFAEVELGAQELEAAGRFGVHPALLDAALHPLLLADGS
TGQDGDTPTAGRLPFSWTGVSLRATGATTARVTLAFTDGDAVRITVADGDGGLVASVDAL
VTRPIAAGQLAAGRSGLFEVEWAPVSSSPAGSASWAVVGGGEAGVSAGGPGLGSYEDLAA
LRRAMDSGAPVPEVVFAHCGGGAEAADVVGGTHTATHAALVSLREWLADERFAGARLAIV
TGGAVAVRPGDEVSDLAGAAVWGLVRSAQSEHPGQFVLVDTDGAAEPSSAAAALATGEPQ
VAVRGGEVFVPRLARADRTPAADSGVRWDPDKSLLVTGASGVLAGLVVRHAVAEWAVRHV
VLVSRSGADGLAQELAEAGVSVQQARCDVADREAVAAVLAGIPAEHRLGGVIHTAGVLDD
GVIESLTPERLAPVLRPKVDGAWWLHELTADVDLSVFAVFSSAAGVFGAAGQGNYAAANA
FLDALALYRHREGLPATSLSWGLWAERSGMAGQLADAQLERLERTGVHPLSSSEGLALLD
AALATGRPWLVPVGLDLGVMRAQADLGVTPLFRGLVRAPLRRAQVDKAASNAPDELRREL
AVASAADRERMVLDLVRDRTAVVLGFGSRDEVGVDSGFTSMGVDSLAGVDLRNRLSSATG
LRLPTTLIFDYPTPAALARYLHTHLVDDAVDQVDIRSVLAELDRLEATLAQVQAGDVGHM
KIASRLQDLVGQWHGSGGATPGEDTVTDLEEATADEIFSFIDDNFGSTEVH
selected fasta
>polyketide synthase [polyketide synthase]
GTGAGCGTGCCGCCCCCCGGCGCGACCCCCTCAAGGACTTCGCGAACCAAAGGACTTAAG
GACAGACCCCGCATGGAAAACGAAGAGAAGCTCGTCGAATACCTCAAGCGGGCCACCACC
GACCTCCGGCAGGCCCGTCGGCGGCTCCGCGAGGTCGAGGACCAGCAGCAGGAGCCCGTC
GCGATCATCGGGATGAGCTGTCGTTACCCGGGCGACGTGCACTCCCCGGACGACCTGTGG
CGCATGGTGGCCGACGGTGATGACGGCATCTCGACGTTCCCGGCGGAACGGGGGTGGGAC
GTCGAGCGCCTCTACGACCCCGACCCGGACCGGCCCGGCACGACGTACACCACCCGGGGC
GGCTTCCTGCACGACGCGCACCTCTTCGACGCGGAGTTCTTCGGGATCTCACCACGCGAG
GCGCTGGCCACGGACCCGCAGCAGCGGCTGCTGCTGGAGACCTCCTGGGAGGCGTTCGAA
CGGGCCGGTATCGACCCGACTTCCCTGCGGGGCAGCCACACCGGTGTGTTCGCCGGCGTG
ATGTACCAGGACTACGCCCACCGGGTGCGGCCCGTGCCGGAGGAGTTCGAGGGCTACCTC
GGCAACGGCAGCGCGGGCAGCATCGCCTCGGGCCGGGTGGCGTACACCTTCGGGCTGGAG
GGCCCTGCGGTGACCGTGGACACGGCCTGCTCGTCGTCCCTCGTGGCCCTGCACCTGGCC
GTGCAGTCGCTGCGGCAGGGCGACTCCACCCTGGCCCTGGCCGGCGGGGTCGCGATCATG
TCCACCCCGGACGTGTTCGTCGAGTACAGCCGGCAGCGGGGCCTCGCCGCCGACGGCCGC
TGCAAGGCGTTCGCCGAGGCCGCCGACGGCACCGGCTGGGCCGAGGGCGTGGGCATGCTG
CTGCTGGAGCGGCTGTCCGACGCACGGCGCAACGGCCACCCGGTCCTGGCCGTCGTACGC
GGCAGCGCCGTCAACCAGGACGGCGCCAGCAGCCGGCTCACCGCGCCCAACGGCCCCTCC
CAGCAGCGGGTGATCCGGCAGGCCCTCGCCAACGCCCGCCTGACCCCTGCCGACGTGGAC
GTGGTGGAGGCCCACGGCACCGGCACCAAGCTGGGCGACCCCATCGAGGCGCAGGCCCTG
CTCGCCACCTACGGCCAGGACCGGCCCGCGGAACGACCCCTGTGGCTGGGGTCGTTGAAG
TCGAACATCGGTCACACCCAGGCCGCCGCCGGAGTGGGCGGTGTGATCAAGATGGTGATG
GCGATACGGCACGGTGTCGCGCCGCGCACCCTCCACGTCGACCGGCCCACACCGGAAGTC
GACTGGTCGGCCGGAGCGGTGGAACTGCTGACCGAGGCACGGCCCTGGCCGGAGACCGAC
CGGCCCCGCCGCGCCGGCGTCTCCGCCTTCGGCGTCAGCGGCACGAACGCCCACGTCATC
ATCGAACAGCCCCCCGCCATCGAGGGAACCGGTCTCGGCGACGACGCCCCCCCGACTGCC
GAGCATCCGGAGGAACGTACGCCCGCCGACGGCGGCCCCGCCCCCCAGCCGGTCGCCTGG
CCCCTGTCCGCGAAGAGCCCCGAGGCCCTGCGGGACCAGGCCCGGCAACTACGGCACCAC
CTGACCTCGGGCGCCACCGCATCCGCCCTCAGCCACCCCCTCGCCGACATCGGCCACTCC
CTCGCCACCACCCGCACTGCCTTCGACCACCGCGTCGTCGTACTCGGCACCGACCACGAC
GCCCTCCTCCGCAGCCTGGCGGCCCTCGCCGACGGCGGTACCGATCCGTCGGTGGTGCAG
GGCAGCGTGCGGGGGCGGGGCCGGGTCGCGTTCGTCTTCCCCGGCCAAGGCTCCCAATGG
GAGGGAATGGCACGCGAACTCCTCGACACGTCACCTGTCTTCGCCCGGCAGATGCAGGCC
TGCGCGGACGCCCTCTCCGCGTACGTCGACTGGTCCCTCCACGACGTCCTGCGCGGCGCC
CCCGACGCACCCGGCCTCGACCGCGTCGACGTCGTCCAGCCGGTGCTGTGGGCGATCATG
ATCTCCCTGTCCGAGCTGTGGCGTGCGCACGGCGTGCAGCCGAGTGCCGTGGTCGGCCAC
TCGCAGGGCGAGATCGCCGCGGCGTATGTGGCCGGTGCGCTGTCCCTCGACGACTCGGCG
CGTGTGGTCGCGCTGCGCAGCAAGGCCCTGCGTGCCCTGTCCGGCAAGGGCGGCATGCTG
TCCGTACCGCTGTCGGAGGAGGACCTCACTCCCCAACTAGCCGCGCACACGGGCCAGTTG
TCGATCGCCGCCGTGAACGGACCCGGTTCCGTCGTGGTGTCCGGCGACGCCGACGCCCTG
GAGGGCCTCTTCGAGGAGCTGACCGCGGCGGGCGTCAGGGCCCGGAAGGTCGCGGTGGAC
TATGCGTCCCACTCCGCCCACGTCGAGGCCCTCCGTGAGGAACTCCTCACGCGACTCGGC
CCGGTCGCGCCCCGGCCCGCCAAGGTGCCCTTCTACTCCACGGTCACCGGCGAACGCCTC
GCCGGCACCGAGGCGCTGGACGCCGACTACTGGTACCGCAACCTGCGCGAGACCGTCCGC
TTCGAGCAGGCCACGCGGGCCCTGCTCGCCCAGAACATCGGTGTGTTCGTCGAGACCGGC
CCGCACCCGGTGCTCGCCGTCGGCCTTCAGGAGACGATCGACGCCACCGGCGGCAGCGCC
GTCGCCCTCGGCTCACTGCGCCGGGGCGAGGGAGGCCCGGACCGTTTCCTGCGGTCACTG
GCCGAGGCGTACGCGCACGGCGCCCCGCTCGACTGGGACCTGCTGTTCCCCGGAGCGCGC
CGGGTCGAACTGCCCACGTACGCGTTCCAGCGGGACCACTACTGGCTCCAGATCCCGGAG
GGCGGTCCCGCCGACGCCGCCGGGCTGGGCCTCGCCGCAGTCGAGCACCCGCTGCTGGCC
GCCGCGACGAGCCTCGCCGACGGCGACGGACTGATCGTCACCGGCCGCCTTTCGACCCGG
TCCCTGCCGTGGCTGGCCGACCACGCGGTGACCGGCACCGTCCTGCTGCCCGGCACCGCC
TTCGTCGAACTGGCCCTGCGCGCAGCCGATCTGACGGACTGCCATCTACTCGACGAACTC
ACCCTGCACACGCCCCTGGTGGTCCCCGACGACGACCCCGTACGCGTCCAGGTGCGGGTC
GCCGCCCCCGACCCGGCCACCGGCCGACGCGCCCTGACCGTGCACGCCCGCCCCGAGAGC
CCCGACGGCGACGCGGACCAGGAGGAGCAGGGCGCCGAGTGGACGCTGCACGCCACCGGA
TACCTCGCCGTCGGCGCTCACGAGCCCGCCGTACCCGATCAGGGACAGTGGCCGCCCGCC
GGAGCCACACCGCTGGACGTCACCGACCTCTACCCCCGGCTCGCCGACGCCGGCTACGGC
TACGGACTCGCCTTCCAGGGCCTGCGAGCCGCCTGGCGGCTCGGTGACGACGTGTACGCC
GAGGCCGAACTGCCCGACGAGCACAGCGACCAGGCGGGCCGCTACGGACTGCACCCCGCG
CTGCTCGACGCAGCCCTGCACGCGGCCGGGTTCGCCGGTTTCCCCGACGGTGACGGCGCA
CTCCCCGGGCCCCGGCTGCCGTTCTCCTGGACCGGAGTCACCCTCTCCGCCGTGGGCGCA
CGGGCCCTCCGCATCCGTCTCGCGCGCACCGGCGACGACACCCTGACCGTCACACTCACC
GACCCGGCAGGCGAGCCCGTCGCCACCGTGGAATCCCTTGCGCTACGGCCGCTCGCGACC
AACCAGGCCCCCCGCACGCCGTCCGACCTCCACCGTGTGGCGTACACCCCGCGTGACCTG
CCCGCCGACGCGTCCACCGCGCACTGGGCCGTGCTGGACGCCGACGATCTCGCATACGCG
CTGAACCTGCCGAGCCACCCCGACCGCGACGCGCTCGCCGCCCTCGACCCGGCCCCGCCC
GTCGTCCTCACCGGCTGGCCCGTCCCCGACGATCCCGCCCCGCAGGCCGCCCGTACCGTC
CTCGCCCGGGCCCTGCACGACATCCAGGACTGGCTCGCCGACGACCGCCTCGCCGACACC
CGCCTCGTCGTCGTCACCCACAACGCCCTCCCGGCCGACGACTGGCAGGACACCGACCCC
GTCGCGGCCTCCCTGACCGGCCTGCTGCGCACCGCCCAGTCCGAGAACCCCGGCCGGCTC
GTCCTGATCGACACCGACGGACACCCCGCCTCCTGGCAGGCACTGCCCGCGCTCGTCGCG
ACCGGCGAACCCCAGGCCGCGCTCCGGCTCGGCGAGGCCCGCGTCCCGCGCCTGGCCCCG
GCCGCCACCGACGCCGCACTGTCCGTTCCCGCCGCCGTCCCTGCCGCCACCGACGCCTCC
CTGCCCGTCCCGGCCGACACCAGCGCCTGGCGGCTGGCCGTGGAGAGCCCCGGCACCCTC
GACCACCTGACCCTGATCCCCTGGGCCGCCGCGACGGCTCCCCTGGAGGAGGGACAGGTA
CGGATCGCCGTCCGCACCTGTGGTGTCAACTTCCGTGACGTCCTCATCGCCCTCGGCATG
TACCCCGACCCGGACATGCTCGGCAGCGAAGGCGCGGGCCGTGTCGTCGAGGTCGGTCCC
GGTGTCACCGATCTGGCCGTGGGCGACCGGGTGGCCGGCATCCTCGCCGGTGGATTCGGG
CCTCTCGCGGTCATCGACGCGCCCAAGGTCGCCCGCATCCCCGACAGTTGGACATGGGAG
CAGGCCGCCTCCGTACCGCTCGCCTTCGCGACCGCCTGGTACGCCCTCGTCGACCTGGCC
GCCCTCGCCCCCGGCGAGAAGGTGCTGGTCCACGCGGCCGCCGGTGGCGTCGGCATGGCG
GCCGTGCAGATCGCCCGGCACCTCGGCGCCGAGGTGTACGCCACGGCGAGCCCCGCCAAG
TGGGACACCCTGCGCGCACTCGGCCTGGACGACGACCACATCGCCTCCTCCCGCGACACC
GCGTTCGCCGAGAAGTTCCCGGCCGTCGACGTCGTCCTGGACTCCCTCGCCGGGGAGTTC
GTGGACGCCTCGCTGCGCCTGCTGCCCCACGGCGGCCGGTTCGTCGAGATGGGCAAGACC
GACCGACGCGACCCGGAGCGGATCGCCGCCGACCACCCCGGTGTCCACTACCGCGCCTTC
GACCTGCGGGAGAGCGGCGACCGGCGGCTGCGCGAGATGCTGGACGAGATCTTCGCCCTC
GTCGAGGACGGGACGCTCCACCCGCTGCCGTACCGCAGCTGGGATCTGCGCCGGGCCCCG
GAGGCGTTCCGCCACATGCAGCAGGCCCGGCACATCGGCAAGATCGTGCTGACCGTGCCG
CCCGCCCTCGACCCCGACGGCACCGTCCTGGTCACCGGCGCCACCGGCACCCTCGGCGCA
CTCGTCACCCGCCACCTCGTCACCGAGCACGGCGTACGACGGCTGCTGCTCGTCAGCCGC
TCCGGACCGCAGGCGCCGGGCGCCGACGCACTCCTGGCCGATCTCGCCGCCGCCGGAGCC
GAGGCCACGCTCACGGCCTGCGACACCGCCGACCGCGACCAACTGCGCGCCGTACTGGAC
GCCGTCCCCGCCGACCACCCCCTCACCGCCGTCATCCACACCGCCGGCGCCCTCGACGAC
GGCGTGCTGTCCGCCCTCACCCCCGAGCGACTCGACGCCGTACTGCGGCCCAAGGCCGAC
GCGGCCTGGCACCTGCACGAACTGACCGCCGGCCACGACCTCGCGGCGTTCGTGCTCTTC
TCCTCCGCCGCCGGGCTCTTCGGCAACGCCGGACAGGGCAACTACGCGGCCGCCAACGCC
TTCCTCGACGCGCTCGCCCAGCACCGCCGCGCCCTCGGCCTGCCCGCCACCTCGCTGGCC
TGGGGCCTGTGGGAGGAGCGCGGCGGCATGACCGGCCACCTCGACACGGCCGACGTCGGC
CGCCTGTCCCGGACGGGCGTCGCCACCCTGGACTCCGCACACGGTCTGGCGCTCTTCGAC
GCCGCGCTGAGCACTGGGCAGACCCTGCTGGTGCCGCTTCCCCTGGACCGGGCCGCCCTG
CACCGCCAGGCCCGCACCGGCAGCCTGCCCGCCCTCCTCAGCGGCCTCGTCCGCACCACC
CCGGCCCGCAGGACCGCCACCGGTACCGCCGCCACGGGCAGTGTCGGGGACACCCTGGCC
CGGCGTCTGACGGCCGCCGCGCCCGCCGACCGCGACCGGATCGTCAACGACCTCGTACGC
GACCACGCCGCCGCCGTCCTCGGCCATGGCTCCGCGACCGCCGTGGGCCTCGGACGCGCC
TTCCGCGACCTCGGCTTCGACTCGCTGACCGCCGTCGAACTCCGCAACCGCCTCGGCGCC
GCCACCGGACTGCGACTGCCCGCGACGCTGGTCTTCGACCACCCCACACCGGAAGAGCTC
GCCGCCCACCTCCGCGACACCCTGCTCGGCGCCGCCGACTCCGGCGCCGCTGCCGTGGTC
ACGACGTCCGCCGAGGCCGACGAGCCGCTGGCCGTCGTCGCCATGAGCTGCCGCTTCCCC
GGCGGAACCGGCTCCCCGGAGGAACTGTGGGAGCTGCTGGCCGACGGCGGCGACGCCATC
GGCGCCCTGCCCGCCGACCGGGGCTGGGACCTCGCAGGGCTCTACCACCCGGACCCCGAC
CAACCCGGCACCTCCTACGCCCGCCACGGCGGATTCCTGCACGACGCCGGAGACTTCGAC
GCCTCCCTGTTCGGCATCTCACCGCGCGAGGCACTGGCGATGGACCCGCAGCAGCGACTG
CTGCTGGAGACCTCCTGGGAGGCGTTCGAACGCGCGGGCCTCGACCTGCGGACCCTGCGC
GGCAGCCGCACCGGCGTCTACGTCGGCGCCCTGCCCTCCAGCTACGGCGGCACCCTGCAC
GACGCGCCCGACGGCCTCGAAGGCCACCTGATGACGGGCAACTCCACCAGCATCGTCTCC
GGCCGCCTCGCCTACACCTTCGGCCTCCAGGGCCCCGCGGTCACCGTGGACACGGCCTGC
TCGTCGTCCCTGGTCGCCCTGCACCTGGCCGTCCAGGCGCTGCGCTCCGGCGAGGTCACC
ATGGCGCTCGTCGGCGGGGCCACGGTCATGTCCAACCCGGGCGGACTGATCGCCTTCAGC
CGCCAGCGCGGACTCGCCGCCGACGGCCGCTGCAAGGCGTTCTCCGCCGCCGCCGACGGC
ATGGGCATGGCCGAAGGCGTGGGCATGCTGCTCGTGGAGCGGCTCTCCGACGCCGAACGG
CTCGGCCACCCGGTGCTCGCCGTCGTCCGCGGCTCGGCGATCAACCAGGACGGCGCCTCC
AACGGCCTCACCGCCCCCAACGGCCCCTCCCAGCAGCGCGTCATCCGCGACGCCCTCGCC
GACGCCCGCCTCAACGCCTCCGAGGTCGACGTGGTCGAGGCGCACGGCACGGGCACGAAG
CTGGGCGACCCGATCGAGGCGCAGGCCCTGCTCGCCACCTACGGCCAGGACCGGCCCGAG
GAGCGGCCGGTGCTGCTGGGCTCGGTGAAGTCCAACATCGGCCACACCCAGGCCGCCGCC
GGTGTCGCCGGCGTCATCAAGATGGTCCTGGCCATGCGCCACGGCTTGCTCCCGCGCACC
CTCCACGTCGACGAACCCAGCACCCAGATCGACTGGAACGCGGGCGCGTTGTCCCTGCTC
GCCGAGGAGACACCGTGGCCGGAGACCGGCCGTCCGCGCCGGGCCGCGGTGTCGTCGTTC
GGGATCAGCGGGACGAACGCGCACGTCATCCTGGAGCAGGCCCCGGCCTCGGTCCCAGCT
CCGGCCTCGGCTTCGGTCCCGGGTGACTCGGGCGAGGCGCCGGACCCCGTGGTGGTGCCA
TGGGTGGTCTCCGGACGTTCGGCGGACGCGCTGCGGGCCCAGGCCGGACAGCTGGCCGCG
TGGGCCGATTCCGCAGCCGGACGGGACACGGAACCGGTCGACGTGGGCCGCGCGCTGGCC
ACGGCACGTTCCTTCCTCGAACACCGGGCCGTGGTGGTCGGCGGCGACCGGGCCGAACTG
GTCGAGGCGCTACGGGCGCTGGCCACGGACCCGGCCGCCGGGTCGACGGCGGCGGACCCC
GACGGCCCGGGCGGTCGGCTGGGGCTGGTCTTCTCCGGGCAGGGGTCTCAACGGCCCGGT
ATGGGGAGGGAGTTGTACACCGCGTATCCGGTGTTCGCCGCAGCCCTCGACGAAGTGTGC
GGGGTGCTCGACGAGGTGATGGGCGCGCAGCCGCCCTCGGAAGGCTGGACCGGTTCTCTG
CGTGAGGTGATGTTCGAGGTCTCTTCCGACCTGCTGGATGAGACGGGGTTCACGCAGCCG
GCGTTGTTCGCGTTCGAGGTGGCGTTGTACCGGCTGCTGGAGTCGTGGGGTGTGGCCGGT
GAGGTCGTAGCCGGTCACTCGGTGGGCGAGATCGCGGCGGCGCATGTGGCCGGGGTGTTG
TCGCTGGCGGACGCGTGTGCGTTGGTGGCGGCGCGTGGCCGGTTGATGCAGGCGTTGCCT
TCGGGCGGCGCGATGGTGGCGGTGGAGGCGTCCGAGGAGGAGGTCGCCGCTGTGCTGGCC
GGTCGTGGGGACGAGGGAGCCGGGATCGGTGCGGTCAACGCGCCCGGCTCGGTGGTGGTC
TCCGGTGTCGAGGCCGCGGTGGAGGAAGTCGCGGCGCGTTTCGCCGGCTTGGGGCGTCGT
ACACGGCGGCTGAAGGTCTCGCACGCGTTCCACTCCCCGCTGATGGACCCGATGCTGGCG
GAGTTCCGGCGGGTGGTCGAGGGCCTGTCTTTCGCTCCGCCGCGTATGACTGTCGTATCG
ACGCTGACCGGTGCGGTCGCTTCGGACGAGGAACTGTGCTCGGTCGACTACTGGGTCCGC
CATGCCCGGGAGACGGTGCGCTTCGGTGACGCGGTGCGGTGCATGGCGGGCGCGGAGGTC
GACCGTTTCGCCGAGGTCGGGCCCAGCGGTGTGCTGGCCGGGCTGGTCCGGGCGAGTGTG
ACCGGGGAGGGCACGCGGGCGGCGGTGGCCTTGCAGCGGGGCAACCGGACCGAACCGGGC
GCGCTGGTGTCGGCGTTGGGCGAGCTGTTCGTCAGCGGCCTGCCGGTGGACTGGGCGACG
TACTTCGCGGGGCGGCCCCTGCGGCGGGTGGAGCTGCCGACGTACGCCTTCCAGCGGGCG
CGTTACTGGCTGGAGGGGGCGGCCGGTGCGGGCGGTCGACAGAGCGCGGCCGATGGCCAG
GACGAGGTGGACGCGGCCTTCTGGGAGGCGGTGGAGCACGGAGATCTCTCTGCTCTGGGC
GCCGGTTTGGACGTGGACGGCGAGGCCCGGCTCGCGGATGTGCTGCCCGCCCTGTCGTCC
TGGCGCCGCCGGGCCGAGCAGGCGTCGGTCGTGGACGCCTGGCGCTACCGGGTGACCTGG
GCGCCGCTGCCCGAACCCGCCCGTGCTTCCGCGACCGGGGTGTGGCTGCTGCTGGTTCCG
GCCGGGGCCGAGGACGCGGCGGATGCCACACGGACCGTCGAGGGCGCGCTGGCCGAACAC
GGCGGCGAGGTGGTGAAGGTGGACGTCGCCCACCCCGAGGCCGACGAGGCGCGTACCGCC
CTCGCCCAACAGATCACCGAGCAGTTCATCGAACGGTTCGGCGTCACGGAGATCGGCCGG
CTGCGTGGGGTGGTGTCGCTGCTGGCGCTGGCCGACGGCGACGACCCTCGGCATCCGTCG
GTGTCGCGTGGGCTGGCGTTGACCCTGGGACTCGTACAGGCGCTCGGTGACATGGAGTTG
ACCGCACCGCTGTGGTGCCTGACGCGGGGCGCGGTCGCCGTGGACGCCTCGGACGGGGTG
GACGGTGCGGTGCAGGCGCAGGTGTGGGGCCTGGGCCGGGCCGTGGCGTTGGAGCACCCG
GATCGTTGGGGTGGTCTGGTCGACCTGCCCGAGTACGTCGACCCGCGTACGGCTCGGCGT
CTGACCGGTGTCCTGACCGGTACGGGTGCGGGTGCGGGTGCTGGGGGCCTCGGTCGCGAG
GATCAGATCGCTCTGCGCGCCACCGGCGCCTTCGGCTGCCGTCTGACCCGCGACACCGTG
GCCCCGGCCGGAGATCCGGGGGAGTGGACGCTGTCGGGCACGGTCCTGGTGACCGGCGGT
ACCGGTGCCGTCGGTGGGCATGTGGCCCGTTGGCTGGCCGCCCGGGGAGCCGAACGGCTG
GTCCTGGTCAGCCGCCGGGGACCCCGGGCGCCCGGAGCGGACGCGCTGCGGGACGAACTG
ACGGCCGCCGGCGCACAGGTGGAGATGCTCGCCTGCGACCTGAGCGACGGGTCCGCGGTG
ACCGCGTTGGTGGCCGGGCTGGCCGCCGGGGGCGACCTCACGGCGGTGGTCCACGCCGCG
GGCGTACTCGACGACGGTGTCCTCGCCTCGCTGTCGGTCGAACGCTGCGCCGAGGTCCTG
GCGGCGAAGGCGCGGGCCGCCCACCACCTGGACCTGGCCACTCGTGACGTGAACCTGGAC
GCCTTCGTGCTGTTCTCGTCCGTCTCCGGGGTGCTGGGCGCCGCCGGACAGGCCAACTAC
GCCGCCGCCAACGCCCACCTGGACGCCGTAGCCCTCCACCGGCACGCCCTCGGCCTGCCC
GCGGTCTCCGTCGCCTGGGGCCCATGGGCCGAGGGCGGCATGGCCGGCGAGGACGCGGCC
GCCGGGCGACTGAGCCGGGACGGATGGACGGCCATGGCCCCGGAGCCGGCCGCCACGGCC
ATGGCCCGCGCCGTGGCCGCCGGGCACCCCGCCGTGATGATCGCCGACGTCGACTGGCAG
CGCTTCGCACCGGCCTACGCCGCCGTACGACCGGGCAACTCCCTGCTGACCGGCGTACCG
GAGGCCCGACAGGCTCAGCCGCAGCCCTGGTCGGCCGACGGCGAGCGGTCCGCCTGGGCG
AGCCGCCTGGCGGGACTGCCGGAGGAGGAACAGCGCACGGCTCTGCTGGACCTGGTGCGT
GGGCAGGTGGCGAGTGTGCTGGGGCATGCCTCGATGCAGACGATCGATCCGGCGCGGGCG
TTCAAGGAGATCGGTTTCGACTCGCTGACGGCGGTGGAGCTGCGGAACCGTCTGAATGCG
GCCACCGGCCTGGCCCTGCCCGCCACGTTGGTCTTCGACTACCCGACCCCGGTGGCGCTG
GCCGAGTACGTCGGCTCTCAGGTGCTCGGTACGTCATCGCCCGCGGTCACAGGTCCGCTG
GTCGTGGCGGCTGTGGATGAACCGGTCGCGATCATCGGGATGAGCTGCCGGTTCCCCGGT
GGAGTCCAGAGCCCCGAGGAACTGTGGGATCTGGTGGTCGGGGGCCGGGACGCGATCTCG
TCCTTCCCCACCGACCGAGGCTGGGACGTCGACGCACTGTTCGATCCGGACCCTGAGAAG
CCGGGCAAGACGTACACCCGTCACGGCGCGTTCCTGCATGACGCGGCCGAGTTCGACCCC
CGCTTCTTCGGGATCTCACCCCGTGAGGCCTCGGCCATGGACCCGCAGCAGCGGCTGCTG
CTGGAGACGGCGTGGGAGGCGTTCGAACGGGCCGGTATCGACCCGGCCGCGCTGCGCGGC
AGCGCGACCGGCGTCTTCACCGGCACCAACGGCCAGGACTACGCCACTCGACTGCGGGAG
ACCCCGCAGGGCGTCGAGGGGTACCTGATGACCGGCAACGCCGGGAGTGTGATCTCCGGG
CGGCTGGCCTACACGTTCGGCCTGGAGGGGCCGGCCATGACCGTGGACACGGCGTGCTCC
GCGTCGCTGGTCGCCCTGCACCTGGCCGCGCAGGCGCTGCGGCAGGGCGAGTGCTCGCTG
GCGTTGGCCGGTGGTGCGACGGTGATGTCGACTCCGGGGGCGTTCGTGGAGTTCAGCAGG
CAGGGCGGGCTGGCGGCGGACGGCCGGTGCAAGGCGTTCTCGGCTTCGGCGGACGGTACG
GGCTGGGGCGAGGGCGTCGGTCTGTTGCTGCTGGAGCGGCTCTCGGACGCCGAACGCAAC
GGACATCCCGTTCTGGCGGTGGTGCGGGGCAGCGCCGTCAACCAGGACGGTGCCTCGAAC
GGGCTGACGGCGCCGAATGGTCCGTCGCAGCAGCGGGTGATCCGTCAGGCGCTCGCGAAC
GCCCGTCTGTCCGCGTCCGAGGTGGATGTGGTGGAGGCGCACGGTACGGGGACGAGGCTG
GGTGACCCGATCGAGGCGCAGGCGTTGCTGGCGACGTATGGCCAGGACCGGCCGGAGGAT
CGGCCGTTGTGGCTGGGTTCGGTGAAGTCGAACCTCGGTCACACGCAGGCGGCTGCGGGT
GTCGCCGGGATCATCAAGTCGGTGATGGCGATGCGGCATGGTGTGCTGCCGGCCACGTTG
CATGTGGACGAGCCGACGTCGGAGGTGGACTGGTCGGCGGGGGCGGTGGAGCTGCTGACC
GAGGCGAGGCCTTGGCCCGAGGTGGGGCGTCCGCGTAGGGCGGCGGTCTCCGGCTTCGGC
GTCAGCGGTACCAACGCCCACGTCATCCTCGAACAGGCCGCCGAGACCGGCTCGACGTCC
GAGGAAGGGCCCGCCGCCCTCGTGCCGACGGTGGTCTGGCCGATCTCGGGCAGGGACGAG
CAGGCCCTGCGTGGGCAGGCTCGGAGGTTGCGGGAGCGTTTGGTGGTCGAGCCGGGCCTG
TCGGCTGCGGATGTGGGTCTTTCGCTGGCGACGACTCGTTCGTGCTTCGAGCAGCGTGCG
GTGGTGGTCGGGGAGACGCGGGACGAGCTTCTGGCGGGGCTTGAGGCGTTGGCTGAGGGT
CGGGAGGCGTCGGGGCTGGTGCGTGGTTCGGCCCGGGGCAGCGTGAATGTGGGCTTCCTG
TTCTCTGGTCAGGGTTCTCAGCGGGTTGGTATGGGCCGGGAGTTGGCGGAGCGTTTCCCG
GTGTTCGCCGGGGTGTTCGGTGAGGTGTGCGGGTTGCTGGATCCGTTGCTGCCGAGGCCG
TTGGGTGAGGTGATCGCTGCTGGTCCGGGGGTGTTGGGGCGGACGGTGTTCACGCAGCCG
GCGTTGTTCGCGGTGGAGGTGGCGGCGGCGCGGTTGTTGTTGTCGTGGGGTGTGCGGCCG
CAGGTGGTGGCCGGGCATTCGGTGGGGGAGATCGCGGCGGCGCACGTTGCCGGGGTGTTG
TCGCTGGAGGACGCGTGCGCGCTGGTGGCGGCGCGGGGTCGGTTGATGGAGGCGTTGCCC
GCCGGCGGCGTGATGGTGGCTCTGGAGGCGACTGAGGGTGAGGTCGCGGAGCTGCTGGAG
GCTCATGCGGGTGCGCCGGTCGGCGTGGCAGCGGTGAACGGTCCTCGGGCTGTGGTCGTC
TCCGGCGACGCGAGCCCTGTCGGAGAGATCGCGGATGTGGTGCGCTCGTGGGGGCGTCGT
ACGAAGCGGCTTGAGGTGTCGCACGCGTTTCACTCGCCGTTGATGGAGCCGATGCTCGCC
GAGTTCACCGAGGTCGTGTCGGGGCTGGAGTTCGCGGCGCCGCAGATCGGGTTCGTGTCG
GCGGTCACTGGTGGGCTGGTCGGGGCTGATGTGGTGTCGCGCCCGGAGTACTGGGTGGAG
CATGTGGCCCAGCCGGTGCGTTTCGCGGACGCGGTACGGGCGGCCGTGGATGAGGCGGGT
GTGTCGCTGTTCGTCGAGGTGGGCCCCGGTGGTGCGCTCTCGGCGATGGGTCCGGACTGC
CTCGACGAGACCGTCGGGGACAAGCAGCCGGTGGTGTTCGTGCCGTCCCTGCGCGCGGAC
CGTCCCGAGCCGCTGGCGGTGACGACTGCGCTGGCCACGGCCCACGTCAACGGCGTCCAG
CCCGACTGGCAGGCCGTCTTCGCCGGCACGGGCGCGGCCCGCGTGGAACTGCCGACCTAC
GCCTTCCAACGCGGGCGTTACTGGCTGGACGCGTCCGTGGGCGGTACCGGGGACGCGTCG
GCCGTCGGGTTGGCGACTCTCGAACACCCCTTGCTGGCCGGTGTGGTGGACCTGGCCGAG
GAGGACCGGACGGTGTTCACGGGCCGGTTGTCCCTGACGACGCACCCGTGGCTGGCCGAT
CACGCCGTGTTCGGTTCGGTGCTGCTGCCGGGCACGGGCTTCGTCGAGTTGGCGTTGGCC
GCCGGTCAGTACACCGGCTTCGGTCATCTGGACGAACTGACCGTCCATGCCCCGCTGGTC
CTGCCCGCACGGGGTGCCGTCCACGTCCAACTGGTGCTCGACGGCGTGGACGACTCCGGG
CGACGCGCTCTCACCGTTCACTCCCGGCCCGAGGGAGTGGCCGGGGAGCAGACGTGGACG
CGGCACGCCACGGGTGCGCTGACCGTGGCGGAGGCCGTCGACCCGCCCGCCGTGTCGGCC
GTGTGGCCCCCGGCTGGCGCCATCGAGGTCGAACTCGACGACCCGTACGAGCGCTTCGCC
GCAGAGGGCTACGCGTACGGCCCGGCGTTCCAGGGGCTGCGCCGAGTGTGGCGCGGCGAC
GGGGAACTGTTCGCCGAGGTCGAGCTGGGTGCGCAGGAGCTGGAGGCGGCCGGTCGCTTC
GGTGTCCATCCGGCCCTGCTGGACGCGGCGCTGCACCCGCTGCTGCTGGCGGACGGTTCG
ACAGGGCAGGACGGCGATACGCCGACGGCGGGGCGGCTGCCCTTCTCCTGGACCGGCGTG
TCTCTTCGCGCCACGGGGGCGACGACGGCTCGGGTGACGCTGGCCTTCACGGACGGGGAC
GCCGTACGTATCACCGTGGCGGACGGCGACGGTGGGCTCGTGGCATCGGTGGACGCGCTG
GTGACGCGTCCGATCGCGGCCGGGCAGCTTGCGGCAGGGCGGTCGGGGCTCTTCGAGGTG
GAGTGGGCGCCCGTGTCGTCCTCGCCTGCCGGGTCCGCGAGTTGGGCGGTCGTCGGCGGT
GGGGAGGCCGGAGTTTCGGCCGGCGGTCCGGGTCTCGGCTCGTACGAGGATCTGGCCGCT
CTACGGCGGGCTATGGACTCCGGCGCACCGGTGCCCGAGGTGGTCTTCGCCCACTGCGGC
GGCGGAGCCGAGGCTGCCGACGTGGTCGGCGGGACACATACGGCGACGCACGCGGCGTTG
GTGTCGCTGCGGGAGTGGCTTGCCGACGAGCGGTTCGCCGGGGCGCGTCTCGCGATCGTG
ACCGGTGGCGCGGTCGCTGTCCGGCCGGGGGACGAGGTGTCGGACCTGGCGGGCGCGGCG
GTGTGGGGCCTGGTGCGGTCGGCGCAGTCCGAGCACCCGGGACAGTTCGTGCTCGTCGAC
ACCGACGGCGCGGCGGAGCCTTCGTCCGCGGCGGCGGCCCTGGCCACGGGCGAGCCGCAG
GTCGCGGTACGCGGTGGCGAGGTGTTCGTGCCCAGGCTGGCCCGGGCGGACAGGACCCCG
GCGGCCGACAGCGGCGTCCGCTGGGATCCGGACAAGTCGCTGTTGGTGACGGGCGCTTCG
GGTGTTCTGGCGGGGCTGGTCGTCCGGCATGCGGTCGCCGAGTGGGCCGTACGGCATGTG
GTGCTGGTCAGCCGTAGCGGAGCCGACGGGCTGGCTCAGGAACTGGCCGAGGCGGGCGTG
TCCGTCCAGCAGGCGCGTTGCGATGTGGCCGACCGGGAGGCTGTGGCGGCCGTACTGGCC
GGCATCCCCGCCGAACACCGGCTCGGCGGTGTGATCCACACGGCAGGTGTCCTGGACGAC
GGCGTGATCGAGTCGCTGACCCCGGAGCGCTTGGCGCCCGTACTGCGGCCCAAGGTGGAC
GGCGCTTGGTGGCTGCACGAGCTGACCGCCGACGTTGACCTGTCGGTGTTCGCGGTGTTC
TCCTCCGCGGCCGGTGTGTTCGGCGCGGCGGGTCAGGGCAACTATGCCGCTGCCAATGCC
TTCCTCGACGCCCTCGCCCTGTACCGGCACCGTGAAGGCCTCCCGGCGACGTCCCTCTCC
TGGGGCCTGTGGGCCGAACGCAGCGGTATGGCCGGTCAGTTGGCCGACGCCCAGCTCGAA
CGACTGGAACGTACCGGTGTCCACCCTCTCTCCTCCTCCGAGGGACTCGCCCTGCTCGAC
GCGGCGCTGGCCACAGGCCGCCCCTGGCTGGTCCCGGTCGGGTTGGACCTCGGGGTGATG
CGTGCTCAGGCGGACCTCGGGGTGACACCCCTGTTCCGTGGTCTCGTCCGGGCCCCGCTG
CGGCGGGCCCAGGTCGACAAGGCCGCGTCGAACGCGCCGGACGAGCTCCGGAGGGAGCTT
GCGGTGGCGTCGGCGGCGGACCGGGAGCGCATGGTGCTGGACCTGGTCCGGGACCGTACG
GCGGTCGTGCTCGGCTTCGGCAGTCGGGACGAGGTGGGCGTGGACAGCGGCTTCACCAGC
ATGGGTGTCGACTCGCTCGCCGGAGTCGACCTGCGCAACCGGCTGAGTTCCGCGACCGGG
CTGCGGCTTCCGACGACACTGATCTTCGACTACCCCACCCCCGCCGCCCTGGCCCGCTAT
CTGCACACCCACCTGGTCGACGACGCCGTCGACCAGGTGGACATCCGCTCCGTGCTGGCG
GAACTCGACCGACTGGAAGCCACGCTCGCACAGGTGCAGGCCGGCGACGTCGGCCATATG
AAGATCGCGAGCCGGCTCCAGGACCTGGTGGGGCAGTGGCACGGATCCGGTGGCGCGACC
CCCGGAGAAGACACGGTGACCGACCTCGAAGAGGCGACCGCCGACGAGATCTTCTCCTTC
ATCGACGACAACTTCGGATCCACCGAGGTCCATTAG
[5] KS58..434
[5] AT611..928
[5] methylmalonyl-CoA801..805
[5] DH976..1148
[5] ER1478..1777
[5] KR1787..1967
[5] ACP2075..2145
[6] KS2168..2544
[6] AT2710..3033
[6] malonyl-CoA2908..2912
[6] KR3373..3552
[6] ACP3655..3725
[7] KS3746..4123
[7] AT4279..4601
[7] malonyl-CoA4468..4472
[7] DH4649..4813
[7] KR5132..5307
[7] ACP5412..5482
[5] KS172..1302
[5] AT1831..2784
[5] methylmalonyl-CoA2401..2415
[5] DH2926..3444
[5] ER4432..5331
[5] KR5359..5901
[5] ACP6223..6435
[6] KS6502..7632
[6] AT8128..9099
[6] malonyl-CoA8722..8736
[6] KR10117..10656
[6] ACP10963..11175
[7] KS11236..12369
[7] AT12835..13803
[7] malonyl-CoA13402..13416
[7] DH13945..14439
[7] KR15394..15921
[7] ACP16234..16446

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001227 Acyl transferase domain (Domain)
[604-733] G3DSA:3.40.366.10 [801-919] G3DSA:3.40.366.10 [2708-2836] G3DSA:3.40.366.10 [2907-3015] G3DSA:3.40.366.10 [4270-4399] G3DSA:3.40.366.10 [4468-4589] G3DSA:3.40.366.10
G3DSA:3.40.366.10   Ac_transferase_reg
IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site (Conserved_site)
[1605-1626] PS01162
PS01162   QOR_ZETA_CRYSTAL
IPR006162 Phosphopantetheine attachment site (PTM)
[2103-2118] PS00012 [3683-3698] PS00012 [5440-5455] PS00012
PS00012   PHOSPHOPANTETHEINE
IPR009081 Acyl carrier protein-like (Domain)
[2075-2148] 4.2e-67 G3DSA:1.10.1200.10 [3652-3728] 4.2e-67 G3DSA:1.10.1200.10 [5411-5485] 4.2e-67 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
[2075-2145] PS50075 [3655-3725] PS50075 [5412-5482] PS50075
PS50075   ACP_DOMAIN
[2078-2144] 4.70000000000001e-12 PF00550 [3658-3724] 6.3e-12 PF00550 [5422-5481] 9e-11 PF00550
PF00550   PP-binding
[2068-2184] 2.70000183580794e-28 SSF47336 [3648-3763] 1e-29 SSF47336 [5403-5489] 1.99999636034521e-20 SSF47336
SSF47336   ACP_like
IPR011032 GroES-like (Domain)
[1469-1623] 5.89998809405691e-35 SSF50129
SSF50129   GroES_like
IPR013154 Alcohol dehydrogenase GroES-like (Domain)
[1498-1553] 1.2e-09 PF08240
PF08240   ADH_N
IPR013968 Polyketide synthase, KR (Domain)
[1787-1966] 4.9e-63 PF08659 [3373-3551] 4.30000000000003e-60 PF08659 [5134-5306] 3.2e-55 PF08659
PF08659   KR
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[58-308] 2.20000000000002e-96 PF00109 [2168-2418] 8.80000000000003e-94 PF00109 [3746-3997] 6.90000000000007e-102 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[316-434] 2.89999999999999e-48 PF02801 [2426-2544] 2.50000000000001e-49 PF02801 [4005-4123] 2.70000000000002e-49 PF02801
PF02801   Ketoacyl-synt_C
IPR014043 Acyl transferase (Domain)
[611-928] 7.09999999999991e-107 PF00698 [2710-3033] 3.40000000000004e-56 PF00698 [4279-4601] 3.60000000000002e-61 PF00698
PF00698   Acyl_transf_1
IPR015083 Polyketide synthase, docking (Domain)
[25-51] 3.5e-12 PF08990
PF08990   Docking
[28-58] 4.89999951782359e-07 SSF101173
SSF101173   Polyketide_synth_docking
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
[608-911] 4.20003460493095e-69 SSF52151 [2706-3007] 4.69998262513189e-71 SSF52151 [4276-4564] 1.69998802370953e-67 SSF52151
SSF52151   Acyl_Trfase/lysoPlipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
[735-800] 1.20000117458134e-18 SSF55048 [2841-2907] 2.09999806691534e-16 SSF55048 [4401-4467] 9.5000102816722e-15 SSF55048
SSF55048   Malonyl_transacylase_ACP-bd
IPR016038 Thiolase-like, subgroup (Domain)
[60-320] G3DSA:3.40.47.10 [321-485] G3DSA:3.40.47.10 [2171-2430] G3DSA:3.40.47.10 [2431-2596] G3DSA:3.40.47.10 [3749-4009] G3DSA:3.40.47.10 [4010-4175] G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[50-432] 9.30000048475962e-105 SSF53901 [2160-2542] 2.7000136937899e-103 SSF53901 [3739-4121] 3.699978135861e-108 SSF53901
SSF53901   Thiolase-like
IPR016040 NAD(P)-binding domain (Domain)
[1570-1751] 1e-51 G3DSA:3.40.50.720 [1787-1973] 1.29999999999998e-108 G3DSA:3.40.50.720 [3374-3558] 1.29999999999998e-108 G3DSA:3.40.50.720 [5131-5306] 1.29999999999998e-108 G3DSA:3.40.50.720
G3DSA:3.40.50.720   NAD(P)-bd
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[221-237] PS00606 [2331-2347] PS00606 [3910-3926] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
[612-910] 9.20006495413801e-130 SM00827 [2710-3015] 3.89999861795218e-113 SM00827 [4280-4581] 7.80005155399507e-115 SM00827
SM00827   PKS_AT
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
[2076-2148] 5.20000089003336e-35 SM00823 [3656-3728] 1.10000150671643e-35 SM00823 [5413-5485] 4.60000044330862e-31 SM00823
SM00823   PKS_PP
IPR020807 Polyketide synthase, dehydratase domain (Domain)
[976-1148] 3.10001307370203e-81 SM00826 [4649-4813] 7.90003079443025e-80 SM00826
SM00826   PKS_DH
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
[60-486] SM00825 [2170-2596] SM00825 [3749-4175] SM00825
SM00825   PKS_KS
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
[1787-1967] 8.00002659346736e-64 SM00822 [3373-3552] 3.39999972437719e-54 SM00822 [5132-5307] 1.3000049540733e-51 SM00822
SM00822   PKS_KR
IPR020843 Polyketide synthase, enoylreductase (Domain)
[1478-1777] SM00829
SM00829   PKS_ER
SignalP No significant hit
TMHMM No significant hit
FD891_00010 FD891_00010   FD891_00030 FD891_00030
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