遺伝子 : Dihydrofolate reductase FolM (FOLM)

遺伝子情報

ID	NRULE_0146
遺伝子ID	FOLM
作成日	2013/02/20
タンパク質名	Protein name Full Dihydrofolate reductase FolM Short DHFR EC EC 1.5.1.3
遺伝子名	folM
遺伝子条件	BLASTP; P0AFS3; hit=1; score=600; pid=62
参照	Gene Ontology GO GO:0004146, F:dihydrofolate reductase activity, IEA:EC GO:0071172, F:dihydromonapterin reductase activity, IDA:EcoCyc GO:0000166, F:nucleotide binding, IEA:InterPro GO:0009257, P:10-formyltetrahydrofolate biosynthetic process, IGI:EcoCyc GO:0046656, P:folic acid biosynthetic process, IGI:EcoCyc GO:0006730, P:one-carbon metabolic process, IEA:UniProtKB-KW Phylogenomic databases KO K13938, - Family and domain databases InterPro IPR002198, DH_sc/Rdtase_SDR IPR002347, Glc/ribitol_DH IPR020904, Sc_DH/Rdtase_CS Pfam PF00106, adh_short, 1 PRINTS PR00081, GDHRDH PROSITE PS00061, ADH_SHORT, 1
配列の特徴	P0AFS3 Escherichia coli (strain K12). ACT_SITE 152 Proton acceptor (By similarity).
注釈	Function Catalyzes the reduction of dihydrofolate to tetrahydrofolate Catalytic activity 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + NADPH Sequence similarities Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily
参考文献	P0AFS3 Escherichia coli (strain K12). 14617668 FolM, a new chromosomally encoded dihydrofolate reductase in Escherichia coli. (J Bacteriol. 2003)

関与する機能

機能名
Folate biosynthesis

該当CDS

学名	NBRC番号	CDS	タンパク質名
Enterobacter aerogenes	13534	EAE_18090	dihydromonapterin reductase
Enterobacter cloacae subsp. cloacae	13535	ECL_02267	short chain dehydrogenase
Enterobacter hormaechei	105718	HMPREF9086_0413	short chain dehydrogenase/reductase family oxidoreductase
Escherichia coli	3972	EcolC_2024	short-chain dehydrogenase/reductase SDR
Escherichia coli	13500	WFL_08675	dihydromonapterin reductase
Escherichia coli	12713	Y75_1602	dihydrofolate reductase isozyme
Escherichia fergusonii	102419	EFER_1431	dihydrofolate reductase isozyme
Escherichia hermannii	105704	EH105704_05_00380	dihydrofolate reductase FolM
Klebsiella pneumoniae	14438	KPR_2820
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_3011	oxidoreductase, short chain dehydrogenase/reductase family protein
Serratia odorifera	102598	HMPREF0758_3637	oxidoreductase, short chain dehydrogenase/reductase family protein
Shimwellia blattae	105725	EB105725_05_02010	dihydrofolate reductase FolM