Tautomycin : Cluster information
Compound
| Entry name | Tautomycin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | isobutyryl-CoA |
| Chain Length | 13 |
| Sugar Unit | none |
| Classification | Tetronic Acid Derivative |
| Activity | Antibacterial Antifungal Antitumor |
| Composition | C41H66O13 |
Original source
| Organism | Streptomyces spiroverticillatus |
|---|---|
| Strain | |
| Contig | EF990140 |
PKS/NRPS Module
| Tauto_00110 ttmJ | 0 |  | |
| 1 |  | methoxymalonyl-ACP | |
| 2 |  | malonyl-CoA | |
| 3 |  | methylmalonyl-CoA | |
| 4 | | malonyl-CoA | |
| 5 |  | methylmalonyl-CoA | |
| 6 | | methylmalonyl-CoA | |
| Tauto_00100 ttmI | 7 | | malonyl-CoA |
| 8 |  | malonyl-CoA | |
| 9 | | methylmalonyl-CoA | |
| Tauto_00090 ttmH | 10 | | malonyl-CoA |
| 11 | | methylmalonyl-CoA | |
| 12 |  | malonyl-CoA |
Reference
- Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.
- Li W, Ju J, Osada H, Shen B[PMID: 16707708]J Bacteriol. 188 (2006) 4148-52
- Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.
- Li W, Ju J, Rajski SR, Osada H, Shen B[PMID: 18708355]J Biol Chem. 283 (2008) 28607-17
- Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.
- Ju J, Li W, Yuan Q, Peters NR, Hoffmann FM, Rajski SR, Osada H, Shen B[PMID: 19281218]Org Lett. 11 (2009) 1639-42
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Tautomycin |
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History
- 2012-06-04[Release]
