FD-891 : Cluster information
Compound
| Entry name | FD-891 |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | malonyl-CoA |
| Chain Length | 13 |
| Sugar Unit | none |
| Classification | Other Macrocyclic Lactone |
| Activity | Antitumor Toxic |
| Composition | C33H54O8 |
Original source
| Organism | Streptomyces graminofaciens |
|---|---|
| Strain | A-8890 |
| Contig | AB469193 |
PKS/NRPS Module
| FD891_00010 gfsA | 0 |  | malonyl-CoA |
| 1 |  | methylmalonyl-CoA | |
| 2 | | methylmalonyl-CoA | |
| 3 | | malonyl-CoA | |
| 4 |  | malonyl-CoA | |
| FD891_00020 gfsB | 5 |  | methylmalonyl-CoA |
| 6 | | malonyl-CoA | |
| 7 | | malonyl-CoA | |
| FD891_00030 gfsC | 8 | | malonyl-CoA |
| FD891_00040 gfsD | 9 | | malonyl-CoA |
| 10 |  | methylmalonyl-CoA | |
| FD891_00050 gfsE | 11 | | methylmalonyl-CoA |
| 12 |  | methylmalonyl-CoA |
Reference
- Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.
- Kudo F, Motegi A, Mizoue K, Eguchi T[PMID: 20589823]Chembiochem. 11 (2010) 1574-82
- Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis in Streptomyces graminofaciens A-8890.
- Kudo F, Kawamura K, Furuya T, Yamanishi H, Motegi A, Komatsubara A, Numakura M, Miyanaga A, Eguchi T[PMID: 26630077]Chembiochem. 17 (2016) 233-8
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 FD-891 |
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History
- 2016-12-27[Update]
- 2014-06-25[Update]
- 2014-03-10[Release]
