Lydi_00030 Lydi_00030   Lydi_00050 Lydi_00050

Lydi_00040 : CDS information

close this sectionLocation

Organism
StrainTP-A0598 (=NBRC 110027)
Entry nameLydicamycin
Contig
Start / Stop / Direction7,438 / 9,336 / + [in whole cluster]
7,438 / 9,336 / + [in contig]
Location7438..9336 [in whole cluster]
7438..9336 [in contig]
TypeCDS
Length1,899 bp (632 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category5.1 general function
Productputative two-component system histidine kinase
Product (GenBank)putative two-component histidine kinase
GeneTPA0598_03_00680
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[26380643] Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins. (Stand Genomic Sci. , 2015)
comment
Streptomyces sp. TP-A0598におけるputative lydicamycin biosynthetic gene clusterの報告。
このclusterが実際にlydicamycin産生に関わるかどうかの実験的な確認はされていない。

TPA0598_03_00680(632aa): two-component system histidine kinase

本文中にコメントなし。
Family/Domain
FD
IPR011712
comment
[IPR011712] Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain (Domain)

Molecular Function
GO:0000155 phosphorelay sensor kinase activity
GO:0046983 protein dimerization activity
FD
IPR003594
comment
[IPR003594] ATPase-like, ATP-binding domain (Domain)
現在のentry nameはHistidine kinase-like ATPase, C-terminal domain

close this sectionSequence

selected fasta
>putative two-component system histidine kinase [putative two-component histidine kinase]
MFGRHLWAPLRGLVLFGLGLTAGPMLAAIGLGMLFGIQSLAQWYRDPLNVYRTFAGRWCG
VDIPVPYQPPPPPPEPEPDGWYRYKNRLYLTPKKLSYERRWDWLVKDPATSRDILWMLIN
PIAGSFTALLPLTLVVVGATSPWYWPGHPGITVPVAVATALAGFGFGPALLHLHGRWTCQ
LLASAADSGIRRALIRIGRGGLATWRLALTAGLAVAELAAALMHLLAMVPILLWAWPTVL
VAGRQLTSWRRQQIQEWTGIRIDRPYLPEPVLPPPRPDGTYQIGRTLYRTPEMALRSLRY
RQNARDLATWRDLLWLLLDPVVGVLLAAVPVLVTGYCFFGLIWSWAWASLLQLFVDFHTF
ESWPLLTRGVPVLGDYPIATAPLIGVVGTLTGSLLAIPLLRLHGLWSWLLLGPTKSALLG
RRVDQLTETRMEARETLSSELRRIERDLHDGAQAQWVAMGMKLGAIEALIERDPAAAKTM
VGTAREASAKALIELRHLIRGINPPVLAERGIADAIRGLALDSPLSVGLRIELPGRPERP
VESAAYFAVSELLTNVSKHADAGRVHIDVRYTANQLRIALTDNGVGGADPAKGSGLRGVQ
RRLATFDGSLAVHSPLGGPTTVTLEIPCVLSS
selected fasta
>putative two-component system histidine kinase [putative two-component histidine kinase]
ATGTTCGGACGGCACCTCTGGGCGCCCCTGCGCGGCCTTGTGCTCTTCGGGCTGGGACTC
ACCGCCGGGCCGATGCTGGCCGCCATCGGCCTCGGCATGCTCTTCGGCATCCAGTCGCTT
GCCCAGTGGTACCGCGATCCGCTCAACGTCTACCGCACCTTCGCCGGCCGGTGGTGCGGG
GTGGACATCCCGGTGCCGTACCAGCCCCCGCCGCCACCACCCGAACCCGAACCCGACGGC
TGGTACCGCTACAAGAACCGGCTCTACCTGACCCCGAAGAAGCTCTCCTACGAACGGCGC
TGGGACTGGCTGGTCAAGGACCCGGCCACCTCCCGGGACATCCTCTGGATGCTGATCAAC
CCCATCGCCGGAAGCTTCACGGCGCTGCTGCCGCTCACCCTGGTCGTGGTGGGCGCCACC
TCCCCGTGGTACTGGCCCGGACACCCCGGAATCACCGTCCCGGTCGCCGTGGCGACGGCA
CTGGCCGGCTTCGGGTTCGGGCCGGCCCTGCTCCATCTGCACGGCCGCTGGACCTGCCAA
CTCCTCGCGTCCGCCGCCGACTCCGGAATACGCCGTGCGCTGATCCGGATCGGCCGTGGG
GGGCTCGCCACCTGGCGGCTGGCCCTGACCGCCGGGCTCGCGGTCGCCGAACTGGCCGCC
GCCCTCATGCATCTGCTGGCGATGGTGCCGATCCTGCTGTGGGCCTGGCCGACCGTGCTG
GTCGCCGGCCGGCAGCTCACCTCCTGGCGCCGGCAGCAGATCCAGGAGTGGACCGGCATC
CGGATCGACCGGCCCTATCTGCCCGAACCGGTGCTGCCACCACCCCGGCCCGACGGCACG
TACCAGATCGGCCGCACGCTGTACCGCACCCCGGAGATGGCGCTGCGGTCCCTGCGGTAC
CGGCAGAACGCCCGGGACCTGGCCACTTGGCGGGACCTGCTGTGGCTGCTGCTCGACCCG
GTCGTGGGGGTGCTGCTCGCCGCGGTCCCCGTGCTGGTCACCGGATACTGCTTCTTCGGC
CTGATCTGGTCCTGGGCCTGGGCCTCGCTGCTTCAGCTCTTCGTCGACTTCCACACCTTC
GAGAGCTGGCCCCTGCTGACCCGTGGCGTCCCGGTCCTCGGCGACTACCCGATCGCCACC
GCCCCCCTGATCGGTGTGGTCGGCACCCTGACCGGCAGTCTGCTCGCCATCCCGCTGCTG
CGGCTGCACGGCCTGTGGAGCTGGCTCCTGCTCGGGCCCACCAAGTCGGCGCTGCTCGGC
CGCCGGGTGGACCAGCTCACCGAGACCCGGATGGAGGCCCGGGAGACCCTCTCTTCGGAG
CTGCGCCGGATCGAACGCGATCTGCACGACGGGGCGCAGGCGCAGTGGGTGGCCATGGGG
ATGAAACTCGGCGCCATCGAGGCCCTCATCGAACGGGACCCGGCTGCTGCCAAGACGATG
GTCGGGACCGCCAGGGAAGCCTCCGCGAAGGCGCTCATCGAGTTACGCCATCTGATCCGC
GGCATCAACCCGCCGGTGCTCGCCGAACGCGGTATCGCGGACGCCATCCGCGGACTGGCC
CTGGACTCGCCGCTCTCCGTCGGTCTGCGGATCGAGCTGCCCGGCCGTCCCGAGCGCCCG
GTCGAATCCGCCGCCTATTTCGCGGTGTCCGAACTGCTCACCAATGTTTCCAAACACGCC
GACGCGGGCCGTGTGCACATCGATGTGCGCTACACGGCGAACCAGCTGCGGATCGCGCTC
ACCGACAACGGGGTCGGGGGCGCCGATCCGGCGAAGGGCAGCGGGCTGCGCGGCGTCCAG
CGGCGGCTCGCTACCTTCGACGGAAGTCTCGCCGTGCACAGTCCACTCGGCGGCCCCACC
ACAGTCACTCTGGAGATTCCGTGCGTGTTGTCCTCGTAG

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09 		show BLAST table
InterPro
Database:interpro:38.0
IPR003594 ATPase-like, ATP-binding domain (Domain)
[512-631] 2e-15 SSF55874
SSF55874   ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
[545-627] 1.8e-09 PF02518
PF02518   HATPase_c
[548-628] 1.4e-07 G3DSA:3.30.565.10
G3DSA:3.30.565.10   no description
[540-630] 0.0091 SM00387
SM00387   Histidine kinase-like ATPases
IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain (Domain)
[440-507] 6.6e-13 PF07730
PF07730   HisKA_3
IPR025828 Putative sensor domain (Domain)
[12-178] 1.5e-10 PF13796 [210-411] 1.1e-13 PF13796
PF13796   Sensor
SignalP No significant hit
TMHMM
[15-37] Transmembrane (o-i) [114-136] Transmembrane (i-o) [151-173] Transmembrane (o-i) [194-216] Transmembrane (i-o) [221-243] Transmembrane (o-i) [313-347] Transmembrane (i-o) [378-400] Transmembrane (o-i)
Transmembrane 7   
Lydi_00030 Lydi_00030   Lydi_00050 Lydi_00050
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