FD891_00030 FD891_00030   FD891_00050 FD891_00050

FD891_00040 : CDS information

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Organism
StrainA-8890
Entry nameFD-891
Contig
Start / Stop / Direction47,477 / 58,396 / + [in whole cluster]
47,477 / 58,396 / + [in contig]
Location47477..58396 [in whole cluster]
47477..58396 [in contig]
TypeCDS
Length10,920 bp (3,639 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)polyketide synthase
Gene
Gene (GenBank)gfsD
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[20589823] Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation. (Chembiochem. , 2010)
comment
FD-891生合成gene clusterの報告。

gfsD: PKS modules 9-10

module 9 (KS-MT-DH-KR-ACP)
module 10 (KS-MMT-DH*-KR-ACP)

MT = malonyltransferase
MMT = methylmalonyltransferase

KR9 domainはB1-type KRsで、2R-methyl and 3R-hydroxyl configurationを産生。
KR10 domainはB2-type KRsで、2S-methyl and 3R-hydroxyl configurationを産生。

DH10 domainはFD-891の構造上必要のないドメインであるが、Gfs PKSsの他の活性型DH domainsとよく似ており、DH10 domainが不活性型であるという根拠がない。
FD-891の立体化学からKR10は2S-methyl and 3R-hydroxyl functionalityを提供すると考えられるので、DH10 domainはalpha-置換基でS配置をもつ伸長されたポリケチド中間体を基質として許容しないのかもしれない。そしてこのようにスキップされた基質は次のmodule 11によって加工されるだろう。

close this sectionPKS/NRPS Module

9 malonyl-CoA
10 methylmalonyl-CoA
KS34..410
AT572..894
DH943..1106
KR1383..1558
ACP1660..1730
KS1753..2128
AT2289..2643
dh2691..2849
KR3185..3365
ACP3469..3539

close this sectionSequence

selected fasta
>polyketide synthase [polyketide synthase]
MDNEEKLVEYLKRVTADLRQVRRRLREVEDQQREPIAIIGMSCRFPGGIHTPEDLWDLVA
GGQDAITSFPTDRGWDLDALLDPDPDRPGTSHTRHGAFLHDAPEFDAAFFDIGPSEATAM
DPQQRLLLETSWEAFERAGIDPAALRGSRTGVFVGTNVHDYLTGVRETPQEVEGYLMTGN
TPSVASGRLAYTFGLEGPAVTVDTACSASLVALHLAAHSLRRDECSLALAGGATVMSAPG
AFVEFSRQGGLAADGRCKAFSASADGTGWGEGVGLLLLERLSDAERNGHPILAVVRGSAV
NQDGASNGLTAPNGPSQQRVIRQALADARLSPADVDLVEAHGTGTQLGDPIEAQALLATY
GQDRPEDRPLWLGSVKSNIGHTQAAAGAAGVIKTVMAMRHGVAPQTLHVDEPTPEVDWSA
GAVELLTEARPWPAASAAGRPRRAAVSGFGVSGTNAHVILEQGPEQADTDPLPAQRQPLE
DTVFPWALSARNTDALLGQARRLRERLVVEPGLSAADVAFSLGTVRSSFEQRAVVVGETR
DELLAGLEALAEGREASGLVRGSARGSVNLGFLFSGQGSQRVGMGRELAERFPVFAGVFG
EVCGLLDPLLPRPLGEVIAAGPGVLGRTVFTQPALFAVEVAAARLLLSWGVRPQVVAGHS
VGEIAAAHVAGVLSLEDACALVAARGRLMEALPAGGVMVALEATEEEVAELLEAHAGAPV
GVAAVNGPRAVVVSGDASPVGEIADVVRSWGRRTKRLEVSHAFHSPLMEPMLAEFTDVVT
GLSFSAPRIGFVSAVTGGLVGADVVSRPEYWVEHVAQPVRFADAVRAAVDEAGVSLFVEV
GPGGALSAMGPDCLDETVGDKQPVVFVPSLRADRPEPLAVTTALATAHVNGVQPDWQAVF
AGTGAARVELPTYAFQRRRFWLDGGRYGNGGGVASAGLASAGHPLLGAVVEVAGDDRTLL
SGRLSLASHPWLADHAVRGVVLVPGAAFVELALCAGERVGCGAVEELTLQAPLVLPVEGA
VQVQFAVEAPDERGHRAFTVYGRSDEAAEPVSWQEYASGVLELEARPEPEGLAQWPPADA
EAVPVESLYDLLRGLGYEYGPAFQGLRRVWRRGEELFAEVSLAEELDGQADQFGIHPALL
DGALHTSAVALLEHDDADHREVTGVRLPFAWRGVSLFATGASAARVRLSPAGQDAVSVLV
ADQDGVPVARVEGLVSRPVAEEQLGAGGGVGRDSLFGVEWVPFAGGDSDALAADVLEVHR
FDGLVQDPQGVREAIERALGLIQGWLARERPRGSRLVVVTRGAVGGEVSDLAGAAVWGLV
RSAQSEHPGQFVLVDTDGDALAGLPADEPHVMVREGQVLVPRLARVVPATEGGAGGVVWD
PEKSLLVTGASGVLAGLVVRHAVAEWAVRHVVLVSRSGADGLAQELAEAGVSVQQARCDV
ADREAVAAVLAGIPAEHRLGGVIHTAGVLDDGVIESLTPERLAPVLRPKVDGAWWLHELT
ADVDLSVFAVFSSAAGVFGAAGQGNYAAANAFLDALALYRHREGLPATSLSWGLWAERSG
MAGQLADAQLERLERTGARPLSSSEGLALLDAALATGRPWLVPARLDLGVLRTSDQPVPP
LLRGLVRRITRRAVTAGANGADSFVQRIAGLSPTEAERAVLELVCGETAAVLGHANAGAV
PPGQAFQELGFDSLSAVELRNRLNSATGLRLPATLIFDYPTPAVLAAHIHSATAGTTAGP
IAPLTVPGTAVDEAIAIVGMACRYPGGVASPEDLWRLVADGTDAISRFPQDRGWDLEGLF
DPQRARGTSLTREGGFLYDADQFDAAFFGISPREALAMDPQQRLLLETSWEALERAGIDP
ATLRGSATGVFAGVMYHDYATRILEAPEEVEGYLANGNAGSIASGRVAYTFGLEGPAVTV
DTACSSSLVTLHLAAQALRQGECSLALAGGVTVMATPGTFIEFSRQQGLSSDGRCKSFSA
TADGTGWSEGVGMLILERLSDAERNGHPILAVVRGSAVNQDGASNGLTAPNGPSQQRVIR
QALANARLTPADIDLVEAHGTGTRLGDPIEAQALLATYGQDRTDDQPLWLGSIKSNIGHT
QAAAGVAGIIKAVMAMRHGTLPASLHVDEPTPEVDWDAGAVELLTRARPWPTTDRPRRAA
VSSFGISGTNAHVILEHATDTVPATDLTGTASPLSPAATVVPWVLSARGQDALRAQAQRL
RDSLHDRPDPALADIGLSLATTRGALDDRAVVLGGDRQQMLDGLAALAAGEPSARLVLGQ
ARPRPPRVVFVFPGQGSQWGGMAVELMDTCPVFAESIARCGQALAQVVDWDLEEVLRDGT
FERVDVIQPVLWAVMVSLAELWRACGVRPDAVVGHSQGEIAAACVAGSLSVEDAARVVAL
RSRALLDLAGQGAMASVFASAEQTELLVAEAAGAAGAVGATGATGVTGEADAADREGRLS
VAAVNGPESTVVSGETAAVEAFLDLCERRQIRARRIPVDYASHSAQVEAVADQVREALSG
VTGRTGDVPLFSTVTGEWVDGEALDADYWLRNLRRPVRFHEAVRHLARQGHDLFIEVSPH
PVLTMGLEDSVTAPGQATTPAADPTDTPTTATAPPGVVATLRRDEGDWSRFLASLAEVHA
YGQPVNWAAVLGPARIVDLPTYAFQHRGYWLSDIGGRTPDVAAAGLDPARHPLLGAAVET
AGGEQVLLTGRLSTGTHPWLADHVIGGTALLPVSAFVEMALRAGRHVGLPRLDELTLHTP
LVVSAADVVRLQVQLDPDDGTGRRPVQIFARTADAPWVRHASGTLTGDAPADFGLLVWPP
ADATPLPVEGHYDHLAALGYAYGPSFQALRAAWRDGDDLYAEVALDTSENTADYGLHPIL
LDAAAQTLTLDHRADADTGARMPFAWTGVTLHAPGGGTARVKVSPAGDSAVTIRIADAAG
QPVASVESLVLRPVSLQQIAAASSVTQNSLFLVDWTDIPAGPATTTGDTDRRPVLRSRDE
LEALRRAVADGQPAPALAAFICAAPGATEAPGTDALGNDLAQAVRATTADTLDALRAWLD
DDRLEESRLAIVTCRAVVTGTDGAGAGGLNLAQTPVWGLVRSAQAENPGRFLLVDVDDLD
AVPDVLARLEGPEGPEGLNEPQVAVRGGQFTVPRLVRPATPTPTADTDTAARDLDPDLDR
WNPDGTVLLVGASGGLGQVLARHLVVERGVRRLVLTSRRGEAADGMAELRAELTEAGAVV
DIAACDATDRDALAAVLDAIPERHPLTAVVHAAAVLDDGVVTALTPERLDRVLRPKVDTA
LLLDELTRGLDLGAFVLFSSLSSTLGSPGVANYAAANAFLDGLAQRRRDAGLPATSLAWG
LWAQSGGMGDRLSDADLSRMSSGGVTALTTQEGLALFDRALTLDLPVVVPAKIDLAELRR
LSGDLLPALLRGLVPGTVRTAAQTADVRTAPALAERLAALGEEERARALLDLVRSQAAAV
LGHADVTAVQADTPFRDIGADSLAAVQIRNRLAAATGLRLKATLVFDHPTPAAVARLLLD
ELAPEPTDAQPAVFADLDALEATLAGLTEAGANSGSSDGAGTDDAVRDRVTARLKSLLWK
WTDAQGGGEDMSRPEAGGDTAPVSDDEMFDLIDKELGSL
selected fasta
>polyketide synthase [polyketide synthase]
ATGGACAACGAAGAGAAGCTCGTCGAATACCTCAAGCGGGTCACCGCCGACCTCCGTCAG
GTTCGCCGACGTCTCCGCGAGGTCGAGGACCAGCAGCGGGAACCGATCGCGATCATCGGG
ATGAGCTGCCGCTTCCCCGGCGGCATCCACACCCCCGAGGACCTCTGGGACCTGGTGGCC
GGGGGCCAGGACGCGATCACCTCGTTCCCGACGGACCGGGGATGGGACCTCGACGCGCTC
CTCGACCCCGATCCGGACCGGCCCGGCACGAGCCACACCCGGCACGGCGCGTTCCTGCAC
GACGCGCCCGAGTTCGACGCCGCGTTCTTCGACATCGGGCCGAGCGAGGCGACGGCGATG
GATCCCCAGCAGCGGCTGCTGCTGGAGACCTCCTGGGAGGCGTTCGAACGGGCCGGTATC
GACCCGGCGGCGCTGCGCGGCAGCCGTACCGGTGTCTTCGTCGGCACCAACGTCCACGAC
TACCTCACCGGGGTGCGGGAGACCCCGCAGGAGGTCGAGGGCTACCTGATGACGGGCAAC
ACCCCCAGCGTGGCCTCCGGGCGGCTGGCCTACACGTTCGGTCTGGAGGGGCCGGCGGTC
ACCGTGGACACGGCGTGCTCCGCGTCGCTGGTCGCCCTGCACCTGGCCGCTCATTCGCTG
CGCCGGGACGAGTGCTCGCTGGCGTTGGCCGGAGGCGCGACGGTGATGTCCGCTCCGGGG
GCGTTCGTGGAGTTCAGCAGGCAGGGCGGGCTGGCGGCGGACGGCCGGTGCAAGGCGTTC
TCGGCTTCGGCGGACGGTACGGGCTGGGGCGAGGGCGTCGGTCTGTTGCTGCTGGAGCGG
CTCTCGGACGCCGAACGCAACGGTCACCCGATCCTGGCCGTCGTACGCGGCAGCGCGGTC
AATCAGGACGGCGCCTCGAACGGCCTGACCGCCCCGAACGGCCCCTCCCAGCAACGGGTG
ATCCGCCAGGCCCTGGCCGACGCCCGTCTGTCCCCGGCCGACGTCGACCTTGTCGAGGCC
CACGGCACCGGCACCCAGCTGGGTGACCCGATCGAGGCCCAGGCCCTGCTCGCCACCTAC
GGCCAGGACCGGCCCGAGGACCGGCCGCTGTGGCTGGGGTCGGTGAAGTCGAACATCGGC
CACACCCAGGCCGCGGCCGGAGCCGCCGGGGTGATCAAGACGGTGATGGCGATGCGGCAC
GGTGTCGCGCCGCAGACCCTGCACGTGGACGAGCCGACGCCGGAGGTGGACTGGTCGGCG
GGAGCGGTGGAACTGCTGACCGAGGCGCGGCCTTGGCCCGCAGCGTCGGCAGCGGGGCGT
CCGCGTCGGGCCGCGGTGTCCGGCTTCGGCGTCAGCGGCACCAACGCGCACGTCATCCTC
GAACAGGGCCCGGAGCAGGCGGACACCGATCCACTGCCGGCGCAACGGCAACCGCTCGAA
GACACCGTGTTTCCTTGGGCGTTGTCCGCCCGGAACACCGACGCACTCCTAGGGCAGGCT
CGGAGGTTGCGGGAACGCTTGGTGGTCGAGCCGGGCCTGTCGGCTGCGGATGTGGCGTTT
TCGCTGGGTACCGTCCGTTCGTCGTTCGAGCAGCGTGCGGTGGTGGTCGGGGAGACGCGG
GACGAGCTTCTGGCGGGGCTTGAGGCGTTGGCTGAGGGTCGGGAGGCGTCGGGGCTGGTG
CGTGGTTCGGCCCGGGGCAGCGTGAATCTGGGCTTCCTGTTCTCTGGTCAGGGTTCTCAG
CGGGTTGGTATGGGCCGGGAGTTGGCGGAGCGTTTCCCGGTGTTCGCCGGGGTGTTCGGT
GAGGTGTGCGGGTTGCTGGATCCGTTGCTGCCGAGGCCGTTGGGTGAGGTGATCGCTGCT
GGTCCGGGGGTGTTGGGGCGGACGGTGTTCACGCAGCCGGCGTTGTTCGCGGTGGAGGTG
GCGGCGGCGCGGTTGTTGTTGTCGTGGGGTGTGCGGCCGCAGGTGGTGGCCGGGCATTCG
GTGGGGGAGATCGCGGCGGCGCACGTTGCCGGGGTGTTGTCGCTGGAGGACGCGTGCGCG
CTGGTGGCGGCGCGGGGTCGGTTGATGGAGGCGTTGCCCGCCGGCGGCGTGATGGTGGCT
CTGGAGGCGACCGAGGAGGAGGTCGCGGAGCTGCTGGAGGCTCATGCGGGTGCGCCGGTC
GGCGTGGCAGCGGTGAACGGTCCCCGGGCTGTGGTCGTCTCCGGCGACGCGAGCCCTGTC
GGAGAGATCGCGGATGTGGTGCGCTCGTGGGGGCGTCGTACGAAGCGGCTTGAGGTCTCG
CACGCGTTTCACTCACCGTTGATGGAGCCGATGCTCGCCGAGTTCACCGACGTCGTCACG
GGACTGTCCTTCTCCGCACCCCGGATCGGGTTCGTGTCGGCGGTCACTGGTGGGCTGGTC
GGGGCTGATGTGGTGTCGCGCCCGGAGTACTGGGTGGAGCATGTGGCCCAGCCGGTGCGT
TTCGCGGACGCGGTACGGGCGGCCGTGGACGAGGCGGGTGTGTCGCTGTTCGTCGAGGTG
GGCCCCGGTGGTGCGCTCTCGGCGATGGGTCCGGACTGCCTCGACGAGACCGTCGGGGAC
AAGCAGCCGGTGGTGTTCGTGCCGTCCCTGCGCGCGGACCGTCCCGAGCCGCTGGCGGTG
ACGACTGCGCTGGCGACGGCCCACGTCAACGGCGTCCAGCCCGACTGGCAGGCCGTCTTC
GCCGGCACGGGCGCGGCCCGCGTGGAACTGCCGACCTACGCCTTCCAACGGCGGCGCTTC
TGGCTGGACGGCGGACGCTACGGCAACGGGGGCGGTGTGGCTTCGGCGGGCTTGGCTTCG
GCGGGTCATCCGTTGCTGGGTGCGGTGGTCGAGGTGGCCGGTGATGATCGGACGCTGCTG
AGCGGCCGGTTGTCGTTGGCGTCCCATCCATGGCTGGCCGATCACGCCGTACGAGGTGTC
GTGCTGGTTCCCGGCGCTGCATTTGTCGAACTCGCTCTGTGCGCGGGGGAGCGGGTCGGC
TGTGGCGCGGTGGAGGAGCTGACGCTCCAGGCTCCGCTGGTGTTGCCGGTGGAGGGTGCT
GTTCAGGTCCAGTTCGCGGTGGAGGCGCCGGACGAGCGGGGGCATCGGGCGTTCACGGTG
TACGGACGGTCGGACGAGGCCGCAGAGCCGGTCTCCTGGCAGGAGTACGCCTCGGGTGTG
CTGGAGCTGGAAGCGCGTCCCGAGCCGGAGGGGCTGGCGCAGTGGCCGCCGGCGGACGCC
GAGGCGGTGCCGGTCGAAAGCCTGTACGACCTGCTGCGCGGCTTGGGCTATGAGTACGGT
CCGGCTTTCCAGGGGTTGCGGCGGGTGTGGCGTCGTGGCGAGGAACTCTTCGCGGAGGTC
AGCCTCGCCGAGGAACTGGACGGCCAGGCGGACCAGTTCGGCATCCACCCGGCTCTGCTG
GACGGCGCCCTGCATACCTCGGCGGTGGCTCTGCTGGAGCACGACGATGCCGACCACAGG
GAAGTGACCGGGGTACGTCTGCCGTTCGCCTGGCGGGGTGTGTCCTTGTTCGCGACGGGT
GCGTCCGCGGCCCGTGTGCGGCTGTCCCCGGCGGGGCAGGACGCGGTGTCCGTGCTGGTC
GCCGATCAGGACGGTGTGCCGGTGGCGCGGGTGGAGGGGCTGGTGTCACGGCCCGTCGCG
GAGGAGCAGCTCGGGGCAGGGGGTGGGGTGGGGCGTGACTCGCTGTTCGGTGTGGAGTGG
GTGCCGTTCGCCGGAGGGGACTCCGATGCGCTGGCGGCGGATGTCCTGGAGGTGCATCGT
TTCGACGGCCTCGTGCAGGATCCGCAGGGGGTGCGCGAGGCGATTGAGCGTGCTCTTGGG
CTGATCCAGGGGTGGCTGGCGCGGGAGCGTCCGCGTGGTTCGCGTCTGGTGGTGGTGACG
CGGGGTGCTGTCGGGGGCGAGGTGTCGGACCTGGCGGGTGCGGCGGTGTGGGGTCTGGTG
CGGTCGGCGCAGTCCGAGCACCCGGGTCAGTTCGTGCTCGTCGACACAGACGGGGACGCT
CTTGCGGGTCTGCCCGCGGATGAGCCGCACGTGATGGTGCGTGAGGGTCAGGTGCTGGTC
CCTCGGCTTGCGCGGGTGGTGCCCGCGACGGAGGGCGGCGCCGGTGGTGTCGTATGGGAT
CCGGAGAAGTCCCTGCTGGTGACGGGCGCTTCGGGTGTTCTGGCGGGGCTGGTGGTACGG
CATGCGGTCGCGGAGTGGGCCGTACGGCATGTGGTGCTGGTCAGCCGTAGCGGAGCCGAC
GGGCTGGCTCAGGAACTGGCCGAGGCGGGCGTGTCCGTCCAGCAGGCGCGTTGCGATGTG
GCGGACCGGGAGGCTGTGGCGGCCGTGCTGGCCGGCATCCCCGCGGAACACCGGCTCGGC
GGTGTGATCCACACGGCGGGTGTCCTGGACGACGGCGTGATCGAGTCGCTGACCCCGGAG
CGCTTGGCGCCCGTACTGCGGCCCAAGGTGGACGGCGCCTGGTGGCTGCACGAGCTGACC
GCCGACGTTGACCTGTCGGTGTTCGCGGTGTTCTCCTCCGCGGCCGGTGTGTTCGGCGCG
GCGGGCCAGGGCAACTATGCCGCCGCCAATGCCTTCCTCGACGCCCTCGCCCTGTACCGG
CACCGTGAAGGCCTCCCGGCGACCTCCCTCTCCTGGGGCCTGTGGGCCGAACGCAGCGGT
ATGGCCGGTCAGTTGGCCGACGCCCAGCTCGAACGACTGGAACGTACCGGCGCCCGCCCC
CTCTCCTCCTCCGAGGGACTCGCCCTGCTGGACGCGGCGCTGGCCACGGGCCGCCCCTGG
CTGGTCCCGGCCCGGCTGGACCTCGGTGTGCTGCGGACCTCGGACCAACCGGTCCCGCCC
TTGCTGCGGGGCCTGGTGCGCCGGATCACCCGCCGCGCGGTGACCGCAGGCGCGAACGGC
GCCGACTCCTTCGTGCAGCGGATCGCCGGGCTCTCACCCACGGAGGCCGAGCGAGCGGTC
CTGGAACTGGTGTGCGGCGAGACCGCGGCCGTCCTCGGTCACGCCAACGCCGGCGCTGTC
CCGCCCGGGCAGGCCTTCCAGGAACTCGGCTTCGACTCCCTCTCGGCCGTGGAACTGCGC
AACCGCCTCAACAGCGCCACCGGCCTGCGCCTGCCCGCCACCCTGATCTTCGACTACCCC
ACGCCCGCCGTCCTCGCCGCCCACATCCACTCCGCCACCGCAGGCACCACCGCCGGCCCG
ATCGCACCCCTCACCGTGCCAGGGACCGCCGTCGACGAGGCGATCGCCATCGTCGGGATG
GCGTGCCGTTACCCGGGCGGGGTGGCCTCGCCCGAAGACCTGTGGCGACTCGTCGCGGAC
GGGACGGACGCCATATCCCGCTTCCCCCAGGACCGCGGCTGGGACCTGGAAGGACTCTTC
GATCCGCAGCGGGCCAGAGGCACCAGCCTGACCCGCGAGGGCGGGTTCCTTTACGACGCC
GACCAGTTCGACGCCGCGTTCTTCGGGATCTCCCCCCGCGAGGCCCTCGCCATGGACCCG
CAGCAGCGGCTGCTGCTGGAGACCTCCTGGGAGGCGTTGGAACGGGCGGGCATCGACCCG
GCGACGCTCCGAGGCAGCGCCACCGGCGTCTTCGCCGGCGTCATGTACCACGACTACGCC
ACCCGGATCCTTGAGGCACCCGAGGAGGTCGAGGGCTATCTGGCCAACGGCAACGCGGGC
AGCATCGCCTCCGGACGGGTCGCCTACACCTTCGGTCTCGAAGGACCGGCGGTCACCGTG
GACACCGCCTGCTCCTCCTCCCTCGTCACCCTCCACCTCGCCGCCCAAGCCCTGCGCCAA
GGTGAGTGCTCGCTCGCCCTGGCCGGTGGCGTGACGGTGATGGCCACCCCCGGGACCTTC
ATCGAGTTCTCGCGTCAGCAGGGGCTGTCCTCCGACGGCCGCTGCAAGTCCTTCTCCGCC
ACGGCGGACGGCACCGGCTGGAGCGAGGGCGTCGGCATGCTGATACTCGAACGCCTCTCC
GACGCCGAGCGCAACGGCCACCCGATCCTGGCCGTCGTACGCGGCAGTGCCGTCAATCAG
GACGGCGCGTCGAACGGCCTGACCGCCCCGAACGGCCCCTCCCAGCAACGCGTGATCCGC
CAGGCCCTGGCCAACGCCCGCCTGACCCCCGCCGACATCGACCTCGTCGAGGCCCACGGC
ACCGGCACCCGCCTCGGCGACCCCATCGAGGCCCAGGCCCTGCTCGCCACCTACGGCCAG
GACCGAACCGACGACCAGCCGCTCTGGCTCGGGTCCATCAAGTCCAACATCGGACACACG
CAGGCCGCCGCCGGTGTCGCCGGAATCATCAAGGCCGTCATGGCGATGCGACACGGCACG
CTGCCCGCCAGCCTGCACGTGGACGAGCCCACCCCCGAGGTCGACTGGGACGCCGGAGCG
GTCGAACTCCTCACCCGGGCCCGCCCCTGGCCCACCACCGACCGCCCCCGCCGCGCCGCA
GTCTCCTCCTTCGGTATCAGCGGCACCAACGCCCACGTCATCCTCGAACACGCCACCGAC
ACAGTCCCGGCCACGGACCTGACCGGCACCGCCTCCCCACTGTCCCCCGCCGCCACAGTC
GTCCCCTGGGTGCTCTCCGCCCGAGGCCAGGACGCCCTCCGGGCGCAGGCCCAACGGCTG
CGGGACTCCCTGCACGACCGACCGGACCCGGCCCTCGCCGACATCGGCCTGTCCCTGGCC
ACCACCCGCGGCGCGCTGGACGACCGGGCCGTCGTCCTCGGCGGGGACCGGCAGCAGATG
CTGGACGGGCTGGCCGCCCTCGCGGCCGGTGAACCGTCGGCACGGCTGGTGCTGGGCCAG
GCCCGGCCCCGCCCGCCCAGGGTCGTGTTCGTCTTCCCCGGCCAGGGCTCGCAATGGGGG
GGAATGGCCGTCGAGTTGATGGACACATGTCCGGTGTTCGCCGAGTCGATCGCCCGTTGC
GGGCAGGCGCTCGCCCAGGTCGTGGACTGGGACCTCGAAGAGGTGCTGCGCGACGGCACG
TTCGAGCGGGTCGACGTCATCCAGCCGGTGCTGTGGGCGGTGATGGTGTCGCTGGCCGAG
CTGTGGCGTGCGTGCGGGGTGCGTCCGGACGCCGTCGTGGGCCACTCCCAGGGCGAGATC
GCGGCGGCCTGCGTCGCCGGGTCCCTGTCGGTCGAGGACGCCGCCCGCGTCGTCGCGCTG
CGCAGCCGGGCCCTGCTGGACCTGGCCGGACAAGGAGCCATGGCGTCGGTCTTCGCCTCG
GCCGAGCAGACCGAGCTGCTTGTGGCCGAAGCAGCCGGAGCAGCCGGAGCGGTCGGCGCG
ACCGGCGCGACCGGCGTAACCGGCGAGGCCGATGCGGCCGATCGGGAGGGTCGCCTGTCC
GTCGCGGCCGTGAACGGACCCGAGAGCACGGTCGTCTCCGGGGAGACGGCCGCGGTCGAG
GCATTCCTCGACCTGTGCGAGCGCCGCCAGATCAGGGCCCGGCGCATCCCCGTCGACTAC
GCCTCCCACTCGGCCCAGGTGGAGGCCGTCGCCGACCAGGTCCGCGAGGCCCTGTCGGGA
GTGACGGGCCGTACGGGCGACGTACCGCTGTTCTCCACGGTGACCGGCGAGTGGGTCGAC
GGCGAGGCACTCGACGCCGACTACTGGCTGCGCAACCTGCGCCGACCCGTGCGGTTCCAC
GAGGCGGTGCGGCACCTCGCGCGGCAGGGCCACGACCTGTTCATCGAGGTGAGCCCGCAC
CCCGTACTGACCATGGGGCTCGAGGACAGTGTGACGGCGCCCGGCCAGGCGACCACACCA
GCGGCCGACCCCACGGACACTCCCACGACCGCCACCGCGCCCCCAGGCGTGGTCGCCACC
CTGCGCCGCGACGAGGGCGACTGGTCGCGTTTCCTCGCCTCACTGGCCGAGGTCCACGCG
TACGGGCAGCCGGTGAACTGGGCCGCCGTCCTCGGCCCGGCGCGGATCGTGGACCTGCCG
ACGTACGCCTTCCAACACCGCGGTTACTGGCTGTCGGACATCGGCGGCCGCACCCCGGAC
GTGGCCGCCGCCGGGCTGGATCCCGCGCGGCACCCGCTGCTGGGCGCGGCCGTGGAGACG
GCCGGCGGCGAACAGGTCCTGCTGACCGGCCGACTGTCGACCGGCACCCACCCTTGGCTC
GCCGACCACGTCATCGGCGGCACCGCGCTCCTGCCGGTGTCCGCGTTCGTCGAGATGGCG
CTCCGCGCCGGGCGGCACGTGGGCCTGCCCCGCCTCGACGAACTGACGCTGCACACACCC
CTGGTGGTGTCCGCGGCGGACGTCGTACGGCTTCAGGTGCAGCTCGACCCCGATGACGGA
ACGGGCCGCCGACCGGTGCAGATCTTCGCCCGGACCGCCGACGCCCCATGGGTCCGGCAC
GCCAGCGGCACCCTGACCGGTGACGCCCCCGCCGACTTCGGCCTGCTCGTCTGGCCGCCC
GCCGACGCGACCCCGCTGCCGGTCGAGGGCCACTACGACCACCTCGCCGCCCTCGGCTAC
GCCTACGGCCCGTCCTTCCAGGCCCTGCGCGCGGCCTGGCGCGACGGCGACGACCTGTAC
GCCGAGGTCGCACTGGACACGAGCGAGAACACCGCCGACTACGGCCTCCACCCCATCCTG
CTGGACGCGGCCGCGCAGACCCTCACCCTCGACCACCGGGCCGACGCCGACACCGGCGCC
CGTATGCCGTTCGCCTGGACCGGCGTCACGCTCCACGCGCCCGGCGGCGGTACGGCCCGT
GTGAAGGTGAGCCCCGCCGGGGACTCGGCCGTCACCATCCGGATCGCGGACGCGGCCGGG
CAGCCGGTGGCGTCGGTGGAGTCGCTCGTCCTGCGGCCGGTGTCCCTCCAGCAGATCGCC
GCGGCGAGCAGCGTGACCCAGAACTCCCTGTTCCTGGTCGACTGGACGGACATCCCGGCG
GGCCCCGCGACGACCACCGGCGACACGGACCGGCGGCCCGTGCTGCGCAGCAGGGACGAA
CTGGAAGCACTGCGCAGGGCCGTCGCCGACGGACAGCCGGCACCCGCACTGGCCGCCTTC
ATCTGCGCCGCCCCAGGCGCCACCGAGGCCCCCGGCACTGATGCGCTGGGCAACGACCTC
GCACAGGCGGTCCGCGCCACGACCGCCGACACGCTCGACGCGCTCCGCGCCTGGCTCGAC
GACGACCGGCTGGAGGAGTCCCGCCTCGCGATCGTCACCTGCCGCGCGGTCGTCACCGGC
ACCGACGGGGCCGGGGCCGGGGGCCTCAACCTGGCCCAGACCCCCGTGTGGGGCCTGGTC
CGCTCGGCACAGGCCGAGAACCCGGGGCGGTTCCTCCTCGTCGACGTCGACGACCTCGAC
GCCGTACCCGATGTGCTCGCCCGCCTGGAAGGCCCGGAAGGCCCGGAAGGCCTGAACGAG
CCACAAGTGGCCGTACGCGGCGGACAGTTCACCGTCCCACGCCTCGTCCGTCCCGCCACA
CCGACCCCGACCGCCGACACGGACACCGCCGCCCGCGACCTCGACCCTGACCTCGACCGG
TGGAACCCCGACGGCACGGTCCTCCTCGTCGGCGCCTCCGGCGGGCTGGGGCAGGTGCTG
GCCCGTCACCTGGTCGTCGAGCGAGGTGTCAGGAGGCTGGTTCTCACCAGCCGTCGCGGC
GAGGCCGCCGACGGAATGGCCGAGCTGCGTGCCGAACTCACCGAGGCGGGCGCCGTCGTC
GACATCGCGGCCTGCGACGCCACGGACCGGGACGCGCTCGCCGCCGTACTGGACGCGATA
CCCGAACGGCACCCGCTGACCGCCGTGGTGCACGCCGCCGCCGTGCTCGACGACGGCGTC
GTGACGGCGCTGACCCCCGAACGGCTCGACCGTGTGCTCCGGCCCAAGGTCGACACCGCG
CTCCTGCTGGACGAACTGACACGAGGCCTCGACCTGGGGGCGTTCGTGCTGTTCTCCTCC
CTCTCCAGCACCCTCGGCAGCCCCGGCGTGGCGAACTACGCGGCCGCCAACGCCTTCCTG
GACGGCCTCGCCCAACGCCGCCGCGACGCCGGCCTGCCCGCCACCTCCCTGGCGTGGGGT
CTGTGGGCGCAGAGCGGCGGCATGGGCGACCGGCTGTCCGACGCGGACCTGAGCCGGATG
TCCAGCGGCGGCGTGACGGCGCTGACCACACAGGAGGGGCTGGCCCTGTTCGACCGGGCC
CTCACCCTCGACCTGCCCGTGGTGGTCCCCGCCAAGATCGACCTCGCGGAGCTGCGCAGG
CTCTCCGGCGACCTCCTGCCCGCGCTGCTGCGCGGCCTGGTGCCCGGCACCGTCCGTACG
GCCGCGCAGACTGCGGACGTCCGCACTGCGCCGGCACTCGCCGAACGCCTCGCCGCACTG
GGCGAGGAGGAACGGGCACGGGCGCTGCTGGACCTCGTACGCAGTCAGGCGGCCGCCGTG
CTCGGCCACGCCGACGTCACCGCCGTACAGGCCGACACCCCCTTCCGGGACATCGGCGCC
GACTCGCTGGCCGCCGTGCAGATCCGCAACCGGCTGGCGGCGGCGACCGGCCTGCGCCTG
AAGGCGACGCTCGTCTTCGACCATCCGACGCCCGCCGCGGTCGCCCGTCTGCTTCTCGAC
GAGCTGGCCCCGGAGCCCACCGACGCGCAGCCCGCGGTCTTCGCCGACCTCGACGCCCTG
GAGGCCACGCTCGCCGGCCTCACCGAAGCCGGTGCCAACTCCGGTTCCAGCGACGGTGCC
GGTACTGACGACGCCGTACGCGACCGCGTCACCGCACGGCTGAAGTCGCTGCTGTGGAAG
TGGACCGACGCCCAGGGCGGTGGCGAGGACATGAGCCGTCCGGAGGCGGGCGGCGACACC
GCGCCCGTCAGCGACGACGAGATGTTCGACCTCATCGACAAGGAACTCGGATCCCTCTGA
[9] KS34..410
[9] AT572..894
[9] malonyl-CoA761..765
[9] DH943..1106
[9] KR1383..1558
[9] ACP1660..1730
[10] KS1753..2128
[10] AT2289..2643
[10] methylmalonyl-CoA2500..2504
[10] dh2691..2849
[10] KR3185..3365
[10] ACP3469..3539
[9] KS100..1230
[9] AT1714..2682
[9] malonyl-CoA2281..2295
[9] DH2827..3318
[9] KR4147..4674
[9] ACP4978..5190
[10] KS5257..6384
[10] AT6865..7929
[10] methylmalonyl-CoA7498..7512
[10] dh8071..8547
[10] KR9553..10095
[10] ACP10405..10617

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR001227 Acyl transferase domain (Domain)
[563-692] G3DSA:3.40.366.10 [761-882] G3DSA:3.40.366.10 [2280-2408] G3DSA:3.40.366.10 [2500-2633] G3DSA:3.40.366.10
G3DSA:3.40.366.10   Ac_transferase_reg
IPR006162 Phosphopantetheine attachment site (PTM)
[1688-1703] PS00012 [3497-3512] PS00012
PS00012   PHOSPHOPANTETHEINE
IPR009081 Acyl carrier protein-like (Domain)
[1653-1769] 2.800005042611e-27 SSF47336 [3460-3546] 3.0999994589937e-23 SSF47336
SSF47336   ACP_like
[1658-1732] 3.7e-44 G3DSA:1.10.1200.10 [3467-3543] 3.7e-44 G3DSA:1.10.1200.10
G3DSA:1.10.1200.10   ACP_like
[1660-1730] PS50075 [3469-3539] PS50075
PS50075   ACP_DOMAIN
[1665-1729] 9.40000000000003e-11 PF00550 [3472-3538] 4.80000000000001e-12 PF00550
PF00550   PP-binding
IPR013968 Polyketide synthase, KR (Domain)
[1385-1557] 1.99999999999999e-55 PF08659 [3185-3364] 6.90000000000001e-59 PF08659
PF08659   KR
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[34-284] 1.9e-95 PF00109 [1753-2002] 4.40000000000003e-97 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[292-410] 1.80000000000002e-50 PF02801 [2010-2128] 1.80000000000002e-50 PF02801
PF02801   Ketoacyl-synt_C
IPR014043 Acyl transferase (Domain)
[572-894] 5.89999999999994e-62 PF00698 [2289-2643] 8.80000000000003e-97 PF00698
PF00698   Acyl_transf_1
IPR015083 Polyketide synthase, docking (Domain)
[1-27] 1.8e-13 PF08990
PF08990   Docking
[4-34] 1.40000045763982e-07 SSF101173
SSF101173   Polyketide_synth_docking
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
[569-857] 2.99998750445706e-67 SSF52151 [2287-2609] 3.60002015031011e-69 SSF52151
SSF52151   Acyl_Trfase/lysoPlipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
[694-760] 2.89999717862184e-15 SSF55048 [2431-2499] 1.89999859865864e-14 SSF55048
SSF55048   Malonyl_transacylase_ACP-bd
IPR016038 Thiolase-like, subgroup (Domain)
[33-295] G3DSA:3.40.47.10 [296-466] G3DSA:3.40.47.10 [1752-2013] G3DSA:3.40.47.10 [2014-2179] G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[26-408] 2.1000026783403e-104 SSF53901 [1752-2180] 3.19999899046355e-106 SSF53901
SSF53901   Thiolase-like
IPR016040 NAD(P)-binding domain (Domain)
[1383-1565] 1.79999999999997e-70 G3DSA:3.40.50.720 [3185-3368] 3.2e-64 G3DSA:3.40.50.720
G3DSA:3.40.50.720   NAD(P)-bd
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[197-213] PS00606 [1915-1931] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
[573-874] 5.6999970878395e-116 SM00827 [2291-2625] 1.50000965748778e-114 SM00827
SM00827   PKS_AT
IPR020806 Polyketide synthase, phosphopantetheine-binding domain (Domain)
[1661-1733] 2.30000440726534e-33 SM00823 [3470-3542] 1.10000150671642e-31 SM00823
SM00823   PKS_PP
IPR020807 Polyketide synthase, dehydratase domain (Domain)
[943-1106] 7.19996395544006e-80 SM00826 [2691-2849] 1.59998835313644e-78 SM00826
SM00826   PKS_DH
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain (Domain)
[36-465] SM00825 [1755-2180] SM00825
SM00825   PKS_KS
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
[1383-1558] 1.3000049540733e-51 SM00822 [3185-3365] 1.70000295590053e-60 SM00822
SM00822   PKS_KR
SignalP No significant hit
TMHMM No significant hit
FD891_00030 FD891_00030   FD891_00050 FD891_00050
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