遺伝子 : Histidine decarboxylase proenzyme (HDCA)

遺伝子情報

ID	NRULE_0244
遺伝子ID	HDCA
作成日	2013/10/08
タンパク質名	Protein name Full Histidine decarboxylase proenzyme EC EC 4.1.1.22 Synonym Full Pi chain
遺伝子名	hdcA, hdc
遺伝子条件	PFAM; PF02329; hit=1
参照	Gene Ontology GO GO:0004398, F:histidine decarboxylase activity, IEA:EC GO:0006547, P:histidine metabolic process, IEA:InterPro Enzyme and pathway databases BioCyc MetaCyc:MONOMER-14628, - Family and domain databases InterPro IPR016106, Pyr-dep_his-deCO2ase_subdom IPR016104, Pyr-dep_his/arg-deCO2ase IPR016105, Pyr-dep_his/arg-deCO2ase_sand IPR016004, Pyr-dep_his_deCO2ase_PI_Gm-pos IPR003427, Pyruvoyl-dep_his_de-COase_PI Pfam PF02329, HDC, 1 PIRSF PIRSF001341, His_decarboxylas, 1 ProDom PD024462, Pyruvoyl-dep_his_de-COase_PI, 1 TIGRFAMs TIGR00541, hisDCase_pyru, 1
配列の特徴	P00862 Lactobacillus sp. (strain 30a). ACT_SITE 198 Proton donor. BINDING 64 Substrate. BINDING 82 Substrate. SITE 82 - 83 Cleavage (non-hydrolytic). MOD_RES 83 Pyruvic acid (Ser).
注釈	Catalytic activity L-histidine = histamine + CO(2) Cofactor Pyruvoyl group Subunit structure The proenzyme is a hexamer of identical pi chains; each pi chain monomer is cleaved to form a small (or beta) chain and a large (or alpha) chain by non-hydrolytic self-catalysis
参考文献	P00862 Lactobacillus sp. (strain 30a). 3021766 Cloning and nucleotide sequence of wild type and a mutant histidine decarboxylase from Lactobacillus 30a. (J Biol Chem. 1986) 8464063 Refined structure of the pyruvoyl-dependent histidine decarboxylase from Lactobacillus 30a. (J Mol Biol. 1993) 11243783 pH-induced structural changes regulate histidine decarboxylase activity in Lactobacillus 30a. (J Mol Biol. 2001)

関与する機能

機能名
Histamine biosynthesis

該当CDS

学名	NBRC番号	CDS	タンパク質名
Bacteroides vulgatus	14291	BVU_0329	putative histidine decarboxylase
Labrenzia aggregata	16684	SIAM614_11398	histidine decarboxylase
Lactobacillus fructivorans	13954	LACFR_08_01950	pyruvoyl dependent histidine decarboxylase
Lactobacillus reuteri	15892	LAR_1717	histidine decarboxylase